GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H513_LEIBR

TriTrypDb:

LbrM.07.0690 , LBRM2903_070013400 , LBRM2903_070013500

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H513

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H513

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.523
CLV_NRD_NRD_1	374	376	PF00675	0.543
CLV_NRD_NRD_1	396	398	PF00675	0.732
CLV_PCSK_KEX2_1	35	37	PF00082	0.430
CLV_PCSK_KEX2_1	374	376	PF00082	0.543
CLV_PCSK_KEX2_1	477	479	PF00082	0.647
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.430
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.397
CLV_PCSK_PC7_1	31	37	PF00082	0.430
CLV_PCSK_SKI1_1	140	144	PF00082	0.418
CLV_PCSK_SKI1_1	198	202	PF00082	0.463
CLV_PCSK_SKI1_1	281	285	PF00082	0.397
CLV_PCSK_SKI1_1	374	378	PF00082	0.516
CLV_Separin_Metazoa	492	496	PF03568	0.644
DEG_APCC_DBOX_1	15	23	PF00400	0.677
DEG_APCC_DBOX_1	458	466	PF00400	0.426
DEG_Kelch_Keap1_1	166	171	PF01344	0.541
DOC_MAPK_MEF2A_6	138	146	PF00069	0.545
DOC_PP2B_LxvP_1	257	260	PF13499	0.558
DOC_USP7_MATH_1	185	189	PF00917	0.461
DOC_USP7_MATH_1	224	228	PF00917	0.555
DOC_USP7_MATH_1	317	321	PF00917	0.462
DOC_USP7_MATH_1	348	352	PF00917	0.639
DOC_USP7_MATH_1	52	56	PF00917	0.721
DOC_USP7_MATH_1	88	92	PF00917	0.479
DOC_USP7_UBL2_3	286	290	PF12436	0.396
DOC_WW_Pin1_4	240	245	PF00397	0.640
DOC_WW_Pin1_4	415	420	PF00397	0.538
DOC_WW_Pin1_4	447	452	PF00397	0.613
LIG_14-3-3_CanoR_1	112	120	PF00244	0.536
LIG_14-3-3_CanoR_1	36	44	PF00244	0.678
LIG_14-3-3_CanoR_1	459	463	PF00244	0.426
LIG_14-3-3_CanoR_1	61	67	PF00244	0.578
LIG_APCC_ABBA_1	439	444	PF00400	0.545
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_deltaCOP1_diTrp_1	357	366	PF00928	0.418
LIG_FHA_1	254	260	PF00498	0.803
LIG_FHA_1	4	10	PF00498	0.766
LIG_FHA_1	432	438	PF00498	0.544
LIG_FHA_2	40	46	PF00498	0.587
LIG_FHA_2	82	88	PF00498	0.567
LIG_LIR_Gen_1	126	134	PF02991	0.679
LIG_LIR_Nem_3	126	130	PF02991	0.684
LIG_NRBOX	461	467	PF00104	0.418
LIG_PDZ_Class_2	514	519	PF00595	0.475
LIG_SH2_CRK	127	131	PF00017	0.684
LIG_SH3_3	215	221	PF00018	0.547
LIG_SH3_3	242	248	PF00018	0.708
LIG_SH3_3	445	451	PF00018	0.617
LIG_SH3_3	497	503	PF00018	0.697
LIG_SUMO_SIM_par_1	450	456	PF11976	0.746
LIG_TRAF2_1	147	150	PF00917	0.660
LIG_TRAF2_1	15	18	PF00917	0.434
LIG_TRAF2_1	51	54	PF00917	0.723
LIG_UBA3_1	19	25	PF00899	0.677
LIG_WRC_WIRS_1	349	354	PF05994	0.424
LIG_WRC_WIRS_1	40	45	PF05994	0.432
MOD_CK1_1	166	172	PF00069	0.764
MOD_CK1_1	243	249	PF00069	0.636
