Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H578_LEIBR

TriTrypDb:

LbrM.08.0110 , LBRM2903_080006500

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H578

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H578

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	651	655	PF00656	0.367
CLV_C14_Caspase3-7	739	743	PF00656	0.570
CLV_NRD_NRD_1	204	206	PF00675	0.711
CLV_NRD_NRD_1	238	240	PF00675	0.636
CLV_NRD_NRD_1	427	429	PF00675	0.550
CLV_NRD_NRD_1	612	614	PF00675	0.396
CLV_NRD_NRD_1	657	659	PF00675	0.517
CLV_NRD_NRD_1	681	683	PF00675	0.602
CLV_NRD_NRD_1	693	695	PF00675	0.630
CLV_NRD_NRD_1	698	700	PF00675	0.588
CLV_PCSK_FUR_1	679	683	PF00082	0.549
CLV_PCSK_KEX2_1	204	206	PF00082	0.711
CLV_PCSK_KEX2_1	238	240	PF00082	0.636
CLV_PCSK_KEX2_1	427	429	PF00082	0.594
CLV_PCSK_KEX2_1	657	659	PF00082	0.379
CLV_PCSK_KEX2_1	679	681	PF00082	0.535
CLV_PCSK_KEX2_1	693	695	PF00082	0.522
CLV_PCSK_KEX2_1	698	700	PF00082	0.504
CLV_PCSK_PC7_1	423	429	PF00082	0.643
CLV_PCSK_PC7_1	694	700	PF00082	0.577
CLV_PCSK_SKI1_1	438	442	PF00082	0.533
CLV_PCSK_SKI1_1	557	561	PF00082	0.553
CLV_PCSK_SKI1_1	581	585	PF00082	0.377
CLV_PCSK_SKI1_1	658	662	PF00082	0.523
CLV_PCSK_SKI1_1	664	668	PF00082	0.447
CLV_PCSK_SKI1_1	698	702	PF00082	0.698
CLV_Separin_Metazoa	453	457	PF03568	0.369
CLV_Separin_Metazoa	626	630	PF03568	0.552
DEG_APCC_DBOX_1	642	650	PF00400	0.537
DEG_SCF_FBW7_1	338	343	PF00400	0.561
DOC_CDC14_PxL_1	92	100	PF14671	0.529
DOC_CKS1_1	6	11	PF01111	0.530
DOC_CKS1_1	62	67	PF01111	0.570
DOC_MAPK_gen_1	238	248	PF00069	0.622
DOC_MAPK_gen_1	657	663	PF00069	0.520
DOC_MAPK_gen_1	669	676	PF00069	0.396
DOC_MAPK_MEF2A_6	239	248	PF00069	0.677
DOC_MAPK_MEF2A_6	539	548	PF00069	0.369
DOC_PP2B_LxvP_1	105	108	PF13499	0.642
DOC_USP7_MATH_1	152	156	PF00917	0.784
DOC_USP7_MATH_1	208	212	PF00917	0.610
DOC_USP7_MATH_1	249	253	PF00917	0.552
DOC_USP7_MATH_1	259	263	PF00917	0.612
DOC_USP7_MATH_1	264	268	PF00917	0.664
DOC_USP7_MATH_1	282	286	PF00917	0.564
DOC_USP7_MATH_1	340	344	PF00917	0.650
DOC_USP7_MATH_1	430	434	PF00917	0.655
DOC_USP7_MATH_1	436	440	PF00917	0.726
DOC_USP7_MATH_1	596	600	PF00917	0.522
DOC_USP7_MATH_1	692	696	PF00917	0.646
DOC_WW_Pin1_4	148	153	PF00397	0.632
DOC_WW_Pin1_4	16	21	PF00397	0.494
DOC_WW_Pin1_4	206	211	PF00397	0.628
DOC_WW_Pin1_4	260	265	PF00397	0.770
DOC_WW_Pin1_4	28	33	PF00397	0.530
DOC_WW_Pin1_4	322	327	PF00397	0.658
DOC_WW_Pin1_4	336	341	PF00397	0.578
DOC_WW_Pin1_4	346	351	PF00397	0.678
DOC_WW_Pin1_4	376	381	PF00397	0.686
DOC_WW_Pin1_4	441	446	PF00397	0.540
DOC_WW_Pin1_4	5	10	PF00397	0.528
DOC_WW_Pin1_4	526	531	PF00397	0.593
