LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H571_LEIBR

TriTrypDb:

LbrM.08.0040 , LBRM2903_080005700

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H571

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H571

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.512
CLV_C14_Caspase3-7	2	6	PF00656	0.680
CLV_NRD_NRD_1	105	107	PF00675	0.443
CLV_NRD_NRD_1	38	40	PF00675	0.505
CLV_PCSK_KEX2_1	105	107	PF00082	0.462
CLV_PCSK_KEX2_1	38	40	PF00082	0.505
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.486
CLV_PCSK_SKI1_1	39	43	PF00082	0.574
DEG_APCC_DBOX_1	131	139	PF00400	0.493
DEG_APCC_DBOX_1	209	217	PF00400	0.587
DEG_Nend_UBRbox_2	1	3	PF02207	0.701
DOC_MAPK_gen_1	105	114	PF00069	0.447
DOC_MAPK_gen_1	207	217	PF00069	0.598
DOC_MAPK_MEF2A_6	210	217	PF00069	0.581
DOC_PP2B_LxvP_1	124	127	PF13499	0.438
DOC_USP7_MATH_1	67	71	PF00917	0.722
DOC_USP7_MATH_1	72	76	PF00917	0.748
DOC_USP7_UBL2_3	60	64	PF12436	0.605
DOC_WW_Pin1_4	180	185	PF00397	0.548
DOC_WW_Pin1_4	63	68	PF00397	0.650
LIG_14-3-3_CanoR_1	172	181	PF00244	0.474
LIG_14-3-3_CanoR_1	210	214	PF00244	0.579
LIG_14-3-3_CanoR_1	38	48	PF00244	0.602
LIG_FHA_1	173	179	PF00498	0.530
LIG_FHA_1	40	46	PF00498	0.581
LIG_FHA_2	8	14	PF00498	0.698
LIG_LIR_Gen_1	7	17	PF02991	0.619
LIG_LIR_Nem_3	7	12	PF02991	0.606
LIG_NRBOX	177	183	PF00104	0.314
LIG_PTB_Apo_2	215	222	PF02174	0.574
LIG_PTB_Phospho_1	215	221	PF10480	0.571
LIG_SH2_NCK_1	118	122	PF00017	0.412
LIG_SH2_STAP1	118	122	PF00017	0.412
LIG_SH2_STAP1	174	178	PF00017	0.524
LIG_SH2_STAP1	92	96	PF00017	0.464
LIG_SH2_STAT5	152	155	PF00017	0.544
LIG_SH2_STAT5	174	177	PF00017	0.487
LIG_SH2_STAT5	35	38	PF00017	0.438
LIG_SH3_3	156	162	PF00018	0.518
MOD_CDC14_SPxK_1	183	186	PF00782	0.629
MOD_CDK_SPxK_1	180	186	PF00069	0.592
MOD_CK1_1	54	60	PF00069	0.507
MOD_CK1_1	7	13	PF00069	0.694
MOD_CK2_1	7	13	PF00069	0.662
MOD_CK2_1	92	98	PF00069	0.487
MOD_CMANNOS	219	222	PF00535	0.483
MOD_GlcNHglycan	74	77	PF01048	0.716
MOD_GlcNHglycan	97	102	PF01048	0.633
MOD_GSK3_1	139	146	PF00069	0.435
MOD_GSK3_1	172	179	PF00069	0.497
MOD_GSK3_1	51	58	PF00069	0.442
MOD_GSK3_1	63	70	PF00069	0.513
MOD_NEK2_1	143	148	PF00069	0.437
MOD_NEK2_1	31	36	PF00069	0.546
MOD_NEK2_1	41	46	PF00069	0.457
MOD_PK_1	186	192	PF00069	0.656
MOD_PKA_2	209	215	PF00069	0.587
MOD_Plk_1	143	149	PF00069	0.318
MOD_Plk_1	186	192	PF00069	0.566
MOD_Plk_1	4	10	PF00069	0.700
MOD_Plk_4	4	10	PF00069	0.671
MOD_Plk_4	51	57	PF00069	0.456
MOD_ProDKin_1	180	186	PF00069	0.556
MOD_ProDKin_1	63	69	PF00069	0.648
TRG_DiLeu_BaEn_1	77	82	PF01217	0.506
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.452
TRG_ER_diArg_1	132	135	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAM0	Leptomonas seymouri	59%	100%
A0A1X0NQK9	Trypanosomatidae	36%	91%
A0A3S7WQ20	Leishmania donovani	80%	100%
A0A422N813	Trypanosoma rangeli	33%	83%
A4HTF4	Leishmania infantum	80%	100%
C9ZPN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
E9AM82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QIG5	Leishmania major	80%	100%
V5BLP0	Trypanosoma cruzi	30%	78%