Putative ribosomal protein L2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L2, putative

Species:

Leishmania braziliensis

UniProt:

A4H598_LEIBR

TriTrypDb:

LbrM.08.0320 , LBRM2903_080008100

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4H598

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H598

PDB structure(s): 7aih_BL , 7ane_BL

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.506
CLV_NRD_NRD_1	213	215	PF00675	0.454
CLV_NRD_NRD_1	3	5	PF00675	0.529
CLV_NRD_NRD_1	324	326	PF00675	0.248
CLV_NRD_NRD_1	58	60	PF00675	0.515
CLV_PCSK_KEX2_1	181	183	PF00082	0.480
CLV_PCSK_KEX2_1	200	202	PF00082	0.564
CLV_PCSK_KEX2_1	213	215	PF00082	0.435
CLV_PCSK_KEX2_1	3	5	PF00082	0.529
CLV_PCSK_KEX2_1	324	326	PF00082	0.248
CLV_PCSK_KEX2_1	338	340	PF00082	0.248
CLV_PCSK_KEX2_1	356	358	PF00082	0.187
CLV_PCSK_KEX2_1	58	60	PF00082	0.489
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.483
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.285
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.176
CLV_PCSK_PC7_1	334	340	PF00082	0.280
CLV_PCSK_SKI1_1	174	178	PF00082	0.569
CLV_PCSK_SKI1_1	216	220	PF00082	0.490
CLV_PCSK_SKI1_1	59	63	PF00082	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.508
DOC_CKS1_1	373	378	PF01111	0.606
DOC_CYCLIN_RxL_1	1	10	PF00134	0.600
DOC_MAPK_gen_1	213	221	PF00069	0.392
DOC_MAPK_MEF2A_6	106	115	PF00069	0.605
DOC_PP1_RVXF_1	2	9	PF00149	0.453
DOC_PP2B_LxvP_1	304	307	PF13499	0.462
DOC_PP2B_LxvP_1	54	57	PF13499	0.629
DOC_USP7_MATH_1	49	53	PF00917	0.604
DOC_USP7_UBL2_3	200	204	PF12436	0.402
DOC_USP7_UBL2_3	350	354	PF12436	0.480
DOC_WW_Pin1_4	117	122	PF00397	0.564
DOC_WW_Pin1_4	133	138	PF00397	0.529
DOC_WW_Pin1_4	145	150	PF00397	0.545
DOC_WW_Pin1_4	367	372	PF00397	0.505
DOC_WW_Pin1_4	38	43	PF00397	0.674
LIG_14-3-3_CanoR_1	213	219	PF00244	0.458
LIG_14-3-3_CanoR_1	357	362	PF00244	0.461
LIG_14-3-3_CanoR_1	405	410	PF00244	0.620
LIG_APCC_ABBA_1	102	107	PF00400	0.515
LIG_CSL_BTD_1	134	137	PF09270	0.531
LIG_deltaCOP1_diTrp_1	133	138	PF00928	0.529
LIG_deltaCOP1_diTrp_1	153	157	PF00928	0.545
LIG_FHA_1	110	116	PF00498	0.570
LIG_FHA_1	256	262	PF00498	0.467
LIG_FHA_1	287	293	PF00498	0.462
LIG_FHA_1	353	359	PF00498	0.462
LIG_FHA_1	42	48	PF00498	0.659
LIG_FHA_2	373	379	PF00498	0.607
LIG_FHA_2	406	412	PF00498	0.520
LIG_HCF-1_HBM_1	122	125	PF13415	0.627
LIG_LIR_Nem_3	133	138	PF02991	0.529
LIG_LIR_Nem_3	146	150	PF02991	0.521
LIG_LIR_Nem_3	153	157	PF02991	0.477
LIG_LIR_Nem_3	217	221	PF02991	0.372
LIG_LIR_Nem_3	235	239	PF02991	0.382
LIG_LIR_Nem_3	92	98	PF02991	0.528
LIG_LIR_Nem_3	99	105	PF02991	0.517
LIG_MYND_1	299	303	PF01753	0.448
LIG_Pex14_1	392	396	PF04695	0.425
LIG_Pex14_2	218	222	PF04695	0.364
LIG_PTB_Apo_2	223	230	PF02174	0.387
LIG_PTB_Apo_2	242	249	PF02174	0.496
LIG_PTB_Phospho_1	223	229	PF10480	0.390
LIG_SH2_CRK	147	151	PF00017	0.537
LIG_SH2_CRK	236	240	PF00017	0.407
LIG_SH2_GRB2like	224	227	PF00017	0.396
