ABC1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 family, putative

Species:

Leishmania braziliensis

UniProt:

A4H590_LEIBR

TriTrypDb:

LbrM.08.0240 , LBRM2903_080007600

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H590

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H590

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.201
CLV_NRD_NRD_1	354	356	PF00675	0.392
CLV_NRD_NRD_1	83	85	PF00675	0.512
CLV_PCSK_KEX2_1	131	133	PF00082	0.417
CLV_PCSK_KEX2_1	269	271	PF00082	0.342
CLV_PCSK_KEX2_1	354	356	PF00082	0.392
CLV_PCSK_KEX2_1	83	85	PF00082	0.483
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.427
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.278
CLV_PCSK_SKI1_1	269	273	PF00082	0.358
CLV_PCSK_SKI1_1	42	46	PF00082	0.448
CLV_PCSK_SKI1_1	501	505	PF00082	0.567
DEG_APCC_DBOX_1	473	481	PF00400	0.464
DOC_AGCK_PIF_2	212	217	PF00069	0.392
DOC_CYCLIN_RxL_1	39	46	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.421
DOC_MAPK_DCC_7	474	482	PF00069	0.338
DOC_MAPK_gen_1	406	415	PF00069	0.639
DOC_MAPK_MEF2A_6	335	343	PF00069	0.427
DOC_MAPK_MEF2A_6	474	482	PF00069	0.536
DOC_PP1_RVXF_1	259	265	PF00149	0.427
DOC_USP7_MATH_1	162	166	PF00917	0.307
DOC_USP7_MATH_1	206	210	PF00917	0.427
DOC_WW_Pin1_4	156	161	PF00397	0.392
DOC_WW_Pin1_4	366	371	PF00397	0.364
LIG_14-3-3_CanoR_1	147	156	PF00244	0.374
LIG_14-3-3_CanoR_1	199	204	PF00244	0.415
LIG_14-3-3_CanoR_1	406	416	PF00244	0.492
LIG_14-3-3_CanoR_1	467	471	PF00244	0.406
LIG_Actin_WH2_2	427	445	PF00022	0.418
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	149	153	PF00533	0.340
LIG_BRCT_BRCA1_1	201	205	PF00533	0.442
LIG_BRCT_BRCA1_1	208	212	PF00533	0.407
LIG_FHA_1	198	204	PF00498	0.310
LIG_FHA_1	21	27	PF00498	0.539
LIG_FHA_1	360	366	PF00498	0.282
LIG_FHA_1	367	373	PF00498	0.341
LIG_FHA_1	446	452	PF00498	0.502
LIG_FHA_1	55	61	PF00498	0.430
LIG_FHA_1	64	70	PF00498	0.360
LIG_FHA_2	300	306	PF00498	0.398
LIG_FHA_2	470	476	PF00498	0.535
LIG_FHA_2	68	74	PF00498	0.581
LIG_GBD_Chelix_1	137	145	PF00786	0.392
LIG_LIR_Apic_2	209	213	PF02991	0.431
LIG_LIR_Gen_1	150	161	PF02991	0.359
LIG_LIR_Gen_1	301	312	PF02991	0.373
LIG_LIR_Gen_1	437	446	PF02991	0.356
LIG_LIR_Gen_1	492	503	PF02991	0.482
LIG_LIR_Gen_1	76	86	PF02991	0.462
LIG_LIR_Nem_3	150	156	PF02991	0.384
LIG_LIR_Nem_3	209	215	PF02991	0.403
LIG_LIR_Nem_3	216	220	PF02991	0.376
LIG_LIR_Nem_3	301	307	PF02991	0.373
LIG_LIR_Nem_3	382	387	PF02991	0.378
LIG_LIR_Nem_3	437	441	PF02991	0.350
LIG_LIR_Nem_3	46	51	PF02991	0.292
LIG_LIR_Nem_3	492	498	PF02991	0.466
LIG_LIR_Nem_3	76	81	PF02991	0.482
LIG_LYPXL_SIV_4	133	141	PF13949	0.454
LIG_MAD2	270	278	PF02301	0.458
