Spindle assembly checkpoint component MAD1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H544_LEIBR

TriTrypDb:

LbrM.07.1010 , LBRM2903_070019100

Length:

1095

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H544

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H544

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	670	674	PF00656	0.719
CLV_NRD_NRD_1	116	118	PF00675	0.493
CLV_NRD_NRD_1	126	128	PF00675	0.469
CLV_NRD_NRD_1	145	147	PF00675	0.530
CLV_NRD_NRD_1	187	189	PF00675	0.544
CLV_NRD_NRD_1	290	292	PF00675	0.428
CLV_NRD_NRD_1	305	307	PF00675	0.517
CLV_NRD_NRD_1	33	35	PF00675	0.438
CLV_NRD_NRD_1	427	429	PF00675	0.512
CLV_NRD_NRD_1	485	487	PF00675	0.514
CLV_NRD_NRD_1	496	498	PF00675	0.452
CLV_NRD_NRD_1	510	512	PF00675	0.480
CLV_NRD_NRD_1	580	582	PF00675	0.477
CLV_NRD_NRD_1	61	63	PF00675	0.574
CLV_NRD_NRD_1	644	646	PF00675	0.594
CLV_NRD_NRD_1	691	693	PF00675	0.565
CLV_NRD_NRD_1	85	87	PF00675	0.555
CLV_PCSK_FUR_1	83	87	PF00082	0.431
CLV_PCSK_KEX2_1	116	118	PF00082	0.502
CLV_PCSK_KEX2_1	125	127	PF00082	0.477
CLV_PCSK_KEX2_1	187	189	PF00082	0.547
CLV_PCSK_KEX2_1	285	287	PF00082	0.461
CLV_PCSK_KEX2_1	290	292	PF00082	0.456
CLV_PCSK_KEX2_1	305	307	PF00082	0.385
CLV_PCSK_KEX2_1	33	35	PF00082	0.438
CLV_PCSK_KEX2_1	385	387	PF00082	0.512
CLV_PCSK_KEX2_1	427	429	PF00082	0.512
CLV_PCSK_KEX2_1	485	487	PF00082	0.512
CLV_PCSK_KEX2_1	510	512	PF00082	0.496
CLV_PCSK_KEX2_1	579	581	PF00082	0.531
CLV_PCSK_KEX2_1	61	63	PF00082	0.574
CLV_PCSK_KEX2_1	644	646	PF00082	0.582
CLV_PCSK_KEX2_1	691	693	PF00082	0.541
CLV_PCSK_KEX2_1	85	87	PF00082	0.425
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.539
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.563
CLV_PCSK_PC7_1	286	292	PF00082	0.352
CLV_PCSK_PC7_1	423	429	PF00082	0.567
CLV_PCSK_PC7_1	57	63	PF00082	0.530
CLV_PCSK_PC7_1	576	582	PF00082	0.444
CLV_PCSK_SKI1_1	285	289	PF00082	0.494
CLV_PCSK_SKI1_1	345	349	PF00082	0.534
CLV_PCSK_SKI1_1	371	375	PF00082	0.609
CLV_PCSK_SKI1_1	417	421	PF00082	0.544
CLV_PCSK_SKI1_1	453	457	PF00082	0.600
CLV_PCSK_SKI1_1	497	501	PF00082	0.497
CLV_PCSK_SKI1_1	559	563	PF00082	0.580
CLV_PCSK_SKI1_1	631	635	PF00082	0.481
CLV_Separin_Metazoa	447	451	PF03568	0.370
CLV_Separin_Metazoa	494	498	PF03568	0.362
DEG_APCC_DBOX_1	231	239	PF00400	0.482
DEG_COP1_1	909	917	PF00400	0.690
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DEG_SCF_FBW7_1	970	975	PF00400	0.505
DOC_ANK_TNKS_1	901	908	PF00023	0.651
DOC_CKS1_1	914	919	PF01111	0.641
DOC_CKS1_1	957	962	PF01111	0.603
