RIBOSOMAL_L9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H591_LEIBR

TriTrypDb:

LbrM.08.0250 , LBRM2903_080007700

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005840	ribosome	5	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2

Expansion

Sequence features

A4H591

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H591

PDB structure(s): 7aih_C , 7am2_C , 7ane_C

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.503
CLV_NRD_NRD_1	2	4	PF00675	0.514
CLV_NRD_NRD_1	207	209	PF00675	0.433
CLV_NRD_NRD_1	246	248	PF00675	0.614
CLV_NRD_NRD_1	253	255	PF00675	0.549
CLV_NRD_NRD_1	256	258	PF00675	0.543
CLV_PCSK_KEX2_1	2	4	PF00082	0.514
CLV_PCSK_KEX2_1	246	248	PF00082	0.735
CLV_PCSK_KEX2_1	53	55	PF00082	0.407
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.735
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.407
CLV_PCSK_SKI1_1	186	190	PF00082	0.561
CLV_PCSK_SKI1_1	257	261	PF00082	0.547
CLV_PCSK_SKI1_1	54	58	PF00082	0.402
CLV_PCSK_SKI1_1	97	101	PF00082	0.444
DEG_APCC_KENBOX_2	64	68	PF00400	0.469
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DEG_SPOP_SBC_1	235	239	PF00917	0.572
DOC_CKS1_1	179	184	PF01111	0.458
DOC_CYCLIN_RxL_1	180	193	PF00134	0.573
DOC_CYCLIN_RxL_1	93	104	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.496
DOC_MAPK_gen_1	2	9	PF00069	0.596
DOC_MAPK_gen_1	252	261	PF00069	0.548
DOC_MAPK_gen_1	95	102	PF00069	0.453
DOC_MAPK_MEF2A_6	17	24	PF00069	0.481
DOC_MAPK_MEF2A_6	95	102	PF00069	0.469
DOC_PP1_RVXF_1	124	130	PF00149	0.541
DOC_PP2B_LxvP_1	165	168	PF13499	0.434
DOC_PP2B_LxvP_1	8	11	PF13499	0.487
DOC_PP4_MxPP_1	24	27	PF00568	0.464
DOC_USP7_MATH_1	235	239	PF00917	0.619
DOC_USP7_UBL2_3	159	163	PF12436	0.223
DOC_USP7_UBL2_3	187	191	PF12436	0.515
DOC_USP7_UBL2_3	248	252	PF12436	0.574
DOC_WW_Pin1_4	178	183	PF00397	0.461
DOC_WW_Pin1_4	46	51	PF00397	0.401
DOC_WW_Pin1_4	71	76	PF00397	0.570
DOC_WW_Pin1_4	85	90	PF00397	0.405
LIG_14-3-3_CanoR_1	2	9	PF00244	0.568
LIG_14-3-3_CanoR_1	54	64	PF00244	0.447
LIG_14-3-3_CanoR_1	84	88	PF00244	0.566
LIG_APCC_ABBA_1	87	92	PF00400	0.463
LIG_CSL_BTD_1	11	14	PF09270	0.456
LIG_eIF4E_1	201	207	PF01652	0.419
LIG_FHA_1	108	114	PF00498	0.494
LIG_FHA_1	134	140	PF00498	0.315
LIG_FHA_1	57	63	PF00498	0.500
LIG_KLC1_Yacidic_2	135	140	PF13176	0.358
LIG_LIR_Nem_3	160	165	PF02991	0.313
LIG_LIR_Nem_3	204	210	PF02991	0.420
LIG_LIR_Nem_3	222	228	PF02991	0.449
LIG_SH2_CRK	162	166	PF00017	0.411
LIG_SH2_CRK	185	189	PF00017	0.489
LIG_SH2_NCK_1	134	138	PF00017	0.385
LIG_SH2_STAP1	134	138	PF00017	0.383
LIG_SH2_STAP1	153	157	PF00017	0.192