LIG_MLH1_MIPbox_1	208	212	PF16413	0.411
LIG_MYND_1	36	40	PF01753	0.609
LIG_Pex14_1	63	67	PF04695	0.276
LIG_Pex14_2	312	316	PF04695	0.306
LIG_Pex14_2	387	391	PF04695	0.392
LIG_SH2_CRK	118	122	PF00017	0.448
LIG_SH2_CRK	438	442	PF00017	0.367
LIG_SH2_CRK	495	499	PF00017	0.538
LIG_SH2_NCK_1	495	499	PF00017	0.480
LIG_SH2_SRC	134	137	PF00017	0.454
LIG_SH2_SRC	155	158	PF00017	0.427
LIG_SH2_SRC	187	190	PF00017	0.322
LIG_SH2_SRC	396	399	PF00017	0.347
LIG_SH2_STAP1	134	138	PF00017	0.454
LIG_SH2_STAP1	396	400	PF00017	0.503
LIG_SH2_STAP1	438	442	PF00017	0.351
LIG_SH2_STAP1	495	499	PF00017	0.558
LIG_SH2_STAP1	65	69	PF00017	0.469
LIG_SH2_STAT5	100	103	PF00017	0.361
LIG_SH2_STAT5	118	121	PF00017	0.370
LIG_SH2_STAT5	155	158	PF00017	0.427
LIG_SH2_STAT5	187	190	PF00017	0.322
LIG_SH2_STAT5	210	213	PF00017	0.427
LIG_SH2_STAT5	56	59	PF00017	0.374
LIG_SH2_STAT5	65	68	PF00017	0.434
LIG_SH3_3	127	133	PF00018	0.392
LIG_SH3_3	24	30	PF00018	0.506
LIG_SH3_3	254	260	PF00018	0.364
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.395
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.427
LIG_SUMO_SIM_anti_2	409	419	PF11976	0.389
LIG_SUMO_SIM_par_1	136	142	PF11976	0.395
LIG_SUMO_SIM_par_1	337	342	PF11976	0.308
LIG_SUMO_SIM_par_1	88	95	PF11976	0.415
LIG_TYR_ITIM	185	190	PF00017	0.307
LIG_UBA3_1	482	488	PF00899	0.416
MOD_CDK_SPK_2	366	371	PF00069	0.454
MOD_CK1_1	399	405	PF00069	0.526
MOD_CK1_1	469	475	PF00069	0.512
MOD_CK2_1	292	298	PF00069	0.390
MOD_CK2_1	469	475	PF00069	0.520
MOD_GlcNHglycan	332	335	PF01048	0.452
MOD_GlcNHglycan	397	401	PF01048	0.586
MOD_GSK3_1	147	154	PF00069	0.458
MOD_GSK3_1	288	295	PF00069	0.340
MOD_GSK3_1	355	362	PF00069	0.334
MOD_GSK3_1	366	373	PF00069	0.300
MOD_GSK3_1	441	448	PF00069	0.480
MOD_GSK3_1	466	473	PF00069	0.444
MOD_GSK3_1	514	521	PF00069	0.598
MOD_GSK3_1	63	70	PF00069	0.460
MOD_N-GLC_1	224	229	PF02516	0.307
MOD_N-GLC_1	264	269	PF02516	0.201
MOD_NEK2_1	224	229	PF00069	0.331
MOD_NEK2_1	3	8	PF00069	0.591
MOD_NEK2_1	386	391	PF00069	0.359
MOD_NEK2_1	416	421	PF00069	0.548
MOD_NEK2_1	466	471	PF00069	0.390
MOD_NEK2_1	514	519	PF00069	0.587
MOD_NEK2_1	67	72	PF00069	0.441
MOD_NEK2_1	92	97	PF00069	0.283
MOD_NEK2_2	63	68	PF00069	0.422
MOD_PIKK_1	67	73	PF00454	0.523
MOD_PK_1	292	298	PF00069	0.201
MOD_PKA_2	238	244	PF00069	0.402
MOD_PKA_2	3	9	PF00069	0.567
MOD_PKA_2	407	413	PF00069	0.504
MOD_PKA_2	416	422	PF00069	0.569
MOD_PKA_2	466	472	PF00069	0.356
MOD_Plk_1	224	230	PF00069	0.305
MOD_Plk_1	63	69	PF00069	0.381
MOD_Plk_2-3	151	157	PF00069	0.384
MOD_Plk_4	120	126	PF00069	0.361
MOD_Plk_4	206	212	PF00069	0.409
MOD_Plk_4	299	305	PF00069	0.394
