Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H538_LEIBR

TriTrypDb:

LbrM.07.0950 , LBRM2903_070018300

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H538

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H538

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.529
CLV_C14_Caspase3-7	581	585	PF00656	0.615
CLV_C14_Caspase3-7	690	694	PF00656	0.542
CLV_NRD_NRD_1	135	137	PF00675	0.645
CLV_NRD_NRD_1	178	180	PF00675	0.718
CLV_NRD_NRD_1	300	302	PF00675	0.547
CLV_NRD_NRD_1	409	411	PF00675	0.720
CLV_NRD_NRD_1	494	496	PF00675	0.531
CLV_NRD_NRD_1	57	59	PF00675	0.549
CLV_PCSK_KEX2_1	135	137	PF00082	0.645
CLV_PCSK_KEX2_1	334	336	PF00082	0.502
CLV_PCSK_KEX2_1	408	410	PF00082	0.510
CLV_PCSK_KEX2_1	46	48	PF00082	0.529
CLV_PCSK_KEX2_1	490	492	PF00082	0.518
CLV_PCSK_KEX2_1	517	519	PF00082	0.575
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.502
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.510
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.536
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.518
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.525
CLV_PCSK_SKI1_1	221	225	PF00082	0.549
CLV_PCSK_SKI1_1	335	339	PF00082	0.595
DEG_APCC_DBOX_1	334	342	PF00400	0.501
DEG_SCF_FBW7_1	439	444	PF00400	0.532
DOC_ANK_TNKS_1	708	715	PF00023	0.554
DOC_CYCLIN_RxL_1	123	134	PF00134	0.534
DOC_MAPK_DCC_7	179	189	PF00069	0.547
DOC_MAPK_MEF2A_6	180	189	PF00069	0.545
DOC_MAPK_MEF2A_6	283	290	PF00069	0.642
DOC_MAPK_RevD_3	504	518	PF00069	0.522
DOC_PP1_RVXF_1	506	512	PF00149	0.524
DOC_PP2B_LxvP_1	128	131	PF13499	0.538
DOC_PP2B_LxvP_1	376	379	PF13499	0.519
DOC_USP7_MATH_1	105	109	PF00917	0.535
DOC_USP7_MATH_1	166	170	PF00917	0.548
DOC_USP7_MATH_1	208	212	PF00917	0.723
DOC_USP7_MATH_1	22	26	PF00917	0.545
DOC_USP7_MATH_1	355	359	PF00917	0.603
DOC_USP7_MATH_1	360	364	PF00917	0.628
DOC_USP7_MATH_1	441	445	PF00917	0.533
DOC_USP7_MATH_1	548	552	PF00917	0.625
DOC_USP7_MATH_1	565	569	PF00917	0.575
DOC_USP7_MATH_1	621	625	PF00917	0.708
DOC_USP7_MATH_1	634	638	PF00917	0.548
DOC_USP7_MATH_1	667	671	PF00917	0.593
DOC_USP7_MATH_1	684	688	PF00917	0.641
DOC_USP7_MATH_1	93	97	PF00917	0.544
DOC_USP7_UBL2_3	176	180	PF12436	0.559
DOC_USP7_UBL2_3	513	517	PF12436	0.572
DOC_WW_Pin1_4	114	119	PF00397	0.548
DOC_WW_Pin1_4	262	267	PF00397	0.710
DOC_WW_Pin1_4	353	358	PF00397	0.633
DOC_WW_Pin1_4	365	370	PF00397	0.523
DOC_WW_Pin1_4	437	442	PF00397	0.527
DOC_WW_Pin1_4	459	464	PF00397	0.723
DOC_WW_Pin1_4	468	473	PF00397	0.605
