Radial spoke protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H541_LEIBR

TriTrypDb:

LbrM.07.0980 , LBRM2903_070018700

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0001534	radial spoke	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

A4H541

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H541

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0003341	cilium movement	4	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0030030	cell projection organization	4	3
GO:0030031	cell projection assembly	5	3
GO:0035082	axoneme assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	3
GO:0060271	cilium assembly	6	3
GO:0060294	cilium movement involved in cell motility	5	3
GO:0070925	organelle assembly	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0120031	plasma membrane bounded cell projection assembly	6	3
GO:0120036	plasma membrane bounded cell projection organization	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.498
CLV_NRD_NRD_1	173	175	PF00675	0.629
CLV_PCSK_KEX2_1	175	177	PF00082	0.520
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.520
CLV_PCSK_SKI1_1	176	180	PF00082	0.655
CLV_PCSK_SKI1_1	207	211	PF00082	0.498
CLV_PCSK_SKI1_1	292	296	PF00082	0.439
DEG_SCF_FBW7_1	125	131	PF00400	0.414
DOC_CKS1_1	125	130	PF01111	0.555
DOC_MAPK_gen_1	174	185	PF00069	0.444
DOC_MAPK_gen_1	34	42	PF00069	0.457
DOC_USP7_MATH_1	66	70	PF00917	0.449
DOC_USP7_UBL2_3	175	179	PF12436	0.493
DOC_WW_Pin1_4	124	129	PF00397	0.591
DOC_WW_Pin1_4	35	40	PF00397	0.445
LIG_14-3-3_CanoR_1	174	183	PF00244	0.595
LIG_14-3-3_CanoR_1	221	226	PF00244	0.535
LIG_BIR_II_1	1	5	PF00653	0.352
LIG_FHA_1	261	267	PF00498	0.385
LIG_FHA_1	283	289	PF00498	0.386
LIG_FHA_2	125	131	PF00498	0.476
LIG_FHA_2	15	21	PF00498	0.495
LIG_LIR_Apic_2	263	268	PF02991	0.460
LIG_LIR_Apic_2	299	305	PF02991	0.323
LIG_LIR_Gen_1	237	245	PF02991	0.334
LIG_LIR_Gen_1	78	85	PF02991	0.543
LIG_LIR_Nem_3	177	183	PF02991	0.368
LIG_LIR_Nem_3	51	56	PF02991	0.337
LIG_LIR_Nem_3	69	73	PF02991	0.374
LIG_LIR_Nem_3	78	82	PF02991	0.409
LIG_Pex14_1	278	282	PF04695	0.323
LIG_Pex14_2	322	326	PF04695	0.411
LIG_PTB_Apo_2	2	9	PF02174	0.420
LIG_PTB_Apo_2	219	226	PF02174	0.385
LIG_PTB_Apo_2	290	297	PF02174	0.311
LIG_PTB_Apo_2	58	65	PF02174	0.502
LIG_PTB_Phospho_1	2	8	PF10480	0.426
LIG_PTB_Phospho_1	290	296	PF10480	0.349
LIG_SH2_CRK	100	104	PF00017	0.417
LIG_SH2_STAP1	106	110	PF00017	0.490
LIG_SH2_STAT5	239	242	PF00017	0.313
LIG_SH2_STAT5	265	268	PF00017	0.479
LIG_SH2_STAT5	314	317	PF00017	0.333
LIG_SH2_STAT5	8	11	PF00017	0.475
LIG_SH3_3	120	126	PF00018	0.582
LIG_SH3_3	165	171	PF00018	0.624
LIG_SH3_5	261	265	PF00018	0.479
LIG_SUMO_SIM_par_1	181	187	PF11976	0.391
LIG_TRAF2_1	158	161	PF00917	0.720
LIG_TYR_ITSM	49	56	PF00017	0.240
MOD_CK1_1	14	20	PF00069	0.492
MOD_CK1_1	69	75	PF00069	0.388
MOD_CK1_1	83	89	PF00069	0.458
MOD_CK2_1	14	20	PF00069	0.353
MOD_CK2_1	155	161	PF00069	0.750
MOD_CK2_1	181	187	PF00069	0.450
MOD_GlcNHglycan	316	319	PF01048	0.436
MOD_GlcNHglycan	82	85	PF01048	0.295
MOD_GSK3_1	124	131	PF00069	0.602
MOD_GSK3_1	44	51	PF00069	0.451
MOD_GSK3_1	7	14	PF00069	0.342
MOD_LATS_1	232	238	PF00433	0.362
MOD_N-GLC_1	11	16	PF02516	0.267
MOD_N-GLC_1	221	226	PF02516	0.512
MOD_N-GLC_1	282	287	PF02516	0.426
MOD_NEK2_1	11	16	PF00069	0.454
MOD_NEK2_1	24	29	PF00069	0.289
MOD_NEK2_1	326	331	PF00069	0.327
MOD_NEK2_2	128	133	PF00069	0.395
MOD_NEK2_2	276	281	PF00069	0.467
MOD_NEK2_2	296	301	PF00069	0.384
MOD_NEK2_2	66	71	PF00069	0.444
MOD_PIKK_1	29	35	PF00454	0.505
MOD_PK_1	181	187	PF00069	0.498
MOD_PKA_1	174	180	PF00069	0.380
MOD_PKA_1	234	240	PF00069	0.469
MOD_PKA_2	220	226	PF00069	0.534
MOD_Plk_1	128	134	PF00069	0.565
MOD_Plk_1	19	25	PF00069	0.435
MOD_Plk_1	221	227	PF00069	0.546
MOD_Plk_2-3	155	161	PF00069	0.619
MOD_Plk_4	296	302	PF00069	0.318
MOD_Plk_4	66	72	PF00069	0.418
MOD_ProDKin_1	124	130	PF00069	0.587
MOD_ProDKin_1	35	41	PF00069	0.443
TRG_DiLeu_BaEn_4	87	93	PF01217	0.451
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.363
TRG_ENDOCYTIC_2	100	103	PF00928	0.502
TRG_ENDOCYTIC_2	239	242	PF00928	0.306
TRG_ENDOCYTIC_2	53	56	PF00928	0.322
TRG_ENDOCYTIC_2	8	11	PF00928	0.487
TRG_ER_diArg_1	108	111	PF00400	0.350
TRG_ER_diArg_1	173	176	PF00400	0.569
TRG_ER_diArg_1	250	253	PF00400	0.395
TRG_NLS_MonoExtN_4	171	178	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E1	Leptomonas seymouri	26%	100%
A0A0N1IL99	Leptomonas seymouri	71%	98%
A0A0S4J8G1	Bodo saltans	40%	100%
A0A1X0NQ76	Trypanosomatidae	48%	100%
A0A1X0P3V0	Trypanosomatidae	26%	100%
A0A3Q8IKD9	Leishmania donovani	24%	100%
A0A3R7MSU5	Trypanosoma rangeli	48%	99%
A0A3S7WQ16	Leishmania donovani	86%	100%
A0A422P0B0	Trypanosoma rangeli	26%	100%
A4HLW1	Leishmania braziliensis	22%	100%
A4HTB7	Leishmania infantum	85%	99%
C9ZUK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHR8	Leishmania infantum	24%	100%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q3T7	Leishmania major	25%	90%
Q4QIJ4	Leishmania major	86%	100%
Q5TYW6	Danio rerio	27%	100%
Q6DFN5	Xenopus tropicalis	24%	100%
Q9D9V4	Mus musculus	25%	100%
Q9H1X1	Homo sapiens	24%	100%
V5B8M6	Trypanosoma cruzi	27%	100%