Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H594_LEIBR

TriTrypDb:

LbrM.08.0280 , LBRM2903_080008000

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H594

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H594

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.437
CLV_C14_Caspase3-7	291	295	PF00656	0.609
CLV_C14_Caspase3-7	419	423	PF00656	0.556
CLV_C14_Caspase3-7	469	473	PF00656	0.690
CLV_C14_Caspase3-7	51	55	PF00656	0.449
CLV_NRD_NRD_1	11	13	PF00675	0.581
CLV_NRD_NRD_1	157	159	PF00675	0.597
CLV_NRD_NRD_1	333	335	PF00675	0.615
CLV_NRD_NRD_1	369	371	PF00675	0.587
CLV_NRD_NRD_1	431	433	PF00675	0.779
CLV_NRD_NRD_1	590	592	PF00675	0.658
CLV_NRD_NRD_1	602	604	PF00675	0.729
CLV_NRD_NRD_1	694	696	PF00675	0.615
CLV_NRD_NRD_1	827	829	PF00675	0.637
CLV_PCSK_KEX2_1	11	13	PF00082	0.581
CLV_PCSK_KEX2_1	157	159	PF00082	0.743
CLV_PCSK_KEX2_1	209	211	PF00082	0.640
CLV_PCSK_KEX2_1	333	335	PF00082	0.508
CLV_PCSK_KEX2_1	430	432	PF00082	0.783
CLV_PCSK_KEX2_1	590	592	PF00082	0.658
CLV_PCSK_KEX2_1	602	604	PF00082	0.752
CLV_PCSK_KEX2_1	694	696	PF00082	0.568
CLV_PCSK_KEX2_1	827	829	PF00082	0.751
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.640
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.751
CLV_PCSK_PC7_1	205	211	PF00082	0.621
CLV_PCSK_SKI1_1	164	168	PF00082	0.591
CLV_PCSK_SKI1_1	25	29	PF00082	0.677
CLV_PCSK_SKI1_1	333	337	PF00082	0.506
CLV_PCSK_SKI1_1	651	655	PF00082	0.599
CLV_PCSK_SKI1_1	683	687	PF00082	0.571
CLV_PCSK_SKI1_1	706	710	PF00082	0.566
CLV_PCSK_SKI1_1	759	763	PF00082	0.677
CLV_PCSK_SKI1_1	778	782	PF00082	0.653
DEG_APCC_DBOX_1	332	340	PF00400	0.512
DEG_APCC_DBOX_1	590	598	PF00400	0.497
DEG_SCF_FBW7_2	357	363	PF00400	0.578
DEG_SCF_FBW7_2	395	400	PF00400	0.545
DEG_SCF_FBW7_2	767	772	PF00400	0.563
DEG_SIAH_1	481	489	PF03145	0.563
DOC_CDC14_PxL_1	815	823	PF14671	0.504
DOC_CKS1_1	103	108	PF01111	0.598
DOC_CKS1_1	114	119	PF01111	0.551
DOC_CKS1_1	357	362	PF01111	0.576
DOC_CKS1_1	394	399	PF01111	0.540
DOC_CKS1_1	745	750	PF01111	0.735
DOC_MAPK_DCC_7	139	148	PF00069	0.615
DOC_MAPK_gen_1	139	148	PF00069	0.615
DOC_MAPK_gen_1	333	341	PF00069	0.515
DOC_MAPK_MEF2A_6	139	148	PF00069	0.615
DOC_PP2B_LxvP_1	508	511	PF13499	0.805
DOC_PP2B_LxvP_1	816	819	PF13499	0.511
DOC_USP7_MATH_1	109	113	PF00917	0.668
DOC_USP7_MATH_1	123	127	PF00917	0.550
DOC_USP7_MATH_1	221	225	PF00917	0.585
DOC_USP7_MATH_1	27	31	PF00917	0.667
DOC_USP7_MATH_1	275	279	PF00917	0.599
DOC_USP7_MATH_1	352	356	PF00917	0.828
DOC_USP7_MATH_1	382	386	PF00917	0.776
DOC_USP7_MATH_1	416	420	PF00917	0.567
DOC_USP7_MATH_1	442	446	PF00917	0.827
DOC_USP7_MATH_1	475	479	PF00917	0.568
DOC_USP7_MATH_1	495	499	PF00917	0.694
DOC_USP7_MATH_1	512	516	PF00917	0.559
DOC_USP7_MATH_1	560	564	PF00917	0.691
DOC_USP7_MATH_1	649	653	PF00917	0.662
