Inositol phosphosphingolipid phospholipase C-Like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inositol phosphosphingolipids phospholipase C

Species:

Leishmania braziliensis

UniProt:

A4H587_LEIBR

TriTrypDb:

LbrM.08.0210 , LBRM2903_080007300

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071944	cell periphery	2	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H587

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H587

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006672	ceramide metabolic process	4	1
GO:0006684	sphingomyelin metabolic process	4	1
GO:0006685	sphingomyelin catabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009268	response to pH	3	1
GO:0009395	phospholipid catabolic process	5	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0010447	response to acidic pH	4	1
GO:0016042	lipid catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030149	sphingolipid catabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046466	membrane lipid catabolic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046513	ceramide biosynthetic process	5	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071467	cellular response to pH	4	1
GO:0071468	cellular response to acidic pH	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004620	phospholipase activity	5	11
GO:0004767	sphingomyelin phosphodiesterase activity	6	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.368
CLV_C14_Caspase3-7	405	409	PF00656	0.452
CLV_NRD_NRD_1	164	166	PF00675	0.467
CLV_NRD_NRD_1	469	471	PF00675	0.472
CLV_NRD_NRD_1	76	78	PF00675	0.519
CLV_PCSK_KEX2_1	218	220	PF00082	0.554
CLV_PCSK_KEX2_1	346	348	PF00082	0.725
CLV_PCSK_KEX2_1	469	471	PF00082	0.472
CLV_PCSK_KEX2_1	511	513	PF00082	0.401
CLV_PCSK_KEX2_1	581	583	PF00082	0.631
CLV_PCSK_KEX2_1	76	78	PF00082	0.489
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.554
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.725
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.354
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.631
CLV_PCSK_SKI1_1	225	229	PF00082	0.426
CLV_PCSK_SKI1_1	258	262	PF00082	0.547
CLV_PCSK_SKI1_1	340	344	PF00082	0.648
CLV_PCSK_SKI1_1	581	585	PF00082	0.624
DEG_SCF_FBW7_1	571	577	PF00400	0.638
DEG_SPOP_SBC_1	490	494	PF00917	0.611
DEG_SPOP_SBC_1	574	578	PF00917	0.705
DOC_CKS1_1	287	292	PF01111	0.205
DOC_CKS1_1	571	576	PF01111	0.636
DOC_CYCLIN_RxL_1	267	277	PF00134	0.339
DOC_CYCLIN_RxL_1	337	344	PF00134	0.344
DOC_CYCLIN_yClb5_NLxxxL_5	269	278	PF00134	0.205
DOC_MAPK_gen_1	165	173	PF00069	0.337
DOC_MAPK_gen_1	28	36	PF00069	0.358
DOC_MAPK_MEF2A_6	121	130	PF00069	0.282
DOC_PP1_RVXF_1	13	20	PF00149	0.374
DOC_PP4_FxxP_1	287	290	PF00568	0.335
DOC_USP7_MATH_1	186	190	PF00917	0.292
DOC_USP7_MATH_1	260	264	PF00917	0.358
DOC_USP7_MATH_1	310	314	PF00917	0.307
DOC_USP7_MATH_1	329	333	PF00917	0.333
DOC_USP7_MATH_1	454	458	PF00917	0.349
DOC_USP7_MATH_1	561	565	PF00917	0.794
DOC_WW_Pin1_4	227	232	PF00397	0.205
DOC_WW_Pin1_4	236	241	PF00397	0.180
DOC_WW_Pin1_4	286	291	PF00397	0.269
DOC_WW_Pin1_4	419	424	PF00397	0.436
DOC_WW_Pin1_4	546	551	PF00397	0.717
DOC_WW_Pin1_4	570	575	PF00397	0.697
DOC_WW_Pin1_4	582	587	PF00397	0.778
LIG_14-3-3_CanoR_1	15	20	PF00244	0.362
LIG_14-3-3_CanoR_1	174	181	PF00244	0.282
