Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4H575_LEIBR

TriTrypDb:

LbrM.08.0080 , LBRM2903_080006100 , LBRM2903_080006200

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H575

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H575

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003724	RNA helicase activity	3	10
GO:0003743	translation initiation factor activity	4	10
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	10
GO:0008186	ATP-dependent activity, acting on RNA	2	10
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	684	688	PF00656	0.612
CLV_C14_Caspase3-7	777	781	PF00656	0.595
CLV_NRD_NRD_1	160	162	PF00675	0.537
CLV_NRD_NRD_1	500	502	PF00675	0.272
CLV_NRD_NRD_1	635	637	PF00675	0.434
CLV_NRD_NRD_1	804	806	PF00675	0.424
CLV_NRD_NRD_1	818	820	PF00675	0.519
CLV_PCSK_KEX2_1	3	5	PF00082	0.584
CLV_PCSK_KEX2_1	71	73	PF00082	0.598
CLV_PCSK_KEX2_1	818	820	PF00082	0.644
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.673
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.622
CLV_PCSK_SKI1_1	210	214	PF00082	0.486
CLV_PCSK_SKI1_1	269	273	PF00082	0.247
CLV_PCSK_SKI1_1	349	353	PF00082	0.333
CLV_PCSK_SKI1_1	476	480	PF00082	0.396
CLV_PCSK_SKI1_1	520	524	PF00082	0.325
CLV_PCSK_SKI1_1	652	656	PF00082	0.601
CLV_PCSK_SKI1_1	71	75	PF00082	0.541
CLV_PCSK_SKI1_1	726	730	PF00082	0.631
CLV_PCSK_SKI1_1	818	822	PF00082	0.571
DEG_APCC_DBOX_1	209	217	PF00400	0.549
DEG_APCC_DBOX_1	842	850	PF00400	0.551
DEG_SPOP_SBC_1	50	54	PF00917	0.591
DOC_CKS1_1	359	364	PF01111	0.459
DOC_CYCLIN_RxL_1	361	370	PF00134	0.447
DOC_CYCLIN_RxL_1	476	487	PF00134	0.405
DOC_CYCLIN_RxL_1	742	753	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.391
DOC_MAPK_DCC_7	556	565	PF00069	0.459
DOC_MAPK_gen_1	298	308	PF00069	0.463
DOC_MAPK_gen_1	349	359	PF00069	0.447
DOC_MAPK_gen_1	587	597	PF00069	0.528
DOC_MAPK_gen_1	649	658	PF00069	0.545
DOC_MAPK_gen_1	856	863	PF00069	0.376
DOC_MAPK_HePTP_8	553	565	PF00069	0.459
DOC_MAPK_JIP1_4	825	831	PF00069	0.329
DOC_MAPK_MEF2A_6	301	310	PF00069	0.447
DOC_MAPK_MEF2A_6	556	565	PF00069	0.447
DOC_MIT_MIM_1	506	515	PF04212	0.552
DOC_PP1_RVXF_1	379	385	PF00149	0.474
DOC_PP1_RVXF_1	591	598	PF00149	0.391
DOC_PP1_RVXF_1	743	750	PF00149	0.647
DOC_PP1_RVXF_1	804	811	PF00149	0.479
DOC_PP2B_LxvP_1	163	166	PF13499	0.373
DOC_PP2B_LxvP_1	558	561	PF13499	0.459
DOC_USP7_MATH_1	14	18	PF00917	0.684
DOC_USP7_MATH_1	229	233	PF00917	0.475
DOC_USP7_MATH_1	256	260	PF00917	0.452
DOC_USP7_MATH_1	264	268	PF00917	0.456
DOC_USP7_MATH_1	588	592	PF00917	0.647
DOC_USP7_MATH_1	61	65	PF00917	0.643
DOC_USP7_MATH_1	702	706	PF00917	0.695
DOC_USP7_MATH_1	87	91	PF00917	0.596
DOC_USP7_MATH_1	97	101	PF00917	0.615
DOC_USP7_UBL2_3	821	825	PF12436	0.629
DOC_WW_Pin1_4	259	264	PF00397	0.468
DOC_WW_Pin1_4	358	363	PF00397	0.459
DOC_WW_Pin1_4	444	449	PF00397	0.450
DOC_WW_Pin1_4	471	476	PF00397	0.567
LIG_14-3-3_CanoR_1	127	136	PF00244	0.570
LIG_14-3-3_CanoR_1	228	234	PF00244	0.443
LIG_14-3-3_CanoR_1	334	340	PF00244	0.447
LIG_14-3-3_CanoR_1	381	385	PF00244	0.460
LIG_14-3-3_CanoR_1	511	516	PF00244	0.464
