LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H562_LEIBR
TriTrypDb:
LbrM.07.1210 , LBRM2903_070021300
Length:
576

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial outer membrane GTPases.. The lone C-terminal TM segment has a high positive charge at both ends, characteristic of mitochondrial outer membrane anchored proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1
GO:0005856 cytoskeleton 5 1
GO:0005886 plasma membrane 3 1
GO:0005938 cell cortex 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4H562
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H562

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007015 actin filament organization 5 1
GO:0007163 establishment or maintenance of cell polarity 2 1
GO:0008360 regulation of cell shape 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022603 regulation of anatomical structure morphogenesis 4 1
GO:0022604 regulation of cell morphogenesis 5 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0050789 regulation of biological process 2 1
GO:0050793 regulation of developmental process 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0003924 GTPase activity 7 1
GO:0005488 binding 1 4
GO:0005515 protein binding 2 1
GO:0005525 GTP binding 5 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1
GO:0019001 guanyl nucleotide binding 5 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032561 guanyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 4
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1
GO:0005509 calcium ion binding 5 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 371 375 PF00656 0.532
CLV_C14_Caspase3-7 412 416 PF00656 0.247
CLV_C14_Caspase3-7 440 444 PF00656 0.281
CLV_C14_Caspase3-7 457 461 PF00656 0.434
CLV_C14_Caspase3-7 93 97 PF00656 0.407
CLV_NRD_NRD_1 163 165 PF00675 0.583
CLV_NRD_NRD_1 208 210 PF00675 0.496
CLV_NRD_NRD_1 309 311 PF00675 0.577
CLV_NRD_NRD_1 332 334 PF00675 0.578
CLV_NRD_NRD_1 361 363 PF00675 0.523
CLV_NRD_NRD_1 548 550 PF00675 0.450
CLV_PCSK_FUR_1 263 267 PF00082 0.430
CLV_PCSK_FUR_1 572 576 PF00082 0.439
CLV_PCSK_KEX2_1 265 267 PF00082 0.507
CLV_PCSK_KEX2_1 309 311 PF00082 0.539
CLV_PCSK_KEX2_1 332 334 PF00082 0.578
CLV_PCSK_KEX2_1 361 363 PF00082 0.523
CLV_PCSK_KEX2_1 51 53 PF00082 0.601
CLV_PCSK_KEX2_1 548 550 PF00082 0.450
CLV_PCSK_KEX2_1 572 574 PF00082 0.421
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.573
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.615
CLV_PCSK_SKI1_1 112 116 PF00082 0.564
CLV_PCSK_SKI1_1 137 141 PF00082 0.527
CLV_PCSK_SKI1_1 51 55 PF00082 0.607
CLV_PCSK_SKI1_1 548 552 PF00082 0.541
CLV_PCSK_SKI1_1 78 82 PF00082 0.567
DEG_MDM2_SWIB_1 181 189 PF02201 0.392
DEG_SPOP_SBC_1 387 391 PF00917 0.308
DEG_SPOP_SBC_1 408 412 PF00917 0.317
DEG_SPOP_SBC_1 506 510 PF00917 0.408
DOC_MAPK_DCC_7 290 298 PF00069 0.230
DOC_MAPK_gen_1 110 118 PF00069 0.373
DOC_MAPK_gen_1 48 56 PF00069 0.395
DOC_MAPK_gen_1 545 555 PF00069 0.252
DOC_MAPK_MEF2A_6 110 118 PF00069 0.323
DOC_MAPK_MEF2A_6 290 298 PF00069 0.324
