Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H5A0_LEIBR

TriTrypDb:

LbrM.08.0340 , LBRM2903_080008300

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.311
CLV_NRD_NRD_1	180	182	PF00675	0.253
CLV_NRD_NRD_1	216	218	PF00675	0.269
CLV_NRD_NRD_1	236	238	PF00675	0.438
CLV_NRD_NRD_1	38	40	PF00675	0.294
CLV_PCSK_KEX2_1	164	166	PF00082	0.311
CLV_PCSK_KEX2_1	180	182	PF00082	0.247
CLV_PCSK_KEX2_1	232	234	PF00082	0.567
CLV_PCSK_KEX2_1	236	238	PF00082	0.567
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.548
CLV_PCSK_SKI1_1	136	140	PF00082	0.257
CLV_PCSK_SKI1_1	39	43	PF00082	0.395
CLV_PCSK_SKI1_1	45	49	PF00082	0.322
CLV_Separin_Metazoa	161	165	PF03568	0.511
DEG_Nend_UBRbox_2	1	3	PF02207	0.448
DEG_SIAH_1	14	22	PF03145	0.459
DOC_CKS1_1	109	114	PF01111	0.424
DOC_CYCLIN_yClb3_PxF_3	108	114	PF00134	0.485
DOC_MAPK_gen_1	116	123	PF00069	0.585
DOC_MAPK_gen_1	164	171	PF00069	0.483
DOC_MAPK_gen_1	180	188	PF00069	0.426
DOC_MAPK_gen_1	217	225	PF00069	0.521
DOC_MAPK_MEF2A_6	217	225	PF00069	0.395
DOC_PP4_FxxP_1	216	219	PF00568	0.491
DOC_PP4_FxxP_1	231	234	PF00568	0.678
DOC_USP7_UBL2_3	218	222	PF12436	0.384
DOC_USP7_UBL2_3	56	60	PF12436	0.511
DOC_WW_Pin1_4	108	113	PF00397	0.461
LIG_14-3-3_CanoR_1	20	28	PF00244	0.454
LIG_14-3-3_CanoR_1	236	244	PF00244	0.524
LIG_14-3-3_CanoR_1	30	38	PF00244	0.554
LIG_14-3-3_CanoR_1	39	48	PF00244	0.450
LIG_Actin_WH2_2	149	166	PF00022	0.511
LIG_APCC_ABBA_1	74	79	PF00400	0.511
LIG_FHA_1	198	204	PF00498	0.441
LIG_FHA_1	44	50	PF00498	0.212
LIG_FHA_1	65	71	PF00498	0.489
LIG_FHA_2	156	162	PF00498	0.531
LIG_LIR_Apic_2	213	219	PF02991	0.560
LIG_LIR_Gen_1	84	92	PF02991	0.457
LIG_LIR_Nem_3	192	197	PF02991	0.574
LIG_LIR_Nem_3	84	88	PF02991	0.451
LIG_SH2_CRK	206	210	PF00017	0.412
LIG_SH2_CRK	85	89	PF00017	0.537
LIG_SH2_SRC	129	132	PF00017	0.505
LIG_SH2_STAP1	206	210	PF00017	0.412
LIG_SH2_STAT5	129	132	PF00017	0.515
LIG_SH2_STAT5	85	88	PF00017	0.456
LIG_SH3_3	106	112	PF00018	0.518
LIG_SH3_3	22	28	PF00018	0.619
LIG_SH3_3	89	95	PF00018	0.553
LIG_SH3_4	218	225	PF00018	0.448
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.511
LIG_UBA3_1	188	193	PF00899	0.508
MOD_CK1_1	192	198	PF00069	0.494
MOD_CK1_1	9	15	PF00069	0.527
MOD_CK2_1	155	161	PF00069	0.515
MOD_GlcNHglycan	194	197	PF01048	0.414
MOD_GlcNHglycan	33	36	PF01048	0.565
MOD_GSK3_1	235	242	PF00069	0.574
MOD_GSK3_1	39	46	PF00069	0.331
MOD_GSK3_1	5	12	PF00069	0.587
MOD_GSK3_1	64	71	PF00069	0.521
MOD_NEK2_1	10	15	PF00069	0.467
MOD_NEK2_1	189	194	PF00069	0.527
MOD_NEK2_1	197	202	PF00069	0.383
MOD_NEK2_1	64	69	PF00069	0.511
MOD_PKA_1	39	45	PF00069	0.294
MOD_PKA_2	235	241	PF00069	0.533
MOD_PKA_2	68	74	PF00069	0.426
MOD_Plk_1	23	29	PF00069	0.655
MOD_Plk_1	5	11	PF00069	0.411
MOD_Plk_4	117	123	PF00069	0.478
MOD_ProDKin_1	108	114	PF00069	0.461
TRG_ENDOCYTIC_2	102	105	PF00928	0.470
TRG_ENDOCYTIC_2	206	209	PF00928	0.415
TRG_ENDOCYTIC_2	85	88	PF00928	0.537
TRG_ER_diArg_1	163	165	PF00400	0.511
TRG_ER_diArg_1	180	182	PF00400	0.511
TRG_ER_diArg_1	235	237	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	73%	100%
A0A0N1HWD2	Leptomonas seymouri	34%	100%
A0A0N1I400	Leptomonas seymouri	42%	100%
A0A0N1IAK4	Leptomonas seymouri	52%	100%
A0A0S4IVV9	Bodo saltans	32%	100%
A0A1X0NQH8	Trypanosomatidae	39%	100%
A0A3S5H641	Leishmania donovani	75%	100%
A0A3S5H642	Leishmania donovani	50%	100%
A0A3S5IQS6	Trypanosoma rangeli	37%	100%
A0A3S7WQ71	Leishmania donovani	41%	82%
A0JME6	Danio rerio	32%	100%
A4H5A1	Leishmania braziliensis	39%	85%
A4H5A2	Leishmania braziliensis	54%	100%
A4H6S1	Leishmania braziliensis	33%	100%
A4HTI1	Leishmania infantum	75%	100%
A4HTI2	Leishmania infantum	40%	82%
A4HTI3	Leishmania infantum	50%	100%
A4HV50	Leishmania infantum	32%	100%
B5X0W9	Salmo salar	37%	89%
D0VWV0	Leishmania donovani	32%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	92%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
P85094	Mus musculus	34%	100%
Q08C33	Danio rerio	35%	89%
Q32KX0	Bos taurus	31%	100%
Q4QGT7	Leishmania major	32%	100%
Q4QID7	Leishmania major	51%	100%
Q4QID8	Leishmania major	40%	81%
Q4QID9	Leishmania major	76%	100%
Q4R826	Macaca fascicularis	31%	100%
Q54NZ8	Dictyostelium discoideum	29%	100%
Q54RC7	Dictyostelium discoideum	28%	100%
Q5U3Z3	Rattus norvegicus	32%	100%
Q6DF67	Xenopus tropicalis	32%	100%
Q9DCC7	Mus musculus	31%	100%