Putative dual-specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H577_LEIBR

TriTrypDb:

LbrM.08.0100 , LBRM2903_080006400

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H577

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H577

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	6
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0008330	protein tyrosine/threonine phosphatase activity	4	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5	1
GO:0033549	MAP kinase phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.566
CLV_C14_Caspase3-7	319	323	PF00656	0.543
CLV_C14_Caspase3-7	328	332	PF00656	0.530
CLV_C14_Caspase3-7	425	429	PF00656	0.570
CLV_C14_Caspase3-7	62	66	PF00656	0.294
CLV_NRD_NRD_1	179	181	PF00675	0.351
CLV_NRD_NRD_1	193	195	PF00675	0.351
CLV_NRD_NRD_1	207	209	PF00675	0.491
CLV_NRD_NRD_1	337	339	PF00675	0.621
CLV_PCSK_FUR_1	205	209	PF00082	0.475
CLV_PCSK_KEX2_1	179	181	PF00082	0.351
CLV_PCSK_KEX2_1	207	209	PF00082	0.474
CLV_PCSK_KEX2_1	234	236	PF00082	0.479
CLV_PCSK_KEX2_1	337	339	PF00082	0.621
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.517
CLV_PCSK_SKI1_1	152	156	PF00082	0.297
CLV_PCSK_SKI1_1	229	233	PF00082	0.687
CLV_PCSK_SKI1_1	316	320	PF00082	0.633
CLV_PCSK_SKI1_1	343	347	PF00082	0.648
CLV_PCSK_SKI1_1	367	371	PF00082	0.530
CLV_PCSK_SKI1_1	379	383	PF00082	0.562
CLV_PCSK_SKI1_1	78	82	PF00082	0.261
DEG_SCF_FBW7_1	281	288	PF00400	0.521
DEG_SPOP_SBC_1	437	441	PF00917	0.523
DOC_CKS1_1	282	287	PF01111	0.518
DOC_CYCLIN_RxL_1	226	233	PF00134	0.695
DOC_CYCLIN_yCln2_LP_2	296	299	PF00134	0.504
DOC_MAPK_gen_1	148	156	PF00069	0.296
DOC_MAPK_MEF2A_6	150	158	PF00069	0.220
DOC_MAPK_MEF2A_6	180	189	PF00069	0.294
DOC_PP2B_LxvP_1	296	299	PF13499	0.504
DOC_USP7_MATH_1	24	28	PF00917	0.613
DOC_USP7_MATH_1	285	289	PF00917	0.630
DOC_USP7_MATH_1	438	442	PF00917	0.572
DOC_WW_Pin1_4	198	203	PF00397	0.388
DOC_WW_Pin1_4	20	25	PF00397	0.556
DOC_WW_Pin1_4	281	286	PF00397	0.521
DOC_WW_Pin1_4	29	34	PF00397	0.593
DOC_WW_Pin1_4	301	306	PF00397	0.482
DOC_WW_Pin1_4	320	325	PF00397	0.536
DOC_WW_Pin1_4	331	336	PF00397	0.548
DOC_WW_Pin1_4	414	419	PF00397	0.575
LIG_14-3-3_CanoR_1	150	155	PF00244	0.301
LIG_14-3-3_CanoR_1	207	216	PF00244	0.607
LIG_14-3-3_CanoR_1	240	246	PF00244	0.553
LIG_14-3-3_CanoR_1	276	282	PF00244	0.601
LIG_14-3-3_CanoR_1	316	324	PF00244	0.530
LIG_Actin_RPEL_3	143	162	PF02755	0.294
LIG_BRCT_BRCA1_1	362	366	PF00533	0.698
LIG_BRCT_BRCA1_1	399	403	PF00533	0.527
LIG_CtBP_PxDLS_1	298	302	PF00389	0.508
LIG_FHA_1	105	111	PF00498	0.336
LIG_FHA_1	115	121	PF00498	0.469
LIG_FHA_1	153	159	PF00498	0.294
LIG_FHA_1	242	248	PF00498	0.559
LIG_FHA_1	50	56	PF00498	0.423
LIG_FHA_1	97	103	PF00498	0.297
LIG_FHA_2	317	323	PF00498	0.585
LIG_FHA_2	350	356	PF00498	0.497
LIG_FHA_2	414	420	PF00498	0.662
LIG_FHA_2	423	429	PF00498	0.596
LIG_LIR_Gen_1	206	216	PF02991	0.527
LIG_LIR_Gen_1	56	63	PF02991	0.345
LIG_LIR_Nem_3	206	212	PF02991	0.526
LIG_LIR_Nem_3	363	369	PF02991	0.707
LIG_LIR_Nem_3	56	60	PF02991	0.345
LIG_LIR_Nem_3	86	91	PF02991	0.349
LIG_PCNA_PIPBox_1	225	234	PF02747	0.413
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.416
LIG_PDZ_Class_2	445	450	PF00595	0.566
LIG_REV1ctd_RIR_1	348	358	PF16727	0.539
LIG_SH2_GRB2like	163	166	PF00017	0.294
LIG_SH2_STAT5	160	163	PF00017	0.320
LIG_SH2_STAT5	175	178	PF00017	0.207
LIG_SH2_STAT5	245	248	PF00017	0.730
LIG_SH2_STAT5	59	62	PF00017	0.345