DOC_WW_Pin1_4	53	58	PF00397	0.561
DOC_WW_Pin1_4	61	66	PF00397	0.551
DOC_WW_Pin1_4	699	704	PF00397	0.689
LIG_14-3-3_CanoR_1	142	146	PF00244	0.581
LIG_14-3-3_CanoR_1	317	322	PF00244	0.662
LIG_14-3-3_CanoR_1	391	401	PF00244	0.433
LIG_14-3-3_CanoR_1	409	416	PF00244	0.480
LIG_14-3-3_CanoR_1	427	433	PF00244	0.485
LIG_14-3-3_CanoR_1	449	457	PF00244	0.610
LIG_14-3-3_CanoR_1	600	608	PF00244	0.535
LIG_14-3-3_CanoR_1	634	638	PF00244	0.529
LIG_Actin_WH2_2	598	615	PF00022	0.538
LIG_Actin_WH2_2	625	642	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_BIR_III_1	1	5	PF00653	0.534
LIG_BIR_III_3	1	5	PF00653	0.534
LIG_BIR_III_4	742	746	PF00653	0.734
LIG_FHA_1	109	115	PF00498	0.655
LIG_FHA_1	142	148	PF00498	0.712
LIG_FHA_1	228	234	PF00498	0.751
LIG_FHA_1	394	400	PF00498	0.507
LIG_FHA_1	43	49	PF00498	0.515
LIG_FHA_1	449	455	PF00498	0.529
LIG_FHA_1	463	469	PF00498	0.467
LIG_FHA_1	54	60	PF00498	0.524
LIG_FHA_1	543	549	PF00498	0.617
LIG_FHA_1	600	606	PF00498	0.533
LIG_FHA_1	613	619	PF00498	0.434
LIG_FHA_1	634	640	PF00498	0.533
LIG_FHA_1	708	714	PF00498	0.532
LIG_FHA_2	223	229	PF00498	0.546
LIG_FHA_2	489	495	PF00498	0.554
LIG_FHA_2	520	526	PF00498	0.659
LIG_Integrin_RGD_1	331	333	PF01839	0.725
LIG_LIR_Apic_2	3	9	PF02991	0.522
LIG_LIR_Gen_1	189	199	PF02991	0.418
LIG_LIR_Gen_1	285	295	PF02991	0.626
LIG_LIR_Gen_1	469	479	PF02991	0.411
LIG_LIR_Gen_1	7	18	PF02991	0.534
LIG_LIR_Gen_1	706	717	PF02991	0.477
LIG_LIR_Nem_3	14	18	PF02991	0.505
LIG_LIR_Nem_3	189	194	PF02991	0.397
LIG_LIR_Nem_3	285	291	PF02991	0.648
LIG_LIR_Nem_3	469	474	PF02991	0.440
LIG_LIR_Nem_3	7	13	PF02991	0.531
LIG_LIR_Nem_3	706	712	PF02991	0.479
LIG_MYND_1	373	377	PF01753	0.719
LIG_NRBOX	297	303	PF00104	0.639
LIG_PCNA_TLS_4	584	593	PF02747	0.367
LIG_SH2_CRK	18	22	PF00017	0.499
LIG_SH2_CRK	191	195	PF00017	0.405
LIG_SH2_CRK	6	10	PF00017	0.530
LIG_SH2_GRB2like	132	135	PF00017	0.694
LIG_SH2_NCK_1	133	137	PF00017	0.683
LIG_SH2_NCK_1	6	10	PF00017	0.567
LIG_SH2_PTP2	288	291	PF00017	0.482
LIG_SH2_SRC	106	109	PF00017	0.562
LIG_SH2_STAT5	18	21	PF00017	0.667
LIG_SH2_STAT5	288	291	PF00017	0.482
LIG_SH2_STAT5	334	337	PF00017	0.566
LIG_SH2_STAT5	404	407	PF00017	0.530
LIG_SH2_STAT5	590	593	PF00017	0.530
LIG_SH2_STAT5	63	66	PF00017	0.558
LIG_SH3_2	377	382	PF14604	0.558
LIG_SH3_3	211	217	PF00018	0.566
LIG_SH3_3	241	247	PF00018	0.686
LIG_SH3_3	258	264	PF00018	0.638
LIG_SH3_3	370	376	PF00018	0.613
LIG_SH3_3	383	389	PF00018	0.642
LIG_SH3_3	98	104	PF00018	0.530
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.542
LIG_SUMO_SIM_anti_2	545	550	PF11976	0.519
LIG_SUMO_SIM_par_1	171	177	PF11976	0.628
