Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H523_LEIBR

TriTrypDb:

LbrM.07.0790 , LBRM2903_070015000

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H523

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H523

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.632
CLV_NRD_NRD_1	13	15	PF00675	0.577
CLV_NRD_NRD_1	227	229	PF00675	0.637
CLV_NRD_NRD_1	261	263	PF00675	0.574
CLV_NRD_NRD_1	369	371	PF00675	0.635
CLV_NRD_NRD_1	399	401	PF00675	0.520
CLV_NRD_NRD_1	433	435	PF00675	0.503
CLV_NRD_NRD_1	452	454	PF00675	0.538
CLV_NRD_NRD_1	568	570	PF00675	0.574
CLV_PCSK_KEX2_1	13	15	PF00082	0.577
CLV_PCSK_KEX2_1	227	229	PF00082	0.637
CLV_PCSK_KEX2_1	261	263	PF00082	0.574
CLV_PCSK_KEX2_1	369	371	PF00082	0.514
CLV_PCSK_KEX2_1	398	400	PF00082	0.540
CLV_PCSK_KEX2_1	435	437	PF00082	0.488
CLV_PCSK_KEX2_1	452	454	PF00082	0.579
CLV_PCSK_KEX2_1	568	570	PF00082	0.574
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.503
CLV_PCSK_PC7_1	431	437	PF00082	0.511
CLV_PCSK_PC7_1	9	15	PF00082	0.587
CLV_PCSK_SKI1_1	227	231	PF00082	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.676
DEG_SPOP_SBC_1	189	193	PF00917	0.566
DEG_SPOP_SBC_1	462	466	PF00917	0.534
DEG_SPOP_SBC_1	82	86	PF00917	0.541
DOC_CKS1_1	306	311	PF01111	0.554
DOC_CKS1_1	522	527	PF01111	0.564
DOC_MAPK_gen_1	369	380	PF00069	0.484
DOC_MAPK_gen_1	434	443	PF00069	0.512
DOC_MAPK_gen_1	552	559	PF00069	0.417
DOC_PP1_RVXF_1	19	25	PF00149	0.606
DOC_PP2B_LxvP_1	125	128	PF13499	0.544
DOC_PP2B_LxvP_1	311	314	PF13499	0.674
DOC_PP2B_LxvP_1	355	358	PF13499	0.550
DOC_PP2B_LxvP_1	419	422	PF13499	0.554
DOC_PP4_FxxP_1	515	518	PF00568	0.532
DOC_USP7_MATH_1	181	185	PF00917	0.702
DOC_USP7_MATH_1	189	193	PF00917	0.621
DOC_USP7_MATH_1	263	267	PF00917	0.684
DOC_USP7_MATH_1	274	278	PF00917	0.649
DOC_USP7_MATH_1	334	338	PF00917	0.540
DOC_USP7_MATH_1	349	353	PF00917	0.643
DOC_USP7_MATH_1	40	44	PF00917	0.651
DOC_USP7_MATH_1	45	49	PF00917	0.592
DOC_USP7_MATH_1	460	464	PF00917	0.530
DOC_USP7_MATH_1	500	504	PF00917	0.545
DOC_USP7_MATH_1	508	512	PF00917	0.516
DOC_WW_Pin1_4	1	6	PF00397	0.509
DOC_WW_Pin1_4	227	232	PF00397	0.561
DOC_WW_Pin1_4	269	274	PF00397	0.716
DOC_WW_Pin1_4	278	283	PF00397	0.707
DOC_WW_Pin1_4	288	293	PF00397	0.623
DOC_WW_Pin1_4	305	310	PF00397	0.518
DOC_WW_Pin1_4	353	358	PF00397	0.574
DOC_WW_Pin1_4	458	463	PF00397	0.667
DOC_WW_Pin1_4	46	51	PF00397	0.567
DOC_WW_Pin1_4	514	519	PF00397	0.549
DOC_WW_Pin1_4	521	526	PF00397	0.585
DOC_WW_Pin1_4	527	532	PF00397	0.619
DOC_WW_Pin1_4	535	540	PF00397	0.639
LIG_14-3-3_CanoR_1	104	112	PF00244	0.531
LIG_14-3-3_CanoR_1	182	187	PF00244	0.641
LIG_14-3-3_CanoR_1	195	201	PF00244	0.536
LIG_14-3-3_CanoR_1	262	271	PF00244	0.593