LIG_14-3-3_CanoR_1	520	525	PF00244	0.449
LIG_14-3-3_CanoR_1	593	598	PF00244	0.482
LIG_14-3-3_CanoR_1	708	713	PF00244	0.497
LIG_14-3-3_CanoR_1	768	775	PF00244	0.471
LIG_Actin_WH2_2	121	136	PF00022	0.512
LIG_Actin_WH2_2	320	336	PF00022	0.459
LIG_Actin_WH2_2	411	429	PF00022	0.472
LIG_Actin_WH2_2	621	638	PF00022	0.533
LIG_APCC_ABBA_1	656	661	PF00400	0.424
LIG_APCC_ABBAyCdc20_2	655	661	PF00400	0.423
LIG_APCC_ABBAyCdc20_2	805	811	PF00400	0.439
LIG_BRCT_BRCA1_1	644	648	PF00533	0.565
LIG_BRCT_BRCA1_1	787	791	PF00533	0.510
LIG_CtBP_PxDLS_1	198	202	PF00389	0.561
LIG_EVH1_1	163	167	PF00568	0.372
LIG_FAT_LD_1	505	513	PF03623	0.552
LIG_FHA_1	154	160	PF00498	0.588
LIG_FHA_1	311	317	PF00498	0.451
LIG_FHA_1	413	419	PF00498	0.504
LIG_FHA_1	54	60	PF00498	0.512
LIG_FHA_1	799	805	PF00498	0.417
LIG_FHA_1	858	864	PF00498	0.581
LIG_FHA_2	203	209	PF00498	0.492
LIG_FHA_2	351	357	PF00498	0.421
LIG_LIR_Apic_2	192	198	PF02991	0.420
LIG_LIR_Apic_2	282	288	PF02991	0.447
LIG_LIR_Gen_1	33	43	PF02991	0.531
LIG_LIR_Gen_1	383	390	PF02991	0.462
LIG_LIR_Nem_3	192	197	PF02991	0.459
LIG_LIR_Nem_3	33	39	PF02991	0.533
LIG_LIR_Nem_3	383	387	PF02991	0.462
LIG_LIR_Nem_3	453	459	PF02991	0.374
LIG_LIR_Nem_3	559	565	PF02991	0.466
LIG_LIR_Nem_3	645	651	PF02991	0.498
LIG_MLH1_MIPbox_1	644	648	PF16413	0.599
LIG_NRBOX	364	370	PF00104	0.447
LIG_NRBOX	476	482	PF00104	0.419
LIG_Pex14_2	394	398	PF04695	0.447
LIG_REV1ctd_RIR_1	595	604	PF16727	0.378
LIG_REV1ctd_RIR_1	645	653	PF16727	0.612
LIG_SH2_CRK	187	191	PF00017	0.558
LIG_SH2_CRK	251	255	PF00017	0.535
LIG_SH2_CRK	285	289	PF00017	0.508
LIG_SH2_CRK	569	573	PF00017	0.533
LIG_SH2_CRK	76	80	PF00017	0.472
LIG_SH2_GRB2like	517	520	PF00017	0.508
LIG_SH2_NCK_1	626	630	PF00017	0.435
LIG_SH2_NCK_1	76	80	PF00017	0.601
LIG_SH2_PTP2	195	198	PF00017	0.423
LIG_SH2_SRC	179	182	PF00017	0.366
LIG_SH2_SRC	187	190	PF00017	0.392
LIG_SH2_STAP1	517	521	PF00017	0.533
LIG_SH2_STAP1	575	579	PF00017	0.447
LIG_SH2_STAT5	179	182	PF00017	0.359
LIG_SH2_STAT5	195	198	PF00017	0.497
LIG_SH2_STAT5	562	565	PF00017	0.451
LIG_SH2_STAT5	578	581	PF00017	0.431
LIG_SH2_STAT5	809	812	PF00017	0.524
LIG_SH2_STAT5	828	831	PF00017	0.360
LIG_SH3_1	161	167	PF00018	0.428
LIG_SH3_3	133	139	PF00018	0.584
LIG_SH3_3	161	167	PF00018	0.412
LIG_SH3_3	193	199	PF00018	0.458
LIG_SH3_3	223	229	PF00018	0.462
LIG_SH3_3	306	312	PF00018	0.502
LIG_SH3_3	356	362	PF00018	0.459
LIG_SH3_4	134	141	PF00018	0.502
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.484
LIG_SUMO_SIM_par_1	307	313	PF11976	0.459
LIG_SUMO_SIM_par_1	364	370	PF11976	0.447
LIG_SUMO_SIM_par_1	436	441	PF11976	0.377
LIG_SUMO_SIM_par_1	493	499	PF11976	0.490
LIG_SUMO_SIM_par_1	859	864	PF11976	0.391
LIG_TRAF2_1	312	315	PF00917	0.508
LIG_TRAF2_1	711	714	PF00917	0.643
LIG_TRAF2_1	737	740	PF00917	0.646
LIG_TYR_ITIM	560	565	PF00017	0.459
LIG_TYR_ITIM	74	79	PF00017	0.479
LIG_UBA3_1	212	220	PF00899	0.445
LIG_UBA3_1	494	502	PF00899	0.426
MOD_CDK_SPK_2	471	476	PF00069	0.567
MOD_CDK_SPxK_1	358	364	PF00069	0.459
MOD_CK1_1	111	117	PF00069	0.525
MOD_CK1_1	157	163	PF00069	0.655
MOD_CK1_1	19	25	PF00069	0.668
MOD_CK1_1	259	265	PF00069	0.418
MOD_CK1_1	279	285	PF00069	0.460
MOD_CK1_1	30	36	PF00069	0.542
MOD_CK1_1	338	344	PF00069	0.552
MOD_CK1_1	380	386	PF00069	0.519
MOD_CK1_1	48	54	PF00069	0.571
MOD_CK1_1	596	602	PF00069	0.405
MOD_CK1_1	682	688	PF00069	0.598
MOD_CK2_1	12	18	PF00069	0.589
MOD_CK2_1	202	208	PF00069	0.513
MOD_CK2_1	340	346	PF00069	0.468
MOD_CK2_1	350	356	PF00069	0.386
MOD_CK2_1	447	453	PF00069	0.431
MOD_CK2_1	688	694	PF00069	0.710
MOD_CK2_1	708	714	PF00069	0.709
MOD_CK2_1	734	740	PF00069	0.564
MOD_CK2_1	791	797	PF00069	0.447
MOD_GlcNHglycan	116	119	PF01048	0.487
MOD_GlcNHglycan	148	153	PF01048	0.503
MOD_GlcNHglycan	18	21	PF01048	0.677
MOD_GlcNHglycan	266	269	PF01048	0.250
MOD_GlcNHglycan	278	281	PF01048	0.246
MOD_GlcNHglycan	29	32	PF01048	0.497
MOD_GlcNHglycan	395	398	PF01048	0.245
MOD_GlcNHglycan	418	421	PF01048	0.247
MOD_GlcNHglycan	525	528	PF01048	0.277
MOD_GlcNHglycan	590	593	PF01048	0.520
MOD_GlcNHglycan	637	640	PF01048	0.562
MOD_GlcNHglycan	644	647	PF01048	0.516
MOD_GlcNHglycan	736	739	PF01048	0.553
MOD_GlcNHglycan	787	790	PF01048	0.451
MOD_GlcNHglycan	91	94	PF01048	0.606
MOD_GlcNHglycan	99	102	PF01048	0.682
MOD_GSK3_1	108	115	PF00069	0.565
MOD_GSK3_1	12	19	PF00069	0.689
MOD_GSK3_1	153	160	PF00069	0.502
MOD_GSK3_1	21	28	PF00069	0.723
MOD_GSK3_1	229	236	PF00069	0.435
MOD_GSK3_1	335	342	PF00069	0.488
MOD_GSK3_1	412	419	PF00069	0.509
MOD_GSK3_1	44	51	PF00069	0.596
MOD_GSK3_1	679	686	PF00069	0.580
MOD_GSK3_1	751	758	PF00069	0.658
MOD_GSK3_1	787	794	PF00069	0.377
MOD_GSK3_1	857	864	PF00069	0.585
MOD_N-GLC_1	109	114	PF02516	0.541
MOD_N-GLC_1	202	207	PF02516	0.587
MOD_N-GLC_1	67	72	PF02516	0.536
MOD_N-GLC_1	696	701	PF02516	0.772
MOD_NEK2_1	109	114	PF00069	0.512
MOD_NEK2_1	25	30	PF00069	0.650
MOD_NEK2_1	271	276	PF00069	0.459
MOD_NEK2_1	377	382	PF00069	0.473
MOD_NEK2_1	393	398	PF00069	0.371
MOD_NEK2_1	49	54	PF00069	0.663
MOD_NEK2_1	496	501	PF00069	0.490
MOD_NEK2_1	548	553	PF00069	0.444
MOD_NEK2_1	680	685	PF00069	0.612
MOD_NEK2_1	733	738	PF00069	0.505
MOD_NEK2_1	791	796	PF00069	0.430
MOD_NEK2_1	798	803	PF00069	0.428
MOD_PIKK_1	180	186	PF00454	0.358
MOD_PIKK_1	310	316	PF00454	0.508
MOD_PIKK_1	496	502	PF00454	0.488
MOD_PK_1	708	714	PF00069	0.497
MOD_PK_1	859	865	PF00069	0.610
MOD_PKA_2	380	386	PF00069	0.473
MOD_PKA_2	412	418	PF00069	0.523
MOD_PKA_2	510	516	PF00069	0.472
MOD_PKA_2	635	641	PF00069	0.582
MOD_PKA_2	741	747	PF00069	0.605
MOD_PKB_1	706	714	PF00069	0.751
MOD_Plk_1	180	186	PF00069	0.430
MOD_Plk_1	44	50	PF00069	0.742
MOD_Plk_1	696	702	PF00069	0.730
MOD_Plk_1	799	805	PF00069	0.458
MOD_Plk_2-3	21	27	PF00069	0.622
MOD_Plk_2-3	689	695	PF00069	0.744
MOD_Plk_4	140	146	PF00069	0.495
MOD_Plk_4	154	160	PF00069	0.438
MOD_Plk_4	380	386	PF00069	0.454
MOD_Plk_4	520	526	PF00069	0.533
MOD_Plk_4	593	599	PF00069	0.361
MOD_Plk_4	787	793	PF00069	0.455
MOD_Plk_4	799	805	PF00069	0.382
MOD_ProDKin_1	259	265	PF00069	0.468
MOD_ProDKin_1	358	364	PF00069	0.459
MOD_ProDKin_1	444	450	PF00069	0.451
MOD_ProDKin_1	471	477	PF00069	0.555
MOD_SUMO_for_1	128	131	PF00179	0.539