DOC_CKS1_1	969	974	PF01111	0.528
DOC_CYCLIN_RxL_1	494	505	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	885	891	PF00134	0.679
DOC_MAPK_DCC_7	1024	1032	PF00069	0.655
DOC_MAPK_gen_1	146	153	PF00069	0.659
DOC_MAPK_MEF2A_6	1024	1032	PF00069	0.655
DOC_MAPK_MEF2A_6	146	155	PF00069	0.629
DOC_MAPK_MEF2A_6	857	865	PF00069	0.686
DOC_PP1_RVXF_1	495	502	PF00149	0.360
DOC_PP2B_LxvP_1	755	758	PF13499	0.643
DOC_PP2B_LxvP_1	843	846	PF13499	0.525
DOC_PP2B_LxvP_1	885	888	PF13499	0.671
DOC_PP4_FxxP_1	979	982	PF00568	0.526
DOC_USP7_MATH_1	1040	1044	PF00917	0.649
DOC_USP7_MATH_1	1061	1065	PF00917	0.640
DOC_USP7_MATH_1	180	184	PF00917	0.543
DOC_USP7_MATH_1	221	225	PF00917	0.581
DOC_USP7_MATH_1	484	488	PF00917	0.601
DOC_USP7_MATH_1	765	769	PF00917	0.580
DOC_USP7_MATH_1	818	822	PF00917	0.533
DOC_USP7_MATH_1	847	851	PF00917	0.626
DOC_USP7_MATH_1	855	859	PF00917	0.685
DOC_USP7_MATH_1	972	976	PF00917	0.741
DOC_USP7_MATH_1	980	984	PF00917	0.626
DOC_WW_Pin1_4	1004	1009	PF00397	0.707
DOC_WW_Pin1_4	1012	1017	PF00397	0.688
DOC_WW_Pin1_4	1036	1041	PF00397	0.761
DOC_WW_Pin1_4	1047	1052	PF00397	0.582
DOC_WW_Pin1_4	758	763	PF00397	0.666
DOC_WW_Pin1_4	795	800	PF00397	0.634
DOC_WW_Pin1_4	811	816	PF00397	0.553
DOC_WW_Pin1_4	880	885	PF00397	0.694
DOC_WW_Pin1_4	893	898	PF00397	0.538
DOC_WW_Pin1_4	913	918	PF00397	0.636
DOC_WW_Pin1_4	930	935	PF00397	0.668
DOC_WW_Pin1_4	940	945	PF00397	0.547
DOC_WW_Pin1_4	956	961	PF00397	0.779
DOC_WW_Pin1_4	968	973	PF00397	0.524
LIG_14-3-3_CanoR_1	161	167	PF00244	0.392
LIG_14-3-3_CanoR_1	203	210	PF00244	0.550
LIG_14-3-3_CanoR_1	220	228	PF00244	0.430
LIG_14-3-3_CanoR_1	371	380	PF00244	0.573
LIG_14-3-3_CanoR_1	417	426	PF00244	0.417
LIG_14-3-3_CanoR_1	441	445	PF00244	0.540
LIG_14-3-3_CanoR_1	485	492	PF00244	0.570
LIG_14-3-3_CanoR_1	631	640	PF00244	0.456
LIG_14-3-3_CanoR_1	651	655	PF00244	0.578
LIG_14-3-3_CanoR_1	714	724	PF00244	0.591
LIG_CtBP_PxDLS_1	890	894	PF00389	0.664
LIG_EVH1_1	843	847	PF00568	0.523
LIG_FHA_1	1017	1023	PF00498	0.626
LIG_FHA_1	1066	1072	PF00498	0.501
LIG_FHA_1	209	215	PF00498	0.570
LIG_FHA_1	234	240	PF00498	0.506
LIG_FHA_1	354	360	PF00498	0.638
LIG_FHA_1	382	388	PF00498	0.378
LIG_FHA_1	456	462	PF00498	0.605
LIG_FHA_1	615	621	PF00498	0.484
LIG_FHA_1	628	634	PF00498	0.512
LIG_FHA_1	792	798	PF00498	0.748
LIG_FHA_1	864	870	PF00498	0.757
LIG_FHA_1	909	915	PF00498	0.736
LIG_FHA_2	163	169	PF00498	0.551
LIG_FHA_2	184	190	PF00498	0.587
LIG_FHA_2	220	226	PF00498	0.582
LIG_FHA_2	349	355	PF00498	0.701
LIG_FHA_2	632	638	PF00498	0.587
LIG_FHA_2	658	664	PF00498	0.621