LIG_SH2_STAP1	201	205	PF00017	0.501
LIG_SH2_STAP1	42	46	PF00017	0.394
LIG_SH2_STAP1	60	64	PF00017	0.424
LIG_SH2_STAP1	81	85	PF00017	0.423
LIG_SH2_STAT5	138	141	PF00017	0.318
LIG_SH2_STAT5	194	197	PF00017	0.490
LIG_SH2_STAT5	201	204	PF00017	0.435
LIG_SH2_STAT5	205	208	PF00017	0.327
LIG_SH2_STAT5	85	88	PF00017	0.438
LIG_SH3_2	72	77	PF14604	0.560
LIG_SH3_3	176	182	PF00018	0.449
LIG_SH3_3	19	25	PF00018	0.429
LIG_SH3_3	69	75	PF00018	0.575
LIG_SH3_3	8	14	PF00018	0.461
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.438
LIG_SUMO_SIM_par_1	98	104	PF11976	0.446
LIG_TRAF2_1	144	147	PF00917	0.475
LIG_WW_3	14	18	PF00397	0.458
MOD_CDC14_SPxK_1	74	77	PF00782	0.556
MOD_CDK_SPxK_1	71	77	PF00069	0.565
MOD_CDK_SPxxK_3	46	53	PF00069	0.421
MOD_CK1_1	234	240	PF00069	0.628
MOD_CK1_1	241	247	PF00069	0.633
MOD_CK2_1	170	176	PF00069	0.470
MOD_CK2_1	190	196	PF00069	0.469
MOD_GlcNHglycan	233	236	PF01048	0.605
MOD_GlcNHglycan	242	246	PF01048	0.639
MOD_GlcNHglycan	3	6	PF01048	0.634
MOD_GSK3_1	230	237	PF00069	0.530
MOD_GSK3_1	32	39	PF00069	0.453
MOD_N-GLC_1	170	175	PF02516	0.545
MOD_N-GLC_1	66	71	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	231	236	PF00069	0.603
MOD_NEK2_1	55	60	PF00069	0.411
MOD_NEK2_1	83	88	PF00069	0.556
MOD_PKA_2	1	7	PF00069	0.526
MOD_PKA_2	83	89	PF00069	0.552
MOD_Plk_1	170	176	PF00069	0.551
MOD_Plk_1	66	72	PF00069	0.456
MOD_Plk_2-3	190	196	PF00069	0.502
MOD_Plk_4	107	113	PF00069	0.280
MOD_Plk_4	133	139	PF00069	0.302
MOD_ProDKin_1	178	184	PF00069	0.460
MOD_ProDKin_1	46	52	PF00069	0.405
MOD_ProDKin_1	71	77	PF00069	0.565
MOD_ProDKin_1	85	91	PF00069	0.399
TRG_DiLeu_BaEn_1	160	165	PF01217	0.328
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.245
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.456
TRG_ENDOCYTIC_2	134	137	PF00928	0.385
TRG_ENDOCYTIC_2	162	165	PF00928	0.390
TRG_ENDOCYTIC_2	185	188	PF00928	0.418
TRG_ER_diArg_1	1	3	PF00400	0.536
TRG_ER_diLys_1	258	262	PF00400	0.552
TRG_NLS_Bipartite_1	246	261	PF00514	0.567
TRG_NLS_MonoExtC_3	245	250	PF00514	0.635
TRG_NLS_MonoExtC_3	253	258	PF00514	0.508
TRG_NLS_MonoExtN_4	252	258	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A6	Leptomonas seymouri	83%	100%
A0A0S4KHU8	Bodo saltans	63%	100%
A0A1X0NP98	Trypanosomatidae	70%	100%
A0A3R7M4H0	Trypanosoma rangeli	71%	100%
A0A3S5H637	Leishmania donovani	90%	100%
A4HTH5	Leishmania infantum	90%	100%
C9ZPL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AMA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QIE5	Leishmania major	91%	100%
V5BCI9	Trypanosoma cruzi	73%	100%