Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H557_LEIBR

TriTrypDb:

LbrM.07.1150 , LBRM2903_070020600

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H557

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H557

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.320
CLV_MEL_PAP_1	214	220	PF00089	0.546
CLV_NRD_NRD_1	367	369	PF00675	0.622
CLV_NRD_NRD_1	474	476	PF00675	0.705
CLV_NRD_NRD_1	511	513	PF00675	0.524
CLV_NRD_NRD_1	530	532	PF00675	0.432
CLV_NRD_NRD_1	548	550	PF00675	0.557
CLV_NRD_NRD_1	737	739	PF00675	0.527
CLV_NRD_NRD_1	778	780	PF00675	0.692
CLV_PCSK_KEX2_1	129	131	PF00082	0.438
CLV_PCSK_KEX2_1	241	243	PF00082	0.519
CLV_PCSK_KEX2_1	366	368	PF00082	0.609
CLV_PCSK_KEX2_1	474	476	PF00082	0.705
CLV_PCSK_KEX2_1	530	532	PF00082	0.571
CLV_PCSK_KEX2_1	547	549	PF00082	0.533
CLV_PCSK_KEX2_1	737	739	PF00082	0.508
CLV_PCSK_KEX2_1	749	751	PF00082	0.413
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.438
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.519
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.369
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.454
CLV_PCSK_SKI1_1	360	364	PF00082	0.452
CLV_PCSK_SKI1_1	368	372	PF00082	0.486
CLV_PCSK_SKI1_1	591	595	PF00082	0.455
CLV_PCSK_SKI1_1	634	638	PF00082	0.468
CLV_PCSK_SKI1_1	737	741	PF00082	0.527
CLV_PCSK_SKI1_1	806	810	PF00082	0.443
DEG_APCC_DBOX_1	590	598	PF00400	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.477
DEG_SPOP_SBC_1	234	238	PF00917	0.261
DEG_SPOP_SBC_1	313	317	PF00917	0.447
DOC_ANK_TNKS_1	216	223	PF00023	0.535
DOC_CYCLIN_RxL_1	734	743	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.293
DOC_MAPK_gen_1	334	343	PF00069	0.434
DOC_MAPK_gen_1	408	417	PF00069	0.471
DOC_MAPK_gen_1	589	596	PF00069	0.537
DOC_MAPK_gen_1	97	104	PF00069	0.504
DOC_MAPK_HePTP_8	405	417	PF00069	0.469
DOC_MAPK_MEF2A_6	408	417	PF00069	0.471
DOC_MAPK_MEF2A_6	589	596	PF00069	0.535
DOC_MAPK_MEF2A_6	97	106	PF00069	0.488
DOC_PP2B_LxvP_1	90	93	PF13499	0.432
DOC_PP4_FxxP_1	574	577	PF00568	0.557
DOC_USP7_MATH_1	114	118	PF00917	0.491
DOC_USP7_MATH_1	24	28	PF00917	0.551
DOC_USP7_MATH_1	313	317	PF00917	0.613
DOC_USP7_MATH_1	479	483	PF00917	0.784
DOC_USP7_MATH_1	498	502	PF00917	0.626
DOC_USP7_MATH_1	516	520	PF00917	0.568
DOC_USP7_MATH_1	521	525	PF00917	0.640
DOC_USP7_MATH_1	665	669	PF00917	0.635
DOC_USP7_UBL2_3	434	438	PF12436	0.523
DOC_WW_Pin1_4	136	141	PF00397	0.546
DOC_WW_Pin1_4	773	778	PF00397	0.622
LIG_14-3-3_CanoR_1	252	256	PF00244	0.477
LIG_14-3-3_CanoR_1	360	369	PF00244	0.383
LIG_14-3-3_CanoR_1	480	489	PF00244	0.652
LIG_14-3-3_CanoR_1	601	605	PF00244	0.602
LIG_14-3-3_CanoR_1	634	639	PF00244	0.523
LIG_14-3-3_CanoR_1	750	758	PF00244	0.554
LIG_14-3-3_CanoR_1	779	783	PF00244	0.684
LIG_APCC_ABBA_1	61	66	PF00400	0.472
LIG_BIR_III_4	155	159	PF00653	0.487
LIG_BIR_III_4	461	465	PF00653	0.405
LIG_CaM_IQ_9	466	482	PF13499	0.475
LIG_FHA_1	140	146	PF00498	0.481
LIG_FHA_1	188	194	PF00498	0.469
LIG_FHA_1	223	229	PF00498	0.463
LIG_FHA_1	238	244	PF00498	0.334
LIG_FHA_1	248	254	PF00498	0.504
LIG_FHA_1	313	319	PF00498	0.666
LIG_FHA_1	4	10	PF00498	0.541
LIG_FHA_1	431	437	PF00498	0.392
