Malonyl-coa decarboxylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

malonyl-coa decarboxylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H525_LEIBR

TriTrypDb:

LbrM.07.0810 , LBRM2903_070015200 , LBRM2903_070015300

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005759	mitochondrial matrix	5	1
GO:0005782	peroxisomal matrix	6	1
GO:0031907	microbody lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H525

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H525

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006631	fatty acid metabolic process	4	12
GO:0006633	fatty acid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016053	organic acid biosynthetic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046394	carboxylic acid biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0072330	monocarboxylic acid biosynthetic process	6	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	1
GO:0006085	acetyl-CoA biosynthetic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010565	regulation of cellular ketone metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019216	regulation of lipid metabolic process	5	1
GO:0019217	regulation of fatty acid metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033869	nucleoside bisphosphate catabolic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034031	ribonucleoside bisphosphate catabolic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034034	purine nucleoside bisphosphate catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0035383	thioester metabolic process	3	1
GO:0035384	thioester biosynthetic process	4	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044273	sulfur compound catabolic process	4	1
GO:0045834	positive regulation of lipid metabolic process	5	1
GO:0045923	positive regulation of fatty acid metabolic process	6	1
GO:0046320	regulation of fatty acid oxidation	7	1
GO:0046321	positive regulation of fatty acid oxidation	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0062013	positive regulation of small molecule metabolic process	5	1
GO:0065007	biological regulation	1	1
GO:0071616	acyl-CoA biosynthetic process	5	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:2001293	malonyl-CoA metabolic process	5	1
GO:2001294	malonyl-CoA catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	12
GO:0016831	carboxy-lyase activity	4	12
GO:0050080	malonyl-CoA decarboxylase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.553
CLV_NRD_NRD_1	161	163	PF00675	0.360
CLV_NRD_NRD_1	166	168	PF00675	0.356
CLV_NRD_NRD_1	229	231	PF00675	0.324
CLV_NRD_NRD_1	411	413	PF00675	0.316
CLV_PCSK_KEX2_1	10	12	PF00082	0.553
CLV_PCSK_KEX2_1	161	163	PF00082	0.379
CLV_PCSK_KEX2_1	178	180	PF00082	0.434
CLV_PCSK_KEX2_1	229	231	PF00082	0.326
