Putative lipoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H555_LEIBR

TriTrypDb:

LbrM.07.1130 , LBRM2903_070020400

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H555

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H555

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009249	protein lipoylation	5	8
GO:0018193	peptidyl-amino acid modification	5	8
GO:0018205	peptidyl-lysine modification	6	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0051604	protein maturation	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	6
GO:0016874	ligase activity	2	8
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0017118	lipoyltransferase activity	5	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016979	lipoate-protein ligase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	288	290	PF00675	0.262
CLV_NRD_NRD_1	299	301	PF00675	0.223
CLV_NRD_NRD_1	353	355	PF00675	0.311
CLV_NRD_NRD_1	501	503	PF00675	0.420
CLV_NRD_NRD_1	543	545	PF00675	0.417
CLV_NRD_NRD_1	57	59	PF00675	0.492
CLV_NRD_NRD_1	608	610	PF00675	0.496
CLV_NRD_NRD_1	95	97	PF00675	0.522
CLV_PCSK_KEX2_1	288	290	PF00082	0.262
CLV_PCSK_KEX2_1	299	301	PF00082	0.223
CLV_PCSK_KEX2_1	353	355	PF00082	0.237
CLV_PCSK_KEX2_1	436	438	PF00082	0.425
CLV_PCSK_KEX2_1	501	503	PF00082	0.478
CLV_PCSK_KEX2_1	543	545	PF00082	0.409
CLV_PCSK_KEX2_1	608	610	PF00082	0.500
CLV_PCSK_KEX2_1	89	91	PF00082	0.500
CLV_PCSK_KEX2_1	95	97	PF00082	0.510
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.425
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.500
CLV_PCSK_SKI1_1	262	266	PF00082	0.342
CLV_PCSK_SKI1_1	362	366	PF00082	0.263
CLV_PCSK_SKI1_1	48	52	PF00082	0.470
CLV_PCSK_SKI1_1	600	604	PF00082	0.372
CLV_PCSK_SKI1_1	689	693	PF00082	0.383
CLV_PCSK_SKI1_1	698	702	PF00082	0.343
DEG_APCC_DBOX_1	261	269	PF00400	0.345
DEG_Nend_UBRbox_2	1	3	PF02207	0.491
DEG_SCF_FBW7_1	383	390	PF00400	0.497
DEG_SPOP_SBC_1	529	533	PF00917	0.288
DOC_ANK_TNKS_1	288	295	PF00023	0.495
DOC_CKS1_1	384	389	PF01111	0.538
DOC_CYCLIN_RxL_1	133	142	PF00134	0.439
DOC_CYCLIN_RxL_1	250	260	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.439
DOC_MAPK_FxFP_2	163	166	PF00069	0.459
DOC_MAPK_gen_1	353	359	PF00069	0.384
DOC_MAPK_gen_1	543	550	PF00069	0.417
DOC_MAPK_MEF2A_6	329	338	PF00069	0.470
DOC_MIT_MIM_1	540	548	PF04212	0.412
DOC_PP1_RVXF_1	11	17	PF00149	0.479
DOC_PP1_RVXF_1	260	267	PF00149	0.355
DOC_PP1_RVXF_1	46	52	PF00149	0.460
DOC_PP4_FxxP_1	163	166	PF00568	0.459
DOC_USP7_MATH_1	101	105	PF00917	0.487
DOC_USP7_MATH_1	145	149	PF00917	0.441
DOC_USP7_MATH_1	164	168	PF00917	0.426
DOC_USP7_MATH_1	247	251	PF00917	0.478
DOC_USP7_MATH_1	387	391	PF00917	0.436
DOC_USP7_MATH_1	431	435	PF00917	0.533
DOC_USP7_MATH_1	491	495	PF00917	0.421
DOC_USP7_MATH_1	529	533	PF00917	0.296
DOC_USP7_UBL2_3	517	521	PF12436	0.430
DOC_WW_Pin1_4	104	109	PF00397	0.486
DOC_WW_Pin1_4	114	119	PF00397	0.476
DOC_WW_Pin1_4	17	22	PF00397	0.487
DOC_WW_Pin1_4	217	222	PF00397	0.396
DOC_WW_Pin1_4	28	33	PF00397	0.477
DOC_WW_Pin1_4	383	388	PF00397	0.526
DOC_WW_Pin1_4	411	416	PF00397	0.375
DOC_WW_Pin1_4	475	480	PF00397	0.363