LIG_14-3-3_CanoR_1	310	314	PF00244	0.632
LIG_14-3-3_CanoR_1	317	322	PF00244	0.597
LIG_14-3-3_CanoR_1	452	456	PF00244	0.654
LIG_14-3-3_CanoR_1	81	91	PF00244	0.538
LIG_Actin_WH2_2	8	23	PF00022	0.506
LIG_AP2alpha_2	200	202	PF02296	0.508
LIG_APCC_ABBA_1	545	550	PF00400	0.608
LIG_BIR_III_4	413	417	PF00653	0.436
LIG_BRCT_BRCA1_1	198	202	PF00533	0.518
LIG_BRCT_BRCA1_1	511	515	PF00533	0.590
LIG_CtBP_PxDLS_1	273	277	PF00389	0.540
LIG_EVH1_1	536	540	PF00568	0.538
LIG_FHA_1	174	180	PF00498	0.553
LIG_FHA_1	306	312	PF00498	0.691
LIG_FHA_1	313	319	PF00498	0.602
LIG_FHA_1	463	469	PF00498	0.633
LIG_FHA_2	424	430	PF00498	0.432
LIG_FHA_2	57	63	PF00498	0.566
LIG_LIR_Apic_2	303	309	PF02991	0.553
LIG_LIR_Apic_2	512	518	PF02991	0.533
LIG_LIR_Gen_1	160	165	PF02991	0.671
LIG_LIR_Gen_1	199	209	PF02991	0.586
LIG_LIR_Nem_3	160	164	PF02991	0.675
LIG_LIR_Nem_3	199	205	PF02991	0.589
LIG_MAD2	449	457	PF02301	0.494
LIG_PTAP_UEV_1	112	117	PF05743	0.521
LIG_SH2_CRK	306	310	PF00017	0.552
LIG_SH2_STAP1	36	40	PF00017	0.540
LIG_SH2_STAT5	548	551	PF00017	0.586
LIG_SH3_3	110	116	PF00018	0.525
LIG_SH3_3	126	132	PF00018	0.498
LIG_SH3_3	183	189	PF00018	0.546
LIG_SH3_3	257	263	PF00018	0.712
LIG_SH3_3	268	274	PF00018	0.630
LIG_SH3_3	39	45	PF00018	0.681
LIG_SH3_3	454	460	PF00018	0.636
LIG_SH3_3	534	540	PF00018	0.629
LIG_SH3_CIN85_PxpxPR_1	128	133	PF14604	0.534
LIG_SUMO_SIM_par_1	406	413	PF11976	0.405
LIG_SUMO_SIM_par_1	417	423	PF11976	0.523
LIG_SxIP_EBH_1	449	462	PF03271	0.507
LIG_TRAF2_1	403	406	PF00917	0.352
MOD_CDK_SPK_2	305	310	PF00069	0.552
MOD_CK1_1	111	117	PF00069	0.544
MOD_CK1_1	149	155	PF00069	0.557
MOD_CK1_1	236	242	PF00069	0.540
MOD_CK1_1	305	311	PF00069	0.641
MOD_CK1_1	312	318	PF00069	0.579
MOD_CK1_1	328	334	PF00069	0.632
MOD_CK1_1	423	429	PF00069	0.570
MOD_CK1_1	458	464	PF00069	0.617
MOD_CK1_1	49	55	PF00069	0.561
MOD_CK1_1	517	523	PF00069	0.615
MOD_CK1_1	530	536	PF00069	0.562
MOD_CK1_1	56	62	PF00069	0.550
MOD_CK2_1	400	406	PF00069	0.382
MOD_CK2_1	423	429	PF00069	0.542
MOD_CK2_1	473	479	PF00069	0.647
MOD_CK2_1	56	62	PF00069	0.566
MOD_DYRK1A_RPxSP_1	269	273	PF00069	0.699
MOD_DYRK1A_RPxSP_1	353	357	PF00069	0.515
MOD_GlcNHglycan	121	124	PF01048	0.631
MOD_GlcNHglycan	148	151	PF01048	0.619
MOD_GlcNHglycan	257	260	PF01048	0.596
MOD_GlcNHglycan	311	314	PF01048	0.532
MOD_GlcNHglycan	330	333	PF01048	0.510
MOD_GlcNHglycan	347	350	PF01048	0.735
MOD_GlcNHglycan	387	390	PF01048	0.699
MOD_GlcNHglycan	392	395	PF01048	0.681
MOD_GlcNHglycan	483	486	PF01048	0.695
MOD_GlcNHglycan	502	505	PF01048	0.508
MOD_GlcNHglycan	532	535	PF01048	0.633
MOD_GlcNHglycan	542	545	PF01048	0.642
MOD_GlcNHglycan	55	58	PF01048	0.648
MOD_GlcNHglycan	65	68	PF01048	0.575
MOD_GlcNHglycan	85	88	PF01048	0.631
MOD_GSK3_1	103	110	PF00069	0.594
MOD_GSK3_1	145	152	PF00069	0.609
MOD_GSK3_1	223	230	PF00069	0.666
MOD_GSK3_1	274	281	PF00069	0.742
MOD_GSK3_1	282	289	PF00069	0.717
MOD_GSK3_1	301	308	PF00069	0.680
MOD_GSK3_1	309	316	PF00069	0.604
MOD_GSK3_1	345	352	PF00069	0.546
MOD_GSK3_1	36	43	PF00069	0.634
MOD_GSK3_1	385	392	PF00069	0.643
MOD_GSK3_1	45	52	PF00069	0.538
MOD_GSK3_1	451	458	PF00069	0.749
MOD_GSK3_1	473	480	PF00069	0.567
MOD_GSK3_1	509	516	PF00069	0.647
MOD_GSK3_1	517	524	PF00069	0.575
MOD_GSK3_1	53	60	PF00069	0.503
MOD_GSK3_1	535	542	PF00069	0.624
MOD_GSK3_1	71	78	PF00069	0.599
MOD_N-GLC_1	46	51	PF02516	0.532
MOD_N-GLC_2	105	107	PF02516	0.591
MOD_NEK2_1	190	195	PF00069	0.569
MOD_NEK2_1	276	281	PF00069	0.635
MOD_NEK2_1	385	390	PF00069	0.537
MOD_NEK2_1	451	456	PF00069	0.641
MOD_NEK2_1	513	518	PF00069	0.660
MOD_NEK2_1	557	562	PF00069	0.408
MOD_NEK2_1	83	88	PF00069	0.535
MOD_OFUCOSY	102	107	PF10250	0.529
MOD_PIKK_1	286	292	PF00454	0.664
MOD_PIKK_1	455	461	PF00454	0.535
MOD_PK_1	182	188	PF00069	0.551
MOD_PKA_2	103	109	PF00069	0.529
MOD_PKA_2	146	152	PF00069	0.623
MOD_PKA_2	181	187	PF00069	0.613
MOD_PKA_2	309	315	PF00069	0.642
MOD_PKA_2	335	341	PF00069	0.581
MOD_PKA_2	345	351	PF00069	0.611
MOD_PKA_2	423	429	PF00069	0.662
MOD_PKA_2	451	457	PF00069	0.646
MOD_PKA_2	63	69	PF00069	0.531
MOD_PKB_1	398	406	PF00069	0.370
MOD_Plk_1	236	242	PF00069	0.526
MOD_Plk_1	274	280	PF00069	0.558
MOD_Plk_1	508	514	PF00069	0.610
MOD_Plk_1	557	563	PF00069	0.407
MOD_Plk_2-3	214	220	PF00069	0.550
MOD_Plk_4	157	163	PF00069	0.652
MOD_Plk_4	317	323	PF00069	0.660
MOD_ProDKin_1	1	7	PF00069	0.505
MOD_ProDKin_1	227	233	PF00069	0.558
MOD_ProDKin_1	269	275	PF00069	0.717
MOD_ProDKin_1	278	284	PF00069	0.708
MOD_ProDKin_1	288	294	PF00069	0.620
MOD_ProDKin_1	305	311	PF00069	0.518
MOD_ProDKin_1	353	359	PF00069	0.569
MOD_ProDKin_1	458	464	PF00069	0.668
MOD_ProDKin_1	46	52	PF00069	0.566
MOD_ProDKin_1	514	520	PF00069	0.549
MOD_ProDKin_1	521	527	PF00069	0.586
MOD_ProDKin_1	535	541	PF00069	0.639
MOD_SUMO_rev_2	473	483	PF00179	0.545
TRG_DiLeu_BaEn_2	156	162	PF01217	0.618
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.372
TRG_ER_diArg_1	12	14	PF00400	0.585
TRG_ER_diArg_1	227	229	PF00400	0.572
TRG_ER_diArg_1	260	262	PF00400	0.577
TRG_ER_diArg_1	398	400	PF00400	0.540
TRG_ER_diArg_1	433	436	PF00400	0.502
TRG_ER_diArg_1	451	453	PF00400	0.448
TRG_ER_diArg_1	552	555	PF00400	0.444
TRG_ER_diArg_1	568	570	PF00400	0.539
TRG_NLS_MonoExtN_4	431	438	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX7	Leishmania donovani	59%	100%
A4HT96	Leishmania infantum	59%	100%
E9ACQ2	Leishmania major	57%	100%
E9AL85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%