MOD_ProDKin_1	156	162	PF00069	0.392
MOD_ProDKin_1	366	372	PF00069	0.364
TRG_ENDOCYTIC_2	118	121	PF00928	0.428
TRG_ENDOCYTIC_2	134	137	PF00928	0.427
TRG_ENDOCYTIC_2	187	190	PF00928	0.307
TRG_ENDOCYTIC_2	384	387	PF00928	0.362
TRG_ENDOCYTIC_2	438	441	PF00928	0.352
TRG_ENDOCYTIC_2	495	498	PF00928	0.511
TRG_ER_diArg_1	171	174	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U2	Leptomonas seymouri	25%	98%
A0A0N1IML7	Leptomonas seymouri	76%	100%
A0A0N1PA82	Leptomonas seymouri	30%	83%
A0A0S4KEI7	Bodo saltans	44%	98%
A0A0S4KLC8	Bodo saltans	28%	90%
A0A179HKZ8	Purpureocillium lilacinum	31%	88%
A0A1X0NQM8	Trypanosomatidae	55%	96%
A0A1X0P0M1	Trypanosomatidae	23%	93%
A0A1X0P192	Trypanosomatidae	28%	82%
A0A3Q8IPG5	Leishmania donovani	26%	98%
A0A3R7KBH2	Trypanosoma rangeli	30%	81%
A0A3R7KJM1	Trypanosoma rangeli	54%	99%
A0A3S5H636	Leishmania donovani	84%	100%
A0A3S5H7U4	Leishmania donovani	28%	80%
A0A422NJA2	Trypanosoma rangeli	24%	98%
A1SAK0	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	23%	95%
A4HLI6	Leishmania braziliensis	28%	80%
A4HTH4	Leishmania infantum	84%	100%
A4I8Z6	Leishmania infantum	28%	80%
A4IDN2	Leishmania infantum	26%	98%
A7MTX4	Vibrio campbellii (strain ATCC BAA-1116)	25%	96%
B7VHC3	Vibrio atlanticus (strain LGP32)	24%	96%
B9DGY1	Arabidopsis thaliana	26%	75%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9AMA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B3W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	83%
O04212	Arabidopsis thaliana	28%	97%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	94%
Q06567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
Q3MIX3	Homo sapiens	38%	90%
Q46189	Clostridium pasteurianum	24%	98%
Q4Q0W1	Leishmania major	25%	98%
Q4Q459	Leishmania major	29%	100%
Q4QIE6	Leishmania major	84%	100%
Q54P00	Dictyostelium discoideum	34%	75%
Q54TR5	Dictyostelium discoideum	31%	78%
Q55680	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	77%
Q5BJQ0	Rattus norvegicus	22%	80%
Q5M7P6	Xenopus tropicalis	31%	100%
Q5RGU1	Danio rerio	23%	84%
Q5ZMT7	Gallus gallus	30%	100%
Q6INL7	Xenopus laevis	31%	100%
Q7MZ83	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	22%	96%
Q80V03	Mus musculus	39%	90%
Q86TW2	Homo sapiens	30%	98%
Q87TH2	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	25%	96%
Q8RWG1	Arabidopsis thaliana	25%	77%
Q96D53	Homo sapiens	23%	96%
Q9D0L4	Mus musculus	31%	99%
Q9MA15	Arabidopsis thaliana	29%	73%
Q9SBB2	Arabidopsis thaliana	25%	84%
Q9W133	Drosophila melanogaster	28%	100%
V5AX60	Trypanosoma cruzi	55%	99%
V5BB22	Trypanosoma cruzi	21%	78%
V5BCS0	Trypanosoma cruzi	31%	82%
V5BQ67	Trypanosoma cruzi	23%	100%