DOC_USP7_MATH_1	737	741	PF00917	0.666
DOC_USP7_MATH_1	786	790	PF00917	0.512
DOC_USP7_UBL2_3	79	83	PF12436	0.834
DOC_WW_Pin1_4	113	118	PF00397	0.539
DOC_WW_Pin1_4	119	124	PF00397	0.529
DOC_WW_Pin1_4	302	307	PF00397	0.832
DOC_WW_Pin1_4	322	327	PF00397	0.473
DOC_WW_Pin1_4	356	361	PF00397	0.601
DOC_WW_Pin1_4	373	378	PF00397	0.690
DOC_WW_Pin1_4	393	398	PF00397	0.489
DOC_WW_Pin1_4	490	495	PF00397	0.719
DOC_WW_Pin1_4	517	522	PF00397	0.701
DOC_WW_Pin1_4	524	529	PF00397	0.661
DOC_WW_Pin1_4	634	639	PF00397	0.655
DOC_WW_Pin1_4	642	647	PF00397	0.731
DOC_WW_Pin1_4	71	76	PF00397	0.815
DOC_WW_Pin1_4	733	738	PF00397	0.681
DOC_WW_Pin1_4	744	749	PF00397	0.692
DOC_WW_Pin1_4	765	770	PF00397	0.707
DOC_WW_Pin1_4	99	104	PF00397	0.605
LIG_14-3-3_CanoR_1	11	21	PF00244	0.547
LIG_14-3-3_CanoR_1	186	193	PF00244	0.483
LIG_14-3-3_CanoR_1	31	36	PF00244	0.580
LIG_14-3-3_CanoR_1	436	443	PF00244	0.602
LIG_14-3-3_CanoR_1	548	556	PF00244	0.684
LIG_14-3-3_CanoR_1	606	610	PF00244	0.756
LIG_14-3-3_CanoR_1	651	656	PF00244	0.629
LIG_14-3-3_CanoR_1	694	701	PF00244	0.626
LIG_14-3-3_CanoR_1	739	748	PF00244	0.717
LIG_14-3-3_CanoR_1	759	764	PF00244	0.514
LIG_14-3-3_CanoR_1	799	808	PF00244	0.701
LIG_14-3-3_CterR_2	857	859	PF00244	0.680
LIG_Actin_WH2_2	324	342	PF00022	0.519
LIG_BIR_II_1	1	5	PF00653	0.834
LIG_BIR_III_2	472	476	PF00653	0.566
LIG_BIR_III_4	176	180	PF00653	0.538
LIG_BRCT_BRCA1_1	1	5	PF00533	0.582
LIG_BRCT_BRCA1_1	374	378	PF00533	0.550
LIG_eIF4E_1	776	782	PF01652	0.552
LIG_FHA_1	143	149	PF00498	0.609
LIG_FHA_1	322	328	PF00498	0.544
LIG_FHA_1	457	463	PF00498	0.602
LIG_FHA_1	491	497	PF00498	0.710
LIG_FHA_1	627	633	PF00498	0.569
LIG_FHA_1	707	713	PF00498	0.780
LIG_FHA_1	801	807	PF00498	0.572
LIG_FHA_2	171	177	PF00498	0.806
LIG_FHA_2	289	295	PF00498	0.569
LIG_FHA_2	444	450	PF00498	0.632
LIG_FHA_2	571	577	PF00498	0.686
LIG_LIR_Gen_1	200	211	PF02991	0.639
LIG_LIR_Gen_1	288	295	PF02991	0.569
LIG_LIR_Gen_1	385	395	PF02991	0.789
LIG_LIR_Nem_3	200	206	PF02991	0.619
LIG_LIR_Nem_3	288	292	PF02991	0.573
LIG_LIR_Nem_3	385	390	PF02991	0.753
LIG_LIR_Nem_3	773	779	PF02991	0.644
LIG_LYPXL_SIV_4	786	794	PF13949	0.524
LIG_PTB_Apo_2	385	392	PF02174	0.685
LIG_PTB_Phospho_1	385	391	PF10480	0.684
LIG_RPA_C_Fungi	341	353	PF08784	0.555
LIG_RPA_C_Fungi	690	702	PF08784	0.574
LIG_SH2_CRK	387	391	PF00017	0.786
LIG_SH2_GRB2like	386	389	PF00017	0.685
LIG_SH2_NCK_1	387	391	PF00017	0.689
LIG_SH2_NCK_1	787	791	PF00017	0.772
LIG_SH2_STAT3	391	394	PF00017	0.547
LIG_SH2_STAT5	391	394	PF00017	0.800
LIG_SH2_STAT5	461	464	PF00017	0.615
LIG_SH2_STAT5	620	623	PF00017	0.548
LIG_SH3_2	114	119	PF14604	0.594
LIG_SH3_3	100	106	PF00018	0.608
LIG_SH3_3	111	117	PF00018	0.560
LIG_SH3_3	535	541	PF00018	0.571
LIG_SH3_3	654	660	PF00018	0.608
LIG_SUMO_SIM_par_1	38	43	PF11976	0.667