LIG_14-3-3_CanoR_1	122	127	PF00244	0.466
LIG_14-3-3_CanoR_1	227	232	PF00244	0.342
LIG_14-3-3_CanoR_1	253	258	PF00244	0.426
LIG_14-3-3_CanoR_1	348	357	PF00244	0.462
LIG_14-3-3_CanoR_1	413	423	PF00244	0.414
LIG_14-3-3_CanoR_1	465	469	PF00244	0.374
LIG_14-3-3_CanoR_1	556	561	PF00244	0.408
LIG_14-3-3_CanoR_1	600	606	PF00244	0.373
LIG_14-3-3_CanoR_1	633	640	PF00244	0.443
LIG_14-3-3_CanoR_1	95	102	PF00244	0.507
LIG_APCC_ABBAyCdc20_2	354	360	PF00400	0.446
LIG_BRCT_BRCA1_1	41	45	PF00533	0.434
LIG_BRCT_BRCA1_1	46	50	PF00533	0.440
LIG_Clathr_ClatBox_1	480	484	PF01394	0.397
LIG_deltaCOP1_diTrp_1	522	530	PF00928	0.439
LIG_DLG_GKlike_1	122	129	PF00625	0.463
LIG_eIF4E_1	377	383	PF01652	0.513
LIG_eIF4E_1	634	640	PF01652	0.323
LIG_FHA_1	108	114	PF00498	0.473
LIG_FHA_1	153	159	PF00498	0.437
LIG_FHA_1	220	226	PF00498	0.519
LIG_FHA_1	234	240	PF00498	0.297
LIG_FHA_1	258	264	PF00498	0.372
LIG_FHA_1	328	334	PF00498	0.469
LIG_FHA_1	379	385	PF00498	0.446
LIG_FHA_1	404	410	PF00498	0.384
LIG_FHA_1	529	535	PF00498	0.334
LIG_FHA_1	615	621	PF00498	0.491
LIG_FHA_1	656	662	PF00498	0.492
LIG_FHA_1	666	672	PF00498	0.379
LIG_FHA_1	68	74	PF00498	0.491
LIG_FHA_1	95	101	PF00498	0.507
LIG_FHA_2	416	422	PF00498	0.283
LIG_FHA_2	443	449	PF00498	0.329
LIG_FHA_2	508	514	PF00498	0.390
LIG_FHA_2	593	599	PF00498	0.483
LIG_GBD_Chelix_1	150	158	PF00786	0.443
LIG_LIR_Apic_2	161	166	PF02991	0.456
LIG_LIR_Apic_2	522	528	PF02991	0.443
LIG_LIR_Gen_1	398	409	PF02991	0.467
LIG_LIR_LC3C_4	229	233	PF02991	0.412
LIG_LIR_Nem_3	125	129	PF02991	0.461
LIG_LIR_Nem_3	398	404	PF02991	0.365
LIG_LIR_Nem_3	549	554	PF02991	0.409
LIG_LIR_Nem_3	6	10	PF02991	0.463
LIG_NRBOX	634	640	PF00104	0.438
LIG_Pex14_1	630	634	PF04695	0.381
LIG_REV1ctd_RIR_1	48	54	PF16727	0.474
LIG_SH2_CRK	525	529	PF00017	0.426
LIG_SH2_GRB2like	267	270	PF00017	0.316
LIG_SH2_NCK_1	525	529	PF00017	0.438
LIG_SH2_SRC	394	397	PF00017	0.281
LIG_SH2_STAT3	200	203	PF00017	0.499
LIG_SH2_STAT5	267	270	PF00017	0.316
LIG_SH2_STAT5	394	397	PF00017	0.358
LIG_SH2_STAT5	401	404	PF00017	0.353
LIG_SH2_STAT5	634	637	PF00017	0.406
LIG_SH3_3	265	271	PF00018	0.341
LIG_SH3_3	381	387	PF00018	0.488
LIG_SH3_3	409	415	PF00018	0.384
LIG_SH3_3	670	676	PF00018	0.424
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.241
LIG_SUMO_SIM_par_1	380	386	PF11976	0.446
LIG_SUMO_SIM_par_1	531	538	PF11976	0.333
LIG_TRAF2_1	85	88	PF00917	0.500
LIG_TRFH_1	200	204	PF08558	0.497
LIG_WRC_WIRS_1	165	170	PF05994	0.470
MOD_CDK_SPxxK_3	17	24	PF00069	0.492
MOD_CK1_1	104	110	PF00069	0.488
MOD_CK1_1	153	159	PF00069	0.437
MOD_CK1_1	213	219	PF00069	0.617
MOD_CK1_1	23	29	PF00069	0.511
MOD_CK1_1	40	46	PF00069	0.403
MOD_CK1_1	408	414	PF00069	0.407
MOD_CK1_1	467	473	PF00069	0.452
MOD_CK2_1	415	421	PF00069	0.456
MOD_CK2_1	491	497	PF00069	0.377
MOD_CK2_1	507	513	PF00069	0.381
MOD_CK2_1	534	540	PF00069	0.429
MOD_CK2_1	556	562	PF00069	0.447
MOD_CK2_1	592	598	PF00069	0.481
MOD_Cter_Amidation	360	363	PF01082	0.363
MOD_Cter_Amidation	499	502	PF01082	0.423
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.499
MOD_GlcNHglycan	103	106	PF01048	0.489
