Putative RNA-editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H556_LEIBR

TriTrypDb:

LbrM.07.1140 , LBRM2903_070020500

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H556

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H556

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.589
CLV_NRD_NRD_1	2	4	PF00675	0.617
CLV_NRD_NRD_1	32	34	PF00675	0.504
CLV_PCSK_KEX2_1	11	13	PF00082	0.571
CLV_PCSK_KEX2_1	198	200	PF00082	0.608
CLV_PCSK_KEX2_1	2	4	PF00082	0.595
CLV_PCSK_KEX2_1	32	34	PF00082	0.504
CLV_PCSK_KEX2_1	95	97	PF00082	0.435
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.608
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.435
CLV_PCSK_SKI1_1	198	202	PF00082	0.526
CLV_PCSK_SKI1_1	24	28	PF00082	0.588
CLV_PCSK_SKI1_1	33	37	PF00082	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DEG_SCF_FBW7_2	41	48	PF00400	0.454
DEG_SPOP_SBC_1	120	124	PF00917	0.687
DEG_SPOP_SBC_1	161	165	PF00917	0.747
DOC_CKS1_1	42	47	PF01111	0.663
DOC_MAPK_gen_1	95	103	PF00069	0.672
DOC_MAPK_MEF2A_6	325	333	PF00069	0.535
DOC_MAPK_MEF2A_6	412	421	PF00069	0.382
DOC_PP2B_PxIxI_1	416	422	PF00149	0.382
DOC_PP4_FxxP_1	146	149	PF00568	0.659
DOC_PP4_FxxP_1	358	361	PF00568	0.464
DOC_PP4_FxxP_1	380	383	PF00568	0.513
DOC_SPAK_OSR1_1	393	397	PF12202	0.408
DOC_USP7_MATH_1	162	166	PF00917	0.716
DOC_USP7_MATH_1	178	182	PF00917	0.578
DOC_USP7_MATH_1	189	193	PF00917	0.538
DOC_USP7_MATH_1	250	254	PF00917	0.700
DOC_USP7_UBL2_3	91	95	PF12436	0.594
DOC_WW_Pin1_4	116	121	PF00397	0.624
DOC_WW_Pin1_4	127	132	PF00397	0.705
DOC_WW_Pin1_4	137	142	PF00397	0.560
DOC_WW_Pin1_4	164	169	PF00397	0.715
DOC_WW_Pin1_4	176	181	PF00397	0.712
DOC_WW_Pin1_4	230	235	PF00397	0.746
DOC_WW_Pin1_4	24	29	PF00397	0.698
DOC_WW_Pin1_4	41	46	PF00397	0.512
LIG_14-3-3_CanoR_1	12	20	PF00244	0.647
LIG_CaM_IQ_9	203	219	PF13499	0.447
LIG_Clathr_ClatBox_1	100	104	PF01394	0.663
LIG_FHA_1	207	213	PF00498	0.452
LIG_FHA_1	241	247	PF00498	0.773
LIG_FHA_1	370	376	PF00498	0.386
LIG_FHA_1	395	401	PF00498	0.396
LIG_FHA_1	69	75	PF00498	0.522
LIG_FHA_2	32	38	PF00498	0.710
LIG_LIR_Apic_2	356	361	PF02991	0.452
LIG_LIR_Gen_1	367	376	PF02991	0.403
LIG_LIR_Nem_3	269	273	PF02991	0.663
LIG_LIR_Nem_3	367	373	PF02991	0.421
LIG_LIR_Nem_3	71	75	PF02991	0.512
LIG_LYPXL_yS_3	416	419	PF13949	0.385
LIG_PDZ_Class_2	426	431	PF00595	0.411
LIG_Pex14_2	142	146	PF04695	0.693
LIG_SH2_CRK	414	418	PF00017	0.405
LIG_SH2_STAT3	292	295	PF00017	0.684
LIG_SH2_STAT3	343	346	PF00017	0.329
LIG_SH2_STAT5	292	295	PF00017	0.564