LIG_FHA_2	668	674	PF00498	0.688
LIG_LIR_Apic_2	976	982	PF02991	0.665
LIG_LIR_Gen_1	672	679	PF02991	0.663
LIG_LIR_Nem_3	40	46	PF02991	0.431
LIG_LIR_Nem_3	660	664	PF02991	0.587
LIG_LIR_Nem_3	672	678	PF02991	0.674
LIG_LIR_Nem_3	838	843	PF02991	0.614
LIG_MYND_1	1012	1016	PF01753	0.507
LIG_NRBOX	234	240	PF00104	0.518
LIG_Pex14_1	657	661	PF04695	0.558
LIG_Rb_pABgroove_1	275	283	PF01858	0.507
LIG_RPA_C_Fungi	505	517	PF08784	0.538
LIG_SH2_CRK	2	6	PF00017	0.479
LIG_SH2_CRK	675	679	PF00017	0.690
LIG_SH2_NCK_1	518	522	PF00017	0.360
LIG_SH2_SRC	930	933	PF00017	0.675
LIG_SH2_STAP1	444	448	PF00017	0.538
LIG_SH3_3	1006	1012	PF00018	0.594
LIG_SH3_3	1017	1023	PF00018	0.565
LIG_SH3_3	1025	1031	PF00018	0.662
LIG_SH3_3	1048	1054	PF00018	0.589
LIG_SH3_3	1057	1063	PF00018	0.526
LIG_SH3_3	756	762	PF00018	0.629
LIG_SH3_3	768	774	PF00018	0.645
LIG_SH3_3	805	811	PF00018	0.599
LIG_SH3_3	812	818	PF00018	0.646
LIG_SH3_3	830	836	PF00018	0.685
LIG_SH3_3	841	847	PF00018	0.606
LIG_SH3_3	911	917	PF00018	0.661
LIG_SH3_3	938	944	PF00018	0.674
LIG_SH3_3	951	957	PF00018	0.734
LIG_SH3_3	984	990	PF00018	0.611
LIG_SUMO_SIM_anti_2	341	352	PF11976	0.411
LIG_SUMO_SIM_par_1	1058	1064	PF11976	0.619
LIG_SUMO_SIM_par_1	356	362	PF11976	0.438
LIG_SUMO_SIM_par_1	889	894	PF11976	0.667
LIG_SUMO_SIM_par_1	909	916	PF11976	0.729
LIG_TRAF2_1	165	168	PF00917	0.577
LIG_TRAF2_1	443	446	PF00917	0.486
LIG_TRAF2_1	457	460	PF00917	0.556
LIG_TRAF2_1	502	505	PF00917	0.534
LIG_TRAF2_1	660	663	PF00917	0.522
LIG_WRC_WIRS_1	1062	1067	PF05994	0.484
LIG_WW_3	845	849	PF00397	0.515
MOD_CDK_SPK_2	811	816	PF00069	0.616
MOD_CK1_1	1033	1039	PF00069	0.606
MOD_CK1_1	1064	1070	PF00069	0.705
MOD_CK1_1	183	189	PF00069	0.636
MOD_CK1_1	202	208	PF00069	0.342
MOD_CK1_1	23	29	PF00069	0.472
MOD_CK1_1	615	621	PF00069	0.642
MOD_CK1_1	650	656	PF00069	0.507
MOD_CK1_1	667	673	PF00069	0.561
MOD_CK1_1	783	789	PF00069	0.523
MOD_CK1_1	851	857	PF00069	0.610
MOD_CK1_1	943	949	PF00069	0.660
MOD_CK1_1	975	981	PF00069	0.739
MOD_CK2_1	162	168	PF00069	0.468
MOD_CK2_1	183	189	PF00069	0.522
MOD_CK2_1	219	225	PF00069	0.576
MOD_CK2_1	269	275	PF00069	0.484
MOD_CK2_1	348	354	PF00069	0.661
MOD_CK2_1	440	446	PF00069	0.596
MOD_CK2_1	454	460	PF00069	0.577
MOD_CK2_1	470	476	PF00069	0.624
MOD_CK2_1	488	494	PF00069	0.508
MOD_CK2_1	631	637	PF00069	0.487
MOD_CK2_1	657	663	PF00069	0.574
MOD_CK2_1	724	730	PF00069	0.658
MOD_CK2_1	923	929	PF00069	0.519
MOD_Cter_Amidation	144	147	PF01082	0.422
MOD_GlcNHglycan	1032	1035	PF01048	0.624
MOD_GlcNHglycan	1042	1045	PF01048	0.778