LIG_FHA_1	503	509	PF00498	0.443
LIG_FHA_1	734	740	PF00498	0.583
LIG_FHA_1	798	804	PF00498	0.550
LIG_FHA_1	81	87	PF00498	0.383
LIG_FHA_2	504	510	PF00498	0.684
LIG_FHA_2	601	607	PF00498	0.595
LIG_FHA_2	696	702	PF00498	0.692
LIG_FHA_2	807	813	PF00498	0.363
LIG_FHA_2	83	89	PF00498	0.528
LIG_LIR_Gen_1	606	615	PF02991	0.443
LIG_LIR_Gen_1	781	789	PF02991	0.399
LIG_LIR_Nem_3	380	385	PF02991	0.587
LIG_LIR_Nem_3	606	611	PF02991	0.537
LIG_LIR_Nem_3	781	785	PF02991	0.564
LIG_LRP6_Inhibitor_1	718	724	PF00058	0.679
LIG_MYND_1	304	308	PF01753	0.697
LIG_NRBOX	538	544	PF00104	0.664
LIG_NRBOX	558	564	PF00104	0.322
LIG_PCNA_yPIPBox_3	724	733	PF02747	0.636
LIG_Pex14_2	64	68	PF04695	0.465
LIG_PTB_Apo_2	100	107	PF02174	0.543
LIG_Rb_LxCxE_1	575	588	PF01857	0.692
LIG_RPA_C_Fungi	346	358	PF08784	0.563
LIG_RPA_C_Fungi	733	745	PF08784	0.622
LIG_SH2_CRK	148	152	PF00017	0.523
LIG_SH2_CRK	338	342	PF00017	0.439
LIG_SH2_CRK	608	612	PF00017	0.640
LIG_SH2_NCK_1	79	83	PF00017	0.549
LIG_SH2_SRC	121	124	PF00017	0.536
LIG_SH2_STAP1	148	152	PF00017	0.523
LIG_SH2_STAT5	121	124	PF00017	0.503
LIG_SH2_STAT5	161	164	PF00017	0.476
LIG_SH2_STAT5	527	530	PF00017	0.558
LIG_SH2_STAT5	614	617	PF00017	0.551
LIG_SH2_STAT5	722	725	PF00017	0.547
LIG_SH2_STAT5	807	810	PF00017	0.491
LIG_SH3_3	119	125	PF00018	0.533
LIG_SH3_3	296	302	PF00018	0.648
LIG_SH3_3	551	557	PF00018	0.575
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.545
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.697
LIG_SUMO_SIM_anti_2	742	748	PF11976	0.529
LIG_SUMO_SIM_par_1	225	231	PF11976	0.460
LIG_SUMO_SIM_par_1	5	10	PF11976	0.311
LIG_TRAF2_1	350	353	PF00917	0.592
LIG_UBA3_1	41	47	PF00899	0.326
LIG_UBA3_1	635	641	PF00899	0.471
LIG_UBA3_1	729	735	PF00899	0.627
LIG_WRC_WIRS_1	147	152	PF05994	0.522
MOD_CDK_SPxK_1	773	779	PF00069	0.718
MOD_CDK_SPxxK_3	773	780	PF00069	0.696
MOD_CK1_1	135	141	PF00069	0.546
MOD_CK1_1	34	40	PF00069	0.532
MOD_CK1_1	692	698	PF00069	0.647
MOD_CK1_1	778	784	PF00069	0.550
MOD_CK2_1	174	180	PF00069	0.567
MOD_CK2_1	313	319	PF00069	0.646
MOD_CK2_1	429	435	PF00069	0.567
MOD_CK2_1	503	509	PF00069	0.537
MOD_CK2_1	600	606	PF00069	0.593
MOD_CK2_1	67	73	PF00069	0.514
MOD_CK2_1	696	702	PF00069	0.710
MOD_CK2_1	806	812	PF00069	0.492
MOD_GlcNHglycan	155	159	PF01048	0.399
MOD_GlcNHglycan	218	221	PF01048	0.487
MOD_GlcNHglycan	230	233	PF01048	0.365
MOD_GlcNHglycan	26	29	PF01048	0.523
MOD_GlcNHglycan	33	36	PF01048	0.443
MOD_GlcNHglycan	481	484	PF01048	0.726
MOD_GlcNHglycan	500	503	PF01048	0.607
MOD_GlcNHglycan	519	522	PF01048	0.662
MOD_GlcNHglycan	559	562	PF01048	0.642
MOD_GlcNHglycan	624	627	PF01048	0.436
MOD_GlcNHglycan	662	665	PF01048	0.631
MOD_GlcNHglycan	667	670	PF01048	0.642
MOD_GlcNHglycan	673	676	PF01048	0.653
MOD_GlcNHglycan	691	694	PF01048	0.643
MOD_GlcNHglycan	752	755	PF01048	0.551
MOD_GlcNHglycan	765	768	PF01048	0.532
MOD_GlcNHglycan	770	773	PF01048	0.546
MOD_GSK3_1	112	119	PF00069	0.503
MOD_GSK3_1	130	137	PF00069	0.394
MOD_GSK3_1	189	196	PF00069	0.444
MOD_GSK3_1	230	237	PF00069	0.447
MOD_GSK3_1	24	31	PF00069	0.287
MOD_GSK3_1	247	254	PF00069	0.409
MOD_GSK3_1	373	380	PF00069	0.576
