LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Calcium-transporting ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calcium-transporting ATPase
Gene product:
vacuolar-type Ca2+-ATPase, putative
Species:
Leishmania braziliensis
UniProt:
A4H514_LEIBR
TriTrypDb:
LbrM.07.0700 , LBRM2903_070013900 * , LBRM2903_330017000 *
Length:
1126

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic P-type Ca2+ ATPases.. For some reason, this group has heavily expanded in Kinetoplastida.. Localization: Endosomal (by homology) / ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 3
GO:0016020 membrane 2 20
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 20
Previous1Next

Expansion

Sequence features

A4H514
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H514

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 20
GO:0003824 catalytic activity 1 20
GO:0005215 transporter activity 1 16
GO:0005388 P-type calcium transporter activity 4 16
GO:0005488 binding 1 20
GO:0005524 ATP binding 5 20
GO:0008324 monoatomic cation transmembrane transporter activity 4 16
GO:0015075 monoatomic ion transmembrane transporter activity 3 16
GO:0015085 calcium ion transmembrane transporter activity 6 16
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 16
Previous1234Next

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 527 531 PF00656 0.457
CLV_C14_Caspase3-7 661 665 PF00656 0.558
CLV_MEL_PAP_1 45 51 PF00089 0.322
CLV_NRD_NRD_1 114 116 PF00675 0.254
CLV_NRD_NRD_1 197 199 PF00675 0.301
CLV_NRD_NRD_1 218 220 PF00675 0.356
CLV_NRD_NRD_1 36 38 PF00675 0.456
CLV_NRD_NRD_1 411 413 PF00675 0.383
CLV_NRD_NRD_1 473 475 PF00675 0.383
CLV_NRD_NRD_1 542 544 PF00675 0.259
Previous12345…37Next

Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P3Y1 Leptomonas seymouri 29% 100%
A0A0N1HWG6 Leptomonas seymouri 40% 100%
A0A0N1PFH3 Leptomonas seymouri 27% 93%
A0A0S4J5A1 Bodo saltans 30% 100%
A0A0S4J6U4 Bodo saltans 39% 100%
A0A0S4JA92 Bodo saltans 42% 100%
A0A0S4JDQ9 Bodo saltans 22% 100%
A0A0S4JRV4 Bodo saltans 41% 100%
A0A0S4KIG5 Bodo saltans 29% 100%
A0A0S4KNQ6 Bodo saltans 62% 100%
Previous12345…22Next

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS