Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H595_LEIBR

TriTrypDb:

LbrM.20.0800 , LBRM2903_080005200

Length:

231

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 183
NetGPI	no	yes: 0, no: 193

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	172
GO:0110165	cellular anatomical entity	1	172

Expansion

Sequence features

A4H595

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H595

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.615
CLV_NRD_NRD_1	80	82	PF00675	0.503
CLV_NRD_NRD_1	85	87	PF00675	0.480
CLV_PCSK_KEX2_1	80	82	PF00082	0.500
CLV_PCSK_KEX2_1	85	87	PF00082	0.497
CLV_PCSK_PC7_1	81	87	PF00082	0.412
CLV_PCSK_SKI1_1	8	12	PF00082	0.377
DEG_APCC_DBOX_1	7	15	PF00400	0.531
DEG_SCF_FBW7_1	50	55	PF00400	0.257
DOC_CKS1_1	36	41	PF01111	0.354
DOC_CKS1_1	49	54	PF01111	0.194
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.582
DOC_MAPK_gen_1	13	22	PF00069	0.498
DOC_MAPK_HePTP_8	10	22	PF00069	0.500
DOC_MAPK_MEF2A_6	121	129	PF00069	0.565
DOC_MAPK_MEF2A_6	13	22	PF00069	0.559
DOC_PP1_RVXF_1	11	17	PF00149	0.557
DOC_PP2B_LxvP_1	184	187	PF13499	0.581
DOC_USP7_MATH_1	195	199	PF00917	0.590
DOC_USP7_UBL2_3	201	205	PF12436	0.736
DOC_WW_Pin1_4	35	40	PF00397	0.362
DOC_WW_Pin1_4	48	53	PF00397	0.228
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	73	77	PF00533	0.306
LIG_deltaCOP1_diTrp_1	152	160	PF00928	0.201
LIG_FHA_1	132	138	PF00498	0.400
LIG_FHA_1	143	149	PF00498	0.373
LIG_FHA_1	52	58	PF00498	0.304
LIG_FHA_1	68	74	PF00498	0.237
LIG_FHA_2	36	42	PF00498	0.397
LIG_GBD_Chelix_1	105	113	PF00786	0.320
LIG_GBD_Chelix_1	25	33	PF00786	0.216
LIG_LIR_Nem_3	118	123	PF02991	0.588
LIG_LIR_Nem_3	157	163	PF02991	0.311
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.204
LIG_PDZ_Class_3	226	231	PF00595	0.593
LIG_REV1ctd_RIR_1	117	125	PF16727	0.405
LIG_SH2_CRK	23	27	PF00017	0.371
LIG_SH2_NCK_1	23	27	PF00017	0.216
LIG_SH2_PTP2	49	52	PF00017	0.211
LIG_SH2_SRC	23	26	PF00017	0.226
LIG_SH2_STAT5	115	118	PF00017	0.360
LIG_SH2_STAT5	49	52	PF00017	0.351
LIG_SH3_3	33	39	PF00018	0.367
LIG_Sin3_3	30	37	PF02671	0.383
LIG_SUMO_SIM_par_1	32	38	PF11976	0.357
LIG_TYR_ITIM	21	26	PF00017	0.442
LIG_Vh1_VBS_1	122	140	PF01044	0.199
LIG_Vh1_VBS_1	91	109	PF01044	0.328
MOD_CK1_1	158	164	PF00069	0.205
MOD_CK1_1	2	8	PF00069	0.536
MOD_CK1_1	214	220	PF00069	0.628
MOD_CK2_1	200	206	PF00069	0.676
MOD_CK2_1	214	220	PF00069	0.642
MOD_GlcNHglycan	213	216	PF01048	0.520
MOD_GSK3_1	155	162	PF00069	0.202
MOD_GSK3_1	196	203	PF00069	0.835
MOD_GSK3_1	207	214	PF00069	0.660
MOD_GSK3_1	215	222	PF00069	0.627
MOD_GSK3_1	48	55	PF00069	0.289
MOD_GSK3_1	67	74	PF00069	0.352
MOD_N-GLC_1	52	57	PF02516	0.431
MOD_N-GLC_1	67	72	PF02516	0.440
MOD_NEK2_1	219	224	PF00069	0.613
MOD_NEK2_1	3	8	PF00069	0.730
MOD_NEK2_1	67	72	PF00069	0.331
MOD_NEK2_2	115	120	PF00069	0.309
MOD_NEK2_2	155	160	PF00069	0.342
MOD_NEK2_2	96	101	PF00069	0.456
MOD_Plk_1	215	221	PF00069	0.624
MOD_Plk_1	52	58	PF00069	0.336
MOD_Plk_4	115	121	PF00069	0.346