CLV_PCSK_KEX2_1	398	400	PF00082	0.231
CLV_PCSK_KEX2_1	411	413	PF00082	0.292
CLV_PCSK_KEX2_1	583	585	PF00082	0.243
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.472
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.231
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.256
CLV_PCSK_SKI1_1	167	171	PF00082	0.412
CLV_PCSK_SKI1_1	179	183	PF00082	0.500
CLV_PCSK_SKI1_1	298	302	PF00082	0.266
CLV_PCSK_SKI1_1	395	399	PF00082	0.360
CLV_PCSK_SKI1_1	415	419	PF00082	0.303
CLV_PCSK_SKI1_1	656	660	PF00082	0.505
CLV_Separin_Metazoa	476	480	PF03568	0.341
DEG_SCF_FBW7_1	417	422	PF00400	0.535
DEG_SPOP_SBC_1	211	215	PF00917	0.419
DEG_SPOP_SBC_1	355	359	PF00917	0.474
DOC_CKS1_1	262	267	PF01111	0.535
DOC_CKS1_1	567	572	PF01111	0.392
DOC_CYCLIN_yCln2_LP_2	338	344	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	35	38	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	651	657	PF00134	0.374
DOC_MAPK_gen_1	226	236	PF00069	0.413
DOC_MAPK_MEF2A_6	229	236	PF00069	0.397
DOC_PP1_RVXF_1	605	611	PF00149	0.474
DOC_PP2B_LxvP_1	184	187	PF13499	0.538
DOC_PP2B_LxvP_1	35	38	PF13499	0.497
DOC_PP2B_PxIxI_1	311	317	PF00149	0.442
DOC_PP4_FxxP_1	303	306	PF00568	0.442
DOC_USP7_MATH_1	106	110	PF00917	0.530
DOC_USP7_MATH_1	12	16	PF00917	0.547
DOC_USP7_MATH_1	204	208	PF00917	0.557
DOC_USP7_MATH_1	210	214	PF00917	0.516
DOC_USP7_MATH_1	342	346	PF00917	0.590
DOC_USP7_MATH_1	355	359	PF00917	0.505
DOC_USP7_MATH_1	455	459	PF00917	0.610
DOC_USP7_MATH_1	503	507	PF00917	0.593
DOC_USP7_MATH_1	531	535	PF00917	0.545
DOC_USP7_MATH_1	542	546	PF00917	0.615
DOC_USP7_MATH_1	582	586	PF00917	0.423
DOC_USP7_MATH_1	616	620	PF00917	0.471
DOC_USP7_UBL2_3	178	182	PF12436	0.444
DOC_WW_Pin1_4	140	145	PF00397	0.370
DOC_WW_Pin1_4	182	187	PF00397	0.357
DOC_WW_Pin1_4	202	207	PF00397	0.626
DOC_WW_Pin1_4	261	266	PF00397	0.432
DOC_WW_Pin1_4	333	338	PF00397	0.442
DOC_WW_Pin1_4	415	420	PF00397	0.446
DOC_WW_Pin1_4	424	429	PF00397	0.413
DOC_WW_Pin1_4	463	468	PF00397	0.337
DOC_WW_Pin1_4	545	550	PF00397	0.634
DOC_WW_Pin1_4	566	571	PF00397	0.537
DOC_WW_Pin1_4	612	617	PF00397	0.535
LIG_14-3-3_CanoR_1	11	21	PF00244	0.473
LIG_14-3-3_CanoR_1	167	176	PF00244	0.385
LIG_14-3-3_CanoR_1	190	196	PF00244	0.782
LIG_14-3-3_CanoR_1	239	244	PF00244	0.363
LIG_14-3-3_CanoR_1	412	418	PF00244	0.540
LIG_14-3-3_CanoR_1	573	579	PF00244	0.392
LIG_14-3-3_CanoR_1	647	652	PF00244	0.257
LIG_Actin_WH2_2	560	575	PF00022	0.391
LIG_Actin_WH2_2	78	95	PF00022	0.408
LIG_AP2alpha_1	245	249	PF02296	0.252
LIG_APCC_ABBAyCdc20_2	10	16	PF00400	0.336
LIG_BIR_II_1	1	5	PF00653	0.312
LIG_BRCT_BRCA1_1	241	245	PF00533	0.351
LIG_BRCT_BRCA1_1	457	461	PF00533	0.503
LIG_BRCT_BRCA1_1	539	543	PF00533	0.490
LIG_CtBP_PxDLS_1	389	395	PF00389	0.478
LIG_deltaCOP1_diTrp_1	26	32	PF00928	0.463
LIG_FHA_1	319	325	PF00498	0.442
LIG_FHA_1	455	461	PF00498	0.498
