Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H584_LEIBR

TriTrypDb:

LbrM.08.0180 , LBRM2903_080007100

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4H584

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H584

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	4
GO:0006952	defense response	3	4
GO:0050896	response to stimulus	1	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.504
CLV_C14_Caspase3-7	365	369	PF00656	0.352
CLV_MEL_PAP_1	578	584	PF00089	0.569
CLV_NRD_NRD_1	170	172	PF00675	0.678
CLV_NRD_NRD_1	231	233	PF00675	0.648
CLV_NRD_NRD_1	29	31	PF00675	0.652
CLV_NRD_NRD_1	314	316	PF00675	0.717
CLV_NRD_NRD_1	580	582	PF00675	0.333
CLV_NRD_NRD_1	638	640	PF00675	0.559
CLV_NRD_NRD_1	76	78	PF00675	0.586
CLV_PCSK_FUR_1	312	316	PF00082	0.719
CLV_PCSK_KEX2_1	170	172	PF00082	0.678
CLV_PCSK_KEX2_1	230	232	PF00082	0.612
CLV_PCSK_KEX2_1	29	31	PF00082	0.652
CLV_PCSK_KEX2_1	312	314	PF00082	0.717
CLV_PCSK_KEX2_1	580	582	PF00082	0.333
CLV_PCSK_KEX2_1	638	640	PF00082	0.559
CLV_PCSK_SKI1_1	355	359	PF00082	0.572
CLV_PCSK_SKI1_1	374	378	PF00082	0.281
CLV_PCSK_SKI1_1	477	481	PF00082	0.381
CLV_PCSK_SKI1_1	564	568	PF00082	0.308
CLV_PCSK_SKI1_1	630	634	PF00082	0.568
DEG_Nend_Nbox_1	1	3	PF02207	0.746
DEG_ODPH_VHL_1	58	70	PF01847	0.615
DEG_SCF_FBW7_1	294	301	PF00400	0.642
DEG_SPOP_SBC_1	298	302	PF00917	0.731
DEG_SPOP_SBC_1	336	340	PF00917	0.365
DOC_AGCK_PIF_2	387	392	PF00069	0.336
DOC_CDC14_PxL_1	134	142	PF14671	0.449
DOC_CDC14_PxL_1	393	401	PF14671	0.331
DOC_CDC14_PxL_1	413	421	PF14671	0.483
DOC_CDC14_PxL_1	490	498	PF14671	0.472
DOC_CYCLIN_RxL_1	474	483	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.545
DOC_MAPK_gen_1	170	178	PF00069	0.639
DOC_MAPK_gen_1	312	321	PF00069	0.790
DOC_MAPK_gen_1	371	381	PF00069	0.543
DOC_MAPK_gen_1	635	643	PF00069	0.577
DOC_MAPK_JIP1_4	315	321	PF00069	0.522
DOC_MAPK_MEF2A_6	170	178	PF00069	0.542
DOC_PP1_RVXF_1	409	416	PF00149	0.487
DOC_PP2B_LxvP_1	457	460	PF13499	0.454
DOC_USP7_MATH_1	10	14	PF00917	0.511
DOC_USP7_MATH_1	290	294	PF00917	0.722
DOC_USP7_MATH_1	398	402	PF00917	0.309
DOC_USP7_MATH_1	440	444	PF00917	0.687
DOC_USP7_MATH_1	467	471	PF00917	0.541
DOC_USP7_MATH_1	628	632	PF00917	0.452
DOC_USP7_UBL2_3	214	218	PF12436	0.597
DOC_WW_Pin1_4	129	134	PF00397	0.688
DOC_WW_Pin1_4	163	168	PF00397	0.524
DOC_WW_Pin1_4	195	200	PF00397	0.541
DOC_WW_Pin1_4	208	213	PF00397	0.532
DOC_WW_Pin1_4	294	299	PF00397	0.711
DOC_WW_Pin1_4	516	521	PF00397	0.480
LIG_14-3-3_CanoR_1	123	127	PF00244	0.592
LIG_14-3-3_CanoR_1	183	193	PF00244	0.625
LIG_14-3-3_CanoR_1	204	213	PF00244	0.500
LIG_14-3-3_CanoR_1	242	248	PF00244	0.747
LIG_14-3-3_CanoR_1	259	264	PF00244	0.495
LIG_14-3-3_CanoR_1	374	380	PF00244	0.567
LIG_14-3-3_CanoR_1	466	476	PF00244	0.349
LIG_14-3-3_CanoR_1	477	482	PF00244	0.326
