DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H583_LEIBR

TriTrypDb:

LbrM.08.0170 , LBRM2903_080007000

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H583

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H583

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.523
CLV_NRD_NRD_1	38	40	PF00675	0.477
CLV_PCSK_FUR_1	36	40	PF00082	0.463
CLV_PCSK_KEX2_1	26	28	PF00082	0.521
CLV_PCSK_KEX2_1	38	40	PF00082	0.474
CLV_PCSK_SKI1_1	175	179	PF00082	0.563
CLV_PCSK_SKI1_1	220	224	PF00082	0.754
DEG_APCC_DBOX_1	174	182	PF00400	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.731
DEG_SPOP_SBC_1	77	81	PF00917	0.642
DEG_SPOP_SBC_1	85	89	PF00917	0.631
DOC_CYCLIN_RxL_1	13	23	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.450
DOC_MAPK_gen_1	3	10	PF00069	0.771
DOC_PP2B_LxvP_1	205	208	PF13499	0.404
DOC_USP7_MATH_1	101	105	PF00917	0.638
DOC_USP7_MATH_1	77	81	PF00917	0.718
DOC_USP7_MATH_1	93	97	PF00917	0.672
DOC_WW_Pin1_4	11	16	PF00397	0.746
DOC_WW_Pin1_4	170	175	PF00397	0.369
DOC_WW_Pin1_4	228	233	PF00397	0.578
LIG_14-3-3_CanoR_1	26	30	PF00244	0.674
LIG_14-3-3_CanoR_1	36	44	PF00244	0.736
LIG_14-3-3_CanoR_1	67	71	PF00244	0.817
LIG_CtBP_PxDLS_1	17	21	PF00389	0.607
LIG_FHA_1	131	137	PF00498	0.367
LIG_LIR_Gen_1	158	168	PF02991	0.499
LIG_LIR_Nem_3	104	110	PF02991	0.590
LIG_LIR_Nem_3	158	163	PF02991	0.498
LIG_LYPXL_S_1	187	191	PF13949	0.665
LIG_LYPXL_yS_3	188	191	PF13949	0.422
LIG_RPA_C_Fungi	21	33	PF08784	0.499
LIG_SH2_CRK	107	111	PF00017	0.378
LIG_SH2_CRK	120	124	PF00017	0.476
LIG_SH2_STAT3	168	171	PF00017	0.557
LIG_SH2_STAT5	122	125	PF00017	0.366
LIG_SH2_STAT5	134	137	PF00017	0.407
LIG_SH2_STAT5	180	183	PF00017	0.490
LIG_SH3_3	186	192	PF00018	0.515
LIG_SH3_3	222	228	PF00018	0.590
LIG_SUMO_SIM_par_1	16	21	PF11976	0.749
LIG_SxIP_EBH_1	36	49	PF03271	0.577
LIG_TRFH_1	188	192	PF08558	0.410
LIG_TYR_ITIM	178	183	PF00017	0.558
MOD_CDK_SPK_2	11	16	PF00069	0.506
MOD_CDK_SPK_2	170	175	PF00069	0.466
MOD_CK1_1	84	90	PF00069	0.769
MOD_CK1_1	92	98	PF00069	0.676
MOD_GlcNHglycan	20	23	PF01048	0.500
MOD_GlcNHglycan	228	231	PF01048	0.582
MOD_GlcNHglycan	68	71	PF01048	0.745
MOD_GlcNHglycan	83	86	PF01048	0.691
MOD_GlcNHglycan	91	94	PF01048	0.583
MOD_GlcNHglycan	95	98	PF01048	0.516
MOD_GSK3_1	216	223	PF00069	0.697
MOD_GSK3_1	226	233	PF00069	0.715
MOD_GSK3_1	38	45	PF00069	0.668
MOD_GSK3_1	66	73	PF00069	0.705
MOD_GSK3_1	77	84	PF00069	0.666
MOD_GSK3_1	85	92	PF00069	0.622
MOD_N-GLC_2	184	186	PF02516	0.513
MOD_NEK2_1	124	129	PF00069	0.451
MOD_NEK2_1	130	135	PF00069	0.464
MOD_NEK2_1	216	221	PF00069	0.667
MOD_PKA_1	220	226	PF00069	0.606
MOD_PKA_1	38	44	PF00069	0.589
MOD_PKA_2	25	31	PF00069	0.663
MOD_PKA_2	37	43	PF00069	0.687
MOD_PKA_2	66	72	PF00069	0.675
MOD_PKA_2	81	87	PF00069	0.659
MOD_PKB_1	36	44	PF00069	0.585
MOD_Plk_4	130	136	PF00069	0.415
MOD_Plk_4	145	151	PF00069	0.495
MOD_Plk_4	163	169	PF00069	0.550
MOD_ProDKin_1	11	17	PF00069	0.697
MOD_ProDKin_1	170	176	PF00069	0.444
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.444
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.633
TRG_ENDOCYTIC_2	107	110	PF00928	0.460
TRG_ENDOCYTIC_2	120	123	PF00928	0.394
TRG_ENDOCYTIC_2	180	183	PF00928	0.521
TRG_ENDOCYTIC_2	188	191	PF00928	0.484
TRG_ER_diArg_1	2	5	PF00400	0.741
TRG_ER_diArg_1	36	39	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL2	Leptomonas seymouri	46%	100%
A0A1X0NNX7	Trypanosomatidae	36%	88%
A0A3S7WQ61	Leishmania donovani	71%	100%
A4HTG7	Leishmania infantum	72%	100%
E9AM95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QIF3	Leishmania major	73%	100%