PIG-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI-GlcNAc transferase complex, PIG-H component, putative

Species:

Leishmania braziliensis

UniProt:

A4H582_LEIBR

TriTrypDb:

LbrM.08.0160 , LBRM2903_080006900

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

A4H582

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H582

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.635
CLV_C14_Caspase3-7	325	329	PF00656	0.389
CLV_C14_Caspase3-7	481	485	PF00656	0.630
CLV_NRD_NRD_1	4	6	PF00675	0.448
CLV_PCSK_FUR_1	2	6	PF00082	0.426
CLV_PCSK_KEX2_1	362	364	PF00082	0.354
CLV_PCSK_KEX2_1	4	6	PF00082	0.448
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.354
CLV_PCSK_SKI1_1	219	223	PF00082	0.406
CLV_PCSK_SKI1_1	449	453	PF00082	0.319
CLV_PCSK_SKI1_1	456	460	PF00082	0.338
CLV_Separin_Metazoa	446	450	PF03568	0.459
DEG_APCC_DBOX_1	448	456	PF00400	0.512
DEG_SPOP_SBC_1	262	266	PF00917	0.363
DOC_AGCK_PIF_2	202	207	PF00069	0.606
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.605
DOC_MAPK_gen_1	396	403	PF00069	0.482
DOC_MAPK_MEF2A_6	396	405	PF00069	0.482
DOC_MAPK_MEF2A_6	88	96	PF00069	0.598
DOC_MAPK_RevD_3	350	363	PF00069	0.325
DOC_PP1_RVXF_1	217	223	PF00149	0.658
DOC_PP1_RVXF_1	432	439	PF00149	0.482
DOC_USP7_MATH_1	262	266	PF00917	0.405
DOC_USP7_MATH_1	277	281	PF00917	0.471
DOC_USP7_MATH_1	295	299	PF00917	0.382
DOC_USP7_MATH_1	3	7	PF00917	0.674
DOC_USP7_MATH_1	32	36	PF00917	0.713
DOC_USP7_MATH_1	39	43	PF00917	0.679
DOC_USP7_MATH_1	82	86	PF00917	0.678
DOC_USP7_MATH_2	463	469	PF00917	0.664
DOC_WW_Pin1_4	106	111	PF00397	0.607
DOC_WW_Pin1_4	152	157	PF00397	0.666
DOC_WW_Pin1_4	172	177	PF00397	0.717
DOC_WW_Pin1_4	291	296	PF00397	0.507
DOC_WW_Pin1_4	311	316	PF00397	0.375
DOC_WW_Pin1_4	338	343	PF00397	0.286
DOC_WW_Pin1_4	497	502	PF00397	0.719
DOC_WW_Pin1_4	70	75	PF00397	0.647
DOC_WW_Pin1_4	88	93	PF00397	0.797
LIG_14-3-3_CanoR_1	111	115	PF00244	0.626
LIG_14-3-3_CanoR_1	159	167	PF00244	0.702
LIG_14-3-3_CanoR_1	186	191	PF00244	0.621
LIG_Actin_RPEL_3	391	410	PF02755	0.421
LIG_Actin_WH2_2	235	251	PF00022	0.261
LIG_Actin_WH2_2	435	451	PF00022	0.517
LIG_AP_GAE_1	490	496	PF02883	0.709
LIG_APCC_ABBAyCdc20_2	456	462	PF00400	0.538
LIG_BRCT_BRCA1_1	346	350	PF00533	0.236
LIG_Clathr_ClatBox_1	13	17	PF01394	0.617
LIG_deltaCOP1_diTrp_1	473	482	PF00928	0.537
LIG_EH1_1	398	406	PF00400	0.546
LIG_eIF4E_1	372	378	PF01652	0.566
LIG_FHA_1	110	116	PF00498	0.541
LIG_FHA_1	121	127	PF00498	0.506