MOD_GSK3_1	415	422	PF00069	0.585
MOD_GSK3_1	426	433	PF00069	0.584
MOD_GSK3_1	443	450	PF00069	0.527
MOD_GSK3_1	498	505	PF00069	0.630
MOD_GSK3_1	517	524	PF00069	0.509
MOD_GSK3_1	596	603	PF00069	0.626
MOD_GSK3_1	692	699	PF00069	0.650
MOD_GSK3_1	763	770	PF00069	0.582
MOD_GSK3_1	82	89	PF00069	0.532
MOD_LATS_1	128	134	PF00433	0.563
MOD_LATS_1	748	754	PF00433	0.545
MOD_N-GLC_1	102	107	PF02516	0.540
MOD_N-GLC_1	291	296	PF02516	0.508
MOD_N-GLC_1	658	663	PF02516	0.560
MOD_N-GLC_1	763	768	PF02516	0.662
MOD_NEK2_1	134	139	PF00069	0.542
MOD_NEK2_1	517	522	PF00069	0.541
MOD_NEK2_1	525	530	PF00069	0.539
MOD_NEK2_1	563	568	PF00069	0.499
MOD_NEK2_1	596	601	PF00069	0.586
MOD_NEK2_1	653	658	PF00069	0.549
MOD_NEK2_1	660	665	PF00069	0.565
MOD_NEK2_1	671	676	PF00069	0.582
MOD_NEK2_1	689	694	PF00069	0.532
MOD_NEK2_1	740	745	PF00069	0.565
MOD_NEK2_1	763	768	PF00069	0.557
MOD_NEK2_1	86	91	PF00069	0.420
MOD_NEK2_2	116	121	PF00069	0.527
MOD_NEK2_2	28	33	PF00069	0.270
MOD_PIKK_1	307	313	PF00454	0.611
MOD_PIKK_1	415	421	PF00454	0.531
MOD_PKA_2	216	222	PF00069	0.455
MOD_PKA_2	251	257	PF00069	0.325
MOD_PKA_2	479	485	PF00069	0.629
MOD_PKA_2	600	606	PF00069	0.629
MOD_PKA_2	778	784	PF00069	0.620
MOD_PKB_1	358	366	PF00069	0.411
MOD_Plk_1	102	108	PF00069	0.546
MOD_Plk_1	377	383	PF00069	0.527
MOD_Plk_1	415	421	PF00069	0.586
MOD_Plk_1	525	531	PF00069	0.555
MOD_Plk_1	763	769	PF00069	0.591
MOD_Plk_2-3	437	443	PF00069	0.587
MOD_Plk_4	116	122	PF00069	0.475
MOD_Plk_4	146	152	PF00069	0.453
MOD_Plk_4	189	195	PF00069	0.433
MOD_Plk_4	230	236	PF00069	0.456
MOD_Plk_4	563	569	PF00069	0.508
MOD_Plk_4	740	746	PF00069	0.462
MOD_Plk_4	82	88	PF00069	0.508
MOD_ProDKin_1	136	142	PF00069	0.538
MOD_ProDKin_1	773	779	PF00069	0.619
MOD_SUMO_rev_2	316	322	PF00179	0.573
MOD_SUMO_rev_2	461	467	PF00179	0.532
TRG_DiLeu_BaEn_1	180	185	PF01217	0.548
TRG_DiLeu_BaEn_1	365	370	PF01217	0.619
TRG_DiLeu_BaEn_1	535	540	PF01217	0.699
TRG_DiLeu_BaEn_1	627	632	PF01217	0.497
TRG_DiLeu_BaEn_1	742	747	PF01217	0.475
TRG_DiLeu_BaEn_4	352	358	PF01217	0.582
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.455
TRG_DiLeu_BaLyEn_6	735	740	PF01217	0.634
TRG_ENDOCYTIC_2	148	151	PF00928	0.531
TRG_ENDOCYTIC_2	338	341	PF00928	0.440
TRG_ENDOCYTIC_2	382	385	PF00928	0.384
TRG_ENDOCYTIC_2	608	611	PF00928	0.532
TRG_ER_diArg_1	214	217	PF00400	0.474
TRG_ER_diArg_1	357	360	PF00400	0.528
TRG_ER_diArg_1	367	369	PF00400	0.478
TRG_ER_diArg_1	474	476	PF00400	0.686
TRG_ER_diArg_1	529	531	PF00400	0.570
TRG_ER_diArg_1	546	549	PF00400	0.536
TRG_ER_diArg_1	589	592	PF00400	0.412
TRG_ER_diArg_1	737	739	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	710	715	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	737	742	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV16	Leptomonas seymouri	55%	93%
A0A1X0NPL3	Trypanosomatidae	33%	89%
A0A3S5H617	Leishmania donovani	76%	98%
A0A3S5IQT7	Trypanosoma rangeli	38%	90%
A4HTD4	Leishmania infantum	76%	98%
C9ZUI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
E9ALC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
Q4QIH8	Leishmania major	75%	100%
V5BTL6	Trypanosoma cruzi	35%	90%