Splicing factor ptsr1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor ptsr1-like protein

Species:

Leishmania braziliensis

UniProt:

A4H537_LEIBR

TriTrypDb:

LbrM.07.0940 , LBRM2903_070017900

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H537

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H537

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.603
CLV_NRD_NRD_1	156	158	PF00675	0.706
CLV_NRD_NRD_1	211	213	PF00675	0.596
CLV_NRD_NRD_1	251	253	PF00675	0.701
CLV_NRD_NRD_1	268	270	PF00675	0.601
CLV_NRD_NRD_1	283	285	PF00675	0.630
CLV_NRD_NRD_1	298	300	PF00675	0.644
CLV_NRD_NRD_1	322	324	PF00675	0.797
CLV_NRD_NRD_1	335	337	PF00675	0.638
CLV_NRD_NRD_1	338	340	PF00675	0.608
CLV_NRD_NRD_1	348	350	PF00675	0.798
CLV_NRD_NRD_1	359	361	PF00675	0.776
CLV_NRD_NRD_1	362	364	PF00675	0.738
CLV_NRD_NRD_1	367	369	PF00675	0.581
CLV_NRD_NRD_1	372	374	PF00675	0.726
CLV_PCSK_FUR_1	296	300	PF00082	0.798
CLV_PCSK_FUR_1	320	324	PF00082	0.798
CLV_PCSK_FUR_1	333	337	PF00082	0.639
CLV_PCSK_FUR_1	360	364	PF00082	0.770
CLV_PCSK_KEX2_1	156	158	PF00082	0.706
CLV_PCSK_KEX2_1	211	213	PF00082	0.596
CLV_PCSK_KEX2_1	227	229	PF00082	0.436
CLV_PCSK_KEX2_1	253	255	PF00082	0.744
CLV_PCSK_KEX2_1	268	270	PF00082	0.622
CLV_PCSK_KEX2_1	282	284	PF00082	0.646
CLV_PCSK_KEX2_1	298	300	PF00082	0.678
CLV_PCSK_KEX2_1	322	324	PF00082	0.797
CLV_PCSK_KEX2_1	335	337	PF00082	0.638
CLV_PCSK_KEX2_1	338	340	PF00082	0.608
CLV_PCSK_KEX2_1	348	350	PF00082	0.790
CLV_PCSK_KEX2_1	359	361	PF00082	0.776
CLV_PCSK_KEX2_1	362	364	PF00082	0.738
CLV_PCSK_KEX2_1	367	369	PF00082	0.581
CLV_PCSK_KEX2_1	372	374	PF00082	0.726
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.695
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.468
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.744
CLV_PCSK_PC7_1	264	270	PF00082	0.777
CLV_PCSK_PC7_1	279	285	PF00082	0.622
CLV_PCSK_PC7_1	355	361	PF00082	0.782
CLV_PCSK_PC7_1	363	369	PF00082	0.684
CLV_PCSK_SKI1_1	110	114	PF00082	0.567
CLV_PCSK_SKI1_1	178	182	PF00082	0.567
CLV_PCSK_SKI1_1	81	85	PF00082	0.611
DEG_APCC_KENBOX_2	152	156	PF00400	0.682
DEG_SPOP_SBC_1	114	118	PF00917	0.556
DOC_CYCLIN_yClb5_NLxxxL_5	123	129	PF00134	0.425
DOC_MAPK_gen_1	135	142	PF00069	0.596
DOC_MAPK_gen_1	208	218	PF00069	0.476
DOC_MAPK_MEF2A_6	135	144	PF00069	0.598
DOC_MAPK_MEF2A_6	211	220	PF00069	0.472
DOC_MAPK_MEF2A_6	67	76	PF00069	0.604
DOC_USP7_MATH_1	11	15	PF00917	0.788
DOC_USP7_MATH_1	19	23	PF00917	0.665
DOC_USP7_MATH_1	202	206	PF00917	0.570
DOC_USP7_MATH_1	53	57	PF00917	0.722
DOC_WW_Pin1_4	256	261	PF00397	0.822
DOC_WW_Pin1_4	299	304	PF00397	0.795
DOC_WW_Pin1_4	323	328	PF00397	0.805
DOC_WW_Pin1_4	51	56	PF00397	0.783
LIG_14-3-3_CanoR_1	23	31	PF00244	0.783
LIG_14-3-3_CanoR_1	282	290	PF00244	0.674
LIG_14-3-3_CanoR_1	296	302	PF00244	0.847
LIG_14-3-3_CanoR_1	306	312	PF00244	0.838
LIG_14-3-3_CanoR_1	320	326	PF00244	0.585
LIG_14-3-3_CanoR_1	81	86	PF00244	0.612
LIG_BIR_II_1	1	5	PF00653	0.765
LIG_FHA_1	114	120	PF00498	0.570
LIG_FHA_1	163	169	PF00498	0.607
LIG_FHA_1	224	230	PF00498	0.594
LIG_FHA_1	80	86	PF00498	0.597
LIG_FHA_1	87	93	PF00498	0.512
LIG_FHA_2	115	121	PF00498	0.582
LIG_FHA_2	146	152	PF00498	0.671
LIG_FHA_2	205	211	PF00498	0.459
LIG_FHA_2	38	44	PF00498	0.769
LIG_FHA_2	82	88	PF00498	0.596
