Putative vesicle-associated membrane protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicle-associated membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H570_LEIBR

TriTrypDb:

LbrM.08.0030 , LBRM2903_080005600

Length:

215

Annotations

LeishMANIAdb annotations

A conserved SNARE protein with a tail anchor. Distantly similar to mammalian VAMP7.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4H570

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H570

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0016192	vesicle-mediated transport	4	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.640
CLV_NRD_NRD_1	171	173	PF00675	0.250
CLV_PCSK_KEX2_1	171	173	PF00082	0.266
CLV_PCSK_KEX2_1	177	179	PF00082	0.262
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.273
CLV_PCSK_SKI1_1	106	110	PF00082	0.378
CLV_PCSK_SKI1_1	183	187	PF00082	0.268
CLV_PCSK_SKI1_1	78	82	PF00082	0.342
DOC_CYCLIN_RxL_1	177	188	PF00134	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	180	189	PF00134	0.539
DOC_MAPK_gen_1	183	191	PF00069	0.473
DOC_MAPK_MEF2A_6	183	191	PF00069	0.473
LIG_14-3-3_CanoR_1	171	180	PF00244	0.516
LIG_14-3-3_CanoR_1	76	81	PF00244	0.526
LIG_Actin_WH2_2	173	188	PF00022	0.516
LIG_Actin_WH2_2	88	105	PF00022	0.651
LIG_FHA_1	186	192	PF00498	0.332
LIG_FHA_2	152	158	PF00498	0.481
LIG_FHA_2	159	165	PF00498	0.473
LIG_FHA_2	44	50	PF00498	0.548
LIG_FHA_2	69	75	PF00498	0.531
LIG_GBD_Chelix_1	196	204	PF00786	0.423
LIG_Integrin_RGD_1	148	150	PF01839	0.273
LIG_LIR_Apic_2	114	119	PF02991	0.554
LIG_LIR_Gen_1	79	89	PF02991	0.535
LIG_LIR_Nem_3	79	84	PF02991	0.511
LIG_NRP_CendR_1	213	215	PF00754	0.656
LIG_PCNA_PIPBox_1	77	86	PF02747	0.539
LIG_PCNA_yPIPBox_3	123	135	PF02747	0.484
LIG_SH2_CRK	116	120	PF00017	0.568
LIG_SH2_CRK	5	9	PF00017	0.499
LIG_SH2_CRK	56	60	PF00017	0.530
LIG_SH2_NCK_1	116	120	PF00017	0.568
LIG_SH2_NCK_1	5	9	PF00017	0.499
LIG_SH2_STAT5	58	61	PF00017	0.525
LIG_TYR_ITIM	3	8	PF00017	0.504
LIG_TYR_ITIM	54	59	PF00017	0.525
LIG_UBA3_1	138	144	PF00899	0.484
LIG_UBA3_1	200	208	PF00899	0.312
MOD_CK1_1	97	103	PF00069	0.715
MOD_CK2_1	151	157	PF00069	0.493
MOD_CK2_1	57	63	PF00069	0.522
MOD_Cter_Amidation	104	107	PF01082	0.381
MOD_LATS_1	156	162	PF00433	0.516
MOD_N-GLC_1	209	214	PF02516	0.608
MOD_N-GLC_2	179	181	PF02516	0.284
MOD_NEK2_1	185	190	PF00069	0.485
MOD_NEK2_1	26	31	PF00069	0.581
MOD_PIKK_1	94	100	PF00454	0.718
MOD_PKA_1	171	177	PF00069	0.454
MOD_PKA_2	170	176	PF00069	0.499
MOD_Plk_4	185	191	PF00069	0.474
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.565
TRG_ENDOCYTIC_2	5	8	PF00928	0.497
TRG_ENDOCYTIC_2	56	59	PF00928	0.521
TRG_ER_diArg_1	75	78	PF00400	0.554
TRG_NES_CRM1_1	129	143	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I418	Leptomonas seymouri	91%	99%
A0A0N1IMB1	Leptomonas seymouri	27%	98%
A0A0S4IUW0	Bodo saltans	78%	100%
A0A0S4IXW4	Bodo saltans	44%	96%
A0A0S4JCC4	Bodo saltans	28%	92%
A0A0S4JYF9	Bodo saltans	33%	100%
A0A1X0NF95	Trypanosomatidae	29%	97%
A0A1X0NQE9	Trypanosomatidae	85%	100%
A0A1X0P780	Trypanosomatidae	31%	100%
A0A3S7WQ28	Leishmania donovani	94%	100%
A0A3S7X115	Leishmania donovani	25%	98%
A0A422N3E0	Trypanosoma rangeli	29%	100%
A0A422N7W7	Trypanosoma rangeli	84%	100%
A0A422NDY3	Trypanosoma rangeli	28%	97%
A4HG15	Leishmania braziliensis	26%	98%
A4HTF3	Leishmania infantum	94%	100%
A4I337	Leishmania infantum	25%	98%
C9ZJK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	97%
C9ZPM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9ACV5	Leishmania major	24%	97%
E9AM81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AZE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	98%
O48850	Arabidopsis thaliana	28%	75%
O49377	Arabidopsis thaliana	28%	98%
P47192	Arabidopsis thaliana	29%	97%
P51809	Homo sapiens	26%	98%
P70280	Mus musculus	26%	98%
Q17QI5	Bos taurus	26%	98%
Q4QIG6	Leishmania major	94%	100%
Q54NW7	Dictyostelium discoideum	25%	100%
Q5RF94	Pongo abelii	26%	98%
Q5ZL74	Gallus gallus	25%	98%
Q86AQ7	Dictyostelium discoideum	24%	83%
Q9FMR5	Arabidopsis thaliana	26%	97%
Q9JHW5	Rattus norvegicus	25%	98%
Q9LFP1	Arabidopsis thaliana	28%	97%
Q9MAS5	Arabidopsis thaliana	30%	98%
Q9SIQ9	Arabidopsis thaliana	27%	98%
Q9ZTW3	Arabidopsis thaliana	28%	98%
V5BFM1	Trypanosoma cruzi	25%	97%