DOC_WW_Pin1_4	477	482	PF00397	0.555
DOC_WW_Pin1_4	563	568	PF00397	0.547
DOC_WW_Pin1_4	653	658	PF00397	0.761
DOC_WW_Pin1_4	699	704	PF00397	0.744
DOC_WW_Pin1_4	708	713	PF00397	0.533
DOC_WW_Pin1_4	8	13	PF00397	0.499
LIG_14-3-3_CanoR_1	111	116	PF00244	0.597
LIG_14-3-3_CanoR_1	179	184	PF00244	0.549
LIG_14-3-3_CanoR_1	248	255	PF00244	0.619
LIG_14-3-3_CanoR_1	301	305	PF00244	0.661
LIG_14-3-3_CanoR_1	310	316	PF00244	0.578
LIG_14-3-3_CanoR_1	32	37	PF00244	0.505
LIG_14-3-3_CanoR_1	442	446	PF00244	0.593
LIG_14-3-3_CanoR_1	47	51	PF00244	0.587
LIG_14-3-3_CanoR_1	495	504	PF00244	0.535
LIG_14-3-3_CanoR_1	97	103	PF00244	0.604
LIG_Actin_WH2_2	645	662	PF00022	0.533
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	163	167	PF00533	0.533
LIG_BRCT_BRCA1_1	44	48	PF00533	0.517
LIG_eIF4E_1	336	342	PF01652	0.501
LIG_EVH1_2	118	122	PF00568	0.534
LIG_FHA_1	184	190	PF00498	0.542
LIG_FHA_1	215	221	PF00498	0.547
LIG_FHA_1	269	275	PF00498	0.576
LIG_FHA_2	618	624	PF00498	0.709
LIG_FHA_2	664	670	PF00498	0.563
LIG_FHA_2	82	88	PF00498	0.544
LIG_LIR_Apic_2	606	612	PF02991	0.549
LIG_LIR_Apic_2	99	105	PF02991	0.559
LIG_LIR_Gen_1	346	355	PF02991	0.523
LIG_LIR_Gen_1	368	379	PF02991	0.530
LIG_LIR_LC3C_4	429	434	PF02991	0.532
LIG_LIR_Nem_3	31	36	PF02991	0.504
LIG_LIR_Nem_3	346	351	PF02991	0.536
LIG_LIR_Nem_3	368	374	PF02991	0.540
LIG_LIR_Nem_3	471	476	PF02991	0.517
LIG_LIR_Nem_3	5	9	PF02991	0.498
LIG_LIR_Nem_3	510	514	PF02991	0.531
LIG_SH2_CRK	6	10	PF00017	0.501
LIG_SH2_SRC	602	605	PF00017	0.556
LIG_SH2_STAT3	502	505	PF00017	0.533
LIG_SH2_STAT5	127	130	PF00017	0.536
LIG_SH2_STAT5	297	300	PF00017	0.543
LIG_SH2_STAT5	476	479	PF00017	0.517
LIG_SH2_STAT5	529	532	PF00017	0.647
LIG_SH2_STAT5	602	605	PF00017	0.685
LIG_SH3_1	577	583	PF00018	0.551
LIG_SH3_1	709	715	PF00018	0.555
LIG_SH3_3	229	235	PF00018	0.526
LIG_SH3_3	260	266	PF00018	0.546
LIG_SH3_3	354	360	PF00018	0.580
LIG_SH3_3	501	507	PF00018	0.521
LIG_SH3_3	577	583	PF00018	0.617
LIG_SH3_3	709	715	PF00018	0.548
LIG_SUMO_SIM_anti_2	284	292	PF11976	0.515
LIG_SUMO_SIM_anti_2	480	487	PF11976	0.508
LIG_SUMO_SIM_par_1	185	191	PF11976	0.542
LIG_SUMO_SIM_par_1	265	271	PF11976	0.565
LIG_TRAF2_1	149	152	PF00917	0.558
LIG_TRAF2_1	305	308	PF00917	0.542
LIG_TYR_ITIM	125	130	PF00017	0.520
LIG_WRC_WIRS_1	348	353	PF05994	0.522
MOD_CAAXbox	730	733	PF01239	0.564
MOD_CDK_SPK_2	437	442	PF00069	0.527
MOD_CDK_SPxxK_3	563	570	PF00069	0.552
MOD_CDK_SPxxK_3	653	660	PF00069	0.532
MOD_CDK_SPxxK_3	699	706	PF00069	0.535