MOD_SUMO_for_1	849	852	PF00179	0.451
MOD_SUMO_rev_2	847	851	PF00179	0.488
TRG_DiLeu_BaEn_1	208	213	PF01217	0.435
TRG_DiLeu_BaEn_1	504	509	PF01217	0.518
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.472
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.447
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.483
TRG_ENDOCYTIC_2	187	190	PF00928	0.407
TRG_ENDOCYTIC_2	36	39	PF00928	0.659
TRG_ENDOCYTIC_2	525	528	PF00928	0.447
TRG_ENDOCYTIC_2	562	565	PF00928	0.459
TRG_ENDOCYTIC_2	76	79	PF00928	0.476
TRG_ENDOCYTIC_2	828	831	PF00928	0.360
TRG_ER_diArg_1	818	820	PF00400	0.644
TRG_NES_CRM1_1	472	487	PF08389	0.420
TRG_NLS_Bipartite_1	161	176	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P942	Leptomonas seymouri	75%	100%
A0A0S4IVE5	Bodo saltans	46%	92%
A0A1X0NPK0	Trypanosomatidae	57%	87%
A0A3Q8IF94	Leishmania donovani	33%	100%
A0A3R7LQQ6	Trypanosoma rangeli	57%	91%
A0A3S7WQ33	Leishmania donovani	92%	100%
A0A3S7X579	Leishmania donovani	29%	100%
A2QQA8	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	33%	74%
A3LQ55	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	34%	99%
A4H4Y0	Leishmania braziliensis	36%	100%
A4HK20	Leishmania braziliensis	33%	100%
A4HK38	Leishmania braziliensis	30%	100%
A4HTF8	Leishmania infantum	92%	100%
A4I7K4	Leishmania infantum	33%	100%
A4I7M5	Leishmania infantum	30%	100%
A6RW79	Botryotinia fuckeliana (strain B05.10)	34%	75%
A6ZLH6	Saccharomyces cerevisiae (strain YJM789)	29%	100%
A7TJK8	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	29%	100%
C9ZPN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	92%
E9AM86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AWL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
P21372	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q0D1K3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	34%	73%
Q0J7Y8	Oryza sativa subsp. japonica	33%	92%
Q0UN57	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	32%	73%
Q2HAD8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	34%	82%
Q2U2J6	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	33%	73%
Q4IP34	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	72%
Q4Q1K8	Leishmania major	35%	100%
Q4Q5M6	Leishmania major	30%	100%
Q4Q5P5	Leishmania major	33%	100%
Q4QAV6	Leishmania major	24%	100%
Q4QHK6	Leishmania major	26%	100%
Q4QIG1	Leishmania major	91%	100%
Q4QIQ9	Leishmania major	35%	100%
Q4TVV3	Danio rerio	32%	85%
Q569Z5	Mus musculus	32%	84%
Q5R6D8	Pongo abelii	32%	84%
Q62780	Rattus norvegicus	32%	84%
Q6BML1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	95%
Q6CCZ1	Yarrowia lipolytica (strain CLIB 122 / E 150)	33%	89%
Q6FML5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q754U8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	100%
Q7L014	Homo sapiens	32%	84%
Q7SH33	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	73%
Q84UQ1	Oryza sativa subsp. japonica	36%	83%
Q8H0U8	Arabidopsis thaliana	36%	74%
Q9P7C7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	86%
Q9SF41	Arabidopsis thaliana	34%	88%
V5DDC5	Trypanosoma cruzi	57%	92%