MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit h

Species:

Leishmania braziliensis

UniProt:

A4H515_LEIBR

TriTrypDb:

LbrM.07.0710 , LBRM2903_070014000

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H515

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H515

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016579	protein deubiquitination	6	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.427
CLV_C14_Caspase3-7	316	320	PF00656	0.559
CLV_NRD_NRD_1	105	107	PF00675	0.582
CLV_NRD_NRD_1	108	110	PF00675	0.562
CLV_NRD_NRD_1	151	153	PF00675	0.530
CLV_NRD_NRD_1	207	209	PF00675	0.657
CLV_PCSK_KEX2_1	206	208	PF00082	0.578
CLV_PCSK_PC7_1	202	208	PF00082	0.610
CLV_PCSK_SKI1_1	109	113	PF00082	0.519
CLV_PCSK_SKI1_1	116	120	PF00082	0.480
CLV_PCSK_SKI1_1	56	60	PF00082	0.537
CLV_PCSK_SKI1_1	62	66	PF00082	0.502
DEG_APCC_DBOX_1	158	166	PF00400	0.503
DEG_APCC_DBOX_1	238	246	PF00400	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DOC_CYCLIN_RxL_1	104	115	PF00134	0.608
DOC_MAPK_DCC_7	159	167	PF00069	0.494
DOC_MAPK_gen_1	104	114	PF00069	0.398
DOC_MAPK_MEF2A_6	159	167	PF00069	0.494
DOC_MAPK_MEF2A_6	83	90	PF00069	0.620
DOC_PP2B_LxvP_1	35	38	PF13499	0.502
DOC_PP2B_PxIxI_1	85	91	PF00149	0.648
DOC_USP7_MATH_1	214	218	PF00917	0.602
DOC_USP7_MATH_1	256	260	PF00917	0.535
DOC_USP7_MATH_1	58	62	PF00917	0.580
DOC_USP7_UBL2_3	27	31	PF12436	0.602
DOC_WW_Pin1_4	183	188	PF00397	0.466
LIG_14-3-3_CanoR_1	206	211	PF00244	0.652
LIG_14-3-3_CanoR_1	56	65	PF00244	0.548
LIG_14-3-3_CanoR_1	7	17	PF00244	0.576
LIG_14-3-3_CanoR_1	95	102	PF00244	0.679
LIG_AP2alpha_2	170	172	PF02296	0.423
LIG_BRCT_BRCA1_1	139	143	PF00533	0.548
LIG_Clathr_ClatBox_1	111	115	PF01394	0.385
LIG_EH_1	143	147	PF12763	0.494
LIG_eIF4E_1	192	198	PF01652	0.561
LIG_FHA_1	128	134	PF00498	0.544
LIG_FHA_1	172	178	PF00498	0.573
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	302	308	PF00498	0.468
LIG_FHA_1	31	37	PF00498	0.526
LIG_FHA_1	313	319	PF00498	0.384
LIG_FHA_2	95	101	PF00498	0.626
LIG_LIR_Gen_1	235	245	PF02991	0.478
LIG_LIR_Gen_1	325	335	PF02991	0.384
LIG_LIR_Nem_3	140	146	PF02991	0.536
LIG_LIR_Nem_3	168	172	PF02991	0.523
LIG_LIR_Nem_3	188	194	PF02991	0.421
LIG_LIR_Nem_3	235	240	PF02991	0.468
LIG_LIR_Nem_3	252	257	PF02991	0.565
LIG_LIR_Nem_3	44	48	PF02991	0.421
LIG_PTB_Apo_2	39	46	PF02174	0.467
LIG_SH2_CRK	194	198	PF00017	0.450
LIG_SH2_STAP1	194	198	PF00017	0.509
LIG_SH2_STAP1	328	332	PF00017	0.573
LIG_SH2_STAT5	185	188	PF00017	0.398
LIG_SUMO_SIM_par_1	110	115	PF11976	0.387
LIG_SUMO_SIM_par_1	75	81	PF11976	0.469
LIG_TRAF2_1	97	100	PF00917	0.666
LIG_UBA3_1	305	309	PF00899	0.509
MOD_CK1_1	147	153	PF00069	0.488
MOD_CK1_1	196	202	PF00069	0.594
MOD_CK1_1	217	223	PF00069	0.615
MOD_CK2_1	94	100	PF00069	0.691
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.509
MOD_GlcNHglycan	139	142	PF01048	0.454
MOD_GlcNHglycan	216	219	PF01048	0.543
MOD_GSK3_1	193	200	PF00069	0.610
MOD_GSK3_1	246	253	PF00069	0.461
MOD_GSK3_1	256	263	PF00069	0.573
MOD_GSK3_1	322	329	PF00069	0.357
MOD_GSK3_1	54	61	PF00069	0.525
MOD_LATS_1	310	316	PF00433	0.557
MOD_N-GLC_1	274	279	PF02516	0.533
MOD_N-GLC_1	41	46	PF02516	0.533
MOD_N-GLC_1	8	13	PF02516	0.558
MOD_NEK2_1	136	141	PF00069	0.540
MOD_NEK2_1	260	265	PF00069	0.570
MOD_NEK2_1	269	274	PF00069	0.348
MOD_NEK2_1	321	326	PF00069	0.451
MOD_NEK2_1	327	332	PF00069	0.427
MOD_PKA_1	206	212	PF00069	0.655
MOD_PKA_2	158	164	PF00069	0.609
MOD_PKA_2	206	212	PF00069	0.655
MOD_PKA_2	94	100	PF00069	0.650
MOD_Plk_1	322	328	PF00069	0.391
MOD_Plk_1	41	47	PF00069	0.461
MOD_Plk_2-3	94	100	PF00069	0.755
MOD_Plk_4	193	199	PF00069	0.523
MOD_Plk_4	301	307	PF00069	0.449
MOD_Plk_4	322	328	PF00069	0.462
MOD_Plk_4	64	70	PF00069	0.570
MOD_ProDKin_1	183	189	PF00069	0.476
MOD_SUMO_for_1	230	233	PF00179	0.485
MOD_SUMO_rev_2	103	112	PF00179	0.567
MOD_SUMO_rev_2	75	84	PF00179	0.483
TRG_DiLeu_BaEn_1	303	308	PF01217	0.564
TRG_ENDOCYTIC_2	169	172	PF00928	0.397
TRG_ENDOCYTIC_2	194	197	PF00928	0.461
TRG_ENDOCYTIC_2	2	5	PF00928	0.576
TRG_ENDOCYTIC_2	328	331	PF00928	0.568
TRG_ER_diArg_1	206	208	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B4	Leptomonas seymouri	71%	100%
A0A0S4KFQ8	Bodo saltans	27%	99%
A0A1X0NPP9	Trypanosomatidae	35%	100%
A0A3S7WPX1	Leishmania donovani	94%	100%
A0A422MVQ1	Trypanosoma rangeli	33%	100%
A4HTE9	Leishmania infantum	94%	100%
E9AL77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QIM7	Leishmania major	94%	100%
V5BNS6	Trypanosoma cruzi	33%	100%