Bacterial transferase hexapeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial transferase hexapeptide (six repeats), putative

Species:

Leishmania braziliensis

UniProt:

A4H585_LEIBR

TriTrypDb:

LbrM.08.0190 , LBRM2903_080007200

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H585

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H585

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	255	257	PF00675	0.549
CLV_NRD_NRD_1	265	267	PF00675	0.494
CLV_PCSK_KEX2_1	255	257	PF00082	0.489
CLV_PCSK_KEX2_1	265	267	PF00082	0.538
CLV_PCSK_KEX2_1	36	38	PF00082	0.506
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.499
CLV_PCSK_PC7_1	261	267	PF00082	0.531
CLV_PCSK_SKI1_1	255	259	PF00082	0.515
CLV_PCSK_SKI1_1	3	7	PF00082	0.628
CLV_PCSK_SKI1_1	52	56	PF00082	0.375
DEG_ODPH_VHL_1	64	76	PF01847	0.289
DOC_MAPK_HePTP_8	252	264	PF00069	0.498
DOC_MAPK_MEF2A_6	245	252	PF00069	0.542
DOC_MAPK_MEF2A_6	255	264	PF00069	0.475
DOC_MAPK_RevD_3	242	256	PF00069	0.501
DOC_PP4_FxxP_1	257	260	PF00568	0.509
DOC_PP4_FxxP_1	63	66	PF00568	0.291
DOC_USP7_MATH_1	142	146	PF00917	0.380
DOC_USP7_MATH_1	159	163	PF00917	0.379
DOC_USP7_MATH_1	189	193	PF00917	0.550
DOC_USP7_UBL2_3	207	211	PF12436	0.422
DOC_WW_Pin1_4	185	190	PF00397	0.434
DOC_WW_Pin1_4	92	97	PF00397	0.318
LIG_14-3-3_CanoR_1	108	112	PF00244	0.337
LIG_14-3-3_CanoR_1	25	29	PF00244	0.374
LIG_14-3-3_CanoR_1	272	276	PF00244	0.582
LIG_14-3-3_CanoR_1	3	9	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_CSL_BTD_1	282	285	PF09270	0.561
LIG_FHA_1	218	224	PF00498	0.398
LIG_FHA_1	93	99	PF00498	0.285
LIG_LIR_Apic_2	136	142	PF02991	0.376
LIG_LIR_Apic_2	60	66	PF02991	0.316
LIG_LYPXL_yS_3	40	43	PF13949	0.531
LIG_Pex14_2	11	15	PF04695	0.451
LIG_Rb_LxCxE_1	128	145	PF01857	0.435
LIG_SH2_CRK	84	88	PF00017	0.304
LIG_SH2_PTP2	139	142	PF00017	0.406
LIG_SH2_STAT5	122	125	PF00017	0.303
LIG_SH2_STAT5	139	142	PF00017	0.311
LIG_SH2_STAT5	14	17	PF00017	0.382
LIG_SH2_STAT5	69	72	PF00017	0.211
LIG_SH3_1	279	285	PF00018	0.550
LIG_SH3_3	279	285	PF00018	0.550
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.412
LIG_TYR_ITIM	82	87	PF00017	0.297
MOD_CK1_1	24	30	PF00069	0.462
MOD_CK2_1	230	236	PF00069	0.489
MOD_GlcNHglycan	161	164	PF01048	0.453
MOD_GlcNHglycan	286	289	PF01048	0.632
MOD_GlcNHglycan	66	69	PF01048	0.246
MOD_GSK3_1	185	192	PF00069	0.541
MOD_GSK3_1	284	291	PF00069	0.641
MOD_GSK3_1	55	62	PF00069	0.350
MOD_GSK3_1	90	97	PF00069	0.431
MOD_LATS_1	92	98	PF00433	0.393
MOD_N-GLC_1	277	282	PF02516	0.662
MOD_N-GLC_1	3	8	PF02516	0.591
MOD_NEK2_1	271	276	PF00069	0.554
MOD_NEK2_1	83	88	PF00069	0.343
MOD_PIKK_1	55	61	PF00454	0.351
MOD_PKA_2	107	113	PF00069	0.335
MOD_PKA_2	24	30	PF00069	0.444
MOD_PKA_2	271	277	PF00069	0.554
MOD_Plk_1	100	106	PF00069	0.365
MOD_Plk_1	3	9	PF00069	0.587
MOD_Plk_1	59	65	PF00069	0.431
MOD_Plk_2-3	230	236	PF00069	0.561
MOD_Plk_4	107	113	PF00069	0.252
MOD_Plk_4	118	124	PF00069	0.321
MOD_Plk_4	230	236	PF00069	0.385
MOD_Plk_4	24	30	PF00069	0.465
MOD_Plk_4	59	65	PF00069	0.222
MOD_Plk_4	77	83	PF00069	0.270
MOD_Plk_4	94	100	PF00069	0.309
MOD_ProDKin_1	185	191	PF00069	0.432
MOD_ProDKin_1	92	98	PF00069	0.316
MOD_SUMO_rev_2	218	228	PF00179	0.408
TRG_DiLeu_BaEn_2	252	258	PF01217	0.476
TRG_ENDOCYTIC_2	40	43	PF00928	0.491
TRG_ENDOCYTIC_2	51	54	PF00928	0.322
TRG_ENDOCYTIC_2	84	87	PF00928	0.312
TRG_ER_diArg_1	255	257	PF00400	0.527
TRG_ER_diArg_1	264	266	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A3	Leptomonas seymouri	27%	96%
A0A0N1ICC0	Leptomonas seymouri	85%	100%
A0A0S4JVD5	Bodo saltans	27%	92%
A0A0S4KEG1	Bodo saltans	60%	83%
A0A1X0NNY9	Trypanosomatidae	61%	100%
A0A3S7WQ41	Leishmania donovani	93%	100%
A0A3S7WRH8	Leishmania donovani	28%	96%
A4H9V5	Leishmania braziliensis	27%	96%
A4HTG9	Leishmania infantum	93%	100%
A4HUR5	Leishmania infantum	28%	96%
C9ZPP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AM97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q03YE4	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	25%	100%
Q4QH77	Leishmania major	24%	100%
Q4QIF1	Leishmania major	92%	100%
Q54JC2	Dictyostelium discoideum	29%	100%
Q6LAN4	Listeria ivanovii	25%	100%
Q94AU7	Arabidopsis thaliana	26%	100%
Q97GI6	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	25%	100%
Q9C6B3	Arabidopsis thaliana	27%	100%
Q9FWR5	Arabidopsis thaliana	28%	100%
V5BBY5	Trypanosoma cruzi	27%	97%
V5BCJ4	Trypanosoma cruzi	70%	100%