Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H579_LEIBR

TriTrypDb:

LbrM.08.0120 , LBRM2903_080006600

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H579

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H579

PDB structure(s): 7ane_as

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.596
CLV_NRD_NRD_1	260	262	PF00675	0.392
CLV_PCSK_KEX2_1	222	224	PF00082	0.458
CLV_PCSK_KEX2_1	260	262	PF00082	0.392
CLV_PCSK_SKI1_1	194	198	PF00082	0.407
DEG_APCC_DBOX_1	193	201	PF00400	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.426
DOC_PP1_RVXF_1	259	266	PF00149	0.382
DOC_PP2B_LxvP_1	218	221	PF13499	0.427
DOC_PP2B_LxvP_1	69	72	PF13499	0.462
DOC_USP7_MATH_1	254	258	PF00917	0.326
DOC_WW_Pin1_4	148	153	PF00397	0.311
DOC_WW_Pin1_4	212	217	PF00397	0.477
DOC_WW_Pin1_4	228	233	PF00397	0.524
LIG_14-3-3_CanoR_1	115	121	PF00244	0.306
LIG_14-3-3_CanoR_1	167	171	PF00244	0.496
LIG_14-3-3_CanoR_1	253	259	PF00244	0.369
LIG_14-3-3_CanoR_1	260	264	PF00244	0.383
LIG_14-3-3_CanoR_1	6	10	PF00244	0.501
LIG_APCC_ABBA_1	139	144	PF00400	0.445
LIG_FHA_1	213	219	PF00498	0.604
LIG_FHA_1	229	235	PF00498	0.545
LIG_FHA_2	128	134	PF00498	0.458
LIG_FHA_2	160	166	PF00498	0.458
LIG_LIR_Gen_1	165	176	PF02991	0.349
LIG_LIR_Gen_1	184	195	PF02991	0.523
LIG_LIR_Gen_1	24	33	PF02991	0.364
LIG_LIR_Nem_3	165	171	PF02991	0.335
LIG_LIR_Nem_3	184	190	PF02991	0.463
LIG_LIR_Nem_3	212	217	PF02991	0.573
LIG_LIR_Nem_3	24	28	PF02991	0.398
LIG_LIR_Nem_3	98	102	PF02991	0.553
LIG_LYPXL_yS_3	19	22	PF13949	0.426
LIG_PDZ_Class_1	264	269	PF00595	0.503
LIG_Pex14_1	265	269	PF04695	0.366
LIG_SH2_CRK	113	117	PF00017	0.389
LIG_SH2_CRK	236	240	PF00017	0.409
LIG_SH2_CRK	25	29	PF00017	0.371
LIG_SH2_CRK	48	52	PF00017	0.325
LIG_SH2_STAP1	48	52	PF00017	0.311
LIG_SH2_STAT5	158	161	PF00017	0.479
LIG_SH2_STAT5	173	176	PF00017	0.371
LIG_SH2_STAT5	242	245	PF00017	0.400
LIG_SH2_STAT5	85	88	PF00017	0.343
LIG_SH3_1	173	179	PF00018	0.275
LIG_SH3_1	229	235	PF00018	0.536
LIG_SH3_2	232	237	PF14604	0.517
LIG_SH3_3	101	107	PF00018	0.332
LIG_SH3_3	173	179	PF00018	0.356
LIG_SH3_3	229	235	PF00018	0.543
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.244
LIG_TRAF2_1	162	165	PF00917	0.485
LIG_TYR_ITIM	17	22	PF00017	0.430
LIG_TYR_ITIM	23	28	PF00017	0.329
LIG_WRC_WIRS_1	200	205	PF05994	0.327
MOD_CK1_1	12	18	PF00069	0.480
MOD_CK1_1	151	157	PF00069	0.428
MOD_CK1_1	199	205	PF00069	0.526
MOD_CK1_1	21	27	PF00069	0.412
MOD_CK2_1	159	165	PF00069	0.416
MOD_CMANNOS	265	268	PF00535	0.360
MOD_Cter_Amidation	258	261	PF01082	0.378
MOD_GlcNHglycan	130	133	PF01048	0.462
MOD_GSK3_1	1	8	PF00069	0.519
MOD_GSK3_1	147	154	PF00069	0.482
MOD_N-GLC_1	148	153	PF02516	0.529
MOD_NEK2_1	1	6	PF00069	0.510
MOD_NEK2_1	147	152	PF00069	0.537
MOD_NEK2_1	264	269	PF00069	0.503
MOD_NEK2_1	9	14	PF00069	0.453
MOD_NEK2_1	97	102	PF00069	0.551
MOD_NEK2_2	166	171	PF00069	0.379
MOD_PIKK_1	160	166	PF00454	0.587
MOD_PIKK_1	181	187	PF00454	0.523
MOD_PKA_1	222	228	PF00069	0.374
MOD_PKA_2	166	172	PF00069	0.236
MOD_PKA_2	2	8	PF00069	0.585
MOD_PKA_2	222	228	PF00069	0.523
MOD_PKA_2	259	265	PF00069	0.379
MOD_Plk_4	18	24	PF00069	0.427
MOD_ProDKin_1	148	154	PF00069	0.304
MOD_ProDKin_1	212	218	PF00069	0.477
MOD_ProDKin_1	228	234	PF00069	0.521
TRG_AP2beta_CARGO_1	165	175	PF09066	0.420
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.368
TRG_ENDOCYTIC_2	113	116	PF00928	0.366
TRG_ENDOCYTIC_2	19	22	PF00928	0.413
TRG_ENDOCYTIC_2	25	28	PF00928	0.355
TRG_ENDOCYTIC_2	48	51	PF00928	0.312
TRG_ER_diArg_1	221	223	PF00400	0.597
TRG_ER_diArg_1	76	79	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B2	Leptomonas seymouri	67%	100%
A0A0S4IR07	Bodo saltans	40%	100%
A0A1X0NNZ6	Trypanosomatidae	50%	99%
A0A3R7NMZ5	Trypanosoma rangeli	50%	100%
A0A3S7WQ50	Leishmania donovani	85%	100%
A4HTG2	Leishmania infantum	86%	100%
C9ZPP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AM90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIF7	Leishmania major	85%	100%
V5DDB9	Trypanosoma cruzi	49%	100%