LIG_SH2_STAT5	79	82	PF00017	0.183
LIG_SH3_3	279	285	PF00018	0.764
LIG_SH3_3	292	298	PF00018	0.679
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.220
LIG_TRAF2_1	201	204	PF00917	0.482
LIG_TRAF2_1	443	446	PF00917	0.523
LIG_TRAF2_1	84	87	PF00917	0.294
LIG_WRC_WIRS_1	97	102	PF05994	0.294
LIG_WW_3	32	36	PF00397	0.534
MOD_CDC14_SPxK_1	32	35	PF00782	0.660
MOD_CDC14_SPxK_1	334	337	PF00782	0.531
MOD_CDK_SPxK_1	29	35	PF00069	0.664
MOD_CDK_SPxK_1	301	307	PF00069	0.521
MOD_CDK_SPxK_1	331	337	PF00069	0.536
MOD_CDK_SPxxK_3	198	205	PF00069	0.391
MOD_CDK_SPxxK_3	320	327	PF00069	0.530
MOD_CDK_SPxxK_3	331	338	PF00069	0.510
MOD_CK1_1	134	140	PF00069	0.297
MOD_CK1_1	220	226	PF00069	0.443
MOD_CK1_1	27	33	PF00069	0.624
MOD_CK1_1	422	428	PF00069	0.555
MOD_CK1_1	6	12	PF00069	0.566
MOD_CK2_1	165	171	PF00069	0.299
MOD_CK2_1	198	204	PF00069	0.512
MOD_CK2_1	349	355	PF00069	0.549
MOD_CK2_1	81	87	PF00069	0.294
MOD_GlcNHglycan	103	107	PF01048	0.294
MOD_GlcNHglycan	219	222	PF01048	0.545
MOD_GlcNHglycan	277	280	PF01048	0.641
MOD_GlcNHglycan	309	312	PF01048	0.628
MOD_GlcNHglycan	35	38	PF01048	0.575
MOD_GlcNHglycan	362	365	PF01048	0.619
MOD_GlcNHglycan	399	402	PF01048	0.501
MOD_GSK3_1	131	138	PF00069	0.483
MOD_GSK3_1	148	155	PF00069	0.311
MOD_GSK3_1	161	168	PF00069	0.294
MOD_GSK3_1	20	27	PF00069	0.646
MOD_GSK3_1	203	210	PF00069	0.482
MOD_GSK3_1	277	284	PF00069	0.681
MOD_GSK3_1	285	292	PF00069	0.618
MOD_GSK3_1	29	36	PF00069	0.658
MOD_GSK3_1	316	323	PF00069	0.573
MOD_GSK3_1	395	402	PF00069	0.544
MOD_GSK3_1	433	440	PF00069	0.541
MOD_N-GLC_1	217	222	PF02516	0.444
MOD_N-GLC_1	81	86	PF02516	0.337
MOD_N-GLC_1	9	14	PF02516	0.516
MOD_NEK2_1	120	125	PF00069	0.344
MOD_NEK2_1	161	166	PF00069	0.294
MOD_NEK2_1	196	201	PF00069	0.419
MOD_NEK2_1	277	282	PF00069	0.702
MOD_NEK2_2	59	64	PF00069	0.345
MOD_NMyristoyl	1	7	PF02799	0.561
MOD_OFUCOSY	347	353	PF10250	0.489
MOD_PIKK_1	223	229	PF00454	0.511
MOD_PIKK_1	268	274	PF00454	0.536
MOD_PIKK_1	49	55	PF00454	0.363
MOD_PIKK_1	81	87	PF00454	0.294
MOD_PIKK_1	9	15	PF00454	0.642
MOD_PK_1	150	156	PF00069	0.220
MOD_PKA_1	207	213	PF00069	0.470
MOD_PKA_2	207	213	PF00069	0.470
MOD_PKA_2	27	33	PF00069	0.741
MOD_PKA_2	275	281	PF00069	0.565
MOD_PKB_1	150	158	PF00069	0.294
MOD_PKB_1	205	213	PF00069	0.526
MOD_Plk_1	341	347	PF00069	0.549
MOD_Plk_1	444	450	PF00069	0.541
MOD_Plk_1	9	15	PF00069	0.517
MOD_Plk_2-3	87	93	PF00069	0.294
MOD_Plk_4	152	158	PF00069	0.311
MOD_Plk_4	241	247	PF00069	0.556
MOD_Plk_4	285	291	PF00069	0.618
MOD_Plk_4	341	347	PF00069	0.581
MOD_Plk_4	399	405	PF00069	0.581
MOD_ProDKin_1	198	204	PF00069	0.387
MOD_ProDKin_1	20	26	PF00069	0.558
MOD_ProDKin_1	281	287	PF00069	0.520
MOD_ProDKin_1	29	35	PF00069	0.591
MOD_ProDKin_1	301	307	PF00069	0.483
MOD_ProDKin_1	320	326	PF00069	0.538
MOD_ProDKin_1	331	337	PF00069	0.548
MOD_ProDKin_1	414	420	PF00069	0.578
MOD_SUMO_rev_2	86	95	PF00179	0.345
TRG_DiLeu_BaEn_2	210	216	PF01217	0.529
TRG_DiLeu_BaEn_4	191	197	PF01217	0.294
TRG_ENDOCYTIC_2	209	212	PF00928	0.475
TRG_ENDOCYTIC_2	88	91	PF00928	0.329
TRG_ER_diArg_1	124	127	PF00400	0.345
TRG_ER_diArg_1	179	181	PF00400	0.349
TRG_ER_diArg_1	205	208	PF00400	0.552
TRG_ER_diArg_1	336	338	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F6	Leptomonas seymouri	53%	85%
A0A3S5H628	Leishmania donovani	76%	100%
A4HTG0	Leishmania infantum	75%	100%
E9AM88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QIF9	Leishmania major	75%	100%