LIG_SUMO_SIM_par_1	453	460	PF11976	0.742
LIG_TRAF2_1	172	175	PF00917	0.768
LIG_TRAF2_1	831	834	PF00917	0.502
LIG_WRC_WIRS_1	289	294	PF05994	0.571
LIG_WW_3	67	71	PF00397	0.545
MOD_CDK_SPK_2	393	398	PF00069	0.537
MOD_CDK_SPxK_1	113	119	PF00069	0.596
MOD_CDK_SPxK_1	733	739	PF00069	0.597
MOD_CDK_SPxxK_3	517	524	PF00069	0.562
MOD_CK1_1	122	128	PF00069	0.604
MOD_CK1_1	130	136	PF00069	0.585
MOD_CK1_1	152	158	PF00069	0.603
MOD_CK1_1	178	184	PF00069	0.741
MOD_CK1_1	220	226	PF00069	0.612
MOD_CK1_1	288	294	PF00069	0.811
MOD_CK1_1	325	331	PF00069	0.770
MOD_CK1_1	355	361	PF00069	0.580
MOD_CK1_1	401	407	PF00069	0.758
MOD_CK1_1	517	523	PF00069	0.591
MOD_CK1_1	563	569	PF00069	0.609
MOD_CK1_1	608	614	PF00069	0.533
MOD_CK1_1	677	683	PF00069	0.556
MOD_CK1_1	716	722	PF00069	0.719
MOD_CK1_1	733	739	PF00069	0.580
MOD_CK1_1	740	746	PF00069	0.563
MOD_CK1_1	750	756	PF00069	0.567
MOD_CK1_1	770	776	PF00069	0.676
MOD_CK1_1	817	823	PF00069	0.528
MOD_CK1_1	91	97	PF00069	0.658
MOD_CK1_1	99	105	PF00069	0.667
MOD_CK2_1	169	175	PF00069	0.768
MOD_CK2_1	524	530	PF00069	0.672
MOD_CK2_1	570	576	PF00069	0.478
MOD_CK2_1	637	643	PF00069	0.637
MOD_CK2_1	92	98	PF00069	0.609
MOD_GlcNHglycan	1	4	PF01048	0.830
MOD_GlcNHglycan	111	114	PF01048	0.658
MOD_GlcNHglycan	14	17	PF01048	0.600
MOD_GlcNHglycan	174	180	PF01048	0.704
MOD_GlcNHglycan	219	222	PF01048	0.596
MOD_GlcNHglycan	316	319	PF01048	0.709
MOD_GlcNHglycan	350	353	PF01048	0.581
MOD_GlcNHglycan	403	406	PF01048	0.833
MOD_GlcNHglycan	418	421	PF01048	0.692
MOD_GlcNHglycan	497	500	PF01048	0.773
MOD_GlcNHglycan	56	59	PF01048	0.555
MOD_GlcNHglycan	610	613	PF01048	0.531
MOD_GlcNHglycan	650	654	PF01048	0.596
MOD_GlcNHglycan	749	752	PF01048	0.751
MOD_GlcNHglycan	755	758	PF01048	0.669
MOD_GlcNHglycan	759	762	PF01048	0.627
MOD_GlcNHglycan	772	775	PF01048	0.466
MOD_GlcNHglycan	788	791	PF01048	0.468
MOD_GlcNHglycan	816	819	PF01048	0.668
MOD_GlcNHglycan	822	825	PF01048	0.540
MOD_GlcNHglycan	94	97	PF01048	0.780
MOD_GlcNHglycan	98	101	PF01048	0.815
MOD_GSK3_1	109	116	PF00069	0.627
MOD_GSK3_1	119	126	PF00069	0.567
MOD_GSK3_1	12	19	PF00069	0.623
MOD_GSK3_1	217	224	PF00069	0.590
MOD_GSK3_1	27	34	PF00069	0.607
MOD_GSK3_1	302	309	PF00069	0.628
MOD_GSK3_1	321	328	PF00069	0.484
MOD_GSK3_1	344	351	PF00069	0.584
MOD_GSK3_1	352	359	PF00069	0.584
MOD_GSK3_1	432	439	PF00069	0.709
MOD_GSK3_1	529	536	PF00069	0.611
MOD_GSK3_1	547	554	PF00069	0.705
MOD_GSK3_1	578	585	PF00069	0.467
MOD_GSK3_1	604	611	PF00069	0.642
MOD_GSK3_1	622	629	PF00069	0.512
MOD_GSK3_1	637	644	PF00069	0.682
MOD_GSK3_1	665	672	PF00069	0.721
MOD_GSK3_1	674	681	PF00069	0.679
MOD_GSK3_1	690	697	PF00069	0.649
MOD_GSK3_1	706	713	PF00069	0.657
MOD_GSK3_1	733	740	PF00069	0.697
MOD_GSK3_1	743	750	PF00069	0.659
MOD_GSK3_1	753	760	PF00069	0.604