DOC_PP1_RVXF_1 546 553 PF00149 0.184
DOC_PP2B_LxvP_1 118 121 PF13499 0.315
DOC_PP2B_LxvP_1 155 158 PF13499 0.392
DOC_PP2B_LxvP_1 502 505 PF13499 0.324
DOC_PP2B_LxvP_1 81 84 PF13499 0.372
DOC_USP7_MATH_1 513 517 PF00917 0.419
DOC_USP7_MATH_1 527 531 PF00917 0.340
DOC_USP7_MATH_1 70 74 PF00917 0.394
DOC_WW_Pin1_4 130 135 PF00397 0.359
DOC_WW_Pin1_4 274 279 PF00397 0.300
LIG_14-3-3_CanoR_1 209 215 PF00244 0.347
LIG_14-3-3_CanoR_1 30 38 PF00244 0.389
LIG_14-3-3_CanoR_1 332 340 PF00244 0.241
LIG_14-3-3_CanoR_1 361 365 PF00244 0.318
LIG_14-3-3_CanoR_1 388 393 PF00244 0.330
LIG_14-3-3_CanoR_1 548 553 PF00244 0.341
LIG_Actin_WH2_2 196 211 PF00022 0.307
LIG_APCC_ABBA_1 201 206 PF00400 0.392
LIG_BIR_II_1 1 5 PF00653 0.399
LIG_BRCT_BRCA1_1 326 330 PF00533 0.307
LIG_BRCT_BRCA1_1 34 38 PF00533 0.411
LIG_BRCT_BRCA1_1 96 100 PF00533 0.348
LIG_CSL_BTD_1 502 505 PF09270 0.324
LIG_FHA_1 113 119 PF00498 0.381
LIG_FHA_1 149 155 PF00498 0.390
LIG_FHA_1 186 192 PF00498 0.420
LIG_FHA_1 346 352 PF00498 0.295
LIG_FHA_1 39 45 PF00498 0.368
LIG_FHA_1 427 433 PF00498 0.385
LIG_FHA_2 103 109 PF00498 0.336
LIG_FHA_2 410 416 PF00498 0.386
LIG_FHA_2 438 444 PF00498 0.388
LIG_FHA_2 470 476 PF00498 0.310
LIG_FHA_2 506 512 PF00498 0.345
LIG_LIR_Gen_1 215 225 PF02991 0.395
LIG_LIR_Gen_1 542 550 PF02991 0.468
LIG_LIR_Gen_1 551 560 PF02991 0.386
LIG_LIR_Nem_3 141 147 PF02991 0.378
LIG_LIR_Nem_3 215 220 PF02991 0.384
LIG_LIR_Nem_3 233 237 PF02991 0.202
LIG_LIR_Nem_3 300 304 PF02991 0.271
LIG_LIR_Nem_3 451 456 PF02991 0.423
LIG_LIR_Nem_3 542 546 PF02991 0.479
LIG_LIR_Nem_3 551 555 PF02991 0.344
LIG_LIR_Nem_3 97 103 PF02991 0.251
LIG_MAD2 112 120 PF02301 0.388
LIG_MLH1_MIPbox_1 96 100 PF16413 0.348
LIG_NRP_CendR_1 573 576 PF00754 0.450
LIG_Pex14_1 32 36 PF04695 0.325
LIG_Pex14_2 140 144 PF04695 0.327
LIG_Pex14_2 181 185 PF04695 0.391
LIG_Pex14_2 298 302 PF04695 0.285
LIG_REV1ctd_RIR_1 390 400 PF16727 0.403
LIG_SH2_CRK 304 308 PF00017 0.308
LIG_SH2_CRK 338 342 PF00017 0.419
LIG_SH2_CRK 453 457 PF00017 0.241
LIG_SH2_NCK_1 526 530 PF00017 0.408
LIG_SH2_PTP2 543 546 PF00017 0.480
LIG_SH2_STAP1 316 320 PF00017 0.275
LIG_SH2_STAP1 448 452 PF00017 0.419
LIG_SH2_STAP1 75 79 PF00017 0.425
LIG_SH2_STAT5 249 252 PF00017 0.290
LIG_SH2_STAT5 328 331 PF00017 0.391
LIG_SH2_STAT5 386 389 PF00017 0.316
LIG_SH2_STAT5 543 546 PF00017 0.480
LIG_SH3_3 275 281 PF00018 0.305
LIG_SH3_3 473 479 PF00018 0.271
LIG_SH3_3 533 539 PF00018 0.369
LIG_SUMO_SIM_anti_2 429 434 PF11976 0.282
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.426
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.463
LIG_SUMO_SIM_par_1 187 192 PF11976 0.245
LIG_SUMO_SIM_par_1 6 13 PF11976 0.363
LIG_SUMO_SIM_par_1 79 85 PF11976 0.324
LIG_TRAF2_1 105 108 PF00917 0.422
LIG_TRAF2_1 173 176 PF00917 0.445
LIG_TYR_ITIM 541 546 PF00017 0.481
MOD_CDK_SPxxK_3 130 137 PF00069 0.402
MOD_CK1_1 356 362 PF00069 0.243
MOD_CK1_1 379 385 PF00069 0.514
MOD_CK1_1 39 45 PF00069 0.355
MOD_CK1_1 410 416 PF00069 0.422
MOD_CK1_1 424 430 PF00069 0.365
MOD_CK1_1 71 77 PF00069 0.347