LIG_SH2_NCK_1	244	248	PF00017	0.438
LIG_SH2_SRC	224	227	PF00017	0.396
LIG_SH2_STAP1	125	129	PF00017	0.586
LIG_SH2_STAP1	98	102	PF00017	0.514
LIG_SH2_STAT3	330	333	PF00017	0.441
LIG_SH2_STAT5	117	120	PF00017	0.570
LIG_SH2_STAT5	147	150	PF00017	0.556
LIG_SH2_STAT5	162	165	PF00017	0.411
LIG_SH2_STAT5	229	232	PF00017	0.361
LIG_SH2_STAT5	396	399	PF00017	0.391
LIG_SH2_STAT5	98	101	PF00017	0.506
LIG_SH3_3	115	121	PF00018	0.587
LIG_SH3_3	343	349	PF00018	0.448
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.617
LIG_SUMO_SIM_par_1	257	263	PF11976	0.448
LIG_SUMO_SIM_par_1	302	308	PF11976	0.448
LIG_TRAF2_1	340	343	PF00917	0.513
LIG_TRFH_1	75	79	PF08558	0.708
LIG_TYR_ITIM	234	239	PF00017	0.374
MOD_CK1_1	15	21	PF00069	0.537
MOD_CK1_1	337	343	PF00069	0.505
MOD_CK1_1	38	44	PF00069	0.565
MOD_CK2_1	15	21	PF00069	0.657
MOD_CK2_1	257	263	PF00069	0.462
MOD_CK2_1	337	343	PF00069	0.513
MOD_Cter_Amidation	322	325	PF01082	0.248
MOD_GlcNHglycan	14	17	PF01048	0.565
MOD_GlcNHglycan	166	169	PF01048	0.462
MOD_GlcNHglycan	286	289	PF01048	0.248
MOD_GlcNHglycan	393	396	PF01048	0.415
MOD_GlcNHglycan	51	54	PF01048	0.561
MOD_GSK3_1	166	173	PF00069	0.501
MOD_GSK3_1	251	258	PF00069	0.393
MOD_GSK3_1	352	359	PF00069	0.448
MOD_GSK3_1	37	44	PF00069	0.654
MOD_GSK3_1	411	418	PF00069	0.528
MOD_N-GLC_1	334	339	PF02516	0.305
MOD_N-GLC_1	405	410	PF02516	0.573
MOD_NEK2_1	313	318	PF00069	0.483
MOD_PIKK_1	123	129	PF00454	0.543
MOD_PIKK_1	69	75	PF00454	0.578
MOD_PIKK_1	84	90	PF00454	0.540
MOD_PKA_1	214	220	PF00069	0.425
MOD_PKA_1	356	362	PF00069	0.448
MOD_PKA_2	284	290	PF00069	0.448
MOD_PKA_2	294	300	PF00069	0.448
MOD_PKA_2	356	362	PF00069	0.461
MOD_Plk_1	184	190	PF00069	0.452
MOD_Plk_1	262	268	PF00069	0.448
MOD_Plk_1	405	411	PF00069	0.652
MOD_Plk_2-3	269	275	PF00069	0.448
MOD_Plk_2-3	96	102	PF00069	0.511
MOD_Plk_4	214	220	PF00069	0.400
MOD_Plk_4	43	49	PF00069	0.668
MOD_ProDKin_1	117	123	PF00069	0.562
MOD_ProDKin_1	133	139	PF00069	0.530
MOD_ProDKin_1	145	151	PF00069	0.549
MOD_ProDKin_1	367	373	PF00069	0.505
MOD_ProDKin_1	38	44	PF00069	0.674
MOD_SUMO_for_1	79	82	PF00179	0.608
MOD_SUMO_rev_2	72	81	PF00179	0.596
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.480
TRG_ENDOCYTIC_2	147	150	PF00928	0.556
TRG_ENDOCYTIC_2	190	193	PF00928	0.548
TRG_ENDOCYTIC_2	236	239	PF00928	0.397
TRG_ER_diArg_1	180	182	PF00400	0.501
TRG_ER_diArg_1	2	4	PF00400	0.487
TRG_ER_diArg_1	398	401	PF00400	0.403
TRG_ER_diArg_1	57	59	PF00400	0.467
TRG_NLS_Bipartite_1	200	218	PF00514	0.422
TRG_NLS_MonoExtN_4	213	218	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP9	Leptomonas seymouri	83%	100%
A0A0S4KG37	Bodo saltans	77%	100%
A0A1X0NNZ0	Trypanosomatidae	87%	100%
A0A3R7NN14	Trypanosoma rangeli	88%	100%
A0A3S5H640	Leishmania donovani	97%	100%
A4HTH9	Leishmania infantum	97%	100%
C9ZPK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9AMA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QIE1	Leishmania major	96%	100%