ASCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative zinc finger motif, C2HC5-type/ASCH domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H574_LEIBR

TriTrypDb:

LbrM.08.0070 , LBRM2903_080006000

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H574

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H574

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0140110	transcription regulator activity	1	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.525
CLV_NRD_NRD_1	301	303	PF00675	0.721
CLV_NRD_NRD_1	354	356	PF00675	0.488
CLV_NRD_NRD_1	404	406	PF00675	0.541
CLV_NRD_NRD_1	621	623	PF00675	0.352
CLV_NRD_NRD_1	82	84	PF00675	0.406
CLV_PCSK_FUR_1	126	130	PF00082	0.694
CLV_PCSK_FUR_1	233	237	PF00082	0.486
CLV_PCSK_KEX2_1	118	120	PF00082	0.618
CLV_PCSK_KEX2_1	125	127	PF00082	0.567
CLV_PCSK_KEX2_1	128	130	PF00082	0.561
CLV_PCSK_KEX2_1	235	237	PF00082	0.481
CLV_PCSK_KEX2_1	260	262	PF00082	0.532
CLV_PCSK_KEX2_1	354	356	PF00082	0.684
CLV_PCSK_KEX2_1	363	365	PF00082	0.682
CLV_PCSK_KEX2_1	4	6	PF00082	0.624
CLV_PCSK_KEX2_1	404	406	PF00082	0.553
CLV_PCSK_KEX2_1	505	507	PF00082	0.411
CLV_PCSK_KEX2_1	81	83	PF00082	0.402
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.646
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.588
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.582
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.506
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.700
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.624
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.411
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.411
CLV_PCSK_SKI1_1	118	122	PF00082	0.626
CLV_PCSK_SKI1_1	5	9	PF00082	0.590
CLV_PCSK_SKI1_1	556	560	PF00082	0.439
CLV_PCSK_SKI1_1	609	613	PF00082	0.342
DEG_APCC_DBOX_1	426	434	PF00400	0.409
DEG_APCC_KENBOX_2	302	306	PF00400	0.720
DEG_SPOP_SBC_1	137	141	PF00917	0.456
DOC_CKS1_1	96	101	PF01111	0.578
DOC_CYCLIN_yCln2_LP_2	598	604	PF00134	0.346
DOC_MAPK_DCC_7	596	604	PF00069	0.346
DOC_MAPK_gen_1	125	133	PF00069	0.646
DOC_MAPK_gen_1	427	435	PF00069	0.560
DOC_MAPK_MEF2A_6	371	380	PF00069	0.558
DOC_MAPK_MEF2A_6	427	434	PF00069	0.413
DOC_MAPK_NFAT4_5	427	435	PF00069	0.418
DOC_PP4_FxxP_1	542	545	PF00568	0.281
DOC_PP4_FxxP_1	600	603	PF00568	0.373
DOC_SPAK_OSR1_1	474	478	PF12202	0.438
DOC_USP7_MATH_1	137	141	PF00917	0.567
DOC_USP7_MATH_1	263	267	PF00917	0.576
DOC_USP7_MATH_1	339	343	PF00917	0.620
DOC_USP7_MATH_1	389	393	PF00917	0.729
DOC_USP7_MATH_1	495	499	PF00917	0.251
DOC_USP7_MATH_1	524	528	PF00917	0.366
DOC_USP7_UBL2_3	4	8	PF12436	0.595
DOC_WW_Pin1_4	18	23	PF00397	0.468
DOC_WW_Pin1_4	246	251	PF00397	0.493