LIG_GBD_Chelix_1	229	237	PF00786	0.601
LIG_NRP_CendR_1	373	376	PF00754	0.743
LIG_PTB_Apo_2	128	135	PF02174	0.585
LIG_PTB_Phospho_1	128	134	PF10480	0.568
LIG_SH2_GRB2like	173	176	PF00017	0.632
LIG_SH2_NCK_1	325	329	PF00017	0.630
LIG_SH2_PTP2	217	220	PF00017	0.452
LIG_SH2_SRC	173	176	PF00017	0.469
LIG_SH2_SRC	217	220	PF00017	0.552
LIG_SH2_STAT5	173	176	PF00017	0.632
LIG_SH2_STAT5	214	217	PF00017	0.572
LIG_SH2_STAT5	301	304	PF00017	0.790
LIG_SH2_STAT5	91	94	PF00017	0.663
LIG_SH3_2	62	67	PF14604	0.744
LIG_SH3_3	215	221	PF00018	0.459
LIG_SH3_3	59	65	PF00018	0.762
LIG_SUMO_SIM_par_1	81	87	PF11976	0.584
LIG_TRAF2_1	118	121	PF00917	0.674
MOD_CDC14_SPxK_1	259	262	PF00782	0.771
MOD_CDK_SPxK_1	256	262	PF00069	0.751
MOD_CDK_SPxxK_3	299	306	PF00069	0.796
MOD_CK1_1	145	151	PF00069	0.659
MOD_CK1_1	22	28	PF00069	0.875
MOD_CK1_1	297	303	PF00069	0.826
MOD_CK1_1	304	310	PF00069	0.843
MOD_CK1_1	312	318	PF00069	0.687
MOD_CK1_1	326	332	PF00069	0.622
MOD_CK2_1	114	120	PF00069	0.631
MOD_CK2_1	145	151	PF00069	0.654
MOD_CK2_1	195	201	PF00069	0.587
MOD_CK2_1	204	210	PF00069	0.517
MOD_CK2_1	81	87	PF00069	0.615
MOD_Cter_Amidation	320	323	PF01082	0.802
MOD_DYRK1A_RPxSP_1	299	303	PF00069	0.793
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.792
MOD_GlcNHglycan	13	16	PF01048	0.710
MOD_GlcNHglycan	17	20	PF01048	0.629
MOD_GlcNHglycan	221	224	PF01048	0.435
MOD_GlcNHglycan	43	46	PF01048	0.831
MOD_GlcNHglycan	7	10	PF01048	0.770
MOD_GSK3_1	1	8	PF00069	0.811
MOD_GSK3_1	17	24	PF00069	0.632
MOD_GSK3_1	219	226	PF00069	0.633
MOD_GSK3_1	297	304	PF00069	0.794
MOD_GSK3_1	305	312	PF00069	0.797
MOD_GSK3_1	37	44	PF00069	0.683
MOD_GSK3_1	79	86	PF00069	0.619
MOD_GSK3_1	9	16	PF00069	0.724
MOD_LATS_1	280	286	PF00433	0.784
MOD_N-GLC_1	41	46	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.794
MOD_NEK2_1	113	118	PF00069	0.558
MOD_PKA_1	282	288	PF00069	0.785
MOD_PKA_2	162	168	PF00069	0.778
MOD_PKA_2	22	28	PF00069	0.856
MOD_PKA_2	275	281	PF00069	0.767
MOD_PKA_2	282	288	PF00069	0.719
MOD_PKA_2	297	303	PF00069	0.650
MOD_PKA_2	305	311	PF00069	0.838
MOD_PKA_2	321	327	PF00069	0.794
MOD_PKA_2	361	367	PF00069	0.647
MOD_PKB_1	282	290	PF00069	0.783
MOD_PKB_1	314	322	PF00069	0.795
MOD_Plk_1	114	120	PF00069	0.615
MOD_Plk_1	168	174	PF00069	0.511
MOD_Plk_2-3	115	121	PF00069	0.571
MOD_Plk_2-3	361	367	PF00069	0.607
MOD_Plk_4	68	74	PF00069	0.616
MOD_ProDKin_1	256	262	PF00069	0.824
MOD_ProDKin_1	299	305	PF00069	0.794
MOD_ProDKin_1	323	329	PF00069	0.806
MOD_ProDKin_1	51	57	PF00069	0.784
MOD_SUMO_rev_2	219	229	PF00179	0.448
TRG_DiLeu_BaEn_1	121	126	PF01217	0.680
TRG_ENDOCYTIC_2	217	220	PF00928	0.552
TRG_ER_diArg_1	105	108	PF00400	0.590
TRG_ER_diArg_1	251	254	PF00400	0.714
TRG_ER_diArg_1	267	269	PF00400	0.614
TRG_ER_diArg_1	281	284	PF00400	0.641
TRG_ER_diArg_1	290	293	PF00400	0.688
TRG_ER_diArg_1	296	299	PF00400	0.646
TRG_ER_diArg_1	320	323	PF00400	0.802
TRG_ER_diArg_1	335	338	PF00400	0.617
TRG_ER_diArg_1	372	375	PF00400	0.737
TRG_NLS_MonoCore_2	155	160	PF00514	0.696
TRG_NLS_MonoExtC_3	155	161	PF00514	0.696
TRG_NLS_MonoExtN_4	153	160	PF00514	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPZ1	Leishmania donovani	80%	100%
A4HTB3	Leishmania infantum	80%	100%
E9ALA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QIK0	Leishmania major	82%	100%