MOD_Plk_4	155	161	PF00069	0.206
MOD_Plk_4	52	58	PF00069	0.319
MOD_Plk_4	96	102	PF00069	0.324
MOD_ProDKin_1	35	41	PF00069	0.362
MOD_ProDKin_1	48	54	PF00069	0.228
TRG_ENDOCYTIC_2	23	26	PF00928	0.449
TRG_ER_diArg_1	79	81	PF00400	0.356
TRG_ER_diArg_1	84	86	PF00400	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	29%	100%
A0A0N0P547	Leptomonas seymouri	40%	100%
A0A0N1HWY5	Leptomonas seymouri	25%	100%
A0A0N1PAD5	Leptomonas seymouri	27%	92%
A0A0N1PDH0	Leptomonas seymouri	36%	100%
A0A1X0NQ58	Trypanosomatidae	32%	100%
A0A1X0NUH1	Trypanosomatidae	27%	100%
A0A1X0NX02	Trypanosomatidae	29%	100%
A0A1X0P2R3	Trypanosomatidae	25%	100%
A0A1X0P988	Trypanosomatidae	35%	100%
A0A381MTA7	Leishmania infantum	46%	100%
A0A381MTB8	Leishmania infantum	43%	100%
A0A381MTC7	Leishmania infantum	42%	100%
A0A381MTN2	Leishmania infantum	42%	100%
A0A381MVY0	Leishmania infantum	45%	100%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IEC2	Leishmania donovani	43%	100%
A0A3Q8IEI1	Leishmania donovani	46%	100%
A0A3Q8IF65	Leishmania donovani	45%	100%
A0A3Q8IFB9	Leishmania donovani	30%	100%
A0A3Q8IFH7	Leishmania donovani	42%	100%
A0A3Q8IH65	Leishmania donovani	42%	100%
A0A3Q8IHN2	Leishmania donovani	46%	100%
A0A3Q8IHW7	Leishmania donovani	46%	100%
A0A3Q8IHZ6	Leishmania donovani	51%	100%
A0A3Q8IIH1	Leishmania donovani	41%	100%
A0A3Q8IL03	Leishmania donovani	40%	100%
A0A3Q8IUK8	Leishmania donovani	42%	100%
A0A3Q8IUR5	Leishmania donovani	42%	100%
A0A3S5H662	Leishmania donovani	43%	100%
A0A3S5H663	Leishmania donovani	45%	100%
A0A3S5H665	Leishmania donovani	45%	100%
A0A3S5H666	Leishmania donovani	44%	100%
A0A3S5H667	Leishmania donovani	45%	100%
A0A3S5H7D2	Leishmania donovani	29%	100%
A0A3S5H7L2	Leishmania donovani	47%	100%
A0A3S5H7V9	Leishmania donovani	47%	100%
A0A3S5H7W2	Leishmania donovani	29%	100%
A0A3S5H7W6	Leishmania donovani	44%	100%
A0A3S7WQA0	Leishmania donovani	45%	100%
A0A3S7WQA8	Leishmania donovani	49%	100%
A0A3S7WQC1	Leishmania donovani	45%	100%
A0A3S7X2E6	Leishmania donovani	45%	100%
A0A3S7X453	Leishmania donovani	44%	100%
A0A3S7X472	Leishmania donovani	43%	100%
A0A3S7X7E5	Leishmania donovani	43%	92%
A0A3S7X7M4	Leishmania donovani	52%	100%
A0A3S7X7U1	Leishmania donovani	41%	100%
A0A3S7X7U4	Leishmania donovani	49%	89%
A0A3S7X7W2	Leishmania donovani	34%	100%
A0A3S7X7Y0	Leishmania donovani	41%	100%
A4H596	Leishmania braziliensis	99%	100%
A4H597	Leishmania braziliensis	99%	100%
A4H5D1	Leishmania braziliensis	53%	100%
A4H5D2	Leishmania braziliensis	38%	100%
A4H5G0	Leishmania braziliensis	45%	100%
A4H5G4	Leishmania braziliensis	46%	100%
A4H5G6	Leishmania braziliensis	69%	100%
A4H5G7	Leishmania braziliensis	79%	100%
A4H5G9	Leishmania braziliensis	48%	100%
A4H5H0	Leishmania braziliensis	49%	100%
A4H5H1	Leishmania braziliensis	47%	100%
A4H5H2	Leishmania braziliensis	48%	100%
A4H5H3	Leishmania braziliensis	45%	100%
A4H6C8	Leishmania braziliensis	46%	100%
A4H7D7	Leishmania braziliensis	51%	100%
A4H9E8	Leishmania braziliensis	52%	100%