LIG_14-3-3_CanoR_1	427	433	PF00244	0.422
LIG_14-3-3_CanoR_1	495	503	PF00244	0.702
LIG_14-3-3_CanoR_1	582	586	PF00244	0.823
LIG_14-3-3_CanoR_1	77	83	PF00244	0.344
LIG_BIR_II_1	1	5	PF00653	0.500
LIG_BRCT_BRCA1_1	383	387	PF00533	0.413
LIG_BRCT_BRCA1_1	617	621	PF00533	0.461
LIG_BRCT_BRCA1_1	629	633	PF00533	0.484
LIG_Clathr_ClatBox_1	271	275	PF01394	0.362
LIG_EH1_1	386	394	PF00400	0.378
LIG_FHA_1	147	153	PF00498	0.285
LIG_FHA_1	190	196	PF00498	0.296
LIG_FHA_1	477	483	PF00498	0.540
LIG_FHA_1	589	595	PF00498	0.744
LIG_FHA_1	622	628	PF00498	0.430
LIG_FHA_2	320	326	PF00498	0.392
LIG_FHA_2	37	43	PF00498	0.386
LIG_FHA_2	420	426	PF00498	0.365
LIG_FHA_2	429	435	PF00498	0.308
LIG_FHA_2	503	509	PF00498	0.633
LIG_GBD_Chelix_1	521	529	PF00786	0.367
LIG_LIR_Gen_1	42	49	PF02991	0.329
LIG_LIR_Gen_1	449	460	PF02991	0.365
LIG_LIR_Gen_1	505	514	PF02991	0.666
LIG_LIR_Gen_1	56	65	PF02991	0.221
LIG_LIR_LC3C_4	316	320	PF02991	0.325
LIG_LIR_Nem_3	265	271	PF02991	0.359
LIG_LIR_Nem_3	337	342	PF02991	0.494
LIG_LIR_Nem_3	42	47	PF02991	0.329
LIG_LIR_Nem_3	449	455	PF02991	0.365
LIG_LIR_Nem_3	505	510	PF02991	0.669
LIG_LIR_Nem_3	551	556	PF02991	0.608
LIG_LIR_Nem_3	56	61	PF02991	0.221
LIG_LIR_Nem_3	598	602	PF02991	0.601
LIG_LIR_Nem_3	72	78	PF02991	0.255
LIG_LIR_Nem_3	91	96	PF02991	0.181
LIG_LYPXL_yS_3	108	111	PF13949	0.350
LIG_LYPXL_yS_3	93	96	PF13949	0.374
LIG_MYND_1	419	423	PF01753	0.291
LIG_NRBOX	337	343	PF00104	0.346
LIG_Pex14_2	113	117	PF04695	0.220
LIG_Pex14_2	78	82	PF04695	0.214
LIG_Pex14_2	99	103	PF04695	0.386
LIG_REV1ctd_RIR_1	115	125	PF16727	0.362
LIG_SH2_CRK	156	160	PF00017	0.249
LIG_SH2_CRK	44	48	PF00017	0.282
LIG_SH2_CRK	452	456	PF00017	0.480
LIG_SH2_STAP1	148	152	PF00017	0.292
LIG_SH2_STAP1	44	48	PF00017	0.282
LIG_SH2_STAP1	487	491	PF00017	0.684
LIG_SH2_STAT5	148	151	PF00017	0.334
LIG_SH2_STAT5	268	271	PF00017	0.385
LIG_SH2_STAT5	439	442	PF00017	0.375
LIG_SH3_3	125	131	PF00018	0.325
LIG_SH3_3	323	329	PF00018	0.390
LIG_SH3_3	560	566	PF00018	0.785
LIG_SH3_3	591	597	PF00018	0.580
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.282
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.445
LIG_SUMO_SIM_anti_2	624	630	PF11976	0.404
LIG_SUMO_SIM_par_1	141	150	PF11976	0.313
LIG_SUMO_SIM_par_1	45	51	PF11976	0.282
LIG_TRAF2_1	473	476	PF00917	0.685
LIG_TYR_ITSM	448	455	PF00017	0.385
LIG_UBA3_1	212	218	PF00899	0.335
LIG_WRC_WIRS_1	16	21	PF05994	0.292
MOD_CDK_SPK_2	227	232	PF00069	0.205
MOD_CDK_SPxK_1	582	588	PF00069	0.639
MOD_CK1_1	189	195	PF00069	0.301
MOD_CK1_1	2	8	PF00069	0.521
MOD_CK1_1	204	210	PF00069	0.317
MOD_CK1_1	263	269	PF00069	0.383
MOD_CK1_1	313	319	PF00069	0.264
MOD_CK1_1	402	408	PF00069	0.497
MOD_CK1_1	533	539	PF00069	0.730
MOD_CK1_1	544	550	PF00069	0.761
MOD_CK1_1	619	625	PF00069	0.289
MOD_CK2_1	319	325	PF00069	0.425
MOD_CK2_1	36	42	PF00069	0.357
MOD_CK2_1	406	412	PF00069	0.523
MOD_CK2_1	419	425	PF00069	0.318
MOD_CK2_1	469	475	PF00069	0.661
MOD_CK2_1	502	508	PF00069	0.727
MOD_Cter_Amidation	344	347	PF01082	0.716
MOD_DYRK1A_RPxSP_1	582	586	PF00069	0.643
MOD_GlcNHglycan	312	315	PF01048	0.636
MOD_GlcNHglycan	331	334	PF01048	0.728
MOD_GlcNHglycan	372	375	PF01048	0.736
MOD_GlcNHglycan	4	7	PF01048	0.640
MOD_GlcNHglycan	408	412	PF01048	0.738
MOD_GlcNHglycan	471	474	PF01048	0.481