MOD_GSK3_1	763	770	PF00069	0.660
MOD_GSK3_1	835	842	PF00069	0.529
MOD_GSK3_1	88	95	PF00069	0.761
MOD_GSK3_1	98	105	PF00069	0.594
MOD_N-GLC_1	170	175	PF02516	0.563
MOD_N-GLC_1	355	360	PF02516	0.578
MOD_N-GLC_1	517	522	PF02516	0.810
MOD_NEK2_1	127	132	PF00069	0.614
MOD_NEK2_1	217	222	PF00069	0.594
MOD_NEK2_1	287	292	PF00069	0.573
MOD_NEK2_1	40	45	PF00069	0.615
MOD_NEK2_1	456	461	PF00069	0.611
MOD_NEK2_1	578	583	PF00069	0.467
MOD_NEK2_1	690	695	PF00069	0.827
MOD_NEK2_1	700	705	PF00069	0.666
MOD_NEK2_1	814	819	PF00069	0.516
MOD_PIKK_1	263	269	PF00454	0.670
MOD_PIKK_1	40	46	PF00454	0.673
MOD_PIKK_1	611	617	PF00454	0.514
MOD_PIKK_1	622	628	PF00454	0.529
MOD_PIKK_1	839	845	PF00454	0.542
MOD_PIKK_1	88	94	PF00454	0.751
MOD_PK_1	582	588	PF00069	0.625
MOD_PKA_1	11	17	PF00069	0.570
MOD_PKA_1	431	437	PF00069	0.773
MOD_PKA_1	694	700	PF00069	0.570
MOD_PKA_2	11	17	PF00069	0.772
MOD_PKA_2	185	191	PF00069	0.564
MOD_PKA_2	342	348	PF00069	0.539
MOD_PKA_2	431	437	PF00069	0.812
MOD_PKA_2	547	553	PF00069	0.776
MOD_PKA_2	605	611	PF00069	0.778
MOD_PKA_2	694	700	PF00069	0.617
MOD_PKA_2	701	707	PF00069	0.645
MOD_PKA_2	88	94	PF00069	0.817
MOD_PKB_1	430	438	PF00069	0.564
MOD_Plk_1	399	405	PF00069	0.628
MOD_Plk_1	554	560	PF00069	0.569
MOD_Plk_2-3	170	176	PF00069	0.775
MOD_Plk_4	457	463	PF00069	0.762
MOD_Plk_4	540	546	PF00069	0.562
MOD_Plk_4	605	611	PF00069	0.791
MOD_Plk_4	651	657	PF00069	0.618
MOD_Plk_4	696	702	PF00069	0.644
MOD_Plk_4	817	823	PF00069	0.737
MOD_ProDKin_1	113	119	PF00069	0.541
MOD_ProDKin_1	302	308	PF00069	0.831
MOD_ProDKin_1	322	328	PF00069	0.466
MOD_ProDKin_1	356	362	PF00069	0.598
MOD_ProDKin_1	373	379	PF00069	0.688
MOD_ProDKin_1	393	399	PF00069	0.491
MOD_ProDKin_1	490	496	PF00069	0.718
MOD_ProDKin_1	517	523	PF00069	0.703
MOD_ProDKin_1	524	530	PF00069	0.663
MOD_ProDKin_1	634	640	PF00069	0.656
MOD_ProDKin_1	642	648	PF00069	0.733
MOD_ProDKin_1	71	77	PF00069	0.816
MOD_ProDKin_1	733	739	PF00069	0.682
MOD_ProDKin_1	744	750	PF00069	0.692
MOD_ProDKin_1	765	771	PF00069	0.699
MOD_ProDKin_1	99	105	PF00069	0.605
MOD_SUMO_rev_2	532	541	PF00179	0.631
TRG_DiLeu_BaEn_1	810	815	PF01217	0.532
TRG_DiLeu_BaEn_4	239	245	PF01217	0.577
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.551
TRG_ENDOCYTIC_2	289	292	PF00928	0.574
TRG_ENDOCYTIC_2	386	389	PF00928	0.782
TRG_ENDOCYTIC_2	618	621	PF00928	0.549
TRG_ENDOCYTIC_2	776	779	PF00928	0.789
TRG_ER_diArg_1	11	13	PF00400	0.581
TRG_ER_diArg_1	156	158	PF00400	0.602
TRG_ER_diArg_1	429	432	PF00400	0.773
TRG_ER_diArg_1	589	591	PF00400	0.653
TRG_ER_diArg_1	601	603	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H639	Leishmania donovani	46%	100%
A4HTH8	Leishmania infantum	46%	100%
E9AMA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QIE2	Leishmania major	45%	91%