Ubiquitin-activating enzyme-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-activating enzyme-like protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H589_LEIBR

TriTrypDb:

LbrM.08.0230 , LBRM2903_080007500

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H589

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H589

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0016925	protein sumoylation	7	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018205	peptidyl-lysine modification	6	3
GO:0019538	protein metabolic process	3	3
GO:0032446	protein modification by small protein conjugation	6	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044238	primary metabolic process	2	3
GO:0070647	protein modification by small protein conjugation or removal	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	3
GO:0016874	ligase activity	2	3
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	3
GO:0017076	purine nucleotide binding	4	3
GO:0019948	SUMO activating enzyme activity	3	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140096	catalytic activity, acting on a protein	2	3
GO:0140657	ATP-dependent activity	1	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.494
CLV_C14_Caspase3-7	298	302	PF00656	0.199
CLV_C14_Caspase3-7	469	473	PF00656	0.477
CLV_NRD_NRD_1	325	327	PF00675	0.258
CLV_NRD_NRD_1	349	351	PF00675	0.326
CLV_NRD_NRD_1	78	80	PF00675	0.447
CLV_PCSK_FUR_1	347	351	PF00082	0.326
CLV_PCSK_KEX2_1	325	327	PF00082	0.300
CLV_PCSK_KEX2_1	349	351	PF00082	0.326
CLV_PCSK_KEX2_1	43	45	PF00082	0.666
CLV_PCSK_KEX2_1	78	80	PF00082	0.682
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.666
CLV_PCSK_SKI1_1	266	270	PF00082	0.199
CLV_PCSK_SKI1_1	287	291	PF00082	0.208
CLV_PCSK_SKI1_1	307	311	PF00082	0.150
CLV_PCSK_SKI1_1	320	324	PF00082	0.199
CLV_PCSK_SKI1_1	326	330	PF00082	0.199
CLV_PCSK_SKI1_1	527	531	PF00082	0.383
CLV_PCSK_SKI1_1	566	570	PF00082	0.278
DEG_APCC_DBOX_1	306	314	PF00400	0.208
DEG_COP1_1	178	187	PF00400	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DEG_SCF_TRCP1_1	550	556	PF00400	0.441
DOC_CYCLIN_RxL_1	279	290	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.208
DOC_MAPK_RevD_3	311	326	PF00069	0.208
DOC_PP1_RVXF_1	564	570	PF00149	0.277
DOC_PP2B_LxvP_1	208	211	PF13499	0.433
DOC_USP7_MATH_1	144	148	PF00917	0.546
DOC_USP7_MATH_1	177	181	PF00917	0.516
DOC_USP7_MATH_1	21	25	PF00917	0.461
DOC_USP7_MATH_1	28	32	PF00917	0.469
DOC_USP7_MATH_1	478	482	PF00917	0.508
DOC_USP7_MATH_1	493	497	PF00917	0.475
DOC_USP7_MATH_1	506	510	PF00917	0.446
DOC_USP7_MATH_1	590	594	PF00917	0.367
DOC_USP7_MATH_1	81	85	PF00917	0.465
DOC_USP7_MATH_1	98	102	PF00917	0.437
DOC_WW_Pin1_4	128	133	PF00397	0.497
DOC_WW_Pin1_4	164	169	PF00397	0.629
DOC_WW_Pin1_4	241	246	PF00397	0.493
DOC_WW_Pin1_4	336	341	PF00397	0.208
DOC_WW_Pin1_4	348	353	PF00397	0.209
DOC_WW_Pin1_4	464	469	PF00397	0.208