LIG_FHA_1	17	23	PF00498	0.671
LIG_FHA_1	25	31	PF00498	0.653
LIG_FHA_1	315	321	PF00498	0.473
LIG_FHA_1	325	331	PF00498	0.454
LIG_FHA_1	339	345	PF00498	0.309
LIG_FHA_1	347	353	PF00498	0.289
LIG_FHA_1	50	56	PF00498	0.654
LIG_FHA_1	99	105	PF00498	0.672
LIG_FHA_2	23	29	PF00498	0.632
LIG_FHA_2	497	503	PF00498	0.769
LIG_FHA_2	508	514	PF00498	0.678
LIG_GBD_Chelix_1	360	368	PF00786	0.436
LIG_IBAR_NPY_1	252	254	PF08397	0.359
LIG_IRF3_LxIS_1	104	109	PF10401	0.567
LIG_LIR_Apic_2	206	210	PF02991	0.605
LIG_LIR_Gen_1	267	278	PF02991	0.443
LIG_LIR_Gen_1	349	359	PF02991	0.469
LIG_LIR_LC3C_4	269	273	PF02991	0.332
LIG_LIR_Nem_3	201	205	PF02991	0.636
LIG_LIR_Nem_3	267	273	PF02991	0.460
LIG_LIR_Nem_3	347	353	PF02991	0.324
LIG_LIR_Nem_3	356	361	PF02991	0.370
LIG_LIR_Nem_3	387	392	PF02991	0.493
LIG_LIR_Nem_3	394	400	PF02991	0.508
LIG_LIR_Nem_3	413	418	PF02991	0.541
LIG_MYND_1	74	78	PF01753	0.702
LIG_MYND_3	442	446	PF01753	0.465
LIG_Pex14_1	218	222	PF04695	0.659
LIG_Pex14_2	222	226	PF04695	0.546
LIG_REV1ctd_RIR_1	413	419	PF16727	0.482
LIG_SH2_CRK	418	422	PF00017	0.416
LIG_SH2_SRC	15	18	PF00017	0.613
LIG_SH2_SRC	418	421	PF00017	0.416
LIG_SH2_STAP1	134	138	PF00017	0.551
LIG_SH2_STAP1	205	209	PF00017	0.606
LIG_SH2_STAT5	15	18	PF00017	0.613
LIG_SH2_STAT5	183	186	PF00017	0.727
LIG_SH2_STAT5	372	375	PF00017	0.509
LIG_SH2_STAT5	437	440	PF00017	0.554
LIG_SH3_3	170	176	PF00018	0.703
LIG_SH3_3	247	253	PF00018	0.328
LIG_SH3_3	317	323	PF00018	0.396
LIG_SH3_3	433	439	PF00018	0.482
LIG_SH3_3	444	450	PF00018	0.522
LIG_SH3_3	477	483	PF00018	0.544
LIG_SH3_3	6	12	PF00018	0.638
LIG_SH3_3	71	77	PF00018	0.707
LIG_SH3_5	203	207	PF00018	0.606
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.600
LIG_SUMO_SIM_par_1	104	109	PF11976	0.629
LIG_SUMO_SIM_par_1	241	246	PF11976	0.290
LIG_SUMO_SIM_par_1	351	356	PF11976	0.385
LIG_SUMO_SIM_par_1	402	408	PF11976	0.546
MOD_CDK_SPK_2	106	111	PF00069	0.547
MOD_CDK_SPxxK_3	152	159	PF00069	0.622
MOD_CK1_1	109	115	PF00069	0.586
MOD_CK1_1	163	169	PF00069	0.702
MOD_CK1_1	181	187	PF00069	0.675
MOD_CK1_1	188	194	PF00069	0.672
MOD_CK1_1	263	269	PF00069	0.421
MOD_CK1_1	314	320	PF00069	0.508
MOD_CK1_1	42	48	PF00069	0.728
MOD_CK1_1	507	513	PF00069	0.728
MOD_CK2_1	34	40	PF00069	0.639
MOD_CK2_1	423	429	PF00069	0.482
MOD_CK2_1	465	471	PF00069	0.606
MOD_CK2_1	489	495	PF00069	0.680
MOD_DYRK1A_RPxSP_1	172	176	PF00069	0.621
MOD_GlcNHglycan	162	165	PF01048	0.543
MOD_GlcNHglycan	190	193	PF01048	0.497
