Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H517_LEIBR

TriTrypDb:

LbrM.07.0730 , LBRM2903_070014300

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H517

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H517

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.368
CLV_C14_Caspase3-7	328	332	PF00656	0.461
CLV_C14_Caspase3-7	50	54	PF00656	0.615
CLV_NRD_NRD_1	234	236	PF00675	0.591
CLV_PCSK_KEX2_1	234	236	PF00082	0.584
CLV_PCSK_SKI1_1	172	176	PF00082	0.421
CLV_PCSK_SKI1_1	463	467	PF00082	0.483
CLV_PCSK_SKI1_1	73	77	PF00082	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.529
DEG_SPOP_SBC_1	317	321	PF00917	0.411
DEG_SPOP_SBC_1	394	398	PF00917	0.523
DOC_CDC14_PxL_1	142	150	PF14671	0.515
DOC_CYCLIN_RxL_1	460	470	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.467
DOC_MAPK_DCC_7	365	375	PF00069	0.392
DOC_MAPK_gen_1	293	301	PF00069	0.274
DOC_MAPK_gen_1	400	409	PF00069	0.405
DOC_MAPK_gen_1	479	486	PF00069	0.596
DOC_MAPK_HePTP_8	362	374	PF00069	0.423
DOC_MAPK_MEF2A_6	293	301	PF00069	0.274
DOC_MAPK_MEF2A_6	365	374	PF00069	0.408
DOC_PP1_RVXF_1	481	487	PF00149	0.594
DOC_PP2B_LxvP_1	116	119	PF13499	0.490
DOC_PP2B_LxvP_1	41	44	PF13499	0.444
DOC_USP7_MATH_1	100	104	PF00917	0.523
DOC_USP7_MATH_1	12	16	PF00917	0.513
DOC_USP7_MATH_1	18	22	PF00917	0.524
DOC_USP7_MATH_1	188	192	PF00917	0.475
DOC_USP7_MATH_1	302	306	PF00917	0.514
DOC_USP7_MATH_1	33	37	PF00917	0.425
DOC_USP7_MATH_1	381	385	PF00917	0.347
DOC_USP7_MATH_1	422	426	PF00917	0.558
DOC_WW_Pin1_4	114	119	PF00397	0.610
DOC_WW_Pin1_4	177	182	PF00397	0.603
DOC_WW_Pin1_4	216	221	PF00397	0.660
DOC_WW_Pin1_4	244	249	PF00397	0.599
DOC_WW_Pin1_4	27	32	PF00397	0.701
DOC_WW_Pin1_4	356	361	PF00397	0.471
DOC_WW_Pin1_4	375	380	PF00397	0.223
DOC_WW_Pin1_4	82	87	PF00397	0.412
LIG_14-3-3_CanoR_1	26	34	PF00244	0.627
LIG_14-3-3_CanoR_1	300	309	PF00244	0.383
LIG_APCC_ABBA_1	407	412	PF00400	0.404
LIG_CtBP_PxDLS_1	44	48	PF00389	0.389
LIG_eIF4E_1	142	148	PF01652	0.412
LIG_FHA_1	111	117	PF00498	0.506
LIG_FHA_1	132	138	PF00498	0.546
LIG_FHA_1	181	187	PF00498	0.511
LIG_FHA_2	151	157	PF00498	0.504
LIG_FHA_2	326	332	PF00498	0.476
LIG_FHA_2	475	481	PF00498	0.475
LIG_FHA_2	48	54	PF00498	0.630
LIG_HP1_1	254	258	PF01393	0.379
LIG_LIR_Gen_1	139	149	PF02991	0.396
LIG_LIR_Gen_1	35	45	PF02991	0.532
LIG_LIR_Gen_1	454	462	PF02991	0.420
LIG_LIR_Nem_3	133	138	PF02991	0.435
LIG_LIR_Nem_3	139	145	PF02991	0.498
LIG_LIR_Nem_3	225	231	PF02991	0.612
LIG_LIR_Nem_3	35	41	PF02991	0.526
LIG_LIR_Nem_3	454	458	PF02991	0.385
LIG_LIR_Nem_3	470	476	PF02991	0.563
LIG_NRBOX	385	391	PF00104	0.322
LIG_PCNA_PIPBox_1	210	219	PF02747	0.497
LIG_Pex14_1	278	282	PF04695	0.325
LIG_Pex14_2	451	455	PF04695	0.284
LIG_SH2_CRK	138	142	PF00017	0.431
LIG_SH2_CRK	303	307	PF00017	0.403
LIG_SH2_CRK	38	42	PF00017	0.505
LIG_SH2_CRK	442	446	PF00017	0.490
LIG_SH2_CRK	93	97	PF00017	0.370
LIG_SH2_NCK_1	142	146	PF00017	0.432
LIG_SH2_NCK_1	218	222	PF00017	0.631
LIG_SH2_NCK_1	303	307	PF00017	0.389
LIG_SH2_SRC	142	145	PF00017	0.440
LIG_SH2_STAP1	138	142	PF00017	0.412
LIG_SH2_STAP1	38	42	PF00017	0.433
LIG_SH2_STAT5	279	282	PF00017	0.446
LIG_SH2_STAT5	303	306	PF00017	0.485
LIG_SH2_STAT5	309	312	PF00017	0.497
LIG_SH2_STAT5	476	479	PF00017	0.609