LIG_SH2_STAT5	343	346	PF00017	0.484
LIG_SH2_STAT5	50	53	PF00017	0.671
LIG_SH3_3	231	237	PF00018	0.720
LIG_SH3_3	249	255	PF00018	0.712
LIG_SH3_3	298	304	PF00018	0.501
LIG_SH3_3	309	315	PF00018	0.476
LIG_SH3_3	360	366	PF00018	0.471
LIG_TRAF2_1	314	317	PF00917	0.475
MOD_CDK_SPK_2	24	29	PF00069	0.497
MOD_CDK_SPxK_1	41	47	PF00069	0.456
MOD_CK1_1	116	122	PF00069	0.640
MOD_CK1_1	132	138	PF00069	0.720
MOD_CK1_1	164	170	PF00069	0.734
MOD_CK1_1	233	239	PF00069	0.633
MOD_CK2_1	154	160	PF00069	0.637
MOD_CK2_1	178	184	PF00069	0.716
MOD_Cter_Amidation	30	33	PF01082	0.498
MOD_GlcNHglycan	134	137	PF01048	0.644
MOD_GlcNHglycan	187	190	PF01048	0.711
MOD_GlcNHglycan	191	194	PF01048	0.682
MOD_GlcNHglycan	287	290	PF01048	0.494
MOD_GlcNHglycan	424	427	PF01048	0.495
MOD_GSK3_1	116	123	PF00069	0.618
MOD_GSK3_1	150	157	PF00069	0.689
MOD_GSK3_1	160	167	PF00069	0.653
MOD_GSK3_1	172	179	PF00069	0.638
MOD_GSK3_1	185	192	PF00069	0.590
MOD_GSK3_1	240	247	PF00069	0.705
MOD_GSK3_1	31	38	PF00069	0.657
MOD_GSK3_1	365	372	PF00069	0.564
MOD_N-GLC_2	328	330	PF02516	0.398
MOD_NEK2_1	14	19	PF00069	0.504
MOD_NEK2_1	150	155	PF00069	0.638
MOD_NEK2_1	201	206	PF00069	0.447
MOD_NEK2_1	350	355	PF00069	0.474
MOD_NEK2_1	394	399	PF00069	0.451
MOD_NEK2_2	206	211	PF00069	0.447
MOD_NEK2_2	266	271	PF00069	0.666
MOD_NEK2_2	68	73	PF00069	0.517
MOD_PIKK_1	405	411	PF00454	0.556
MOD_PKA_2	31	37	PF00069	0.710
MOD_Plk_4	113	119	PF00069	0.514
MOD_Plk_4	14	20	PF00069	0.469
MOD_Plk_4	424	430	PF00069	0.312
MOD_ProDKin_1	116	122	PF00069	0.626
MOD_ProDKin_1	127	133	PF00069	0.700
MOD_ProDKin_1	137	143	PF00069	0.555
MOD_ProDKin_1	164	170	PF00069	0.719
MOD_ProDKin_1	176	182	PF00069	0.711
MOD_ProDKin_1	230	236	PF00069	0.747
MOD_ProDKin_1	24	30	PF00069	0.694
MOD_ProDKin_1	41	47	PF00069	0.513
MOD_SUMO_for_1	94	97	PF00179	0.618
TRG_DiLeu_BaEn_2	196	202	PF01217	0.662
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.688
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.396
TRG_ENDOCYTIC_2	416	419	PF00928	0.385
TRG_ER_diArg_1	1	3	PF00400	0.607
TRG_ER_diArg_1	11	13	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P1	Leptomonas seymouri	53%	92%
A0A0S4IKI2	Bodo saltans	46%	100%
A0A1X0NPK8	Trypanosomatidae	47%	100%
A0A3S5H616	Leishmania donovani	72%	87%
A0A422N9Y4	Trypanosoma rangeli	49%	100%
A4HTD3	Leishmania infantum	72%	96%
C9ZUI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ALC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	86%
Q4QIH9	Leishmania major	73%	100%
V5DQ35	Trypanosoma cruzi	47%	100%