DOC_WW_Pin1_4	347	352	PF00397	0.713
DOC_WW_Pin1_4	583	588	PF00397	0.357
DOC_WW_Pin1_4	95	100	PF00397	0.504
LIG_14-3-3_CanoR_1	236	240	PF00244	0.629
LIG_14-3-3_CanoR_1	371	376	PF00244	0.654
LIG_14-3-3_CanoR_1	466	472	PF00244	0.649
LIG_14-3-3_CanoR_1	616	625	PF00244	0.389
LIG_BIR_III_2	310	314	PF00653	0.499
LIG_BRCT_BRCA1_1	34	38	PF00533	0.334
LIG_BRCT_BRCA1_1	471	475	PF00533	0.393
LIG_BRCT_BRCA1_1	71	75	PF00533	0.452
LIG_Clathr_ClatBox_1	610	614	PF01394	0.374
LIG_EH1_1	474	482	PF00400	0.439
LIG_eIF4E_1	553	559	PF01652	0.266
LIG_FHA_1	115	121	PF00498	0.706
LIG_FHA_1	141	147	PF00498	0.429
LIG_FHA_1	235	241	PF00498	0.397
LIG_FHA_1	283	289	PF00498	0.611
LIG_FHA_1	553	559	PF00498	0.266
LIG_FHA_1	563	569	PF00498	0.266
LIG_FHA_1	66	72	PF00498	0.385
LIG_FHA_2	216	222	PF00498	0.353
LIG_FHA_2	236	242	PF00498	0.602
LIG_FHA_2	333	339	PF00498	0.616
LIG_FHA_2	528	534	PF00498	0.210
LIG_FHA_2	56	62	PF00498	0.479
LIG_LIR_Apic_2	252	257	PF02991	0.480
LIG_LIR_Apic_2	540	545	PF02991	0.360
LIG_LIR_Gen_1	536	545	PF02991	0.281
LIG_LIR_Gen_1	585	595	PF02991	0.350
LIG_LIR_Nem_3	35	41	PF02991	0.405
LIG_LIR_Nem_3	536	542	PF02991	0.266
LIG_LIR_Nem_3	585	591	PF02991	0.340
LIG_Pex14_1	512	516	PF04695	0.266
LIG_SH2_CRK	588	592	PF00017	0.457
LIG_SH2_NCK_1	573	577	PF00017	0.276
LIG_SH2_PTP2	561	564	PF00017	0.266
LIG_SH2_SRC	195	198	PF00017	0.596
LIG_SH2_SRC	561	564	PF00017	0.295
LIG_SH2_STAP1	195	199	PF00017	0.455
LIG_SH2_STAP1	450	454	PF00017	0.495
LIG_SH2_STAP1	539	543	PF00017	0.300
LIG_SH2_STAP1	573	577	PF00017	0.387
LIG_SH2_STAT5	410	413	PF00017	0.589
LIG_SH2_STAT5	561	564	PF00017	0.266
LIG_SH3_3	375	381	PF00018	0.583
LIG_SH3_3	93	99	PF00018	0.561
LIG_SH3_4	8	15	PF00018	0.589
LIG_SUMO_SIM_anti_2	431	436	PF11976	0.666
LIG_SUMO_SIM_par_1	67	73	PF11976	0.414
LIG_TRAF2_1	198	201	PF00917	0.584
LIG_TRAF2_1	381	384	PF00917	0.704
LIG_TYR_ITIM	559	564	PF00017	0.266
MOD_CDK_SPxxK_3	347	354	PF00069	0.596
MOD_CK1_1	100	106	PF00069	0.658
MOD_CK1_1	124	130	PF00069	0.529
MOD_CK1_1	140	146	PF00069	0.382
MOD_CK1_1	249	255	PF00069	0.586
MOD_CK1_1	358	364	PF00069	0.702
MOD_CK1_1	392	398	PF00069	0.717
MOD_CK1_1	467	473	PF00069	0.480
MOD_CK1_1	527	533	PF00069	0.210
MOD_CK1_1	586	592	PF00069	0.357
MOD_CK2_1	138	144	PF00069	0.702
MOD_CK2_1	195	201	PF00069	0.608
MOD_CK2_1	215	221	PF00069	0.313
MOD_CK2_1	263	269	PF00069	0.465
MOD_CK2_1	332	338	PF00069	0.623
MOD_CK2_1	39	45	PF00069	0.530
MOD_CK2_1	443	449	PF00069	0.527
MOD_CK2_1	527	533	PF00069	0.210
MOD_CK2_1	55	61	PF00069	0.316
MOD_Cter_Amidation	352	355	PF01082	0.545
MOD_Cter_Amidation	361	364	PF01082	0.650
MOD_GlcNHglycan	102	105	PF01048	0.459
