NIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H560_LEIBR

TriTrypDb:

LbrM.07.1190 , LBRM2903_070021100

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H560

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H560

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.409
CLV_NRD_NRD_1	229	231	PF00675	0.549
CLV_NRD_NRD_1	250	252	PF00675	0.565
CLV_NRD_NRD_1	260	262	PF00675	0.510
CLV_NRD_NRD_1	27	29	PF00675	0.493
CLV_NRD_NRD_1	292	294	PF00675	0.652
CLV_NRD_NRD_1	302	304	PF00675	0.574
CLV_NRD_NRD_1	32	34	PF00675	0.467
CLV_PCSK_FUR_1	25	29	PF00082	0.472
CLV_PCSK_KEX2_1	250	252	PF00082	0.558
CLV_PCSK_KEX2_1	260	262	PF00082	0.482
CLV_PCSK_KEX2_1	27	29	PF00082	0.493
CLV_PCSK_KEX2_1	292	294	PF00082	0.674
CLV_PCSK_KEX2_1	32	34	PF00082	0.467
CLV_PCSK_PC7_1	246	252	PF00082	0.405
CLV_PCSK_PC7_1	28	34	PF00082	0.499
CLV_PCSK_SKI1_1	115	119	PF00082	0.493
CLV_PCSK_SKI1_1	273	277	PF00082	0.545
CLV_PCSK_SKI1_1	293	297	PF00082	0.490
CLV_PCSK_SKI1_1	42	46	PF00082	0.595
DEG_APCC_DBOX_1	114	122	PF00400	0.376
DOC_CYCLIN_yClb5_NLxxxL_5	133	141	PF00134	0.534
DOC_MAPK_gen_1	292	298	PF00069	0.742
DOC_MAPK_gen_1	318	326	PF00069	0.487
DOC_MAPK_MEF2A_6	133	141	PF00069	0.532
DOC_USP7_MATH_1	180	184	PF00917	0.576
DOC_USP7_MATH_1	186	190	PF00917	0.503
DOC_USP7_MATH_1	310	314	PF00917	0.518
DOC_USP7_MATH_1	343	347	PF00917	0.510
DOC_WW_Pin1_4	218	223	PF00397	0.614
DOC_WW_Pin1_4	287	292	PF00397	0.486
LIG_14-3-3_CanoR_1	151	157	PF00244	0.515
LIG_14-3-3_CanoR_1	264	272	PF00244	0.449
LIG_BIR_II_1	1	5	PF00653	0.538
LIG_BRCT_BRCA1_1	188	192	PF00533	0.422
LIG_FHA_1	144	150	PF00498	0.333
LIG_FHA_1	169	175	PF00498	0.588
LIG_FHA_1	219	225	PF00498	0.665
LIG_FHA_1	277	283	PF00498	0.544
LIG_FHA_1	331	337	PF00498	0.507
LIG_FHA_2	153	159	PF00498	0.409
LIG_FHA_2	234	240	PF00498	0.620
LIG_FHA_2	266	272	PF00498	0.452
LIG_FHA_2	47	53	PF00498	0.579
LIG_FHA_2	54	60	PF00498	0.586
LIG_LIR_Gen_1	346	355	PF02991	0.385
LIG_LIR_Gen_1	38	47	PF02991	0.490
LIG_LIR_Gen_1	84	93	PF02991	0.495
LIG_LIR_Nem_3	24	29	PF02991	0.454
LIG_LIR_Nem_3	346	350	PF02991	0.432
LIG_LIR_Nem_3	38	43	PF02991	0.492
LIG_LIR_Nem_3	84	89	PF02991	0.423
LIG_PCNA_yPIPBox_3	246	259	PF02747	0.540
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.461
LIG_SH2_CRK	210	214	PF00017	0.396
LIG_SH2_CRK	347	351	PF00017	0.319
LIG_SH2_CRK	40	44	PF00017	0.539
LIG_SH2_CRK	86	90	PF00017	0.550
LIG_SH2_NCK_1	86	90	PF00017	0.580
LIG_SH2_STAP1	210	214	PF00017	0.649
LIG_SH2_STAP1	278	282	PF00017	0.565
LIG_SH2_STAP1	40	44	PF00017	0.466
LIG_SH2_STAT5	278	281	PF00017	0.440
LIG_SH2_STAT5	96	99	PF00017	0.448
LIG_SH3_3	171	177	PF00018	0.536
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.537
LIG_TRAF2_1	155	158	PF00917	0.571
LIG_UBA3_1	117	123	PF00899	0.376
LIG_WRC_WIRS_1	47	52	PF05994	0.579
MOD_CDK_SPK_2	287	292	PF00069	0.445
MOD_CDK_SPxK_1	287	293	PF00069	0.493
MOD_CK1_1	13	19	PF00069	0.561
MOD_CK1_1	299	305	PF00069	0.608
MOD_CK1_1	330	336	PF00069	0.547
MOD_CK2_1	152	158	PF00069	0.406
MOD_CK2_1	310	316	PF00069	0.559
MOD_CK2_1	46	52	PF00069	0.530
MOD_CK2_1	53	59	PF00069	0.543
MOD_GlcNHglycan	187	191	PF01048	0.500
MOD_GlcNHglycan	329	332	PF01048	0.461
MOD_GSK3_1	186	193	PF00069	0.495
MOD_GSK3_1	233	240	PF00069	0.687
MOD_GSK3_1	42	49	PF00069	0.453
MOD_NEK2_1	141	146	PF00069	0.491
MOD_NEK2_1	225	230	PF00069	0.684
MOD_NEK2_1	286	291	PF00069	0.585
MOD_NEK2_1	296	301	PF00069	0.651
MOD_PIKK_1	42	48	PF00454	0.363
MOD_PKA_2	327	333	PF00069	0.413
MOD_PKA_2	53	59	PF00069	0.596
MOD_Plk_4	10	16	PF00069	0.584
MOD_Plk_4	169	175	PF00069	0.468
MOD_Plk_4	74	80	PF00069	0.351
MOD_ProDKin_1	218	224	PF00069	0.616
MOD_ProDKin_1	287	293	PF00069	0.493
MOD_SUMO_rev_2	313	320	PF00179	0.580
MOD_SUMO_rev_2	65	71	PF00179	0.600
TRG_DiLeu_BaEn_1	39	44	PF01217	0.610
TRG_ENDOCYTIC_2	114	117	PF00928	0.484
TRG_ENDOCYTIC_2	210	213	PF00928	0.422
TRG_ENDOCYTIC_2	347	350	PF00928	0.434
TRG_ENDOCYTIC_2	40	43	PF00928	0.483
TRG_ENDOCYTIC_2	86	89	PF00928	0.565
TRG_ER_diArg_1	259	261	PF00400	0.608
TRG_ER_diArg_1	26	28	PF00400	0.497
TRG_ER_diArg_1	291	293	PF00400	0.623
TRG_ER_diArg_1	31	33	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I2	Leptomonas seymouri	67%	99%
A0A1X0NRB2	Trypanosomatidae	43%	100%
A0A3R7MAC7	Trypanosoma rangeli	44%	100%
A0A3S7WQ18	Leishmania donovani	85%	100%
A4HTD7	Leishmania infantum	85%	100%
C9ZUH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ALD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIH5	Leishmania major	83%	100%
V5B8H7	Trypanosoma cruzi	45%	100%