MOD_CK1_1	3	9	PF00069	0.774
MOD_CK1_1	432	438	PF00069	0.700
MOD_CK1_1	57	63	PF00069	0.612
MOD_CK1_1	72	78	PF00069	0.780
MOD_CK1_1	79	85	PF00069	0.693
MOD_CK2_1	111	117	PF00069	0.496
MOD_CK2_1	193	199	PF00069	0.545
MOD_CK2_1	224	230	PF00069	0.555
MOD_CK2_1	317	323	PF00069	0.463
MOD_CK2_1	348	354	PF00069	0.561
MOD_CK2_1	35	41	PF00069	0.677
MOD_CK2_1	362	368	PF00069	0.560
MOD_CK2_1	68	74	PF00069	0.586
MOD_GlcNHglycan	168	171	PF01048	0.744
MOD_GlcNHglycan	187	190	PF01048	0.644
MOD_GlcNHglycan	221	224	PF01048	0.678
MOD_GlcNHglycan	319	322	PF01048	0.462
MOD_GlcNHglycan	37	40	PF01048	0.672
MOD_GlcNHglycan	64	67	PF01048	0.647
MOD_GlcNHglycan	74	78	PF01048	0.677
MOD_GlcNHglycan	81	84	PF01048	0.665
MOD_GlcNHglycan	90	93	PF01048	0.573
MOD_GSK3_1	136	143	PF00069	0.416
MOD_GSK3_1	212	219	PF00069	0.612
MOD_GSK3_1	224	231	PF00069	0.602
MOD_GSK3_1	239	246	PF00069	0.514
MOD_GSK3_1	35	42	PF00069	0.579
MOD_GSK3_1	397	404	PF00069	0.658
MOD_GSK3_1	411	418	PF00069	0.652
MOD_GSK3_1	443	450	PF00069	0.560
MOD_GSK3_1	52	59	PF00069	0.572
MOD_GSK3_1	68	75	PF00069	0.775
MOD_GSK3_1	79	86	PF00069	0.622
MOD_N-GLC_1	412	417	PF02516	0.553
MOD_N-GLC_1	69	74	PF02516	0.748
MOD_NEK2_1	253	258	PF00069	0.568
MOD_NEK2_1	411	416	PF00069	0.552
MOD_NEK2_1	43	48	PF00069	0.695
MOD_NEK2_1	56	61	PF00069	0.576
MOD_NEK2_1	68	73	PF00069	0.539
MOD_NEK2_2	348	353	PF00069	0.637
MOD_PIKK_1	203	209	PF00454	0.703
MOD_PIKK_1	399	405	PF00454	0.802
MOD_PIKK_1	54	60	PF00454	0.665
MOD_PIKK_1	90	96	PF00454	0.705
MOD_PKA_1	35	41	PF00069	0.427
MOD_PKA_1	397	403	PF00069	0.552
MOD_PKA_2	111	117	PF00069	0.658
MOD_PKA_2	35	41	PF00069	0.580
MOD_PKA_2	458	464	PF00069	0.428
MOD_Plk_1	253	259	PF00069	0.729
MOD_Plk_1	326	332	PF00069	0.445
MOD_Plk_1	412	418	PF00069	0.674
MOD_Plk_1	443	449	PF00069	0.540
MOD_Plk_1	52	58	PF00069	0.744
MOD_Plk_1	73	79	PF00069	0.588
MOD_Plk_2-3	193	199	PF00069	0.545
MOD_Plk_4	140	146	PF00069	0.419
MOD_Plk_4	228	234	PF00069	0.547
MOD_Plk_4	362	368	PF00069	0.549
MOD_Plk_4	39	45	PF00069	0.466
MOD_Plk_4	443	449	PF00069	0.525
MOD_ProDKin_1	240	246	PF00069	0.641
MOD_ProDKin_1	415	421	PF00069	0.537
MOD_ProDKin_1	447	453	PF00069	0.609
MOD_SUMO_rev_2	470	479	PF00179	0.402
TRG_ENDOCYTIC_2	127	130	PF00928	0.686
TRG_NES_CRM1_1	272	287	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	375	380	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPV9	Leishmania donovani	61%	82%
A4HT87	Leishmania infantum	61%	82%
Q4QIM9	Leishmania major	60%	84%