A4H9E9	Leishmania braziliensis	49%	100%
A4HAJ4	Leishmania braziliensis	55%	100%
A4HAJ5	Leishmania braziliensis	60%	100%
A4HAJ6	Leishmania braziliensis	97%	100%
A4HAL2	Leishmania braziliensis	28%	100%
A4HAM2	Leishmania braziliensis	45%	100%
A4HAM4	Leishmania braziliensis	45%	100%
A4HAR1	Leishmania braziliensis	42%	100%
A4HAZ8	Leishmania braziliensis	41%	100%
A4HB00	Leishmania braziliensis	40%	100%
A4HB02	Leishmania braziliensis	44%	100%
A4HB47	Leishmania braziliensis	30%	100%
A4HBJ0	Leishmania braziliensis	72%	100%
A4HBJ1	Leishmania braziliensis	45%	100%
A4HBJ2	Leishmania braziliensis	48%	100%
A4HDI4	Leishmania braziliensis	29%	100%
A4HDL3	Leishmania braziliensis	29%	100%
A4HDL4	Leishmania braziliensis	29%	100%
A4HTM3	Leishmania infantum	44%	100%
A4HTM4	Leishmania infantum	49%	100%
A4HTM5	Leishmania infantum	44%	100%
A4I0W4	Leishmania infantum	29%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I4J2	Leishmania infantum	46%	100%
A4I4J3	Leishmania infantum	42%	90%
A4I6E5	Leishmania infantum	42%	100%
A4I9Q4	Leishmania infantum	44%	100%
A4I9R4	Leishmania infantum	29%	100%
A4I9R5	Leishmania infantum	29%	100%
A4I9R7	Leishmania infantum	51%	100%
A4I9W8	Leishmania infantum	49%	89%
A4I9X0	Leishmania infantum	35%	100%
A4IA59	Leishmania infantum	40%	89%
A4IAL7	Leishmania infantum	50%	100%
A4IAM1	Leishmania infantum	45%	100%
A4IAM2	Leishmania infantum	46%	100%
E8NHC3	Leishmania infantum	43%	100%
E8NHD3	Leishmania infantum	47%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	67%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	75%
E9AG81	Leishmania infantum	44%	100%
E9AG82	Leishmania infantum	43%	100%
E9AG83	Leishmania infantum	42%	100%
E9AG85	Leishmania infantum	43%	100%
E9AHI9	Leishmania infantum	45%	100%
E9AHT2	Leishmania infantum	53%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	90%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q1U9	Leishmania major	47%	99%
Q4Q305	Leishmania major	44%	97%
Q4Q309	Leishmania major	45%	100%
Q4Q313	Leishmania major	44%	98%
Q4Q317	Leishmania major	43%	100%
Q4Q325	Leishmania major	44%	100%
Q4Q327	Leishmania major	43%	99%
Q4Q329	Leishmania major	44%	97%
Q4Q333	Leishmania major	43%	97%
Q4Q335	Leishmania major	45%	98%
Q4Q337	Leishmania major	47%	98%
Q4Q339	Leishmania major	44%	98%
Q4Q341	Leishmania major	51%	99%
Q4Q397	Leishmania major	51%	100%
Q4Q3A7	Leishmania major	28%	100%
Q4Q3A8	Leishmania major	30%	100%
Q4Q3A9	Leishmania major	51%	100%
Q4Q3F7	Leishmania major	43%	100%
Q4Q6L8	Leishmania major	41%	100%
Q4QAK5	Leishmania major	30%	100%
Q4QAK6	Leishmania major	29%	92%
Q4QI84	Leishmania major	48%	100%
Q4QI85	Leishmania major	45%	100%
Q4QI86	Leishmania major	47%	100%
Q4QI87	Leishmania major	45%	100%
Q4QI88	Leishmania major	43%	100%
Q4QI92	Leishmania major	42%	100%
Q4QI93	Leishmania major	42%	100%
Q4QI95	Leishmania major	43%	100%
Q4QI97	Leishmania major	43%	100%
Q4QIA0	Leishmania major	40%	100%
Q4QIA1	Leishmania major	40%	100%
V5BEW6	Trypanosoma cruzi	30%	71%