MOD_GlcNHglycan	279	282	PF01048	0.725
MOD_GlcNHglycan	297	300	PF01048	0.589
MOD_GlcNHglycan	33	37	PF01048	0.489
MOD_GlcNHglycan	331	334	PF01048	0.598
MOD_GlcNHglycan	364	367	PF01048	0.327
MOD_GlcNHglycan	386	389	PF01048	0.380
MOD_GlcNHglycan	40	44	PF01048	0.487
MOD_GlcNHglycan	477	480	PF01048	0.447
MOD_GlcNHglycan	84	87	PF01048	0.488
MOD_GSK3_1	106	113	PF00069	0.588
MOD_GSK3_1	159	166	PF00069	0.728
MOD_GSK3_1	172	179	PF00069	0.812
MOD_GSK3_1	18	25	PF00069	0.657
MOD_GSK3_1	181	188	PF00069	0.724
MOD_GSK3_1	260	267	PF00069	0.418
MOD_GSK3_1	291	298	PF00069	0.443
MOD_GSK3_1	307	314	PF00069	0.543
MOD_GSK3_1	362	369	PF00069	0.622
MOD_GSK3_1	42	49	PF00069	0.708
MOD_GSK3_1	78	85	PF00069	0.648
MOD_GSK3_1	98	105	PF00069	0.631
MOD_NEK2_1	344	349	PF00069	0.264
MOD_NEK2_1	353	358	PF00069	0.321
MOD_NEK2_1	384	389	PF00069	0.482
MOD_NEK2_1	405	410	PF00069	0.482
MOD_NEK2_1	422	427	PF00069	0.482
MOD_NEK2_1	489	494	PF00069	0.606
MOD_NEK2_2	192	197	PF00069	0.613
MOD_PIKK_1	243	249	PF00454	0.357
MOD_PIKK_1	307	313	PF00454	0.405
MOD_PKA_1	362	368	PF00069	0.615
MOD_PKA_2	110	116	PF00069	0.621
MOD_PKA_2	158	164	PF00069	0.627
MOD_PKA_2	171	177	PF00069	0.600
MOD_PKA_2	185	191	PF00069	0.622
MOD_PKA_2	3	9	PF00069	0.644
MOD_PKA_2	362	368	PF00069	0.618
MOD_Plk_1	344	350	PF00069	0.338
MOD_Plk_1	489	495	PF00069	0.705
MOD_Plk_2-3	465	471	PF00069	0.606
MOD_Plk_4	110	116	PF00069	0.570
MOD_Plk_4	122	128	PF00069	0.556
MOD_Plk_4	18	24	PF00069	0.675
MOD_Plk_4	266	272	PF00069	0.373
MOD_Plk_4	346	352	PF00069	0.459
MOD_Plk_4	353	359	PF00069	0.330
MOD_ProDKin_1	106	112	PF00069	0.603
MOD_ProDKin_1	152	158	PF00069	0.664
MOD_ProDKin_1	172	178	PF00069	0.719
MOD_ProDKin_1	291	297	PF00069	0.506
MOD_ProDKin_1	311	317	PF00069	0.376
MOD_ProDKin_1	338	344	PF00069	0.286
MOD_ProDKin_1	497	503	PF00069	0.724
MOD_ProDKin_1	70	76	PF00069	0.645
MOD_ProDKin_1	88	94	PF00069	0.794
MOD_SUMO_rev_2	425	432	PF00179	0.546
TRG_DiLeu_BaEn_4	464	470	PF01217	0.603
TRG_ENDOCYTIC_2	389	392	PF00928	0.482
TRG_ENDOCYTIC_2	397	400	PF00928	0.482
TRG_ENDOCYTIC_2	418	421	PF00928	0.482
TRG_ER_diArg_1	1	4	PF00400	0.691
TRG_NES_CRM1_1	311	326	PF08389	0.392
TRG_NES_CRM1_1	402	413	PF08389	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I406	Leptomonas seymouri	46%	100%
A0A3S5H631	Leishmania donovani	68%	99%
A4HTG6	Leishmania infantum	68%	100%
E9AM94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QIF4	Leishmania major	69%	99%