LeishMANIAdb
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AP-3 complex subunit delta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AP-3 complex subunit delta
Gene product:
adaptor complex protein (AP) 3 delta subunit 1, putative
Species:
Leishmania braziliensis
UniProt:
A4H576_LEIBR
TriTrypDb:
LbrM.08.0090 , LBRM2903_080006300 *
Length:
1125

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005794 Golgi apparatus 5 11
GO:0010008 endosome membrane 5 1
GO:0012506 vesicle membrane 4 1
GO:0016020 membrane 2 1
GO:0030119 AP-type membrane coat adaptor complex 3 11
GO:0030123 AP-3 adaptor complex 4 11
GO:0030659 cytoplasmic vesicle membrane 5 1
GO:0031090 organelle membrane 3 1
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
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Expansion

Sequence features

A4H576
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H576

Function

Biological processes
TermNameLevelCount
GO:0006605 protein targeting 5 1
GO:0006623 protein targeting to vacuole 5 1
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0006892 post-Golgi vesicle-mediated transport 6 1
GO:0006896 Golgi to vacuole transport 5 1
GO:0007034 vacuolar transport 4 1
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 674 678 PF00656 0.772
CLV_C14_Caspase3-7 689 693 PF00656 0.598
CLV_C14_Caspase3-7 722 726 PF00656 0.726
CLV_C14_Caspase3-7 751 755 PF00656 0.532
CLV_C14_Caspase3-7 970 974 PF00656 0.496
CLV_MEL_PAP_1 442 448 PF00089 0.202
CLV_NRD_NRD_1 1074 1076 PF00675 0.546
CLV_NRD_NRD_1 156 158 PF00675 0.295
CLV_NRD_NRD_1 212 214 PF00675 0.310
CLV_NRD_NRD_1 329 331 PF00675 0.403
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IML9 Leptomonas seymouri 69% 99%
A0A0S4IR09 Bodo saltans 45% 100%
A0A1X0NNX5 Trypanosomatidae 45% 94%
A0A3R7K4J8 Trypanosoma rangeli 47% 100%
A0A3S5H627 Leishmania donovani 84% 99%
A4HTF9 Leishmania infantum 84% 99%
C9ZPN6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AM87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
Q08951 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
Q4QIG0 Leishmania major 82% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS