Putative ubiquitin-protein ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-protein ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4H533_LEIBR

TriTrypDb:

LbrM.07.0900 , LBRM2903_070017100

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H533

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H533

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016740	transferase activity	2	11
GO:0016874	ligase activity	2	8
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	115	117	PF00082	0.403
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.396
CLV_PCSK_SKI1_1	10	14	PF00082	0.530
CLV_PCSK_SKI1_1	128	132	PF00082	0.304
CLV_PCSK_SKI1_1	74	78	PF00082	0.340
CLV_PCSK_SKI1_1	89	93	PF00082	0.256
DEG_APCC_DBOX_1	127	135	PF00400	0.326
DOC_CKS1_1	64	69	PF01111	0.271
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.396
DOC_MAPK_gen_1	72	79	PF00069	0.171
DOC_MAPK_MEF2A_6	72	79	PF00069	0.286
DOC_MAPK_MEF2A_6	95	103	PF00069	0.256
DOC_MAPK_NFAT4_5	72	80	PF00069	0.286
DOC_PP2B_LxvP_1	77	80	PF13499	0.256
DOC_PP2B_LxvP_1	85	88	PF13499	0.256
DOC_USP7_MATH_1	36	40	PF00917	0.665
DOC_USP7_MATH_1	44	48	PF00917	0.171
DOC_WW_Pin1_4	115	120	PF00397	0.256
DOC_WW_Pin1_4	138	143	PF00397	0.280
DOC_WW_Pin1_4	63	68	PF00397	0.271
LIG_14-3-3_CanoR_1	38	45	PF00244	0.260
LIG_FHA_1	103	109	PF00498	0.283
LIG_FHA_2	64	70	PF00498	0.193
LIG_LIR_Gen_1	157	167	PF02991	0.291
LIG_LIR_Gen_1	55	64	PF02991	0.274
LIG_LIR_Nem_3	157	162	PF02991	0.291
LIG_LIR_Nem_3	55	59	PF02991	0.274
LIG_LIR_Nem_3	82	86	PF02991	0.241
LIG_LYPXL_yS_3	83	86	PF13949	0.256
LIG_PCNA_yPIPBox_3	50	61	PF02747	0.345
LIG_SH2_CRK	159	163	PF00017	0.281
LIG_SH2_CRK	73	77	PF00017	0.291
LIG_SH2_SRC	28	31	PF00017	0.601
LIG_SH2_STAP1	159	163	PF00017	0.291
LIG_SH2_STAP1	54	58	PF00017	0.346
LIG_SH3_1	61	67	PF00018	0.316
LIG_SH3_2	84	89	PF14604	0.349
LIG_SH3_3	61	67	PF00018	0.271
LIG_SH3_3	81	87	PF00018	0.286
LIG_SH3_3	93	99	PF00018	0.286
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.346
LIG_TRFH_1	83	87	PF08558	0.396
LIG_TYR_ITIM	163	168	PF00017	0.346
MOD_CK2_1	63	69	PF00069	0.216
MOD_GSK3_1	115	122	PF00069	0.263
MOD_N-GLC_2	107	109	PF02516	0.396
MOD_NEK2_1	45	50	PF00069	0.196
MOD_NEK2_1	75	80	PF00069	0.398
MOD_PIKK_1	37	43	PF00454	0.346
MOD_PIKK_1	45	51	PF00454	0.395
MOD_PKA_2	37	43	PF00069	0.354
MOD_Plk_4	158	164	PF00069	0.291
MOD_Plk_4	52	58	PF00069	0.381
MOD_ProDKin_1	115	121	PF00069	0.256
MOD_ProDKin_1	138	144	PF00069	0.280
MOD_ProDKin_1	63	69	PF00069	0.271
TRG_ENDOCYTIC_2	159	162	PF00928	0.265
TRG_ENDOCYTIC_2	165	168	PF00928	0.505
TRG_ENDOCYTIC_2	54	57	PF00928	0.396
TRG_ENDOCYTIC_2	73	76	PF00928	0.271
TRG_ENDOCYTIC_2	83	86	PF00928	0.233
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R4	Leptomonas seymouri	79%	99%
A0A0N1HXA7	Leptomonas seymouri	33%	67%
A0A0N1I1Z1	Leptomonas seymouri	42%	100%
A0A0N1PB60	Leptomonas seymouri	36%	100%
A0A0S4IWQ9	Bodo saltans	29%	93%
A0A0S4JQY0	Bodo saltans	41%	85%
A0A0S4JRZ8	Bodo saltans	35%	100%
A0A0S4JS17	Bodo saltans	35%	100%
A0A0S4KIJ1	Bodo saltans	59%	100%
A0A0S4KIJ6	Bodo saltans	29%	73%
A0A0S4KJ33	Bodo saltans	36%	100%
A0A1X0NPI5	Trypanosomatidae	60%	100%
A0A1X0NT81	Trypanosomatidae	38%	86%
A0A1X0PAA1	Trypanosomatidae	31%	77%
A0A3Q8II46	Leishmania donovani	37%	100%
A0A3S5H5C0	Leishmania donovani	37%	100%
A0A3S5H604	Leishmania donovani	92%	99%
A0A3S7WYK3	Leishmania donovani	43%	100%
A0A422MVJ2	Trypanosoma rangeli	37%	100%
A0A422MY24	Trypanosoma rangeli	61%	100%
A0A422NKC5	Trypanosoma rangeli	36%	76%
A0A422NWQ7	Trypanosoma rangeli	39%	100%
A0A451EJH5	Leishmania donovani	37%	100%
A1L3K1	Xenopus laevis	36%	81%
A4H402	Leishmania braziliensis	38%	100%
A4H861	Leishmania braziliensis	41%	75%
A4HDS4	Leishmania braziliensis	43%	100%
A4HLY8	Leishmania braziliensis	43%	100%
A4HRN6	Leishmania infantum	37%	100%
A4HS64	Leishmania infantum	37%	100%
A4HTB1	Leishmania infantum	92%	99%