MOD_CK1_1	114	120	PF00069	0.501
MOD_CK1_1	175	181	PF00069	0.555
MOD_CK1_1	2	8	PF00069	0.495
MOD_CK1_1	204	210	PF00069	0.583
MOD_CK1_1	21	27	PF00069	0.475
MOD_CK1_1	284	290	PF00069	0.729
MOD_CK1_1	291	297	PF00069	0.616
MOD_CK1_1	300	306	PF00069	0.692
MOD_CK1_1	428	434	PF00069	0.637
MOD_CK1_1	544	550	PF00069	0.637
MOD_CK1_1	559	565	PF00069	0.559
MOD_CK1_1	568	574	PF00069	0.665
MOD_CK1_1	661	667	PF00069	0.724
MOD_CK1_1	680	686	PF00069	0.569
MOD_CK1_1	687	693	PF00069	0.539
MOD_CK1_1	81	87	PF00069	0.687
MOD_CK1_1	96	102	PF00069	0.709
MOD_CK2_1	146	152	PF00069	0.558
MOD_CK2_1	22	28	PF00069	0.512
MOD_CK2_1	353	359	PF00069	0.539
MOD_CK2_1	621	627	PF00069	0.545
MOD_CK2_1	663	669	PF00069	0.547
MOD_CK2_1	699	705	PF00069	0.619
MOD_CK2_1	81	87	PF00069	0.544
MOD_GlcNHglycan	152	155	PF01048	0.541
MOD_GlcNHglycan	20	23	PF01048	0.482
MOD_GlcNHglycan	206	209	PF01048	0.540
MOD_GlcNHglycan	212	215	PF01048	0.556
MOD_GlcNHglycan	294	297	PF01048	0.561
MOD_GlcNHglycan	312	315	PF01048	0.612
MOD_GlcNHglycan	419	422	PF01048	0.545
MOD_GlcNHglycan	546	549	PF01048	0.572
MOD_GlcNHglycan	550	553	PF01048	0.604
MOD_GlcNHglycan	6	9	PF01048	0.497
MOD_GlcNHglycan	636	639	PF01048	0.744
MOD_GlcNHglycan	640	644	PF01048	0.543
MOD_GlcNHglycan	663	666	PF01048	0.600
MOD_GlcNHglycan	679	682	PF01048	0.635
MOD_GlcNHglycan	693	696	PF01048	0.649
MOD_GlcNHglycan	75	78	PF01048	0.562
MOD_GlcNHglycan	80	83	PF01048	0.536
MOD_GSK3_1	106	113	PF00069	0.640
MOD_GSK3_1	142	149	PF00069	0.562
MOD_GSK3_1	175	182	PF00069	0.678
MOD_GSK3_1	18	25	PF00069	0.489
MOD_GSK3_1	183	190	PF00069	0.703
MOD_GSK3_1	197	204	PF00069	0.605
MOD_GSK3_1	208	215	PF00069	0.593
MOD_GSK3_1	28	35	PF00069	0.474
MOD_GSK3_1	284	291	PF00069	0.700
MOD_GSK3_1	292	299	PF00069	0.723
MOD_GSK3_1	343	350	PF00069	0.540
MOD_GSK3_1	361	368	PF00069	0.631
MOD_GSK3_1	4	11	PF00069	0.498
MOD_GSK3_1	42	49	PF00069	0.503
MOD_GSK3_1	433	440	PF00069	0.529
MOD_GSK3_1	486	493	PF00069	0.669
MOD_GSK3_1	543	550	PF00069	0.742
MOD_GSK3_1	557	564	PF00069	0.568
MOD_GSK3_1	603	610	PF00069	0.784
MOD_GSK3_1	617	624	PF00069	0.605
MOD_GSK3_1	625	632	PF00069	0.527
MOD_GSK3_1	663	670	PF00069	0.612
MOD_GSK3_1	680	687	PF00069	0.544
MOD_GSK3_1	704	711	PF00069	0.670
MOD_GSK3_1	78	85	PF00069	0.691
MOD_GSK3_1	89	96	PF00069	0.586
MOD_N-GLC_1	221	226	PF02516	0.574
MOD_N-GLC_1	246	251	PF02516	0.531
MOD_N-GLC_1	82	87	PF02516	0.677
MOD_NEK2_1	100	105	PF00069	0.674
MOD_NEK2_1	106	111	PF00069	0.610
MOD_NEK2_1	150	155	PF00069	0.555
MOD_NEK2_1	172	177	PF00069	0.650
