Dpy-30 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H554_LEIBR

TriTrypDb:

LbrM.07.1120 , LBRM2903_070020300

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	3
GO:0034708	methyltransferase complex	4	3
GO:0035097	histone methyltransferase complex	3	3
GO:0044666	MLL3/4 complex	4	3
GO:0048188	Set1C/COMPASS complex	4	3
GO:0140513	nuclear protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1990234	transferase complex	3	3

Expansion

Sequence features

A4H554

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H554

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.534
CLV_NRD_NRD_1	87	89	PF00675	0.282
CLV_PCSK_KEX2_1	87	89	PF00082	0.282
CLV_PCSK_SKI1_1	56	60	PF00082	0.308
DEG_APCC_DBOX_1	55	63	PF00400	0.509
DOC_USP7_MATH_1	38	42	PF00917	0.682
LIG_14-3-3_CanoR_1	87	95	PF00244	0.666
LIG_Actin_WH2_2	74	89	PF00022	0.472
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_eIF4E_1	80	86	PF01652	0.521
LIG_FHA_1	92	98	PF00498	0.721
LIG_FHA_2	21	27	PF00498	0.537
LIG_FHA_2	96	102	PF00498	0.522
LIG_SH2_STAP1	99	103	PF00017	0.596
LIG_SH2_STAT5	53	56	PF00017	0.483
LIG_SH2_STAT5	80	83	PF00017	0.521
LIG_SH2_STAT5	84	87	PF00017	0.521
LIG_SH3_1	71	77	PF00018	0.454
LIG_SH3_3	71	77	PF00018	0.450
LIG_SUMO_SIM_par_1	93	98	PF11976	0.598
MOD_CK1_1	46	52	PF00069	0.461
MOD_CK2_1	106	112	PF00069	0.742
MOD_GlcNHglycan	11	14	PF01048	0.513
MOD_GSK3_1	43	50	PF00069	0.621
MOD_GSK3_1	87	94	PF00069	0.607
MOD_GSK3_1	95	102	PF00069	0.564
MOD_N-GLC_1	91	96	PF02516	0.565
MOD_NEK2_1	19	24	PF00069	0.485
MOD_NEK2_1	54	59	PF00069	0.484
MOD_NEK2_1	86	91	PF00069	0.566
MOD_PIKK_1	47	53	PF00454	0.497
MOD_PKA_1	87	93	PF00069	0.648
MOD_PKA_2	86	92	PF00069	0.604
MOD_Plk_1	43	49	PF00069	0.555
MOD_Plk_1	54	60	PF00069	0.433
MOD_Plk_1	91	97	PF00069	0.605
MOD_Plk_1	99	105	PF00069	0.645
MOD_Plk_4	80	86	PF00069	0.521
TRG_ER_diArg_1	71	74	PF00400	0.454
TRG_ER_diArg_1	86	88	PF00400	0.469
TRG_NES_CRM1_1	44	55	PF08389	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9I1	Leptomonas seymouri	67%	100%
A0A3S7WQ32	Leishmania donovani	78%	97%
A4HTD1	Leishmania infantum	77%	97%
C9ZUI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9ALC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QII1	Leishmania major	83%	100%
V5BYE7	Trypanosoma cruzi	46%	100%