Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H559_LEIBR

TriTrypDb:

LbrM.07.1170 , LBRM2903_070020800

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H559

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H559

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.651
CLV_C14_Caspase3-7	216	220	PF00656	0.513
CLV_C14_Caspase3-7	34	38	PF00656	0.579
CLV_NRD_NRD_1	173	175	PF00675	0.644
CLV_NRD_NRD_1	183	185	PF00675	0.479
CLV_NRD_NRD_1	198	200	PF00675	0.662
CLV_NRD_NRD_1	297	299	PF00675	0.557
CLV_NRD_NRD_1	71	73	PF00675	0.519
CLV_PCSK_FUR_1	69	73	PF00082	0.515
CLV_PCSK_KEX2_1	173	175	PF00082	0.642
CLV_PCSK_KEX2_1	185	187	PF00082	0.456
CLV_PCSK_KEX2_1	198	200	PF00082	0.693
CLV_PCSK_KEX2_1	212	214	PF00082	0.564
CLV_PCSK_KEX2_1	293	295	PF00082	0.504
CLV_PCSK_KEX2_1	297	299	PF00082	0.543
CLV_PCSK_KEX2_1	71	73	PF00082	0.528
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.662
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.663
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.550
CLV_PCSK_SKI1_1	290	294	PF00082	0.568
CLV_PCSK_SKI1_1	87	91	PF00082	0.593
CLV_PCSK_SKI1_1	94	98	PF00082	0.490
DEG_SPOP_SBC_1	121	125	PF00917	0.495
DEG_SPOP_SBC_1	19	23	PF00917	0.615
DEG_SPOP_SBC_1	24	28	PF00917	0.617
DOC_ANK_TNKS_1	197	204	PF00023	0.544
DOC_PP2B_LxvP_1	167	170	PF13499	0.429
DOC_USP7_MATH_1	10	14	PF00917	0.679
DOC_USP7_MATH_1	154	158	PF00917	0.496
DOC_USP7_MATH_1	162	166	PF00917	0.637
DOC_USP7_MATH_1	19	23	PF00917	0.665
DOC_USP7_MATH_1	194	198	PF00917	0.546
DOC_USP7_MATH_1	221	225	PF00917	0.525
DOC_USP7_MATH_1	44	48	PF00917	0.650
DOC_WW_Pin1_4	176	181	PF00397	0.713
DOC_WW_Pin1_4	217	222	PF00397	0.506
LIG_14-3-3_CanoR_1	213	221	PF00244	0.598
LIG_14-3-3_CanoR_1	257	263	PF00244	0.599
LIG_14-3-3_CanoR_1	71	79	PF00244	0.545
LIG_14-3-3_CanoR_1	94	104	PF00244	0.601
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_BRCT_BRCA1_1	87	91	PF00533	0.451
LIG_FHA_1	100	106	PF00498	0.565
LIG_FHA_1	162	168	PF00498	0.488
LIG_FHA_1	177	183	PF00498	0.659
LIG_FHA_1	205	211	PF00498	0.774
LIG_FHA_1	238	244	PF00498	0.549
LIG_FHA_2	214	220	PF00498	0.646
LIG_GBD_Chelix_1	129	137	PF00786	0.591
LIG_LIR_Apic_2	147	151	PF02991	0.549
LIG_MLH1_MIPbox_1	87	91	PF16413	0.451
LIG_PTB_Apo_2	138	145	PF02174	0.430
LIG_REV1ctd_RIR_1	88	98	PF16727	0.427
LIG_SH2_CRK	148	152	PF00017	0.620
LIG_SH2_STAP1	277	281	PF00017	0.570
LIG_SH2_STAT5	106	109	PF00017	0.519
LIG_SH2_STAT5	145	148	PF00017	0.631
LIG_SH2_STAT5	262	265	PF00017	0.525
LIG_TRAF2_1	273	276	PF00917	0.642
MOD_CK1_1	13	19	PF00069	0.631
MOD_CK1_1	214	220	PF00069	0.666
MOD_CK1_1	22	28	PF00069	0.503
MOD_CK1_1	260	266	PF00069	0.614
MOD_CK2_1	162	168	PF00069	0.656
MOD_GlcNHglycan	126	129	PF01048	0.563
MOD_GlcNHglycan	156	159	PF01048	0.726
MOD_GlcNHglycan	22	25	PF01048	0.621
MOD_GlcNHglycan	221	224	PF01048	0.624
MOD_GlcNHglycan	48	51	PF01048	0.621
MOD_GlcNHglycan	87	90	PF01048	0.633
MOD_GSK3_1	120	127	PF00069	0.494
MOD_GSK3_1	18	25	PF00069	0.533
MOD_GSK3_1	211	218	PF00069	0.637
MOD_GSK3_1	237	244	PF00069	0.612
MOD_GSK3_1	253	260	PF00069	0.465
MOD_GSK3_1	9	16	PF00069	0.645
MOD_GSK3_1	95	102	PF00069	0.548
MOD_NEK2_1	144	149	PF00069	0.507
MOD_NEK2_1	253	258	PF00069	0.620
MOD_NEK2_1	90	95	PF00069	0.661
MOD_PIKK_1	72	78	PF00454	0.532
MOD_PKA_2	253	259	PF00069	0.690
MOD_Plk_1	13	19	PF00069	0.739
MOD_Plk_1	99	105	PF00069	0.510
MOD_Plk_2-3	241	247	PF00069	0.548
MOD_Plk_4	132	138	PF00069	0.538
MOD_Plk_4	162	168	PF00069	0.593
MOD_Plk_4	99	105	PF00069	0.496
MOD_ProDKin_1	176	182	PF00069	0.720
MOD_ProDKin_1	217	223	PF00069	0.503
MOD_SUMO_rev_2	260	268	PF00179	0.635
MOD_SUMO_rev_2	289	295	PF00179	0.515
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.331
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.420
TRG_ER_diArg_1	172	174	PF00400	0.663
TRG_ER_diArg_1	183	186	PF00400	0.466
TRG_ER_diArg_1	296	298	PF00400	0.514
TRG_ER_diArg_1	69	72	PF00400	0.520
TRG_NLS_Bipartite_1	173	188	PF00514	0.734
TRG_NLS_Bipartite_1	198	216	PF00514	0.542
TRG_NLS_MonoExtN_4	181	188	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L7	Leptomonas seymouri	55%	100%
A0A1X0NPM5	Trypanosomatidae	32%	91%
A0A3R7LS50	Trypanosoma rangeli	35%	99%
A0A3S5H619	Leishmania donovani	75%	100%
A4HTD6	Leishmania infantum	77%	100%
C9ZUH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ALC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QIH6	Leishmania major	76%	100%
V5BYD2	Trypanosoma cruzi	36%	90%