LIG_FHA_1	514	520	PF00498	0.390
LIG_FHA_1	562	568	PF00498	0.442
LIG_FHA_1	646	652	PF00498	0.369
LIG_FHA_2	213	219	PF00498	0.615
LIG_FHA_2	61	67	PF00498	0.540
LIG_IRF3_LxIS_1	57	62	PF10401	0.225
LIG_LIR_Gen_1	170	181	PF02991	0.397
LIG_LIR_Gen_1	242	253	PF02991	0.342
LIG_LIR_Gen_1	26	37	PF02991	0.341
LIG_LIR_Gen_1	422	431	PF02991	0.434
LIG_LIR_Gen_1	55	64	PF02991	0.326
LIG_LIR_Gen_1	86	95	PF02991	0.360
LIG_LIR_Nem_3	170	176	PF02991	0.382
LIG_LIR_Nem_3	242	248	PF02991	0.261
LIG_LIR_Nem_3	26	32	PF02991	0.326
LIG_LIR_Nem_3	374	380	PF02991	0.431
LIG_LIR_Nem_3	422	426	PF02991	0.434
LIG_LIR_Nem_3	472	478	PF02991	0.312
LIG_LIR_Nem_3	54	60	PF02991	0.331
LIG_LIR_Nem_3	86	91	PF02991	0.406
LIG_NRBOX	521	527	PF00104	0.453
LIG_PCNA_yPIPBox_3	388	401	PF02747	0.450
LIG_PCNA_yPIPBox_3	508	522	PF02747	0.403
LIG_PCNA_yPIPBox_3	68	80	PF02747	0.361
LIG_Pex14_2	245	249	PF04695	0.246
LIG_PTB_Apo_2	625	632	PF02174	0.431
LIG_PTB_Phospho_1	625	631	PF10480	0.431
LIG_REV1ctd_RIR_1	246	255	PF16727	0.262
LIG_SH2_CRK	631	635	PF00017	0.583
LIG_SH2_STAP1	147	151	PF00017	0.399
LIG_SH2_STAT5	147	150	PF00017	0.405
LIG_SH2_STAT5	253	256	PF00017	0.485
LIG_SH2_STAT5	350	353	PF00017	0.480
LIG_SH2_STAT5	432	435	PF00017	0.456
LIG_SH2_STAT5	485	488	PF00017	0.507
LIG_SH2_STAT5	521	524	PF00017	0.391
LIG_SH2_STAT5	578	581	PF00017	0.434
LIG_SH2_STAT5	88	91	PF00017	0.490
LIG_SH3_3	183	189	PF00018	0.546
LIG_SH3_3	200	206	PF00018	0.465
LIG_SH3_3	259	265	PF00018	0.565
LIG_SH3_3	306	312	PF00018	0.442
LIG_SH3_3	31	37	PF00018	0.557
LIG_SUMO_SIM_anti_2	86	93	PF11976	0.567
LIG_SUMO_SIM_par_1	646	653	PF11976	0.296
LIG_SxIP_EBH_1	422	434	PF03271	0.462
LIG_TRAF2_1	467	470	PF00917	0.461
LIG_TYR_ITIM	145	150	PF00017	0.362
LIG_WRC_WIRS_1	420	425	PF05994	0.281
LIG_WW_3	187	191	PF00397	0.459
MOD_CDK_SPxxK_3	545	552	PF00069	0.478
MOD_CDK_SPxxK_3	566	573	PF00069	0.210
MOD_CK1_1	191	197	PF00069	0.621
MOD_CK1_1	202	208	PF00069	0.491
MOD_CK1_1	357	363	PF00069	0.304
MOD_CK1_1	379	385	PF00069	0.281
MOD_CK1_1	533	539	PF00069	0.584
MOD_CK1_1	545	551	PF00069	0.744
MOD_CK1_1	574	580	PF00069	0.331
MOD_CK1_1	619	625	PF00069	0.266
MOD_CK2_1	210	216	PF00069	0.668
MOD_CK2_1	463	469	PF00069	0.511
MOD_CK2_1	48	54	PF00069	0.493
MOD_CK2_1	533	539	PF00069	0.607
MOD_CK2_1	60	66	PF00069	0.503
MOD_CK2_1	647	653	PF00069	0.394
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.411
MOD_GlcNHglycan	108	111	PF01048	0.595
MOD_GlcNHglycan	206	209	PF01048	0.659
MOD_GlcNHglycan	381	384	PF01048	0.329
MOD_GlcNHglycan	42	45	PF01048	0.427
MOD_GlcNHglycan	457	460	PF01048	0.574
MOD_GlcNHglycan	50	53	PF01048	0.379
MOD_GlcNHglycan	527	530	PF01048	0.340
MOD_GlcNHglycan	538	542	PF01048	0.671
MOD_GlcNHglycan	544	547	PF01048	0.659
MOD_GlcNHglycan	621	624	PF01048	0.283
MOD_GlcNHglycan	77	80	PF01048	0.502
MOD_GSK3_1	104	111	PF00069	0.543