LIG_14-3-3_CanoR_1	526	534	PF00244	0.463
LIG_14-3-3_CanoR_1	580	585	PF00244	0.554
LIG_14-3-3_CanoR_1	597	603	PF00244	0.308
LIG_Actin_WH2_2	145	163	PF00022	0.509
LIG_Actin_WH2_2	169	185	PF00022	0.445
LIG_Actin_WH2_2	186	203	PF00022	0.619
LIG_Actin_WH2_2	341	357	PF00022	0.351
LIG_Actin_WH2_2	406	422	PF00022	0.571
LIG_Actin_WH2_2	564	582	PF00022	0.303
LIG_APCC_ABBAyCdc20_2	231	237	PF00400	0.522
LIG_DCNL_PONY_1	1	4	PF03556	0.597
LIG_FHA_1	105	111	PF00498	0.638
LIG_FHA_1	205	211	PF00498	0.552
LIG_FHA_1	375	381	PF00498	0.517
LIG_FHA_1	459	465	PF00498	0.395
LIG_FHA_1	473	479	PF00498	0.391
LIG_FHA_1	529	535	PF00498	0.361
LIG_FHA_2	363	369	PF00498	0.346
LIG_FHA_2	567	573	PF00498	0.541
LIG_GBD_Chelix_1	441	449	PF00786	0.412
LIG_LIR_Apic_2	391	397	PF02991	0.343
LIG_LIR_Apic_2	623	628	PF02991	0.336
LIG_LIR_Gen_1	480	490	PF02991	0.464
LIG_LIR_Gen_1	569	578	PF02991	0.522
LIG_LIR_Nem_3	480	485	PF02991	0.430
LIG_LIR_Nem_3	488	493	PF02991	0.428
LIG_LIR_Nem_3	569	573	PF02991	0.510
LIG_MYND_3	496	500	PF01753	0.451
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.626
LIG_PTB_Apo_2	358	365	PF02174	0.588
LIG_PTB_Phospho_1	358	364	PF10480	0.586
LIG_SH2_CRK	394	398	PF00017	0.344
LIG_SH2_NCK_1	364	368	PF00017	0.602
LIG_SH2_SRC	570	573	PF00017	0.531
LIG_SH2_STAT5	227	230	PF00017	0.621
LIG_SH2_STAT5	364	367	PF00017	0.346
LIG_SH2_STAT5	570	573	PF00017	0.429
LIG_SH3_3	461	467	PF00018	0.336
LIG_SH3_3	491	497	PF00018	0.422
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.465
LIG_SUMO_SIM_par_1	172	177	PF11976	0.611
LIG_SUMO_SIM_par_1	377	382	PF11976	0.313
LIG_SUMO_SIM_par_1	477	483	PF11976	0.304
LIG_TRAF2_1	330	333	PF00917	0.358
LIG_TYR_ITIM	568	573	PF00017	0.431
LIG_WRC_WIRS_1	441	446	PF05994	0.467
LIG_WRC_WIRS_1	5	10	PF05994	0.745
MOD_CDC14_SPxK_1	198	201	PF00782	0.550
MOD_CDC14_SPxK_1	211	214	PF00782	0.503
MOD_CDK_SPK_2	516	521	PF00069	0.480
MOD_CDK_SPxK_1	195	201	PF00069	0.546
MOD_CDK_SPxK_1	208	214	PF00069	0.534
MOD_CDK_SPxxK_3	163	170	PF00069	0.635
MOD_CK1_1	129	135	PF00069	0.623
MOD_CK1_1	195	201	PF00069	0.546
MOD_CK1_1	257	263	PF00069	0.714
MOD_CK1_1	274	280	PF00069	0.630
MOD_CK1_1	322	328	PF00069	0.741
MOD_CK1_1	340	346	PF00069	0.312
MOD_CK1_1	369	375	PF00069	0.443
MOD_CK1_1	37	43	PF00069	0.629
MOD_CK1_1	422	428	PF00069	0.391
MOD_CK1_1	432	438	PF00069	0.536
MOD_CK1_1	458	464	PF00069	0.495
MOD_CK1_1	488	494	PF00069	0.383
MOD_CK2_1	447	453	PF00069	0.545
MOD_CK2_1	580	586	PF00069	0.570
MOD_Cter_Amidation	636	639	PF01082	0.554
MOD_Cter_Amidation	75	78	PF01082	0.651
MOD_GlcNHglycan	134	137	PF01048	0.646
MOD_GlcNHglycan	274	277	PF01048	0.788
MOD_GlcNHglycan	301	304	PF01048	0.569
MOD_GlcNHglycan	321	324	PF01048	0.719
MOD_GlcNHglycan	371	374	PF01048	0.532
MOD_GlcNHglycan	432	435	PF01048	0.612
MOD_GlcNHglycan	449	452	PF01048	0.388
