Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H588_LEIBR

TriTrypDb:

LbrM.08.0220 , LBRM2903_080007400

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H588

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H588

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.561
CLV_C14_Caspase3-7	45	49	PF00656	0.555
CLV_C14_Caspase3-7	75	79	PF00656	0.573
CLV_NRD_NRD_1	161	163	PF00675	0.554
CLV_NRD_NRD_1	165	167	PF00675	0.541
CLV_NRD_NRD_1	195	197	PF00675	0.779
CLV_NRD_NRD_1	208	210	PF00675	0.574
CLV_NRD_NRD_1	222	224	PF00675	0.557
CLV_NRD_NRD_1	232	234	PF00675	0.535
CLV_NRD_NRD_1	299	301	PF00675	0.591
CLV_NRD_NRD_1	409	411	PF00675	0.546
CLV_NRD_NRD_1	419	421	PF00675	0.524
CLV_NRD_NRD_1	437	439	PF00675	0.572
CLV_PCSK_FUR_1	435	439	PF00082	0.616
CLV_PCSK_KEX2_1	117	119	PF00082	0.717
CLV_PCSK_KEX2_1	195	197	PF00082	0.788
CLV_PCSK_KEX2_1	208	210	PF00082	0.544
CLV_PCSK_KEX2_1	222	224	PF00082	0.557
CLV_PCSK_KEX2_1	231	233	PF00082	0.564
CLV_PCSK_KEX2_1	299	301	PF00082	0.574
CLV_PCSK_KEX2_1	409	411	PF00082	0.631
CLV_PCSK_KEX2_1	419	421	PF00082	0.614
CLV_PCSK_KEX2_1	437	439	PF00082	0.572
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.693
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.586
CLV_PCSK_SKI1_1	399	403	PF00082	0.576
CLV_PCSK_SKI1_1	410	414	PF00082	0.614
CLV_Separin_Metazoa	394	398	PF03568	0.589
DEG_APCC_DBOX_1	473	481	PF00400	0.482
DOC_MAPK_gen_1	263	270	PF00069	0.581
DOC_MAPK_gen_1	397	406	PF00069	0.547
DOC_MAPK_gen_1	435	445	PF00069	0.600
DOC_MAPK_MEF2A_6	263	270	PF00069	0.714
DOC_PP2B_LxvP_1	375	378	PF13499	0.706
DOC_PP4_MxPP_1	1	4	PF00568	0.554
DOC_USP7_MATH_1	113	117	PF00917	0.572
DOC_USP7_MATH_1	269	273	PF00917	0.640
DOC_USP7_MATH_1	274	278	PF00917	0.660
DOC_USP7_MATH_1	306	310	PF00917	0.699
DOC_USP7_MATH_1	405	409	PF00917	0.594
DOC_USP7_MATH_1	41	45	PF00917	0.684
DOC_USP7_MATH_1	456	460	PF00917	0.650
DOC_USP7_MATH_1	473	477	PF00917	0.455
DOC_USP7_MATH_1	523	527	PF00917	0.564
DOC_USP7_UBL2_3	163	167	PF12436	0.554
DOC_WW_Pin1_4	184	189	PF00397	0.580
DOC_WW_Pin1_4	236	241	PF00397	0.675
DOC_WW_Pin1_4	283	288	PF00397	0.739
DOC_WW_Pin1_4	291	296	PF00397	0.614
DOC_WW_Pin1_4	342	347	PF00397	0.580
DOC_WW_Pin1_4	454	459	PF00397	0.568
LIG_14-3-3_CanoR_1	299	307	PF00244	0.618
LIG_14-3-3_CanoR_1	399	405	PF00244	0.564
LIG_14-3-3_CterR_2	524	527	PF00244	0.566
LIG_Actin_WH2_2	463	480	PF00022	0.455
LIG_APCC_ABBA_1	120	125	PF00400	0.695
LIG_BRCT_BRCA1_1	463	467	PF00533	0.649
LIG_FHA_1	144	150	PF00498	0.540
LIG_FHA_1	27	33	PF00498	0.704
LIG_FHA_1	287	293	PF00498	0.549
LIG_FHA_1	336	342	PF00498	0.705
LIG_FHA_1	401	407	PF00498	0.540
LIG_FHA_1	411	417	PF00498	0.524
LIG_FHA_1	450	456	PF00498	0.585
LIG_FHA_1	498	504	PF00498	0.448
LIG_FHA_2	200	206	PF00498	0.631
LIG_FHA_2	343	349	PF00498	0.611
LIG_FHA_2	75	81	PF00498	0.593
LIG_Integrin_RGD_1	180	182	PF01839	0.575
LIG_LIR_Apic_2	116	122	PF02991	0.552
LIG_LIR_Apic_2	31	36	PF02991	0.678
LIG_LIR_Apic_2	428	434	PF02991	0.650
LIG_LIR_Gen_1	125	135	PF02991	0.541
LIG_LIR_Gen_1	464	475	PF02991	0.541
LIG_LIR_Gen_1	501	512	PF02991	0.503
LIG_LIR_Nem_3	125	131	PF02991	0.589
LIG_LIR_Nem_3	214	219	PF02991	0.541
LIG_LIR_Nem_3	464	470	PF02991	0.588
LIG_LIR_Nem_3	501	507	PF02991	0.495
LIG_PDZ_Class_1	522	527	PF00595	0.562
LIG_Pex14_2	467	471	PF04695	0.586
LIG_PTAP_UEV_1	93	98	PF05743	0.687
LIG_SH2_PTP2	128	131	PF00017	0.513
LIG_SH2_SRC	431	434	PF00017	0.659