MOD_CK2_1 102 108 PF00069 0.400
MOD_CK2_1 170 176 PF00069 0.428
MOD_CK2_1 419 425 PF00069 0.359
MOD_CK2_1 505 511 PF00069 0.334
MOD_CK2_1 517 523 PF00069 0.352
MOD_Cter_Amidation 359 362 PF01082 0.508
MOD_GlcNHglycan 168 171 PF01048 0.565
MOD_GlcNHglycan 172 175 PF01048 0.557
MOD_GlcNHglycan 355 358 PF01048 0.533
MOD_GlcNHglycan 41 44 PF01048 0.517
MOD_GlcNHglycan 412 415 PF01048 0.613
MOD_GlcNHglycan 443 447 PF01048 0.588
MOD_GlcNHglycan 456 459 PF01048 0.595
MOD_GlcNHglycan 96 99 PF01048 0.560
MOD_GSK3_1 166 173 PF00069 0.286
MOD_GSK3_1 21 28 PF00069 0.384
MOD_GSK3_1 216 223 PF00069 0.288
MOD_GSK3_1 245 252 PF00069 0.375
MOD_GSK3_1 32 39 PF00069 0.353
MOD_GSK3_1 324 331 PF00069 0.376
MOD_GSK3_1 341 348 PF00069 0.370
MOD_GSK3_1 356 363 PF00069 0.255
MOD_GSK3_1 382 389 PF00069 0.349
MOD_GSK3_1 403 410 PF00069 0.339
MOD_GSK3_1 444 451 PF00069 0.362
MOD_GSK3_1 513 520 PF00069 0.407
MOD_N-GLC_1 32 37 PF02516 0.617
MOD_NEK2_1 1 6 PF00069 0.416
MOD_NEK2_1 21 26 PF00069 0.196
MOD_NEK2_1 220 225 PF00069 0.306
MOD_NEK2_1 341 346 PF00069 0.267
MOD_NEK2_1 38 43 PF00069 0.260
MOD_NEK2_1 94 99 PF00069 0.393
MOD_NEK2_2 216 221 PF00069 0.368
MOD_NEK2_2 448 453 PF00069 0.409
MOD_PKA_1 548 554 PF00069 0.341
MOD_PKA_2 148 154 PF00069 0.229
MOD_PKA_2 243 249 PF00069 0.314
MOD_PKA_2 331 337 PF00069 0.236
MOD_PKA_2 360 366 PF00069 0.318
MOD_PKA_2 387 393 PF00069 0.333
MOD_PKA_2 548 554 PF00069 0.341
MOD_PKA_2 94 100 PF00069 0.347
MOD_Plk_1 32 38 PF00069 0.402
MOD_Plk_1 324 330 PF00069 0.342
MOD_Plk_2-3 517 523 PF00069 0.419
MOD_Plk_4 230 236 PF00069 0.351
MOD_Plk_4 245 251 PF00069 0.219
MOD_Plk_4 382 388 PF00069 0.392
MOD_Plk_4 403 409 PF00069 0.357
MOD_Plk_4 448 454 PF00069 0.404
MOD_Plk_4 539 545 PF00069 0.482
MOD_Plk_4 548 554 PF00069 0.298
MOD_Plk_4 563 569 PF00069 0.264
MOD_ProDKin_1 130 136 PF00069 0.355
MOD_ProDKin_1 274 280 PF00069 0.298
MOD_SUMO_for_1 15 18 PF00179 0.238
MOD_SUMO_rev_2 107 111 PF00179 0.414
TRG_DiLeu_BaEn_2 462 468 PF01217 0.361
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.236
TRG_DiLeu_BaLyEn_6 49 54 PF01217 0.332
TRG_ENDOCYTIC_2 304 307 PF00928 0.284
TRG_ENDOCYTIC_2 338 341 PF00928 0.310
TRG_ENDOCYTIC_2 453 456 PF00928 0.242
TRG_ENDOCYTIC_2 543 546 PF00928 0.464
TRG_ER_diArg_1 308 310 PF00400 0.376
TRG_ER_diArg_1 547 549 PF00400 0.365
TRG_ER_diArg_1 571 574 PF00400 0.617
TRG_NES_CRM1_1 425 438 PF08389 0.317
TRG_Pf-PMV_PEXEL_1 339 343 PF00026 0.562

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCT6 Leptomonas seymouri 70% 100%
A0A1X0NPJ9 Trypanosomatidae 47% 100%
A0A3R7KVN9 Trypanosoma rangeli 47% 100%
A0A3S5H622 Leishmania donovani 85% 100%
A4HTD9 Leishmania infantum 85% 100%
C9ZUH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9ALD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q2UM43 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 23% 91%
Q4QIH3 Leishmania major 86% 100%
Q5B5L3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 91%
Q8RXF8 Arabidopsis thaliana 21% 89%
V5BTM0 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS