LeishMANIAdb
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PIG-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PIG-H domain-containing protein
Gene product:
GPI-GlcNAc transferase complex, PIG-H component, putative
Species:
Leishmania braziliensis
UniProt:
A4H582_LEIBR
TriTrypDb:
LbrM.08.0160 , LBRM2903_080006900
Length:
515

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex 3 7
GO:0016020 membrane 2 7
GO:0032991 protein-containing complex 1 7
GO:0098796 membrane protein complex 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0140534 endoplasmic reticulum protein-containing complex 2 7
GO:1902494 catalytic complex 2 7
GO:1990234 transferase complex 3 7

Expansion

Sequence features

A4H582
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H582

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 7
GO:0006505 GPI anchor metabolic process 6 7
GO:0006506 GPI anchor biosynthetic process 6 7
GO:0006629 lipid metabolic process 3 7
GO:0006643 membrane lipid metabolic process 4 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006661 phosphatidylinositol biosynthetic process 6 7
GO:0006664 glycolipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009247 glycolipid biosynthetic process 5 7
GO:0009987 cellular process 1 7
GO:0019538 protein metabolic process 3 7
GO:0019637 organophosphate metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046467 membrane lipid biosynthetic process 4 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0046488 phosphatidylinositol metabolic process 6 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901135 carbohydrate derivative metabolic process 3 7
GO:1901137 carbohydrate derivative biosynthetic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901576 organic substance biosynthetic process 3 7
GO:1903509 liposaccharide metabolic process 4 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 25 29 PF00656 0.635
CLV_C14_Caspase3-7 325 329 PF00656 0.389
CLV_C14_Caspase3-7 481 485 PF00656 0.630
CLV_NRD_NRD_1 4 6 PF00675 0.448
CLV_PCSK_FUR_1 2 6 PF00082 0.426
CLV_PCSK_KEX2_1 362 364 PF00082 0.354
CLV_PCSK_KEX2_1 4 6 PF00082 0.448
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.354
CLV_PCSK_SKI1_1 219 223 PF00082 0.406
CLV_PCSK_SKI1_1 449 453 PF00082 0.319
CLV_PCSK_SKI1_1 456 460 PF00082 0.338
CLV_Separin_Metazoa 446 450 PF03568 0.459
DEG_APCC_DBOX_1 448 456 PF00400 0.512
DEG_SPOP_SBC_1 262 266 PF00917 0.363
DOC_AGCK_PIF_2 202 207 PF00069 0.606
DOC_CYCLIN_yCln2_LP_2 196 202 PF00134 0.605
DOC_MAPK_gen_1 396 403 PF00069 0.482
DOC_MAPK_MEF2A_6 396 405 PF00069 0.482
DOC_MAPK_MEF2A_6 88 96 PF00069 0.598
DOC_MAPK_RevD_3 350 363 PF00069 0.325
DOC_PP1_RVXF_1 217 223 PF00149 0.658
DOC_PP1_RVXF_1 432 439 PF00149 0.482
DOC_USP7_MATH_1 262 266 PF00917 0.405
DOC_USP7_MATH_1 277 281 PF00917 0.471
DOC_USP7_MATH_1 295 299 PF00917 0.382
DOC_USP7_MATH_1 3 7 PF00917 0.674
DOC_USP7_MATH_1 32 36 PF00917 0.713