LIG_SUMO_SIM_par_1	219	226	PF11976	0.553
LIG_SUMO_SIM_par_1	541	547	PF11976	0.500
LIG_SUMO_SIM_par_1	672	678	PF11976	0.530
LIG_TRAF2_1	492	495	PF00917	0.556
LIG_TRAF2_1	583	586	PF00917	0.373
LIG_TRAF2_1	623	626	PF00917	0.572
LIG_UBA3_1	548	557	PF00899	0.435
MOD_CDC14_SPxK_1	151	154	PF00782	0.624
MOD_CDC14_SPxK_1	379	382	PF00782	0.554
MOD_CDC14_SPxK_1	446	449	PF00782	0.408
MOD_CDK_SPxK_1	148	154	PF00069	0.629
MOD_CDK_SPxK_1	322	328	PF00069	0.564
MOD_CDK_SPxK_1	350	356	PF00069	0.733
MOD_CDK_SPxK_1	376	382	PF00069	0.555
MOD_CDK_SPxK_1	443	449	PF00069	0.432
MOD_CK1_1	11	17	PF00069	0.535
MOD_CK1_1	192	198	PF00069	0.419
MOD_CK1_1	209	215	PF00069	0.580
MOD_CK1_1	222	228	PF00069	0.581
MOD_CK1_1	252	258	PF00069	0.770
MOD_CK1_1	262	268	PF00069	0.691
MOD_CK1_1	322	328	PF00069	0.651
MOD_CK1_1	439	445	PF00069	0.682
MOD_CK1_1	529	535	PF00069	0.613
MOD_CK1_1	599	605	PF00069	0.531
MOD_CK1_1	707	713	PF00069	0.508
MOD_CK1_1	725	731	PF00069	0.638
MOD_CK2_1	222	228	PF00069	0.610
MOD_CK2_1	297	303	PF00069	0.482
MOD_CK2_1	378	384	PF00069	0.626
MOD_CK2_1	488	494	PF00069	0.553
MOD_CK2_1	519	525	PF00069	0.658
MOD_CK2_1	544	550	PF00069	0.370
MOD_CK2_1	603	609	PF00069	0.465
MOD_CK2_1	620	626	PF00069	0.483
MOD_DYRK1A_RPxSP_1	699	703	PF00069	0.585
MOD_GlcNHglycan	108	111	PF01048	0.716
MOD_GlcNHglycan	126	129	PF01048	0.563
MOD_GlcNHglycan	251	254	PF01048	0.744
MOD_GlcNHglycan	257	260	PF01048	0.754
MOD_GlcNHglycan	284	287	PF01048	0.643
MOD_GlcNHglycan	321	324	PF01048	0.644
MOD_GlcNHglycan	342	345	PF01048	0.636
MOD_GlcNHglycan	410	413	PF01048	0.585
MOD_GlcNHglycan	432	435	PF01048	0.659
MOD_GlcNHglycan	437	441	PF01048	0.681
MOD_GlcNHglycan	531	534	PF01048	0.556
MOD_GlcNHglycan	694	697	PF01048	0.676
MOD_GlcNHglycan	717	720	PF01048	0.654
MOD_GlcNHglycan	87	90	PF01048	0.677
MOD_GlcNHglycan	92	95	PF01048	0.630
MOD_GSK3_1	141	148	PF00069	0.648
MOD_GSK3_1	168	175	PF00069	0.633
MOD_GSK3_1	227	234	PF00069	0.597
MOD_GSK3_1	251	258	PF00069	0.778
MOD_GSK3_1	260	267	PF00069	0.698
MOD_GSK3_1	313	320	PF00069	0.730
MOD_GSK3_1	336	343	PF00069	0.712
MOD_GSK3_1	346	353	PF00069	0.708
MOD_GSK3_1	367	374	PF00069	0.763
MOD_GSK3_1	4	11	PF00069	0.525
MOD_GSK3_1	439	446	PF00069	0.748
MOD_GSK3_1	525	532	PF00069	0.679
MOD_GSK3_1	599	606	PF00069	0.447
MOD_GSK3_1	722	729	PF00069	0.720
MOD_GSK3_1	744	751	PF00069	0.654
MOD_GSK3_1	81	88	PF00069	0.597
MOD_N-GLC_1	197	202	PF02516	0.638
MOD_N-GLC_1	70	75	PF02516	0.559
MOD_N-GLC_1	735	740	PF02516	0.577
MOD_N-GLC_2	182	184	PF02516	0.537
MOD_NEK2_1	197	202	PF00069	0.759
MOD_NEK2_1	393	398	PF00069	0.411
MOD_NEK2_1	542	547	PF00069	0.523
