DNAJ-domain transmembrane-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain transmembrane-like protein

Species:

Leishmania braziliensis

UniProt:

A4H529_LEIBR

TriTrypDb:

LbrM.07.0850 , LBRM2903_070015800

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H529

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H529

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.610
CLV_NRD_NRD_1	106	108	PF00675	0.442
CLV_NRD_NRD_1	188	190	PF00675	0.543
CLV_NRD_NRD_1	234	236	PF00675	0.465
CLV_NRD_NRD_1	483	485	PF00675	0.557
CLV_NRD_NRD_1	74	76	PF00675	0.507
CLV_NRD_NRD_1	9	11	PF00675	0.458
CLV_PCSK_FUR_1	104	108	PF00082	0.394
CLV_PCSK_KEX2_1	106	108	PF00082	0.442
CLV_PCSK_KEX2_1	188	190	PF00082	0.543
CLV_PCSK_KEX2_1	234	236	PF00082	0.465
CLV_PCSK_KEX2_1	483	485	PF00082	0.557
CLV_PCSK_KEX2_1	74	76	PF00082	0.507
CLV_PCSK_KEX2_1	9	11	PF00082	0.472
CLV_PCSK_SKI1_1	65	69	PF00082	0.508
CLV_Separin_Metazoa	366	370	PF03568	0.554
DEG_APCC_DBOX_1	370	378	PF00400	0.558
DEG_SPOP_SBC_1	168	172	PF00917	0.796
DEG_SPOP_SBC_1	244	248	PF00917	0.832
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.611
DOC_MAPK_gen_1	104	114	PF00069	0.588
DOC_MAPK_gen_1	438	446	PF00069	0.431
DOC_MAPK_MEF2A_6	106	114	PF00069	0.586
DOC_MAPK_MEF2A_6	57	66	PF00069	0.595
DOC_MAPK_RevD_3	60	75	PF00069	0.640
DOC_PP2B_LxvP_1	30	33	PF13499	0.612
DOC_PP2B_LxvP_1	444	447	PF13499	0.505
DOC_PP2B_LxvP_1	471	474	PF13499	0.494
DOC_USP7_MATH_1	123	127	PF00917	0.589
DOC_USP7_MATH_1	130	134	PF00917	0.598
DOC_USP7_MATH_1	149	153	PF00917	0.734
DOC_USP7_MATH_1	164	168	PF00917	0.693
DOC_USP7_MATH_1	20	24	PF00917	0.707
DOC_USP7_MATH_1	205	209	PF00917	0.812
DOC_USP7_MATH_1	221	225	PF00917	0.842
DOC_USP7_MATH_1	243	247	PF00917	0.850
DOC_USP7_MATH_1	423	427	PF00917	0.447
DOC_USP7_MATH_1	451	455	PF00917	0.538
DOC_USP7_MATH_1	81	85	PF00917	0.650
DOC_USP7_UBL2_3	57	61	PF12436	0.601
DOC_WW_Pin1_4	145	150	PF00397	0.703
DOC_WW_Pin1_4	16	21	PF00397	0.682
DOC_WW_Pin1_4	25	30	PF00397	0.636
LIG_14-3-3_CanoR_1	134	139	PF00244	0.678
LIG_14-3-3_CanoR_1	189	195	PF00244	0.639
LIG_14-3-3_CanoR_1	369	375	PF00244	0.669
LIG_14-3-3_CanoR_1	441	447	PF00244	0.547
LIG_14-3-3_CanoR_1	483	492	PF00244	0.264
LIG_14-3-3_CanoR_1	65	73	PF00244	0.634
LIG_APCC_ABBA_1	269	274	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_CSL_BTD_1	471	474	PF09270	0.494
