Putative proteasome regulatory non-ATP-ase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H561_LEIBR

TriTrypDb:

LbrM.07.1200 , LBRM2903_070021200

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008540	proteasome regulatory particle, base subcomplex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H561

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H561

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.519
CLV_C14_Caspase3-7	326	330	PF00656	0.387
CLV_NRD_NRD_1	132	134	PF00675	0.336
CLV_NRD_NRD_1	157	159	PF00675	0.257
CLV_NRD_NRD_1	284	286	PF00675	0.315
CLV_PCSK_KEX2_1	108	110	PF00082	0.411
CLV_PCSK_KEX2_1	284	286	PF00082	0.315
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.425
CLV_Separin_Metazoa	281	285	PF03568	0.370
DEG_APCC_KENBOX_2	162	166	PF00400	0.497
DEG_SPOP_SBC_1	306	310	PF00917	0.630
DOC_CYCLIN_yClb1_LxF_4	45	51	PF00134	0.297
DOC_CYCLIN_yClb5_NLxxxL_5	174	181	PF00134	0.493
DOC_MAPK_gen_1	105	113	PF00069	0.202
DOC_MAPK_gen_1	130	141	PF00069	0.315
DOC_MAPK_gen_1	284	291	PF00069	0.315
DOC_MAPK_MEF2A_6	133	141	PF00069	0.308
DOC_MAPK_MEF2A_6	284	291	PF00069	0.315
DOC_MAPK_NFAT4_5	284	292	PF00069	0.315
DOC_PP1_RVXF_1	107	114	PF00149	0.202
DOC_USP7_MATH_1	201	205	PF00917	0.596
DOC_USP7_MATH_1	236	240	PF00917	0.494
DOC_USP7_MATH_1	242	246	PF00917	0.560
DOC_USP7_MATH_1	307	311	PF00917	0.680
DOC_USP7_UBL2_3	130	134	PF12436	0.370
DOC_USP7_UBL2_3	159	163	PF12436	0.475
DOC_WW_Pin1_4	113	118	PF00397	0.252
DOC_WW_Pin1_4	300	305	PF00397	0.723
LIG_14-3-3_CanoR_1	221	225	PF00244	0.277
LIG_BRCT_BRCA1_1	83	87	PF00533	0.147
LIG_CaM_IQ_9	150	165	PF13499	0.400
LIG_FHA_1	176	182	PF00498	0.371
LIG_FHA_1	63	69	PF00498	0.219
LIG_FHA_2	246	252	PF00498	0.564
LIG_FHA_2	57	63	PF00498	0.216
LIG_GBD_Chelix_1	216	224	PF00786	0.255
LIG_LIR_Gen_1	166	173	PF02991	0.343
LIG_LIR_Gen_1	3	14	PF02991	0.241
LIG_LIR_Gen_1	59	68	PF02991	0.258
LIG_LIR_Nem_3	166	171	PF02991	0.331
LIG_LIR_Nem_3	3	9	PF02991	0.265
LIG_LIR_Nem_3	59	64	PF02991	0.290
LIG_MAD2	109	117	PF02301	0.202
LIG_SH3_3	111	117	PF00018	0.297
LIG_SH3_3	249	255	PF00018	0.681
LIG_SH3_3	301	307	PF00018	0.631
LIG_TRAF2_1	278	281	PF00917	0.262
LIG_TRAF2_1	290	293	PF00917	0.352
LIG_TRAF2_1	330	333	PF00917	0.551
MOD_CDC14_SPxK_1	116	119	PF00782	0.256
MOD_CDK_SPxK_1	113	119	PF00069	0.205
MOD_CK1_1	245	251	PF00069	0.617
MOD_CK1_1	298	304	PF00069	0.677
MOD_CK1_1	74	80	PF00069	0.301
MOD_CK1_1	99	105	PF00069	0.202
MOD_CK2_1	101	107	PF00069	0.293
MOD_CK2_1	275	281	PF00069	0.237
MOD_CK2_1	287	293	PF00069	0.237
MOD_CK2_1	305	311	PF00069	0.635
MOD_CK2_1	56	62	PF00069	0.216
MOD_GlcNHglycan	203	206	PF01048	0.566
MOD_GlcNHglycan	239	242	PF01048	0.596
MOD_GlcNHglycan	244	247	PF01048	0.621
MOD_GlcNHglycan	248	251	PF01048	0.638
MOD_GlcNHglycan	88	91	PF01048	0.454
MOD_GSK3_1	242	249	PF00069	0.636
MOD_GSK3_1	292	299	PF00069	0.587
MOD_GSK3_1	56	63	PF00069	0.216
MOD_GSK3_1	70	77	PF00069	0.216
MOD_GSK3_1	81	88	PF00069	0.239
MOD_GSK3_1	92	99	PF00069	0.241
MOD_N-GLC_1	175	180	PF02516	0.379
MOD_N-GLC_1	85	90	PF02516	0.455
MOD_N-GLC_2	56	58	PF02516	0.402
MOD_NEK2_1	323	328	PF00069	0.425
MOD_NEK2_1	50	55	PF00069	0.249
MOD_NEK2_1	96	101	PF00069	0.206
MOD_PIKK_1	292	298	PF00454	0.443
MOD_PKA_2	118	124	PF00069	0.407
MOD_PKA_2	220	226	PF00069	0.255
MOD_Plk_1	163	169	PF00069	0.425
MOD_Plk_1	44	50	PF00069	0.202
MOD_Plk_2-3	275	281	PF00069	0.225
MOD_Plk_4	56	62	PF00069	0.243
MOD_ProDKin_1	113	119	PF00069	0.260
MOD_ProDKin_1	300	306	PF00069	0.721
MOD_SUMO_rev_2	329	339	PF00179	0.545
TRG_DiLeu_BaEn_2	163	169	PF01217	0.477
TRG_ENDOCYTIC_2	274	277	PF00928	0.648
TRG_ENDOCYTIC_2	61	64	PF00928	0.249
TRG_ER_diArg_1	283	285	PF00400	0.315
TRG_NLS_MonoExtC_3	129	134	PF00514	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L9	Leptomonas seymouri	72%	100%
A0A1X0NPW3	Trypanosomatidae	54%	100%
A0A3R7NGB6	Trypanosoma rangeli	57%	98%
A0A3S7WQ17	Leishmania donovani	86%	98%
A4HTD8	Leishmania infantum	86%	98%
C9ZUH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ALD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
O17453	Schistosoma mansoni	37%	81%
O35226	Mus musculus	36%	90%
O61742	Caenorhabditis elegans	39%	98%
O82143	Oryza sativa subsp. japonica	37%	84%
O94444	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P38886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P55034	Arabidopsis thaliana	39%	88%
P55035	Drosophila melanogaster	34%	86%
P55036	Homo sapiens	35%	90%
Q4QIH4	Leishmania major	86%	100%
Q58DA0	Bos taurus	35%	89%
V5DQ49	Trypanosoma cruzi	55%	99%