MOD_GlcNHglycan	1068	1071	PF01048	0.756
MOD_GlcNHglycan	1073	1076	PF01048	0.746
MOD_GlcNHglycan	113	116	PF01048	0.369
MOD_GlcNHglycan	143	146	PF01048	0.508
MOD_GlcNHglycan	17	20	PF01048	0.542
MOD_GlcNHglycan	250	253	PF01048	0.644
MOD_GlcNHglycan	271	274	PF01048	0.547
MOD_GlcNHglycan	351	354	PF01048	0.521
MOD_GlcNHglycan	413	416	PF01048	0.578
MOD_GlcNHglycan	472	475	PF01048	0.709
MOD_GlcNHglycan	752	755	PF01048	0.687
MOD_GlcNHglycan	765	768	PF01048	0.660
MOD_GlcNHglycan	788	791	PF01048	0.670
MOD_GlcNHglycan	8	11	PF01048	0.667
MOD_GlcNHglycan	837	840	PF01048	0.723
MOD_GlcNHglycan	903	906	PF01048	0.714
MOD_GlcNHglycan	925	928	PF01048	0.609
MOD_GlcNHglycan	945	948	PF01048	0.706
MOD_GlcNHglycan	999	1002	PF01048	0.642
MOD_GSK3_1	1012	1019	PF00069	0.731
MOD_GSK3_1	1026	1033	PF00069	0.596
MOD_GSK3_1	1036	1043	PF00069	0.751
MOD_GSK3_1	1061	1068	PF00069	0.698
MOD_GSK3_1	11	18	PF00069	0.576
MOD_GSK3_1	23	30	PF00069	0.373
MOD_GSK3_1	349	356	PF00069	0.533
MOD_GSK3_1	484	491	PF00069	0.606
MOD_GSK3_1	543	550	PF00069	0.561
MOD_GSK3_1	627	634	PF00069	0.518
MOD_GSK3_1	664	671	PF00069	0.577
MOD_GSK3_1	765	772	PF00069	0.576
MOD_GSK3_1	791	798	PF00069	0.712
MOD_GSK3_1	818	825	PF00069	0.677
MOD_GSK3_1	847	854	PF00069	0.637
MOD_GSK3_1	872	879	PF00069	0.673
MOD_GSK3_1	889	896	PF00069	0.588
MOD_GSK3_1	919	926	PF00069	0.731
MOD_GSK3_1	968	975	PF00069	0.747
MOD_NEK2_1	1065	1070	PF00069	0.686
MOD_NEK2_1	1071	1076	PF00069	0.705
MOD_NEK2_1	162	167	PF00069	0.571
MOD_NEK2_1	199	204	PF00069	0.537
MOD_NEK2_1	21	26	PF00069	0.615
MOD_NEK2_1	216	221	PF00069	0.519
MOD_NEK2_1	266	271	PF00069	0.419
MOD_NEK2_1	27	32	PF00069	0.379
MOD_NEK2_1	310	315	PF00069	0.526
MOD_NEK2_1	348	353	PF00069	0.688
MOD_NEK2_1	380	385	PF00069	0.517
MOD_NEK2_1	470	475	PF00069	0.557
MOD_NEK2_1	647	652	PF00069	0.586
MOD_NEK2_1	781	786	PF00069	0.602
MOD_NEK2_1	819	824	PF00069	0.775
MOD_NEK2_1	921	926	PF00069	0.711
MOD_PIKK_1	432	438	PF00454	0.539
MOD_PIKK_1	460	466	PF00454	0.642
MOD_PK_1	848	854	PF00069	0.518
MOD_PKA_1	485	491	PF00069	0.431
MOD_PKA_2	202	208	PF00069	0.548
MOD_PKA_2	219	225	PF00069	0.429
MOD_PKA_2	349	355	PF00069	0.606
MOD_PKA_2	440	446	PF00069	0.549
MOD_PKA_2	484	490	PF00069	0.557
MOD_PKA_2	575	581	PF00069	0.537
MOD_PKA_2	627	633	PF00069	0.580
MOD_PKA_2	650	656	PF00069	0.549
MOD_PKA_2	667	673	PF00069	0.561
MOD_PKA_2	713	719	PF00069	0.593
MOD_PKA_2	847	853	PF00069	0.604
MOD_PKA_2	901	907	PF00069	0.684
MOD_Plk_1	155	161	PF00069	0.529
MOD_Plk_1	27	33	PF00069	0.543
MOD_Plk_1	353	359	PF00069	0.603
MOD_Plk_1	488	494	PF00069	0.458
MOD_Plk_1	855	861	PF00069	0.559
MOD_Plk_4	17	23	PF00069	0.667
MOD_Plk_4	27	33	PF00069	0.491
MOD_Plk_4	804	810	PF00069	0.634
MOD_ProDKin_1	1004	1010	PF00069	0.709
MOD_ProDKin_1	1012	1018	PF00069	0.689
MOD_ProDKin_1	1036	1042	PF00069	0.761
MOD_ProDKin_1	1047	1053	PF00069	0.576
MOD_ProDKin_1	758	764	PF00069	0.659
MOD_ProDKin_1	795	801	PF00069	0.634
MOD_ProDKin_1	811	817	PF00069	0.552
MOD_ProDKin_1	880	886	PF00069	0.695
MOD_ProDKin_1	893	899	PF00069	0.539
MOD_ProDKin_1	913	919	PF00069	0.636
MOD_ProDKin_1	930	936	PF00069	0.664
MOD_ProDKin_1	940	946	PF00069	0.550
MOD_ProDKin_1	956	962	PF00069	0.776
MOD_ProDKin_1	968	974	PF00069	0.523
MOD_SUMO_for_1	138	141	PF00179	0.584
MOD_SUMO_for_1	299	302	PF00179	0.521
MOD_SUMO_for_1	366	369	PF00179	0.488
MOD_SUMO_for_1	376	379	PF00179	0.589
MOD_SUMO_for_1	532	535	PF00179	0.527
MOD_SUMO_rev_2	144	154	PF00179	0.500
MOD_SUMO_rev_2	282	287	PF00179	0.421
MOD_SUMO_rev_2	304	313	PF00179	0.506
MOD_SUMO_rev_2	429	435	PF00179	0.455
MOD_SUMO_rev_2	58	67	PF00179	0.368
MOD_SUMO_rev_2	98	106	PF00179	0.500
TRG_DiLeu_BaEn_1	275	280	PF01217	0.354
TRG_DiLeu_BaEn_1	369	374	PF01217	0.355
TRG_DiLeu_BaEn_4	172	178	PF01217	0.533
TRG_DiLeu_BaEn_4	446	452	PF01217	0.515
TRG_DiLeu_BaEn_4	638	644	PF01217	0.559
TRG_DiLeu_BaLyEn_6	777	782	PF01217	0.502
TRG_DiLeu_BaLyEn_6	961	966	PF01217	0.674
TRG_ENDOCYTIC_2	2	5	PF00928	0.554
TRG_ENDOCYTIC_2	42	45	PF00928	0.430
TRG_ENDOCYTIC_2	661	664	PF00928	0.586
TRG_ENDOCYTIC_2	675	678	PF00928	0.649
TRG_ER_diArg_1	125	127	PF00400	0.481
TRG_ER_diArg_1	290	292	PF00400	0.427
TRG_ER_diArg_1	32	34	PF00400	0.445
TRG_ER_diArg_1	426	428	PF00400	0.527
TRG_ER_diArg_1	579	581	PF00400	0.553
TRG_ER_diArg_1	643	645	PF00400	0.595
TRG_ER_diArg_1	69	72	PF00400	0.615
TRG_ER_diArg_1	691	694	PF00400	0.614
TRG_ER_diArg_1	83	86	PF00400	0.535
TRG_NES_CRM1_1	206	217	PF08389	0.537
TRG_NLS_Bipartite_1	485	501	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	406	411	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	592	596	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	743	748	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G2	Leptomonas seymouri	50%	94%
A0A0S4J512	Bodo saltans	25%	100%
A0A3R7M1Y7	Trypanosoma rangeli	29%	100%
A0A3S5H608	Leishmania donovani	72%	97%
A4HTC0	Leishmania infantum	69%	100%
C9ZUJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ALB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	95%
Q4QIJ1	Leishmania major	72%	100%
V5B8B7	Trypanosoma cruzi	28%	99%