LIG_SH2_STAT5	119	122	PF00017	0.762
LIG_SH2_STAT5	128	131	PF00017	0.611
LIG_SH2_STAT5	219	222	PF00017	0.539
LIG_SH2_STAT5	34	37	PF00017	0.657
LIG_SH2_STAT5	431	434	PF00017	0.659
LIG_SH2_STAT5	510	513	PF00017	0.464
LIG_SH3_3	91	97	PF00018	0.806
LIG_SUMO_SIM_anti_2	124	133	PF11976	0.517
LIG_SUMO_SIM_anti_2	286	294	PF11976	0.539
LIG_SUMO_SIM_par_1	288	294	PF11976	0.684
LIG_TRAF2_1	122	125	PF00917	0.688
LIG_TRAF2_1	203	206	PF00917	0.575
LIG_TRAF2_1	345	348	PF00917	0.566
LIG_TRAF2_1	56	59	PF00917	0.686
LIG_TRAF2_1	70	73	PF00917	0.593
LIG_TRFH_1	430	434	PF08558	0.664
LIG_ULM_U2AF65_1	230	235	PF00076	0.558
MOD_CDK_SPK_2	184	189	PF00069	0.580
MOD_CK1_1	199	205	PF00069	0.573
MOD_CK1_1	236	242	PF00069	0.548
MOD_CK1_1	286	292	PF00069	0.628
MOD_CK1_1	294	300	PF00069	0.691
MOD_CK1_1	301	307	PF00069	0.624
MOD_CK1_1	332	338	PF00069	0.604
MOD_CK1_1	400	406	PF00069	0.541
MOD_CK1_1	44	50	PF00069	0.554
MOD_CK1_1	457	463	PF00069	0.634
MOD_CK1_1	487	493	PF00069	0.570
MOD_CK1_1	505	511	PF00069	0.393
MOD_CK1_1	61	67	PF00069	0.520
MOD_CK1_1	76	82	PF00069	0.564
MOD_CK2_1	199	205	PF00069	0.675
MOD_CK2_1	275	281	PF00069	0.661
MOD_CK2_1	318	324	PF00069	0.796
MOD_CK2_1	342	348	PF00069	0.656
MOD_CK2_1	39	45	PF00069	0.605
MOD_GlcNHglycan	196	199	PF01048	0.640
MOD_GlcNHglycan	235	238	PF01048	0.551
MOD_GlcNHglycan	302	306	PF01048	0.723
MOD_GlcNHglycan	308	311	PF01048	0.677
MOD_GlcNHglycan	370	373	PF01048	0.659
MOD_GlcNHglycan	391	394	PF01048	0.686
MOD_GlcNHglycan	464	467	PF01048	0.571
MOD_GSK3_1	180	187	PF00069	0.579
MOD_GSK3_1	275	282	PF00069	0.603
MOD_GSK3_1	286	293	PF00069	0.712
MOD_GSK3_1	294	301	PF00069	0.762
MOD_GSK3_1	306	313	PF00069	0.526
MOD_GSK3_1	325	332	PF00069	0.642
MOD_GSK3_1	379	386	PF00069	0.600
MOD_GSK3_1	40	47	PF00069	0.652
MOD_GSK3_1	400	407	PF00069	0.669
MOD_GSK3_1	418	425	PF00069	0.541
MOD_GSK3_1	456	463	PF00069	0.678
MOD_GSK3_1	498	505	PF00069	0.506
MOD_GSK3_1	50	57	PF00069	0.574
MOD_N-GLC_1	211	216	PF02516	0.546
MOD_N-GLC_1	342	347	PF02516	0.571
MOD_N-GLC_1	50	55	PF02516	0.568
MOD_NEK2_1	280	285	PF00069	0.561
MOD_NEK2_1	290	295	PF00069	0.526
MOD_NEK2_1	329	334	PF00069	0.702
MOD_NEK2_1	99	104	PF00069	0.584
MOD_NEK2_2	28	33	PF00069	0.703
MOD_PIKK_1	383	389	PF00454	0.561
MOD_PK_1	502	508	PF00069	0.432
MOD_PKA_2	194	200	PF00069	0.621
MOD_PKA_2	298	304	PF00069	0.586
MOD_PKA_2	418	424	PF00069	0.764
MOD_PKA_2	473	479	PF00069	0.505
MOD_PKB_1	397	405	PF00069	0.548
MOD_Plk_1	275	281	PF00069	0.570
MOD_Plk_1	325	331	PF00069	0.619
MOD_Plk_1	397	403	PF00069	0.552
MOD_Plk_1	50	56	PF00069	0.566
MOD_Plk_2-3	276	282	PF00069	0.567
MOD_Plk_4	286	292	PF00069	0.628
MOD_Plk_4	325	331	PF00069	0.619
MOD_ProDKin_1	184	190	PF00069	0.580
MOD_ProDKin_1	236	242	PF00069	0.674
MOD_ProDKin_1	283	289	PF00069	0.737
MOD_ProDKin_1	291	297	PF00069	0.615
MOD_ProDKin_1	342	348	PF00069	0.580
MOD_ProDKin_1	454	460	PF00069	0.563
TRG_ENDOCYTIC_2	128	131	PF00928	0.580
TRG_ENDOCYTIC_2	442	445	PF00928	0.463
TRG_ER_diArg_1	232	234	PF00400	0.571
TRG_ER_diArg_1	434	437	PF00400	0.602
TRG_NLS_MonoCore_2	229	234	PF00514	0.560
TRG_NLS_MonoExtC_3	229	235	PF00514	0.713
TRG_NLS_MonoExtN_4	227	234	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.534
TRG_PTS1	524	527	PF00515	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H635	Leishmania donovani	51%	100%
A4HTH2	Leishmania infantum	51%	100%
E9AMA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4QIE8	Leishmania major	50%	98%