MOD_GlcNHglycan	53	56	PF01048	0.550
MOD_GlcNHglycan	541	544	PF01048	0.541
MOD_GlcNHglycan	563	566	PF01048	0.500
MOD_GlcNHglycan	618	621	PF01048	0.426
MOD_GlcNHglycan	629	632	PF01048	0.318
MOD_GlcNHglycan	84	87	PF01048	0.489
MOD_GSK3_1	143	150	PF00069	0.343
MOD_GSK3_1	157	164	PF00069	0.257
MOD_GSK3_1	173	180	PF00069	0.207
MOD_GSK3_1	185	192	PF00069	0.296
MOD_GSK3_1	223	230	PF00069	0.205
MOD_GSK3_1	260	267	PF00069	0.332
MOD_GSK3_1	402	409	PF00069	0.510
MOD_GSK3_1	442	449	PF00069	0.419
MOD_GSK3_1	490	497	PF00069	0.651
MOD_GSK3_1	502	509	PF00069	0.691
MOD_GSK3_1	570	577	PF00069	0.790
MOD_GSK3_1	611	618	PF00069	0.642
MOD_GSK3_1	619	626	PF00069	0.351
MOD_GSK3_1	78	85	PF00069	0.356
MOD_N-GLC_1	201	206	PF02516	0.496
MOD_N-GLC_1	561	566	PF02516	0.405
MOD_N-GLC_1	589	594	PF02516	0.413
MOD_NEK2_1	147	152	PF00069	0.283
MOD_NEK2_1	173	178	PF00069	0.333
MOD_NEK2_1	184	189	PF00069	0.298
MOD_NEK2_1	201	206	PF00069	0.201
MOD_NEK2_1	253	258	PF00069	0.337
MOD_NEK2_1	264	269	PF00069	0.332
MOD_NEK2_1	341	346	PF00069	0.414
MOD_NEK2_1	406	411	PF00069	0.550
MOD_NEK2_1	453	458	PF00069	0.328
MOD_NEK2_1	489	494	PF00069	0.616
MOD_NEK2_1	525	530	PF00069	0.627
MOD_NEK2_1	556	561	PF00069	0.606
MOD_NEK2_1	621	626	PF00069	0.394
MOD_NEK2_1	627	632	PF00069	0.383
MOD_NEK2_1	82	87	PF00069	0.275
MOD_PIKK_1	157	163	PF00454	0.321
MOD_PIKK_1	173	179	PF00454	0.212
MOD_PIKK_1	201	207	PF00454	0.296
MOD_PIKK_1	356	362	PF00454	0.406
MOD_PIKK_1	442	448	PF00454	0.417
MOD_PKA_1	346	352	PF00069	0.526
MOD_PKA_1	469	475	PF00069	0.657
MOD_PKA_1	581	587	PF00069	0.823
MOD_PKA_2	173	179	PF00069	0.282
MOD_PKA_2	189	195	PF00069	0.282
MOD_PKA_2	346	352	PF00069	0.475
MOD_PKA_2	447	453	PF00069	0.297
MOD_PKA_2	469	475	PF00069	0.623
MOD_PKA_2	494	500	PF00069	0.708
MOD_PKA_2	581	587	PF00069	0.823
MOD_Plk_1	264	270	PF00069	0.205
MOD_Plk_1	589	595	PF00069	0.607
MOD_Plk_4	143	149	PF00069	0.323
MOD_Plk_4	264	270	PF00069	0.356
MOD_Plk_4	334	340	PF00069	0.487
MOD_Plk_4	362	368	PF00069	0.559
MOD_Plk_4	428	434	PF00069	0.376
MOD_Plk_4	454	460	PF00069	0.331
MOD_Plk_4	612	618	PF00069	0.560
MOD_Plk_4	623	629	PF00069	0.235
MOD_Plk_4	78	84	PF00069	0.335
MOD_ProDKin_1	227	233	PF00069	0.205
MOD_ProDKin_1	236	242	PF00069	0.180
MOD_ProDKin_1	286	292	PF00069	0.269
MOD_ProDKin_1	419	425	PF00069	0.431
MOD_ProDKin_1	546	552	PF00069	0.716
MOD_ProDKin_1	570	576	PF00069	0.698
MOD_ProDKin_1	582	588	PF00069	0.777
MOD_SUMO_for_1	473	476	PF00179	0.661
TRG_DiLeu_BaEn_1	56	61	PF01217	0.362
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.346
TRG_ENDOCYTIC_2	108	111	PF00928	0.350
TRG_ENDOCYTIC_2	156	159	PF00928	0.329
TRG_ENDOCYTIC_2	268	271	PF00928	0.328
TRG_ENDOCYTIC_2	380	383	PF00928	0.434
TRG_ENDOCYTIC_2	44	47	PF00928	0.282
TRG_ENDOCYTIC_2	452	455	PF00928	0.411
TRG_ENDOCYTIC_2	93	96	PF00928	0.337
TRG_ER_diArg_1	468	470	PF00400	0.648
TRG_ER_diArg_1	75	77	PF00400	0.334
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P935	Leptomonas seymouri	55%	100%
A0A1X0NNY2	Trypanosomatidae	39%	100%
A0A3S5H634	Leishmania donovani	73%	100%
A0A422NTR5	Trypanosoma rangeli	36%	100%
A4HTH1	Leishmania infantum	73%	100%
C9ZPP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AM99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QIE9	Leishmania major	70%	99%
V5BLM5	Trypanosoma cruzi	43%	100%