Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H569_LEIBR

TriTrypDb:

LbrM.08.0020 , LBRM2903_080005500

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H569

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H569

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.630
CLV_NRD_NRD_1	39	41	PF00675	0.554
CLV_PCSK_KEX2_1	25	27	PF00082	0.599
CLV_PCSK_KEX2_1	39	41	PF00082	0.570
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.610
CLV_PCSK_SKI1_1	143	147	PF00082	0.526
DOC_CYCLIN_RxL_1	230	240	PF00134	0.332
DOC_MAPK_gen_1	39	47	PF00069	0.460
DOC_MAPK_MEF2A_6	160	167	PF00069	0.547
DOC_MAPK_MEF2A_6	40	49	PF00069	0.661
DOC_PP2B_LxvP_1	181	184	PF13499	0.553
DOC_PP2B_PxIxI_1	162	168	PF00149	0.507
DOC_PP4_FxxP_1	82	85	PF00568	0.519
DOC_USP7_MATH_1	11	15	PF00917	0.545
DOC_USP7_MATH_1	260	264	PF00917	0.488
DOC_WW_Pin1_4	195	200	PF00397	0.632
LIG_14-3-3_CanoR_1	172	177	PF00244	0.519
LIG_14-3-3_CanoR_1	255	265	PF00244	0.369
LIG_14-3-3_CanoR_1	70	75	PF00244	0.637
LIG_Actin_WH2_2	127	145	PF00022	0.503
LIG_APCC_ABBA_1	95	100	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_BIR_III_4	66	70	PF00653	0.630
LIG_BRCT_BRCA1_1	72	76	PF00533	0.665
LIG_EVH1_1	181	185	PF00568	0.640
LIG_EVH1_2	184	188	PF00568	0.657
LIG_FHA_1	104	110	PF00498	0.647
LIG_FHA_1	171	177	PF00498	0.522
LIG_FHA_1	238	244	PF00498	0.477
LIG_FHA_1	53	59	PF00498	0.650
LIG_FHA_1	92	98	PF00498	0.620
LIG_FHA_2	102	108	PF00498	0.531
LIG_LIR_Apic_2	112	117	PF02991	0.597
LIG_LIR_Apic_2	266	272	PF02991	0.486
LIG_LIR_Gen_1	54	65	PF02991	0.532
LIG_LIR_Nem_3	54	60	PF02991	0.542
LIG_LIR_Nem_3	73	79	PF02991	0.415
LIG_LYPXL_yS_3	162	165	PF13949	0.585
LIG_MAD2	108	116	PF02301	0.497
LIG_PTB_Apo_2	201	208	PF02174	0.532
LIG_SH2_CRK	269	273	PF00017	0.522
LIG_SH2_CRK	83	87	PF00017	0.647
LIG_SH2_STAP1	32	36	PF00017	0.682
LIG_SH2_STAT5	129	132	PF00017	0.628
LIG_SH2_STAT5	252	255	PF00017	0.550
LIG_SH3_3	113	119	PF00018	0.539
LIG_SH3_3	17	23	PF00018	0.493
LIG_SH3_3	176	182	PF00018	0.593
LIG_SH3_3	71	77	PF00018	0.561
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.610
MOD_CK1_1	101	107	PF00069	0.475
MOD_CK1_1	198	204	PF00069	0.600
MOD_CK1_1	263	269	PF00069	0.454
MOD_CK2_1	101	107	PF00069	0.612
MOD_CK2_1	224	230	PF00069	0.516
MOD_CK2_1	256	262	PF00069	0.582
MOD_GlcNHglycan	217	220	PF01048	0.557
MOD_GlcNHglycan	224	227	PF01048	0.565
MOD_GlcNHglycan	258	261	PF01048	0.435
MOD_GlcNHglycan	262	265	PF01048	0.467
MOD_GlcNHglycan	91	94	PF01048	0.603
MOD_GSK3_1	166	173	PF00069	0.531
MOD_GSK3_1	194	201	PF00069	0.682
MOD_GSK3_1	256	263	PF00069	0.492
MOD_GSK3_1	52	59	PF00069	0.605
MOD_GSK3_1	89	96	PF00069	0.626
MOD_GSK3_1	99	106	PF00069	0.415
MOD_LATS_1	164	170	PF00433	0.378
MOD_N-GLC_1	52	57	PF02516	0.674
MOD_NEK2_1	222	227	PF00069	0.584
MOD_NEK2_1	237	242	PF00069	0.356
MOD_NEK2_1	99	104	PF00069	0.665
MOD_NEK2_2	127	132	PF00069	0.397
MOD_NEK2_2	56	61	PF00069	0.426
MOD_NEK2_2	93	98	PF00069	0.621
MOD_OFUCOSY	51	56	PF10250	0.580
MOD_PIKK_1	166	172	PF00454	0.609
MOD_PK_1	70	76	PF00069	0.436
MOD_Plk_1	11	17	PF00069	0.484
MOD_Plk_1	152	158	PF00069	0.644
MOD_Plk_1	210	216	PF00069	0.550
MOD_Plk_1	52	58	PF00069	0.653
MOD_Plk_4	174	180	PF00069	0.514
MOD_Plk_4	224	230	PF00069	0.353
MOD_ProDKin_1	195	201	PF00069	0.623
TRG_DiLeu_BaEn_1	137	142	PF01217	0.390
TRG_ENDOCYTIC_2	162	165	PF00928	0.590
TRG_ENDOCYTIC_2	83	86	PF00928	0.678
TRG_ER_diArg_1	23	26	PF00400	0.708
TRG_ER_diArg_1	38	40	PF00400	0.668
TRG_NLS_MonoExtC_3	23	28	PF00514	0.669
TRG_NLS_MonoExtN_4	23	28	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE07	Leptomonas seymouri	56%	98%
A0A1X0NNW9	Trypanosomatidae	28%	100%
A0A3S5H624	Leishmania donovani	72%	100%
A0A422N819	Trypanosoma rangeli	31%	100%
A4HTF2	Leishmania infantum	73%	100%
C9ZPM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AM80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QIG7	Leishmania major	72%	100%
V5BLP6	Trypanosoma cruzi	32%	100%