MOD_GSK3_1	257	264	PF00069	0.268
MOD_GSK3_1	318	325	PF00069	0.326
MOD_GSK3_1	415	422	PF00069	0.272
MOD_GSK3_1	449	456	PF00069	0.590
MOD_GSK3_1	533	540	PF00069	0.692
MOD_GSK3_1	574	581	PF00069	0.331
MOD_GSK3_1	597	604	PF00069	0.287
MOD_GSK3_1	612	619	PF00069	0.300
MOD_GSK3_1	643	650	PF00069	0.276
MOD_LATS_1	165	171	PF00433	0.377
MOD_N-GLC_1	182	187	PF02516	0.357
MOD_N-GLC_1	342	347	PF02516	0.411
MOD_N-GLC_1	47	52	PF02516	0.467
MOD_N-GLC_1	612	617	PF02516	0.266
MOD_NEK2_1	145	150	PF00069	0.377
MOD_NEK2_1	172	177	PF00069	0.493
MOD_NEK2_1	525	530	PF00069	0.329
MOD_NEK2_1	559	564	PF00069	0.210
MOD_NEK2_1	571	576	PF00069	0.314
MOD_NEK2_1	59	64	PF00069	0.449
MOD_NEK2_1	597	602	PF00069	0.281
MOD_NEK2_1	611	616	PF00069	0.411
MOD_PIKK_1	342	348	PF00454	0.189
MOD_PIKK_1	4	10	PF00454	0.364
MOD_PIKK_1	547	553	PF00454	0.563
MOD_PIKK_1	97	103	PF00454	0.463
MOD_PK_1	274	280	PF00069	0.331
MOD_PKA_1	167	173	PF00069	0.374
MOD_PKA_2	501	507	PF00069	0.402
MOD_PKA_2	619	625	PF00069	0.281
MOD_PKA_2	75	81	PF00069	0.260
MOD_Plk_1	199	205	PF00069	0.602
MOD_Plk_1	257	263	PF00069	0.281
MOD_Plk_1	446	452	PF00069	0.401
MOD_Plk_1	559	565	PF00069	0.265
MOD_Plk_4	145	151	PF00069	0.479
MOD_Plk_4	239	245	PF00069	0.469
MOD_Plk_4	24	30	PF00069	0.437
MOD_Plk_4	264	270	PF00069	0.350
MOD_Plk_4	481	487	PF00069	0.322
MOD_Plk_4	574	580	PF00069	0.331
MOD_Plk_4	601	607	PF00069	0.281
MOD_Plk_4	84	90	PF00069	0.401
MOD_ProDKin_1	140	146	PF00069	0.364
MOD_ProDKin_1	182	188	PF00069	0.370
MOD_ProDKin_1	202	208	PF00069	0.625
MOD_ProDKin_1	261	267	PF00069	0.267
MOD_ProDKin_1	333	339	PF00069	0.281
MOD_ProDKin_1	415	421	PF00069	0.287
MOD_ProDKin_1	424	430	PF00069	0.241
MOD_ProDKin_1	463	469	PF00069	0.335
MOD_ProDKin_1	545	551	PF00069	0.628
MOD_ProDKin_1	566	572	PF00069	0.414
MOD_ProDKin_1	612	618	PF00069	0.411
MOD_SUMO_for_1	127	130	PF00179	0.396
TRG_DiLeu_BaEn_1	120	125	PF01217	0.332
TRG_DiLeu_BaEn_2	53	59	PF01217	0.329
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.281
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.331
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.281
TRG_ENDOCYTIC_2	147	150	PF00928	0.341
TRG_ENDOCYTIC_2	253	256	PF00928	0.360
TRG_ENDOCYTIC_2	88	91	PF00928	0.466
TRG_ER_diArg_1	160	162	PF00400	0.387
TRG_ER_diArg_1	229	231	PF00400	0.422
TRG_ER_diArg_1	288	291	PF00400	0.418
TRG_ER_diArg_1	9	11	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF8	Leptomonas seymouri	59%	84%
A0A0S4J4K1	Bodo saltans	30%	100%
A0A1X0NPQ8	Trypanosomatidae	41%	86%
A0A3R7N686	Trypanosoma rangeli	42%	92%
A0A3S5H5Z5	Leishmania donovani	78%	83%
A4HT98	Leishmania infantum	78%	83%
C9ZUM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	90%
E9AL87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	83%
Q4QIL8	Leishmania major	77%	100%
V5BY47	Trypanosoma cruzi	44%	100%