J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H530_LEIBR

TriTrypDb:

LbrM.07.0860 , LBRM2903_070015900

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H530

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H530

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.737
CLV_NRD_NRD_1	16	18	PF00675	0.586
CLV_NRD_NRD_1	23	25	PF00675	0.545
CLV_NRD_NRD_1	294	296	PF00675	0.390
CLV_NRD_NRD_1	347	349	PF00675	0.434
CLV_NRD_NRD_1	354	356	PF00675	0.401
CLV_NRD_NRD_1	434	436	PF00675	0.514
CLV_NRD_NRD_1	49	51	PF00675	0.397
CLV_PCSK_FUR_1	292	296	PF00082	0.446
CLV_PCSK_KEX2_1	108	110	PF00082	0.737
CLV_PCSK_KEX2_1	16	18	PF00082	0.582
CLV_PCSK_KEX2_1	23	25	PF00082	0.516
CLV_PCSK_KEX2_1	294	296	PF00082	0.381
CLV_PCSK_KEX2_1	327	329	PF00082	0.429
CLV_PCSK_KEX2_1	346	348	PF00082	0.330
CLV_PCSK_KEX2_1	353	355	PF00082	0.447
CLV_PCSK_KEX2_1	49	51	PF00082	0.478
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.508
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.478
CLV_PCSK_SKI1_1	324	328	PF00082	0.450
CLV_PCSK_SKI1_1	46	50	PF00082	0.415
DEG_SPOP_SBC_1	390	394	PF00917	0.689
DOC_ANK_TNKS_1	110	117	PF00023	0.443
DOC_MAPK_gen_1	346	352	PF00069	0.622
DOC_PP4_FxxP_1	337	340	PF00568	0.584
DOC_USP7_MATH_1	126	130	PF00917	0.408
DOC_USP7_MATH_1	150	154	PF00917	0.448
DOC_USP7_MATH_1	176	180	PF00917	0.442
DOC_USP7_MATH_1	390	394	PF00917	0.733
DOC_USP7_MATH_1	396	400	PF00917	0.717
DOC_WW_Pin1_4	2	7	PF00397	0.462
DOC_WW_Pin1_4	279	284	PF00397	0.700
DOC_WW_Pin1_4	360	365	PF00397	0.750
LIG_14-3-3_CanoR_1	16	25	PF00244	0.385
LIG_14-3-3_CanoR_1	191	201	PF00244	0.339
LIG_14-3-3_CanoR_1	72	76	PF00244	0.229
LIG_14-3-3_CterR_2	435	439	PF00244	0.718
LIG_BIR_II_1	1	5	PF00653	0.347
LIG_BIR_III_4	62	66	PF00653	0.215
LIG_BRCT_BRCA1_1	168	172	PF00533	0.481
LIG_BRCT_BRCA1_1	211	215	PF00533	0.425
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.566
LIG_EH_1	174	178	PF12763	0.420
LIG_EH_1	180	184	PF12763	0.395
LIG_EVH1_2	114	118	PF00568	0.446
LIG_FHA_1	211	217	PF00498	0.476
LIG_FHA_1	386	392	PF00498	0.599
LIG_FHA_2	24	30	PF00498	0.311
LIG_FHA_2	82	88	PF00498	0.272
LIG_LIR_Gen_1	212	222	PF02991	0.277
LIG_LIR_Gen_1	26	34	PF02991	0.312
LIG_LIR_Gen_1	74	83	PF02991	0.238
LIG_LIR_Nem_3	212	218	PF02991	0.277
LIG_LIR_Nem_3	26	30	PF02991	0.323
LIG_LIR_Nem_3	74	80	PF02991	0.238
LIG_PTB_Apo_2	171	178	PF02174	0.412
LIG_RPA_C_Fungi	342	354	PF08784	0.452
LIG_SH2_CRK	120	124	PF00017	0.584
LIG_SH2_GRB2like	159	162	PF00017	0.608
LIG_SH2_NCK_1	120	124	PF00017	0.675
LIG_SH2_NCK_1	186	190	PF00017	0.580
LIG_SH2_NCK_1	267	271	PF00017	0.409
LIG_SH2_STAP1	267	271	PF00017	0.409
LIG_SH2_STAT3	138	141	PF00017	0.565
LIG_SH2_STAT3	290	293	PF00017	0.614
LIG_SH2_STAT5	208	211	PF00017	0.288
LIG_SH2_STAT5	278	281	PF00017	0.663
LIG_SH3_1	109	115	PF00018	0.764
LIG_SH3_1	120	126	PF00018	0.487
LIG_SH3_3	109	115	PF00018	0.764
LIG_SH3_3	120	126	PF00018	0.487
LIG_SH3_3	398	404	PF00018	0.756
LIG_SH3_3	410	416	PF00018	0.651