LIG_SH3_3	112	118	PF00018	0.566
LIG_SH3_3	143	149	PF00018	0.510
LIG_SH3_3	175	181	PF00018	0.362
LIG_SH3_3	296	302	PF00018	0.297
LIG_SH3_3	455	461	PF00018	0.486
LIG_SH3_3	58	64	PF00018	0.703
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.440
LIG_SUMO_SIM_par_1	117	125	PF11976	0.448
LIG_SUMO_SIM_par_1	252	259	PF11976	0.348
LIG_SUMO_SIM_par_1	371	378	PF11976	0.442
LIG_TRFH_1	74	78	PF08558	0.565
LIG_TYR_ITIM	140	145	PF00017	0.421
LIG_TYR_ITIM	301	306	PF00017	0.399
LIG_UBA3_1	1	8	PF00899	0.662
MOD_CK1_1	180	186	PF00069	0.464
MOD_CK1_1	203	209	PF00069	0.580
MOD_CK1_1	244	250	PF00069	0.700
MOD_CK1_1	305	311	PF00069	0.392
MOD_CK1_1	319	325	PF00069	0.408
MOD_CK1_1	36	42	PF00069	0.469
MOD_CK1_1	393	399	PF00069	0.459
MOD_CK1_1	46	52	PF00069	0.594
MOD_CK2_1	393	399	PF00069	0.471
MOD_CK2_1	426	432	PF00069	0.660
MOD_CK2_1	474	480	PF00069	0.482
MOD_Cter_Amidation	232	235	PF01082	0.442
MOD_GlcNHglycan	102	105	PF01048	0.716
MOD_GlcNHglycan	202	205	PF01048	0.528
MOD_GlcNHglycan	243	246	PF01048	0.729
MOD_GlcNHglycan	288	291	PF01048	0.360
MOD_GlcNHglycan	321	324	PF01048	0.554
MOD_GlcNHglycan	420	423	PF01048	0.566
MOD_GlcNHglycan	428	431	PF01048	0.674
MOD_GlcNHglycan	434	437	PF01048	0.558
MOD_GSK3_1	110	117	PF00069	0.555
MOD_GSK3_1	173	180	PF00069	0.461
MOD_GSK3_1	301	308	PF00069	0.468
MOD_GSK3_1	389	396	PF00069	0.376
MOD_GSK3_1	418	425	PF00069	0.591
MOD_GSK3_1	43	50	PF00069	0.484
MOD_GSK3_1	441	448	PF00069	0.397
MOD_N-GLC_2	485	487	PF02516	0.463
MOD_NEK2_1	25	30	PF00069	0.511
MOD_NEK2_1	318	323	PF00069	0.533
MOD_NEK2_1	389	394	PF00069	0.471
MOD_NEK2_1	47	52	PF00069	0.540
MOD_NEK2_1	94	99	PF00069	0.384
MOD_NEK2_2	18	23	PF00069	0.447
MOD_PIKK_1	12	18	PF00454	0.511
MOD_PIKK_1	307	313	PF00454	0.273
MOD_PKA_1	234	240	PF00069	0.592
MOD_PKA_2	234	240	PF00069	0.684
MOD_PKA_2	25	31	PF00069	0.529
MOD_Plk_1	390	396	PF00069	0.463
MOD_Plk_1	474	480	PF00069	0.527
MOD_Plk_2-3	474	480	PF00069	0.605
MOD_Plk_4	36	42	PF00069	0.431
MOD_ProDKin_1	114	120	PF00069	0.606
MOD_ProDKin_1	177	183	PF00069	0.604
MOD_ProDKin_1	216	222	PF00069	0.661
MOD_ProDKin_1	244	250	PF00069	0.593
MOD_ProDKin_1	27	33	PF00069	0.692
MOD_ProDKin_1	356	362	PF00069	0.466
MOD_ProDKin_1	375	381	PF00069	0.222
MOD_ProDKin_1	82	88	PF00069	0.413
TRG_DiLeu_BaEn_2	334	340	PF01217	0.325
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.519
TRG_ENDOCYTIC_2	138	141	PF00928	0.409
TRG_ENDOCYTIC_2	142	145	PF00928	0.422
TRG_ENDOCYTIC_2	279	282	PF00928	0.348
TRG_ENDOCYTIC_2	303	306	PF00928	0.408
TRG_ENDOCYTIC_2	348	351	PF00928	0.426
TRG_ENDOCYTIC_2	38	41	PF00928	0.442
TRG_ENDOCYTIC_2	442	445	PF00928	0.499
TRG_ENDOCYTIC_2	93	96	PF00928	0.615
TRG_ER_diArg_1	292	295	PF00400	0.353
TRG_ER_diArg_1	3	6	PF00400	0.533
TRG_ER_diArg_1	481	484	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	128	133	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX1	Leptomonas seymouri	52%	100%
A0A1X0NPG1	Trypanosomatidae	28%	100%
A0A3S5H5Z0	Leishmania donovani	67%	99%
A0A422N3S3	Trypanosoma rangeli	30%	100%
A4HT90	Leishmania infantum	67%	99%
C9ZUN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AL79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%
Q4QIM5	Leishmania major	65%	99%
V5BTD2	Trypanosoma cruzi	27%	100%