LIG_FHA_1	179	185	PF00498	0.713
LIG_FHA_1	279	285	PF00498	0.617
LIG_FHA_1	402	408	PF00498	0.502
LIG_FHA_1	412	418	PF00498	0.536
LIG_FHA_1	504	510	PF00498	0.562
LIG_FHA_1	66	72	PF00498	0.627
LIG_FHA_2	123	129	PF00498	0.605
LIG_FHA_2	193	199	PF00498	0.639
LIG_FHA_2	258	264	PF00498	0.754
LIG_FHA_2	314	320	PF00498	0.608
LIG_FHA_2	326	332	PF00498	0.591
LIG_FHA_2	371	377	PF00498	0.676
LIG_FHA_2	38	44	PF00498	0.581
LIG_GBD_Chelix_1	496	504	PF00786	0.405
LIG_LIR_Apic_2	469	475	PF02991	0.496
LIG_LIR_Gen_1	274	284	PF02991	0.541
LIG_LIR_Gen_1	328	338	PF02991	0.614
LIG_LIR_Gen_1	478	485	PF02991	0.478
LIG_LIR_Nem_3	274	279	PF02991	0.604
LIG_LIR_Nem_3	328	333	PF02991	0.610
LIG_LIR_Nem_3	426	432	PF02991	0.413
LIG_LIR_Nem_3	478	482	PF02991	0.479
LIG_PCNA_yPIPBox_3	505	517	PF02747	0.556
LIG_Pex14_1	398	402	PF04695	0.458
LIG_SH2_CRK	304	308	PF00017	0.631
LIG_SH2_CRK	330	334	PF00017	0.608
LIG_SH2_CRK	461	465	PF00017	0.506
LIG_SH2_STAP1	150	154	PF00017	0.618
LIG_SH2_STAP1	155	159	PF00017	0.614
LIG_SH2_STAP1	330	334	PF00017	0.608
LIG_SH2_STAP1	492	496	PF00017	0.405
LIG_SH2_STAT5	79	82	PF00017	0.615
LIG_SH3_3	143	149	PF00018	0.639
LIG_SH3_3	267	273	PF00018	0.618
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.657
LIG_SUMO_SIM_par_1	31	38	PF11976	0.612
LIG_SUMO_SIM_par_1	43	49	PF11976	0.588
LIG_TRAF2_1	254	257	PF00917	0.776
LIG_TYR_ITIM	459	464	PF00017	0.506
LIG_TYR_ITSM	326	333	PF00017	0.496
LIG_WRC_WIRS_1	124	129	PF05994	0.592
LIG_WRC_WIRS_1	191	196	PF05994	0.640
MOD_CK1_1	133	139	PF00069	0.676
MOD_CK1_1	145	151	PF00069	0.676
MOD_CK1_1	167	173	PF00069	0.663
MOD_CK1_1	19	25	PF00069	0.674
MOD_CK1_1	192	198	PF00069	0.772
MOD_CK1_1	208	214	PF00069	0.690
MOD_CK1_1	28	34	PF00069	0.655
MOD_CK1_1	370	376	PF00069	0.677
MOD_CK1_1	439	445	PF00069	0.464
MOD_CK1_1	46	52	PF00069	0.643
MOD_CK2_1	122	128	PF00069	0.588
MOD_CK2_1	192	198	PF00069	0.637
MOD_CK2_1	208	214	PF00069	0.636
MOD_CK2_1	251	257	PF00069	0.760
MOD_CK2_1	37	43	PF00069	0.585
MOD_CK2_1	370	376	PF00069	0.677
MOD_GlcNHglycan	161	164	PF01048	0.450
MOD_GlcNHglycan	207	210	PF01048	0.556
MOD_GlcNHglycan	22	25	PF01048	0.505
MOD_GlcNHglycan	223	226	PF01048	0.619
MOD_GlcNHglycan	276	279	PF01048	0.287
MOD_GlcNHglycan	336	339	PF01048	0.421
MOD_GlcNHglycan	37	40	PF01048	0.360
MOD_GlcNHglycan	389	392	PF01048	0.507