DOC_WW_Pin1_4	584	589	PF00397	0.369
DOC_WW_Pin1_4	94	99	PF00397	0.517
LIG_14-3-3_CanoR_1	239	245	PF00244	0.442
LIG_14-3-3_CanoR_1	248	253	PF00244	0.414
LIG_14-3-3_CanoR_1	287	295	PF00244	0.208
LIG_14-3-3_CanoR_1	445	450	PF00244	0.199
LIG_14-3-3_CanoR_1	518	528	PF00244	0.326
LIG_BIR_III_2	186	190	PF00653	0.572
LIG_BRCT_BRCA1_1	155	159	PF00533	0.387
LIG_Clathr_ClatBox_1	294	298	PF01394	0.208
LIG_FHA_1	193	199	PF00498	0.392
LIG_FHA_1	231	237	PF00498	0.605
LIG_FHA_1	341	347	PF00498	0.208
LIG_FHA_1	434	440	PF00498	0.199
LIG_FHA_1	445	451	PF00498	0.199
LIG_FHA_1	58	64	PF00498	0.472
LIG_FHA_2	111	117	PF00498	0.450
LIG_FHA_2	169	175	PF00498	0.502
LIG_FHA_2	181	187	PF00498	0.479
LIG_FHA_2	213	219	PF00498	0.442
LIG_FHA_2	86	92	PF00498	0.498
LIG_GBD_Chelix_1	560	568	PF00786	0.286
LIG_LIR_Gen_1	149	160	PF02991	0.517
LIG_LIR_Gen_1	458	468	PF02991	0.199
LIG_LIR_Nem_3	149	155	PF02991	0.535
LIG_LIR_Nem_3	156	160	PF02991	0.344
LIG_LIR_Nem_3	369	375	PF02991	0.313
LIG_LIR_Nem_3	420	425	PF02991	0.295
LIG_LIR_Nem_3	458	463	PF02991	0.199
LIG_MAD2	197	205	PF02301	0.382
LIG_NRBOX	563	569	PF00104	0.285
LIG_PCNA_yPIPBox_3	415	428	PF02747	0.208
LIG_PDZ_Class_2	593	598	PF00595	0.412
LIG_Pex14_2	371	375	PF04695	0.317
LIG_SH2_NCK_1	367	371	PF00017	0.199
LIG_SH2_NCK_1	80	84	PF00017	0.460
LIG_SH2_SRC	367	370	PF00017	0.199
LIG_SH2_STAP1	367	371	PF00017	0.199
LIG_SH2_STAP1	455	459	PF00017	0.199
LIG_SH2_STAP1	460	464	PF00017	0.199
LIG_SH2_STAT3	410	413	PF00017	0.199
LIG_SH2_STAT5	516	519	PF00017	0.330
LIG_SH3_3	15	21	PF00018	0.594
LIG_SH3_3	160	166	PF00018	0.457
LIG_SH3_3	179	185	PF00018	0.452
LIG_SH3_3	30	36	PF00018	0.620
LIG_SH3_3	334	340	PF00018	0.208
LIG_SH3_3	426	432	PF00018	0.214
LIG_SUMO_SIM_par_1	293	299	PF11976	0.208
LIG_SUMO_SIM_par_1	574	581	PF11976	0.335
LIG_TRAF2_1	495	498	PF00917	0.508
LIG_UBA3_1	576	580	PF00899	0.334
LIG_WRC_WIRS_1	579	584	PF05994	0.379
MOD_CDC14_SPxK_1	131	134	PF00782	0.511
MOD_CDK_SPxK_1	128	134	PF00069	0.501
MOD_CDK_SPxxK_3	241	248	PF00069	0.451
MOD_CK1_1	102	108	PF00069	0.461
MOD_CK1_1	117	123	PF00069	0.418
MOD_CK1_1	142	148	PF00069	0.510
MOD_CK1_1	153	159	PF00069	0.329
MOD_CK1_1	180	186	PF00069	0.559
MOD_CK1_1	24	30	PF00069	0.503
MOD_CK1_1	241	247	PF00069	0.574
MOD_CK1_1	466	472	PF00069	0.208
MOD_CK1_1	481	487	PF00069	0.461
MOD_CK1_1	492	498	PF00069	0.488
MOD_CK1_1	533	539	PF00069	0.457
MOD_CK1_1	54	60	PF00069	0.554
MOD_CK1_1	553	559	PF00069	0.315
MOD_CK1_1	578	584	PF00069	0.365
MOD_CK2_1	110	116	PF00069	0.445
MOD_CK2_1	168	174	PF00069	0.501
MOD_CK2_1	175	181	PF00069	0.498
MOD_CK2_1	212	218	PF00069	0.440
MOD_CK2_1	492	498	PF00069	0.516
MOD_CK2_1	85	91	PF00069	0.494
MOD_Cter_Amidation	347	350	PF01082	0.208
MOD_GlcNHglycan	116	119	PF01048	0.586
MOD_GlcNHglycan	148	151	PF01048	0.505
MOD_GlcNHglycan	152	155	PF01048	0.480
MOD_GlcNHglycan	224	227	PF01048	0.688
