Dpy-30 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H554_LEIBR

TriTrypDb:

LbrM.07.1120 , LBRM2903_070020300

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	3
GO:0034708	methyltransferase complex	4	3
GO:0035097	histone methyltransferase complex	3	3
GO:0044666	MLL3/4 complex	4	3
GO:0048188	Set1C/COMPASS complex	4	3
GO:0140513	nuclear protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1990234	transferase complex	3	3

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Expansion

Sequence features

A4H554

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H554

Function

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Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.534
CLV_NRD_NRD_1	87	89	PF00675	0.282
CLV_PCSK_KEX2_1	87	89	PF00082	0.282
CLV_PCSK_SKI1_1	56	60	PF00082	0.308
DEG_APCC_DBOX_1	55	63	PF00400	0.509
DOC_USP7_MATH_1	38	42	PF00917	0.682
LIG_14-3-3_CanoR_1	87	95	PF00244	0.666
LIG_Actin_WH2_2	74	89	PF00022	0.472
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_eIF4E_1	80	86	PF01652	0.521

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9I1	Leptomonas seymouri	67%	100%
A0A3S7WQ32	Leishmania donovani	78%	97%
A4HTD1	Leishmania infantum	77%	97%
C9ZUI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9ALC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QII1	Leishmania major	83%	100%
V5BYE7	Trypanosoma cruzi	46%	100%

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