DOC_USP7_MATH_1 39 43 PF00917 0.679
DOC_USP7_MATH_1 82 86 PF00917 0.678
DOC_USP7_MATH_2 463 469 PF00917 0.664
DOC_WW_Pin1_4 106 111 PF00397 0.607
DOC_WW_Pin1_4 152 157 PF00397 0.666
DOC_WW_Pin1_4 172 177 PF00397 0.717
DOC_WW_Pin1_4 291 296 PF00397 0.507
DOC_WW_Pin1_4 311 316 PF00397 0.375
DOC_WW_Pin1_4 338 343 PF00397 0.286
DOC_WW_Pin1_4 497 502 PF00397 0.719
DOC_WW_Pin1_4 70 75 PF00397 0.647
DOC_WW_Pin1_4 88 93 PF00397 0.797
LIG_14-3-3_CanoR_1 111 115 PF00244 0.626
LIG_14-3-3_CanoR_1 159 167 PF00244 0.702
LIG_14-3-3_CanoR_1 186 191 PF00244 0.621
LIG_Actin_RPEL_3 391 410 PF02755 0.421
LIG_Actin_WH2_2 235 251 PF00022 0.261
LIG_Actin_WH2_2 435 451 PF00022 0.517
LIG_AP_GAE_1 490 496 PF02883 0.709
LIG_APCC_ABBAyCdc20_2 456 462 PF00400 0.538
LIG_BRCT_BRCA1_1 346 350 PF00533 0.236
LIG_Clathr_ClatBox_1 13 17 PF01394 0.617
LIG_deltaCOP1_diTrp_1 473 482 PF00928 0.537
LIG_EH1_1 398 406 PF00400 0.546
LIG_eIF4E_1 372 378 PF01652 0.566
LIG_FHA_1 110 116 PF00498 0.541
LIG_FHA_1 121 127 PF00498 0.506
LIG_FHA_1 17 23 PF00498 0.671
LIG_FHA_1 25 31 PF00498 0.653
LIG_FHA_1 315 321 PF00498 0.473
LIG_FHA_1 325 331 PF00498 0.454
LIG_FHA_1 339 345 PF00498 0.309
LIG_FHA_1 347 353 PF00498 0.289
LIG_FHA_1 50 56 PF00498 0.654
LIG_FHA_1 99 105 PF00498 0.672
LIG_FHA_2 23 29 PF00498 0.632
LIG_FHA_2 497 503 PF00498 0.769
LIG_FHA_2 508 514 PF00498 0.678
LIG_GBD_Chelix_1 360 368 PF00786 0.436
LIG_IBAR_NPY_1 252 254 PF08397 0.359
LIG_IRF3_LxIS_1 104 109 PF10401 0.567
LIG_LIR_Apic_2 206 210 PF02991 0.605
LIG_LIR_Gen_1 267 278 PF02991 0.443
LIG_LIR_Gen_1 349 359 PF02991 0.469
LIG_LIR_LC3C_4 269 273 PF02991 0.332
LIG_LIR_Nem_3 201 205 PF02991 0.636
LIG_LIR_Nem_3 267 273 PF02991 0.460
LIG_LIR_Nem_3 347 353 PF02991 0.324
LIG_LIR_Nem_3 356 361 PF02991 0.370
LIG_LIR_Nem_3 387 392 PF02991 0.493
LIG_LIR_Nem_3 394 400 PF02991 0.508
LIG_LIR_Nem_3 413 418 PF02991 0.541
LIG_MYND_1 74 78 PF01753 0.702
LIG_MYND_3 442 446 PF01753 0.465
LIG_Pex14_1 218 222 PF04695 0.659
LIG_Pex14_2 222 226 PF04695 0.546
LIG_REV1ctd_RIR_1 413 419 PF16727 0.482
LIG_SH2_CRK 418 422 PF00017 0.416
LIG_SH2_SRC 15 18 PF00017 0.613
LIG_SH2_SRC 418 421 PF00017 0.416
LIG_SH2_STAP1 134 138 PF00017 0.551
LIG_SH2_STAP1 205 209 PF00017 0.606
LIG_SH2_STAT5 15 18 PF00017 0.613
LIG_SH2_STAT5 183 186 PF00017 0.727
LIG_SH2_STAT5 372 375 PF00017 0.509
LIG_SH2_STAT5 437 440 PF00017 0.554
LIG_SH3_3 170 176 PF00018 0.703
LIG_SH3_3 247 253 PF00018 0.328
LIG_SH3_3 317 323 PF00018 0.396
LIG_SH3_3 433 439 PF00018 0.482
LIG_SH3_3 444 450 PF00018 0.522
LIG_SH3_3 477 483 PF00018 0.544
LIG_SH3_3 6 12 PF00018 0.638
LIG_SH3_3 71 77 PF00018 0.707
LIG_SH3_5 203 207 PF00018 0.606
LIG_SUMO_SIM_anti_2 374 380 PF11976 0.600
LIG_SUMO_SIM_par_1 104 109 PF11976 0.629
LIG_SUMO_SIM_par_1 241 246 PF11976 0.290
LIG_SUMO_SIM_par_1 351 356 PF11976 0.385
LIG_SUMO_SIM_par_1 402 408 PF11976 0.546
MOD_CDK_SPK_2 106 111 PF00069 0.547
MOD_CDK_SPxxK_3 152 159 PF00069 0.622
MOD_CK1_1 109 115 PF00069 0.586