MOD_GlcNHglycan	228	231	PF01048	0.575
MOD_GlcNHglycan	23	26	PF01048	0.512
MOD_GlcNHglycan	30	33	PF01048	0.465
MOD_GlcNHglycan	385	388	PF01048	0.215
MOD_GlcNHglycan	404	407	PF01048	0.199
MOD_GlcNHglycan	491	494	PF01048	0.528
MOD_GlcNHglycan	532	535	PF01048	0.449
MOD_GlcNHglycan	550	553	PF01048	0.423
MOD_GlcNHglycan	555	558	PF01048	0.335
MOD_GlcNHglycan	592	595	PF01048	0.393
MOD_GlcNHglycan	6	9	PF01048	0.453
MOD_GlcNHglycan	88	91	PF01048	0.767
MOD_GSK3_1	110	117	PF00069	0.392
MOD_GSK3_1	142	149	PF00069	0.508
MOD_GSK3_1	164	171	PF00069	0.479
MOD_GSK3_1	222	229	PF00069	0.633
MOD_GSK3_1	24	31	PF00069	0.475
MOD_GSK3_1	244	251	PF00069	0.582
MOD_GSK3_1	296	303	PF00069	0.288
MOD_GSK3_1	316	323	PF00069	0.241
MOD_GSK3_1	332	339	PF00069	0.199
MOD_GSK3_1	459	466	PF00069	0.208
MOD_GSK3_1	478	485	PF00069	0.453
MOD_GSK3_1	489	496	PF00069	0.491
MOD_GSK3_1	51	58	PF00069	0.480
MOD_GSK3_1	512	519	PF00069	0.351
MOD_GSK3_1	548	555	PF00069	0.471
MOD_GSK3_1	81	88	PF00069	0.492
MOD_GSK3_1	94	101	PF00069	0.468
MOD_LATS_1	443	449	PF00433	0.199
MOD_N-GLC_1	114	119	PF02516	0.432
MOD_N-GLC_1	383	388	PF02516	0.199
MOD_NEK2_1	332	337	PF00069	0.199
MOD_NEK2_1	402	407	PF00069	0.199
MOD_NEK2_1	459	464	PF00069	0.208
MOD_NEK2_1	479	484	PF00069	0.448
MOD_NEK2_1	85	90	PF00069	0.571
MOD_NEK2_2	358	363	PF00069	0.208
MOD_NEK2_2	438	443	PF00069	0.199
MOD_NEK2_2	575	580	PF00069	0.337
MOD_PIKK_1	287	293	PF00454	0.208
MOD_PIKK_1	493	499	PF00454	0.515
MOD_PIKK_1	55	61	PF00454	0.475
MOD_PKA_2	212	218	PF00069	0.551
MOD_PKA_2	238	244	PF00069	0.555
MOD_PKA_2	444	450	PF00069	0.199
MOD_PKA_2	482	488	PF00069	0.506
MOD_PKB_1	44	52	PF00069	0.504
MOD_PKB_1	525	533	PF00069	0.389
MOD_Plk_1	180	186	PF00069	0.504
MOD_Plk_1	191	197	PF00069	0.368
MOD_Plk_1	512	518	PF00069	0.353
MOD_Plk_2-3	296	302	PF00069	0.199
MOD_Plk_4	117	123	PF00069	0.446
MOD_Plk_4	254	260	PF00069	0.544
MOD_Plk_4	445	451	PF00069	0.199
MOD_Plk_4	459	465	PF00069	0.199
MOD_Plk_4	512	518	PF00069	0.353
MOD_Plk_4	536	542	PF00069	0.460
MOD_Plk_4	578	584	PF00069	0.440
MOD_ProDKin_1	128	134	PF00069	0.501
MOD_ProDKin_1	164	170	PF00069	0.632
MOD_ProDKin_1	241	247	PF00069	0.495
MOD_ProDKin_1	336	342	PF00069	0.208
MOD_ProDKin_1	348	354	PF00069	0.209
MOD_ProDKin_1	464	470	PF00069	0.208
MOD_ProDKin_1	584	590	PF00069	0.363
MOD_ProDKin_1	94	100	PF00069	0.512
MOD_SUMO_rev_2	466	476	PF00179	0.476
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.199
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.283
TRG_ENDOCYTIC_2	372	375	PF00928	0.208
TRG_ENDOCYTIC_2	460	463	PF00928	0.199
TRG_ER_diArg_1	325	327	PF00400	0.313
TRG_ER_diArg_1	346	349	PF00400	0.352
TRG_ER_diArg_1	44	47	PF00400	0.508
TRG_ER_diArg_1	524	527	PF00400	0.341
TRG_ER_diArg_1	77	79	PF00400	0.442
TRG_NLS_MonoExtC_3	42	48	PF00514	0.667
TRG_NLS_MonoExtN_4	40	47	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
V5BH49	Trypanosoma cruzi	39%	100%