MOD_GlcNHglycan	438	441	PF01048	0.644
MOD_GlcNHglycan	468	471	PF01048	0.707
MOD_GlcNHglycan	83	86	PF01048	0.478
MOD_GSK3_1	130	137	PF00069	0.670
MOD_GSK3_1	144	151	PF00069	0.771
MOD_GSK3_1	155	162	PF00069	0.675
MOD_GSK3_1	16	23	PF00069	0.709
MOD_GSK3_1	164	171	PF00069	0.720
MOD_GSK3_1	176	183	PF00069	0.741
MOD_GSK3_1	190	197	PF00069	0.721
MOD_GSK3_1	201	208	PF00069	0.743
MOD_GSK3_1	274	281	PF00069	0.495
MOD_GSK3_1	403	410	PF00069	0.466
MOD_GSK3_1	462	469	PF00069	0.513
MOD_GSK3_1	49	56	PF00069	0.653
MOD_GSK3_1	79	86	PF00069	0.632
MOD_GSK3_1	95	102	PF00069	0.598
MOD_LATS_1	132	138	PF00433	0.620
MOD_N-GLC_1	200	205	PF02516	0.472
MOD_N-GLC_1	326	331	PF02516	0.412
MOD_NEK2_1	142	147	PF00069	0.736
MOD_NEK2_1	180	185	PF00069	0.649
MOD_NEK2_1	332	337	PF00069	0.497
MOD_NEK2_1	35	40	PF00069	0.596
MOD_NEK2_1	367	372	PF00069	0.675
MOD_NEK2_1	4	9	PF00069	0.670
MOD_NEK2_1	401	406	PF00069	0.550
MOD_NEK2_2	99	104	PF00069	0.595
MOD_PIKK_1	208	214	PF00454	0.663
MOD_PIKK_1	65	71	PF00454	0.629
MOD_PKA_2	133	139	PF00069	0.667
MOD_PKA_2	370	376	PF00069	0.677
MOD_PKA_2	417	423	PF00069	0.444
MOD_PKA_2	442	448	PF00069	0.621
MOD_Plk_1	293	299	PF00069	0.530
MOD_Plk_1	326	332	PF00069	0.612
MOD_Plk_2-3	252	258	PF00069	0.766
MOD_Plk_4	137	143	PF00069	0.641
MOD_Plk_4	155	161	PF00069	0.703
MOD_Plk_4	43	49	PF00069	0.667
MOD_Plk_4	503	509	PF00069	0.573
MOD_ProDKin_1	145	151	PF00069	0.702
MOD_ProDKin_1	16	22	PF00069	0.682
MOD_ProDKin_1	25	31	PF00069	0.634
MOD_SUMO_rev_2	252	260	PF00179	0.782
TRG_DiLeu_BaEn_1	363	368	PF01217	0.586
TRG_DiLeu_BaEn_1	376	381	PF01217	0.632
TRG_ENDOCYTIC_2	191	194	PF00928	0.641
TRG_ENDOCYTIC_2	276	279	PF00928	0.599
TRG_ENDOCYTIC_2	304	307	PF00928	0.668
TRG_ENDOCYTIC_2	330	333	PF00928	0.607
TRG_ENDOCYTIC_2	429	432	PF00928	0.416
TRG_ENDOCYTIC_2	461	464	PF00928	0.583
TRG_ER_diArg_1	103	106	PF00400	0.595
TRG_ER_diArg_1	112	115	PF00400	0.570
TRG_ER_diArg_1	234	236	PF00400	0.665
TRG_ER_diArg_1	368	371	PF00400	0.564
TRG_ER_diArg_1	441	444	PF00400	0.435
TRG_ER_diArg_1	482	484	PF00400	0.366
TRG_ER_diArg_1	73	75	PF00400	0.713
TRG_ER_diArg_1	9	12	PF00400	0.670
TRG_NES_CRM1_1	274	288	PF08389	0.615
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX9	Leishmania donovani	72%	100%
A4HTA3	Leishmania infantum	71%	86%
E9AL92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QIL2	Leishmania major	71%	100%