MOD_CK1_1 163 169 PF00069 0.702
MOD_CK1_1 181 187 PF00069 0.675
MOD_CK1_1 188 194 PF00069 0.672
MOD_CK1_1 263 269 PF00069 0.421
MOD_CK1_1 314 320 PF00069 0.508
MOD_CK1_1 42 48 PF00069 0.728
MOD_CK1_1 507 513 PF00069 0.728
MOD_CK2_1 34 40 PF00069 0.639
MOD_CK2_1 423 429 PF00069 0.482
MOD_CK2_1 465 471 PF00069 0.606
MOD_CK2_1 489 495 PF00069 0.680
MOD_DYRK1A_RPxSP_1 172 176 PF00069 0.621
MOD_GlcNHglycan 162 165 PF01048 0.543
MOD_GlcNHglycan 190 193 PF01048 0.497
MOD_GlcNHglycan 279 282 PF01048 0.725
MOD_GlcNHglycan 297 300 PF01048 0.589
MOD_GlcNHglycan 33 37 PF01048 0.489
MOD_GlcNHglycan 331 334 PF01048 0.598
MOD_GlcNHglycan 364 367 PF01048 0.327
MOD_GlcNHglycan 386 389 PF01048 0.380
MOD_GlcNHglycan 40 44 PF01048 0.487
MOD_GlcNHglycan 477 480 PF01048 0.447
MOD_GlcNHglycan 84 87 PF01048 0.488
MOD_GSK3_1 106 113 PF00069 0.588
MOD_GSK3_1 159 166 PF00069 0.728
MOD_GSK3_1 172 179 PF00069 0.812
MOD_GSK3_1 18 25 PF00069 0.657
MOD_GSK3_1 181 188 PF00069 0.724
MOD_GSK3_1 260 267 PF00069 0.418
MOD_GSK3_1 291 298 PF00069 0.443
MOD_GSK3_1 307 314 PF00069 0.543
MOD_GSK3_1 362 369 PF00069 0.622
MOD_GSK3_1 42 49 PF00069 0.708
MOD_GSK3_1 78 85 PF00069 0.648
MOD_GSK3_1 98 105 PF00069 0.631
MOD_NEK2_1 344 349 PF00069 0.264
MOD_NEK2_1 353 358 PF00069 0.321
MOD_NEK2_1 384 389 PF00069 0.482
MOD_NEK2_1 405 410 PF00069 0.482
MOD_NEK2_1 422 427 PF00069 0.482
MOD_NEK2_1 489 494 PF00069 0.606
MOD_NEK2_2 192 197 PF00069 0.613
MOD_PIKK_1 243 249 PF00454 0.357
MOD_PIKK_1 307 313 PF00454 0.405
MOD_PKA_1 362 368 PF00069 0.615
MOD_PKA_2 110 116 PF00069 0.621
MOD_PKA_2 158 164 PF00069 0.627
MOD_PKA_2 171 177 PF00069 0.600
MOD_PKA_2 185 191 PF00069 0.622
MOD_PKA_2 3 9 PF00069 0.644
MOD_PKA_2 362 368 PF00069 0.618
MOD_Plk_1 344 350 PF00069 0.338
MOD_Plk_1 489 495 PF00069 0.705
MOD_Plk_2-3 465 471 PF00069 0.606
MOD_Plk_4 110 116 PF00069 0.570
MOD_Plk_4 122 128 PF00069 0.556
MOD_Plk_4 18 24 PF00069 0.675
MOD_Plk_4 266 272 PF00069 0.373
MOD_Plk_4 346 352 PF00069 0.459
MOD_Plk_4 353 359 PF00069 0.330
MOD_ProDKin_1 106 112 PF00069 0.603
MOD_ProDKin_1 152 158 PF00069 0.664
MOD_ProDKin_1 172 178 PF00069 0.719
MOD_ProDKin_1 291 297 PF00069 0.506
MOD_ProDKin_1 311 317 PF00069 0.376
MOD_ProDKin_1 338 344 PF00069 0.286
MOD_ProDKin_1 497 503 PF00069 0.724
MOD_ProDKin_1 70 76 PF00069 0.645
MOD_ProDKin_1 88 94 PF00069 0.794
MOD_SUMO_rev_2 425 432 PF00179 0.546
TRG_DiLeu_BaEn_4 464 470 PF01217 0.603
TRG_ENDOCYTIC_2 389 392 PF00928 0.482
TRG_ENDOCYTIC_2 397 400 PF00928 0.482
TRG_ENDOCYTIC_2 418 421 PF00928 0.482
TRG_ER_diArg_1 1 4 PF00400 0.691
TRG_NES_CRM1_1 311 326 PF08389 0.392
TRG_NES_CRM1_1 402 413 PF08389 0.482

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I406 Leptomonas seymouri 46% 100%
A0A3S5H631 Leishmania donovani 68% 99%
A4HTG6 Leishmania infantum 68% 100%
E9AM94 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q4QIF4 Leishmania major 69% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS