Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H546_LEIBR

TriTrypDb:

LbrM.07.1030 , LBRM2903_070019300

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H546

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H546

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.378
CLV_PCSK_SKI1_1	60	64	PF00082	0.289
DEG_Nend_UBRbox_2	1	3	PF02207	0.411
DOC_CYCLIN_RxL_1	57	66	PF00134	0.211
DOC_MAPK_MEF2A_6	60	69	PF00069	0.292
DOC_USP7_MATH_1	15	19	PF00917	0.458
DOC_USP7_MATH_1	34	38	PF00917	0.286
DOC_USP7_UBL2_3	45	49	PF12436	0.365
LIG_EH1_1	37	45	PF00400	0.402
LIG_FHA_1	39	45	PF00498	0.346
LIG_FHA_2	115	121	PF00498	0.514
LIG_SH2_CRK	93	97	PF00017	0.513
LIG_SH2_STAP1	93	97	PF00017	0.513
LIG_SH2_STAT5	93	96	PF00017	0.418
LIG_SH3_3	27	33	PF00018	0.376
LIG_TRAF2_1	97	100	PF00917	0.618
LIG_TYR_ITIM	91	96	PF00017	0.402
MOD_GlcNHglycan	19	22	PF01048	0.391
MOD_GlcNHglycan	71	74	PF01048	0.351
MOD_GSK3_1	11	18	PF00069	0.299
MOD_GSK3_1	34	41	PF00069	0.310
MOD_N-GLC_1	34	39	PF02516	0.236
MOD_NEK2_1	25	30	PF00069	0.286
MOD_NEK2_1	69	74	PF00069	0.342
MOD_PIKK_1	25	31	PF00454	0.286
MOD_PIKK_1	91	97	PF00454	0.402
MOD_Plk_4	47	53	PF00069	0.342
MOD_SUMO_for_1	44	47	PF00179	0.402
TRG_DiLeu_BaEn_2	46	52	PF01217	0.402
TRG_ENDOCYTIC_2	93	96	PF00928	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I136	Leptomonas seymouri	74%	100%
A0A1X0NR21	Trypanosomatidae	44%	73%
A0A1X0NR92	Trypanosomatidae	44%	71%
A0A3S5H610	Leishmania donovani	91%	100%
A4HTC2	Leishmania infantum	91%	100%
C9ZUJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ALB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QII9	Leishmania major	91%	100%