MOD_NEK2_1	201	206	PF00069	0.619
MOD_NEK2_1	212	217	PF00069	0.495
MOD_NEK2_1	267	272	PF00069	0.517
MOD_NEK2_1	343	348	PF00069	0.555
MOD_NEK2_1	412	417	PF00069	0.521
MOD_NEK2_1	486	491	PF00069	0.512
MOD_NEK2_1	542	547	PF00069	0.549
MOD_NEK2_1	554	559	PF00069	0.517
MOD_NEK2_1	607	612	PF00069	0.685
MOD_NEK2_1	691	696	PF00069	0.598
MOD_NEK2_1	78	83	PF00069	0.567
MOD_NEK2_2	214	219	PF00069	0.606
MOD_PIKK_1	106	112	PF00454	0.626
MOD_PIKK_1	161	167	PF00454	0.571
MOD_PIKK_1	179	185	PF00454	0.540
MOD_PIKK_1	248	254	PF00454	0.548
MOD_PIKK_1	300	306	PF00454	0.548
MOD_PIKK_1	343	349	PF00454	0.507
MOD_PIKK_1	433	439	PF00454	0.558
MOD_PIKK_1	684	690	PF00454	0.541
MOD_PKA_1	179	185	PF00069	0.548
MOD_PKA_1	46	52	PF00069	0.533
MOD_PKA_1	490	496	PF00069	0.520
MOD_PKA_2	110	116	PF00069	0.547
MOD_PKA_2	134	140	PF00069	0.550
MOD_PKA_2	300	306	PF00069	0.541
MOD_PKA_2	309	315	PF00069	0.549
MOD_PKA_2	441	447	PF00069	0.639
MOD_PKA_2	46	52	PF00069	0.630
MOD_PKA_2	490	496	PF00069	0.579
MOD_PKA_2	646	652	PF00069	0.631
MOD_PKA_2	667	673	PF00069	0.581
MOD_PKA_2	691	697	PF00069	0.577
MOD_PKA_2	78	84	PF00069	0.608
MOD_PKA_2	96	102	PF00069	0.518
MOD_PKB_1	159	167	PF00069	0.538
MOD_PKB_1	52	60	PF00069	0.530
MOD_Plk_1	246	252	PF00069	0.532
MOD_Plk_1	284	290	PF00069	0.628
MOD_Plk_1	554	560	PF00069	0.615
MOD_Plk_2-3	134	140	PF00069	0.550
MOD_Plk_4	183	189	PF00069	0.544
MOD_Plk_4	197	203	PF00069	0.498
MOD_Plk_4	284	290	PF00069	0.641
MOD_Plk_4	381	387	PF00069	0.537
MOD_Plk_4	428	434	PF00069	0.529
MOD_Plk_4	480	486	PF00069	0.509
MOD_ProDKin_1	114	120	PF00069	0.548
MOD_ProDKin_1	262	268	PF00069	0.710
MOD_ProDKin_1	353	359	PF00069	0.636
MOD_ProDKin_1	365	371	PF00069	0.524
MOD_ProDKin_1	437	443	PF00069	0.531
MOD_ProDKin_1	459	465	PF00069	0.721
MOD_ProDKin_1	468	474	PF00069	0.602
MOD_ProDKin_1	477	483	PF00069	0.554
MOD_ProDKin_1	563	569	PF00069	0.548
MOD_ProDKin_1	653	659	PF00069	0.760
MOD_ProDKin_1	699	705	PF00069	0.743
MOD_ProDKin_1	708	714	PF00069	0.532
MOD_ProDKin_1	8	14	PF00069	0.501
MOD_SUMO_for_1	516	519	PF00179	0.532
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.512
TRG_ENDOCYTIC_2	127	130	PF00928	0.536
TRG_ENDOCYTIC_2	348	351	PF00928	0.516
TRG_ENDOCYTIC_2	6	9	PF00928	0.497
TRG_ER_diArg_1	409	411	PF00400	0.581
TRG_ER_diArg_1	52	55	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q6	Leptomonas seymouri	26%	100%
A0A3S7WQ13	Leishmania donovani	26%	100%
A4HTE6	Leishmania infantum	26%	100%
Q4QIJ8	Leishmania major	25%	86%