LIG_SUMO_SIM_anti_2	32	38	PF11976	0.303
LIG_SUMO_SIM_par_1	35	40	PF11976	0.282
LIG_TRAF2_1	418	421	PF00917	0.658
LIG_TYR_ITIM	206	211	PF00017	0.323
LIG_TYR_ITIM	75	80	PF00017	0.243
LIG_UBA3_1	430	436	PF00899	0.609
MOD_CDK_SPK_2	279	284	PF00069	0.406
MOD_CDK_SPxxK_3	279	286	PF00069	0.635
MOD_CK1_1	104	110	PF00069	0.679
MOD_CK1_1	195	201	PF00069	0.313
MOD_CK1_1	367	373	PF00069	0.678
MOD_CK1_1	399	405	PF00069	0.644
MOD_CK1_1	407	413	PF00069	0.557
MOD_CK1_1	81	87	PF00069	0.285
MOD_CK2_1	23	29	PF00069	0.423
MOD_CK2_1	360	366	PF00069	0.663
MOD_CK2_1	415	421	PF00069	0.658
MOD_CK2_1	81	87	PF00069	0.256
MOD_Cter_Amidation	21	24	PF01082	0.539
MOD_GlcNHglycan	103	106	PF01048	0.609
MOD_GlcNHglycan	166	169	PF01048	0.619
MOD_GlcNHglycan	2	5	PF01048	0.649
MOD_GlcNHglycan	331	335	PF01048	0.571
MOD_GlcNHglycan	372	375	PF01048	0.610
MOD_GlcNHglycan	417	420	PF01048	0.430
MOD_GlcNHglycan	80	83	PF01048	0.373
MOD_GSK3_1	100	107	PF00069	0.548
MOD_GSK3_1	162	169	PF00069	0.465
MOD_GSK3_1	192	199	PF00069	0.471
MOD_GSK3_1	358	365	PF00069	0.768
MOD_GSK3_1	385	392	PF00069	0.537
MOD_GSK3_1	404	411	PF00069	0.638
MOD_LATS_1	164	170	PF00433	0.633
MOD_N-GLC_1	407	412	PF02516	0.672
MOD_NEK2_1	194	199	PF00069	0.495
MOD_NEK2_1	209	214	PF00069	0.351
MOD_NEK2_1	233	238	PF00069	0.477
MOD_NEK2_1	93	98	PF00069	0.453
MOD_PIKK_1	126	132	PF00454	0.565
MOD_PIKK_1	367	373	PF00454	0.648
MOD_PKA_1	23	29	PF00069	0.471
MOD_PKA_2	192	198	PF00069	0.361
MOD_PKA_2	23	29	PF00069	0.446
MOD_PKA_2	231	237	PF00069	0.588
MOD_PKA_2	71	77	PF00069	0.262
MOD_PKA_2	78	84	PF00069	0.249
MOD_PKB_1	191	199	PF00069	0.417
MOD_Plk_1	37	43	PF00069	0.455
MOD_Plk_1	407	413	PF00069	0.657
MOD_Plk_1	66	72	PF00069	0.325
MOD_Plk_4	196	202	PF00069	0.299
MOD_Plk_4	210	216	PF00069	0.279
MOD_Plk_4	408	414	PF00069	0.746
MOD_ProDKin_1	2	8	PF00069	0.581
MOD_ProDKin_1	279	285	PF00069	0.638
MOD_ProDKin_1	360	366	PF00069	0.715
MOD_SUMO_rev_2	38	48	PF00179	0.285
MOD_SUMO_rev_2	87	93	PF00179	0.502
TRG_DiLeu_BaEn_3	320	326	PF01217	0.516
TRG_ENDOCYTIC_2	208	211	PF00928	0.288
TRG_ENDOCYTIC_2	52	55	PF00928	0.277
TRG_ENDOCYTIC_2	77	80	PF00928	0.277
TRG_ER_diArg_1	108	110	PF00400	0.693
TRG_ER_diArg_1	191	194	PF00400	0.523
TRG_ER_diArg_1	23	25	PF00400	0.512
TRG_ER_diArg_1	256	259	PF00400	0.375
TRG_ER_diArg_1	292	295	PF00400	0.390
TRG_ER_diArg_1	346	348	PF00400	0.608
TRG_ER_diArg_1	352	355	PF00400	0.576
TRG_NES_CRM1_1	29	42	PF08389	0.371
TRG_NLS_MonoExtC_3	48	53	PF00514	0.334
TRG_NLS_MonoExtN_4	46	53	PF00514	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYH8	Leptomonas seymouri	65%	79%
A0A0S4KL95	Bodo saltans	36%	100%
A0A1X0NR65	Trypanosomatidae	43%	91%
A0A3R7NAN2	Trypanosoma rangeli	44%	88%
A0A3S7WPX5	Leishmania donovani	75%	100%
A4HTA4	Leishmania infantum	78%	78%
C9ZUL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	90%
E9AL93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QIL1	Leishmania major	73%	98%
V5BTE7	Trypanosoma cruzi	44%	84%