MOD_GlcNHglycan	487	490	PF01048	0.376
MOD_GlcNHglycan	622	625	PF01048	0.502
MOD_GlcNHglycan	630	633	PF01048	0.341
MOD_GSK3_1	122	129	PF00069	0.571
MOD_GSK3_1	132	139	PF00069	0.585
MOD_GSK3_1	204	211	PF00069	0.615
MOD_GSK3_1	290	297	PF00069	0.613
MOD_GSK3_1	299	306	PF00069	0.777
MOD_GSK3_1	319	326	PF00069	0.563
MOD_GSK3_1	33	40	PF00069	0.601
MOD_GSK3_1	336	343	PF00069	0.591
MOD_GSK3_1	362	369	PF00069	0.342
MOD_GSK3_1	430	437	PF00069	0.594
MOD_GSK3_1	440	447	PF00069	0.614
MOD_GSK3_1	528	535	PF00069	0.548
MOD_N-GLC_1	257	262	PF02516	0.775
MOD_N-GLC_1	455	460	PF02516	0.554
MOD_N-GLC_1	485	490	PF02516	0.417
MOD_N-GLC_1	597	602	PF02516	0.574
MOD_N-GLC_2	551	553	PF02516	0.535
MOD_N-GLC_2	555	557	PF02516	0.494
MOD_NEK2_1	182	187	PF00069	0.499
MOD_NEK2_1	192	197	PF00069	0.570
MOD_NEK2_1	219	224	PF00069	0.495
MOD_NEK2_1	319	324	PF00069	0.722
MOD_NEK2_1	334	339	PF00069	0.410
MOD_NEK2_1	4	9	PF00069	0.747
MOD_NEK2_1	419	424	PF00069	0.525
MOD_NEK2_1	444	449	PF00069	0.596
MOD_NEK2_1	455	460	PF00069	0.386
MOD_NEK2_1	571	576	PF00069	0.530
MOD_NEK2_1	68	73	PF00069	0.492
MOD_NEK2_2	434	439	PF00069	0.495
MOD_NEK2_2	472	477	PF00069	0.338
MOD_PIKK_1	182	188	PF00454	0.413
MOD_PIKK_1	349	355	PF00454	0.345
MOD_PIKK_1	467	473	PF00454	0.380
MOD_PIKK_1	525	531	PF00454	0.457
MOD_PIKK_1	571	577	PF00454	0.286
MOD_PK_1	259	265	PF00069	0.561
MOD_PK_1	580	586	PF00069	0.317
MOD_PKA_1	580	586	PF00069	0.317
MOD_PKA_2	122	128	PF00069	0.599
MOD_PKA_2	182	188	PF00069	0.413
MOD_PKA_2	203	209	PF00069	0.431
MOD_PKA_2	319	325	PF00069	0.749
MOD_PKA_2	525	531	PF00069	0.494
MOD_PKA_2	580	586	PF00069	0.570
MOD_Plk_1	257	263	PF00069	0.560
MOD_Plk_1	411	417	PF00069	0.598
MOD_Plk_1	455	461	PF00069	0.536
MOD_Plk_1	597	603	PF00069	0.570
MOD_Plk_4	122	128	PF00069	0.599
MOD_Plk_4	375	381	PF00069	0.565
MOD_Plk_4	4	10	PF00069	0.513
MOD_Plk_4	411	417	PF00069	0.471
MOD_Plk_4	434	440	PF00069	0.459
MOD_Plk_4	477	483	PF00069	0.455
MOD_Plk_4	566	572	PF00069	0.520
MOD_Plk_4	580	586	PF00069	0.366
MOD_ProDKin_1	129	135	PF00069	0.698
MOD_ProDKin_1	163	169	PF00069	0.522
MOD_ProDKin_1	195	201	PF00069	0.546
MOD_ProDKin_1	208	214	PF00069	0.534
MOD_ProDKin_1	294	300	PF00069	0.711
MOD_ProDKin_1	516	522	PF00069	0.472
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.522
TRG_DiLeu_BaLyEn_6	574	579	PF01217	0.300
TRG_ENDOCYTIC_2	570	573	PF00928	0.429
TRG_ER_diArg_1	169	171	PF00400	0.671
TRG_ER_diArg_1	229	232	PF00400	0.695
TRG_ER_diArg_1	312	315	PF00400	0.715
TRG_ER_diArg_1	579	581	PF00400	0.331
TRG_NES_CRM1_1	164	177	PF08389	0.536
TRG_NES_CRM1_1	540	554	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P939	Leptomonas seymouri	45%	98%
A0A3S5H632	Leishmania donovani	74%	100%
A4HTG8	Leishmania infantum	75%	100%
E9AM96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QIF2	Leishmania major	73%	100%