IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H552_LEIBR

TriTrypDb:

LbrM.07.1090 , LBRM2903_070020000

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H552

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H552

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.488
CLV_NRD_NRD_1	178	180	PF00675	0.618
CLV_PCSK_FUR_1	176	180	PF00082	0.522
CLV_PCSK_KEX2_1	178	180	PF00082	0.586
CLV_PCSK_SKI1_1	182	186	PF00082	0.525
CLV_PCSK_SKI1_1	2	6	PF00082	0.782
DEG_Nend_UBRbox_1	1	4	PF02207	0.768
DOC_MAPK_MEF2A_6	144	152	PF00069	0.666
DOC_PP2B_LxvP_1	167	170	PF13499	0.670
DOC_PP2B_LxvP_1	84	87	PF13499	0.779
DOC_USP7_MATH_1	11	15	PF00917	0.511
DOC_USP7_MATH_1	47	51	PF00917	0.497
DOC_USP7_MATH_1	93	97	PF00917	0.668
DOC_WW_Pin1_4	15	20	PF00397	0.636
DOC_WW_Pin1_4	7	12	PF00397	0.650
LIG_14-3-3_CanoR_1	151	155	PF00244	0.686
LIG_14-3-3_CanoR_1	156	166	PF00244	0.621
LIG_BRCT_BRCA1_1	20	24	PF00533	0.548
LIG_BRCT_BRCA1_1	59	63	PF00533	0.744
LIG_FHA_1	101	107	PF00498	0.677
LIG_FHA_1	108	114	PF00498	0.546
LIG_FHA_1	147	153	PF00498	0.675
LIG_FHA_1	44	50	PF00498	0.546
LIG_LIR_Apic_2	142	148	PF02991	0.508
LIG_LIR_Gen_1	153	161	PF02991	0.751
LIG_LIR_Nem_3	153	157	PF02991	0.753
LIG_LIR_Nem_3	59	65	PF02991	0.747
LIG_MLH1_MIPbox_1	59	63	PF16413	0.744
LIG_SH2_CRK	154	158	PF00017	0.749
LIG_SH2_CRK	181	185	PF00017	0.717
LIG_SH2_NCK_1	145	149	PF00017	0.514
LIG_SH2_STAP1	102	106	PF00017	0.661
LIG_SH2_STAT5	102	105	PF00017	0.767
LIG_SH2_STAT5	137	140	PF00017	0.504
LIG_SH3_3	103	109	PF00018	0.508
LIG_SH3_3	72	78	PF00018	0.712
LIG_SH3_3	86	92	PF00018	0.710
LIG_SUMO_SIM_par_1	122	129	PF11976	0.515
LIG_TYR_ITIM	152	157	PF00017	0.758
LIG_WRC_WIRS_1	40	45	PF05994	0.510
MOD_CK1_1	18	24	PF00069	0.532
MOD_CK1_1	58	64	PF00069	0.639
MOD_GlcNHglycan	13	16	PF01048	0.554
MOD_GlcNHglycan	141	144	PF01048	0.756
MOD_GlcNHglycan	20	23	PF01048	0.507
MOD_GlcNHglycan	49	52	PF01048	0.695
MOD_GSK3_1	135	142	PF00069	0.675
MOD_GSK3_1	146	153	PF00069	0.656
MOD_GSK3_1	156	163	PF00069	0.642
MOD_GSK3_1	39	46	PF00069	0.622
MOD_GSK3_1	53	60	PF00069	0.637
MOD_GSK3_1	7	14	PF00069	0.592
MOD_N-GLC_1	43	48	PF02516	0.518
MOD_NEK2_1	139	144	PF00069	0.506
MOD_NEK2_1	24	29	PF00069	0.660
MOD_NEK2_1	43	48	PF00069	0.648
MOD_NEK2_1	53	58	PF00069	0.659
MOD_NEK2_2	25	30	PF00069	0.516
MOD_PKA_2	150	156	PF00069	0.765
MOD_PKA_2	157	163	PF00069	0.624
MOD_PKA_2	5	11	PF00069	0.719
MOD_Plk_1	170	176	PF00069	0.603
MOD_Plk_4	135	141	PF00069	0.504
MOD_Plk_4	58	64	PF00069	0.748
MOD_ProDKin_1	15	21	PF00069	0.637
MOD_ProDKin_1	7	13	PF00069	0.649
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.709
TRG_ENDOCYTIC_2	154	157	PF00928	0.750
TRG_ENDOCYTIC_2	181	184	PF00928	0.643
TRG_ER_diArg_1	176	179	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSB8	Leptomonas seymouri	36%	100%
A0A3S5H613	Leishmania donovani	72%	94%
E9ACQ3	Leishmania major	68%	100%
E9AG77	Leishmania infantum	72%	94%
E9ALC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%