A4I122	Leishmania infantum	43%	100%
A4IB24	Leishmania infantum	37%	100%
A5PJC4	Bos taurus	31%	100%
B5DFI8	Rattus norvegicus	36%	81%
C9ZJ18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
C9ZJA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	72%
C9ZMR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZMW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	82%
C9ZMZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZUL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
C9ZW85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACB4	Leishmania major	37%	100%
E9AJK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AK51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ALA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9AX59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B4B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	75%
E9B609	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
O00102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O00103	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O42646	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	79%
O60015	Pichia angusta	42%	96%
O74810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	83%
P0C8G3	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	35%	83%
P0C8G4	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	35%	83%
P0C8G5	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	34%	81%
P21734	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	84%
P23566	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P25868	Triticum aestivum	30%	100%
P25869	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	35%	85%
P27949	African swine fever virus (strain Badajoz 1971 Vero-adapted)	35%	84%
P29340	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	98%
P33296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	72%
P34477	Caenorhabditis elegans	35%	100%
P40984	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P42747	Arabidopsis thaliana	32%	100%
P49427	Homo sapiens	32%	76%
P49428	Komagataella pastoris	36%	88%
P52484	Caenorhabditis elegans	32%	84%
P52485	Drosophila melanogaster	35%	78%
P56616	Xenopus laevis	34%	100%
P60604	Homo sapiens	33%	100%
P60605	Mus musculus	33%	100%
P62837	Homo sapiens	37%	100%
P62838	Mus musculus	37%	100%
P62839	Rattus norvegicus	37%	100%
P62840	Xenopus laevis	37%	100%
P70711	Rattus norvegicus	37%	100%
Q02159	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q06AA9	Sus scrofa	36%	100%
Q16763	Homo sapiens	36%	81%
Q17QG5	Bos taurus	34%	100%
Q1RMX2	Bos taurus	37%	100%
Q29503	Oryctolagus cuniculus	31%	76%
Q4Q3Q8	Leishmania major	34%	74%
Q4QAB7	Leishmania major	43%	100%
Q4QIK2	Leishmania major	93%	100%
Q5JXB2	Homo sapiens	32%	100%
Q5RF84	Pongo abelii	33%	100%
Q5UQC9	Acanthamoeba polyphaga mimivirus	32%	100%
Q5ZKX6	Gallus gallus	28%	97%
Q6BYG4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	74%
Q6FQK7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	73%
Q6ZWY6	Mus musculus	37%	100%
Q6ZWZ2	Mus musculus	31%	76%
Q712K3	Homo sapiens	31%	76%
Q74Z34	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	74%
Q86IZ3	Dictyostelium discoideum	54%	100%
Q8CFI2	Mus musculus	32%	77%
Q8LGF7	Arabidopsis thaliana	48%	100%
Q921J4	Mus musculus	36%	81%
Q94A97	Arabidopsis thaliana	34%	100%
Q95017	Caenorhabditis elegans	32%	100%
Q9C9Y7	Arabidopsis thaliana	32%	100%
Q9FF66	Arabidopsis thaliana	33%	72%
Q9FI61	Arabidopsis thaliana	33%	94%
Q9FZ48	Arabidopsis thaliana	34%	100%
Q9GNC1	Leishmania major	37%	99%
Q9NED4	Leishmania major	37%	100%
Q9P6I1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
Q9SLE4	Arabidopsis thaliana	34%	100%
Q9UTN8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q9VTY6	Drosophila melanogaster	34%	100%
Q9Y818	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
V5BVS1	Trypanosoma cruzi	37%	81%
V5BYE2	Trypanosoma cruzi	65%	100%