MOD_GlcNHglycan	301	304	PF01048	0.304
MOD_GlcNHglycan	366	369	PF01048	0.282
MOD_GlcNHglycan	426	429	PF01048	0.490
MOD_GlcNHglycan	504	507	PF01048	0.541
MOD_GlcNHglycan	537	540	PF01048	0.340
MOD_GlcNHglycan	626	629	PF01048	0.534
MOD_GlcNHglycan	635	638	PF01048	0.307
MOD_GSK3_1	150	157	PF00069	0.441
MOD_GSK3_1	178	185	PF00069	0.544
MOD_GSK3_1	213	220	PF00069	0.362
MOD_GSK3_1	253	260	PF00069	0.260
MOD_GSK3_1	383	390	PF00069	0.465
MOD_GSK3_1	40	47	PF00069	0.436
MOD_GSK3_1	404	411	PF00069	0.399
MOD_GSK3_1	415	422	PF00069	0.393
MOD_GSK3_1	475	482	PF00069	0.408
MOD_GSK3_1	530	537	PF00069	0.386
MOD_GSK3_1	610	617	PF00069	0.623
MOD_LATS_1	120	126	PF00433	0.468
MOD_N-GLC_1	213	218	PF02516	0.363
MOD_N-GLC_1	227	232	PF02516	0.368
MOD_N-GLC_2	313	315	PF02516	0.316
MOD_NEK2_1	150	155	PF00069	0.603
MOD_NEK2_1	192	197	PF00069	0.506
MOD_NEK2_1	210	215	PF00069	0.537
MOD_NEK2_1	257	262	PF00069	0.263
MOD_NEK2_1	349	354	PF00069	0.256
MOD_NEK2_1	39	44	PF00069	0.440
MOD_NEK2_1	404	409	PF00069	0.391
MOD_NEK2_1	419	424	PF00069	0.450
MOD_NEK2_1	464	469	PF00069	0.439
MOD_NEK2_1	530	535	PF00069	0.391
MOD_NEK2_1	601	606	PF00069	0.508
MOD_NEK2_1	665	670	PF00069	0.339
MOD_NEK2_2	431	436	PF00069	0.264
MOD_OFUCOSY	144	149	PF10250	0.442
MOD_PIKK_1	172	178	PF00454	0.483
MOD_PIKK_1	257	263	PF00454	0.256
MOD_PK_1	405	411	PF00069	0.357
MOD_PKA_1	299	305	PF00069	0.298
MOD_PKA_1	362	368	PF00069	0.305
MOD_PKA_2	226	232	PF00069	0.420
MOD_PKA_2	299	305	PF00069	0.295
MOD_PKA_2	347	353	PF00069	0.282
MOD_PKA_2	464	470	PF00069	0.407
MOD_PKA_2	555	561	PF00069	0.394
MOD_PKA_2	94	100	PF00069	0.515
MOD_Plk_1	213	219	PF00069	0.378
MOD_Plk_1	227	233	PF00069	0.354
MOD_Plk_1	247	253	PF00069	0.342
MOD_Plk_1	327	333	PF00069	0.350
MOD_Plk_1	491	497	PF00069	0.276
MOD_Plk_1	655	661	PF00069	0.533
MOD_Plk_2-3	507	513	PF00069	0.474
MOD_Plk_4	122	128	PF00069	0.463
MOD_Plk_4	158	164	PF00069	0.448
MOD_Plk_4	227	233	PF00069	0.499
MOD_Plk_4	378	384	PF00069	0.282
MOD_Plk_4	40	46	PF00069	0.437
MOD_Plk_4	491	497	PF00069	0.408
MOD_Plk_4	530	536	PF00069	0.391
MOD_Plk_4	546	552	PF00069	0.285
MOD_ProDKin_1	104	110	PF00069	0.488
MOD_ProDKin_1	114	120	PF00069	0.474
MOD_ProDKin_1	17	23	PF00069	0.490
MOD_ProDKin_1	217	223	PF00069	0.388
MOD_ProDKin_1	28	34	PF00069	0.468
MOD_ProDKin_1	383	389	PF00069	0.404
MOD_ProDKin_1	411	417	PF00069	0.368
MOD_ProDKin_1	475	481	PF00069	0.352
MOD_SUMO_rev_2	356	364	PF00179	0.206
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.377
TRG_ENDOCYTIC_2	401	404	PF00928	0.366
TRG_ER_diArg_1	196	199	PF00400	0.542
TRG_ER_diArg_1	287	289	PF00400	0.375
TRG_ER_diArg_1	322	325	PF00400	0.341
TRG_ER_diArg_1	45	48	PF00400	0.440
TRG_ER_diArg_1	543	545	PF00400	0.428
TRG_ER_diArg_1	607	609	PF00400	0.531
TRG_ER_diArg_1	94	96	PF00400	0.521
TRG_NES_CRM1_1	540	553	PF08389	0.460
TRG_NLS_MonoExtN_4	55	62	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I310	Leptomonas seymouri	59%	100%
A0A0S4IZJ4	Bodo saltans	33%	100%
A0A3R7MGW3	Trypanosoma rangeli	39%	100%
A0A3S5H615	Leishmania donovani	78%	100%
E9ALC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QII0	Leishmania major	79%	100%