MOD_GlcNHglycan	140	143	PF01048	0.550
MOD_GlcNHglycan	241	246	PF01048	0.564
MOD_GlcNHglycan	251	254	PF01048	0.544
MOD_GlcNHglycan	264	268	PF01048	0.566
MOD_GlcNHglycan	304	308	PF01048	0.695
MOD_GlcNHglycan	359	363	PF01048	0.647
MOD_GlcNHglycan	445	448	PF01048	0.616
MOD_GlcNHglycan	466	469	PF01048	0.617
MOD_GlcNHglycan	84	88	PF01048	0.542
MOD_GSK3_1	110	117	PF00069	0.693
MOD_GSK3_1	136	143	PF00069	0.496
MOD_GSK3_1	384	391	PF00069	0.694
MOD_GSK3_1	44	51	PF00069	0.392
MOD_GSK3_1	523	530	PF00069	0.309
MOD_GSK3_1	65	72	PF00069	0.570
MOD_N-GLC_1	114	119	PF02516	0.655
MOD_N-GLC_1	455	460	PF02516	0.715
MOD_N-GLC_1	464	469	PF02516	0.421
MOD_N-GLC_1	604	609	PF02516	0.298
MOD_N-GLC_2	18	20	PF02516	0.406
MOD_NEK2_1	102	107	PF00069	0.476
MOD_NEK2_1	114	119	PF00069	0.633
MOD_NEK2_1	162	167	PF00069	0.448
MOD_NEK2_1	475	480	PF00069	0.494
MOD_NEK2_1	604	609	PF00069	0.298
MOD_NEK2_2	155	160	PF00069	0.482
MOD_PIKK_1	291	297	PF00454	0.607
MOD_PIKK_1	392	398	PF00454	0.766
MOD_PK_1	371	377	PF00069	0.495
MOD_PKA_1	118	124	PF00069	0.608
MOD_PKA_1	235	241	PF00069	0.625
MOD_PKA_2	118	124	PF00069	0.655
MOD_PKA_2	162	168	PF00069	0.519
MOD_PKA_2	202	208	PF00069	0.451
MOD_PKA_2	235	241	PF00069	0.625
MOD_PKA_2	282	288	PF00069	0.489
MOD_PKA_2	370	376	PF00069	0.655
MOD_PKA_2	392	398	PF00069	0.734
MOD_Plk_1	195	201	PF00069	0.582
MOD_Plk_1	455	461	PF00069	0.605
MOD_Plk_4	235	241	PF00069	0.625
MOD_Plk_4	243	249	PF00069	0.606
MOD_Plk_4	339	345	PF00069	0.568
MOD_Plk_4	371	377	PF00069	0.505
MOD_Plk_4	476	482	PF00069	0.589
MOD_Plk_4	495	501	PF00069	0.171
MOD_Plk_4	586	592	PF00069	0.468
MOD_Plk_4	65	71	PF00069	0.380
MOD_ProDKin_1	18	24	PF00069	0.459
MOD_ProDKin_1	246	252	PF00069	0.481
MOD_ProDKin_1	347	353	PF00069	0.711
MOD_ProDKin_1	583	589	PF00069	0.350
MOD_ProDKin_1	95	101	PF00069	0.507
MOD_SUMO_for_1	428	431	PF00179	0.401
MOD_SUMO_rev_2	589	598	PF00179	0.465
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.485
TRG_ENDOCYTIC_2	539	542	PF00928	0.266
TRG_ENDOCYTIC_2	561	564	PF00928	0.266
TRG_ENDOCYTIC_2	588	591	PF00928	0.437
TRG_ER_diArg_1	354	356	PF00400	0.488
TRG_ER_diArg_1	404	406	PF00400	0.542
TRG_ER_diArg_1	516	519	PF00400	0.281
TRG_NLS_MonoExtC_3	124	129	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGL1	Leptomonas seymouri	69%	100%
A0A0S4IUQ4	Bodo saltans	38%	98%
A0A1X0NNW7	Trypanosomatidae	43%	98%
A0A3S5H626	Leishmania donovani	79%	100%
A0A3S5IQP6	Trypanosoma rangeli	47%	100%
A4HTF7	Leishmania infantum	79%	100%
C9ZPN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AM85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QIG2	Leishmania major	77%	100%
V5BH64	Trypanosoma cruzi	46%	100%