MOD_NEK2_1	656	661	PF00069	0.526
MOD_NEK2_1	726	731	PF00069	0.580
MOD_NEK2_2	108	113	PF00069	0.532
MOD_NEK2_2	749	754	PF00069	0.563
MOD_PIKK_1	174	180	PF00454	0.622
MOD_PIKK_1	393	399	PF00454	0.403
MOD_PIKK_1	550	556	PF00454	0.516
MOD_PIKK_1	565	571	PF00454	0.389
MOD_PIKK_1	620	626	PF00454	0.586
MOD_PIKK_1	707	713	PF00454	0.533
MOD_PIKK_1	81	87	PF00454	0.537
MOD_PK_1	317	323	PF00069	0.574
MOD_PK_1	428	434	PF00069	0.526
MOD_PKA_2	141	147	PF00069	0.607
MOD_PKA_2	408	414	PF00069	0.513
MOD_PKA_2	448	454	PF00069	0.624
MOD_PKA_2	599	605	PF00069	0.531
MOD_PKA_2	612	618	PF00069	0.429
MOD_PKA_2	633	639	PF00069	0.531
MOD_PKA_2	656	662	PF00069	0.526
MOD_PKA_2	692	698	PF00069	0.674
MOD_PKB_1	369	377	PF00069	0.571
MOD_Plk_1	140	146	PF00069	0.627
MOD_Plk_1	197	203	PF00069	0.487
MOD_Plk_1	35	41	PF00069	0.521
MOD_Plk_1	513	519	PF00069	0.588
MOD_Plk_1	596	602	PF00069	0.525
MOD_Plk_2-3	297	303	PF00069	0.482
MOD_Plk_4	189	195	PF00069	0.558
MOD_Plk_4	219	225	PF00069	0.553
MOD_Plk_4	284	290	PF00069	0.502
MOD_Plk_4	297	303	PF00069	0.475
MOD_Plk_4	35	41	PF00069	0.544
MOD_Plk_4	544	550	PF00069	0.527
MOD_Plk_4	8	14	PF00069	0.533
MOD_ProDKin_1	148	154	PF00069	0.629
MOD_ProDKin_1	16	22	PF00069	0.497
MOD_ProDKin_1	206	212	PF00069	0.629
MOD_ProDKin_1	260	266	PF00069	0.763
MOD_ProDKin_1	28	34	PF00069	0.525
MOD_ProDKin_1	322	328	PF00069	0.661
MOD_ProDKin_1	336	342	PF00069	0.573
MOD_ProDKin_1	346	352	PF00069	0.680
MOD_ProDKin_1	376	382	PF00069	0.689
MOD_ProDKin_1	441	447	PF00069	0.527
MOD_ProDKin_1	5	11	PF00069	0.528
MOD_ProDKin_1	526	532	PF00069	0.592
MOD_ProDKin_1	53	59	PF00069	0.564
MOD_ProDKin_1	61	67	PF00069	0.551
MOD_ProDKin_1	699	705	PF00069	0.689
MOD_SUMO_for_1	583	586	PF00179	0.373
MOD_SUMO_rev_2	271	278	PF00179	0.579
MOD_SUMO_rev_2	489	498	PF00179	0.406
MOD_SUMO_rev_2	550	559	PF00179	0.495
MOD_SUMO_rev_2	604	612	PF00179	0.585
TRG_DiLeu_BaEn_1	189	194	PF01217	0.554
TRG_DiLeu_BaEn_1	453	458	PF01217	0.368
TRG_DiLeu_LyEn_5	453	458	PF01217	0.368
TRG_ENDOCYTIC_2	10	13	PF00928	0.540
TRG_ENDOCYTIC_2	133	136	PF00928	0.686
TRG_ENDOCYTIC_2	18	21	PF00928	0.510
TRG_ENDOCYTIC_2	191	194	PF00928	0.401
TRG_ENDOCYTIC_2	288	291	PF00928	0.639
TRG_ER_diArg_1	203	205	PF00400	0.694
TRG_ER_diArg_1	237	239	PF00400	0.523
TRG_ER_diArg_1	369	372	PF00400	0.583
TRG_ER_diArg_1	656	658	PF00400	0.430
TRG_ER_diArg_1	668	671	PF00400	0.464
TRG_ER_diArg_1	679	682	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQ53	Leishmania donovani	68%	100%
A4HTG1	Leishmania infantum	68%	100%
E9AM89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QIF8	Leishmania major	68%	100%