Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H512_LEIBR

TriTrypDb:

LbrM.07.0680 , LBRM2903_070013300

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H512

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H512

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.734
CLV_MEL_PAP_1	116	122	PF00089	0.506
CLV_NRD_NRD_1	22	24	PF00675	0.524
CLV_PCSK_KEX2_1	154	156	PF00082	0.629
CLV_PCSK_KEX2_1	218	220	PF00082	0.790
CLV_PCSK_KEX2_1	22	24	PF00082	0.524
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.629
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.774
DEG_SPOP_SBC_1	132	136	PF00917	0.740
DEG_SPOP_SBC_1	137	141	PF00917	0.696
DOC_MAPK_JIP1_4	2	8	PF00069	0.728
DOC_PP1_RVXF_1	188	194	PF00149	0.591
DOC_PP2B_LxvP_1	34	37	PF13499	0.753
DOC_PP4_FxxP_1	8	11	PF00568	0.577
DOC_USP7_MATH_1	131	135	PF00917	0.768
DOC_USP7_MATH_1	138	142	PF00917	0.606
DOC_USP7_MATH_1	21	25	PF00917	0.617
DOC_USP7_MATH_1	61	65	PF00917	0.792
DOC_USP7_UBL2_3	69	73	PF12436	0.552
DOC_WW_Pin1_4	122	127	PF00397	0.599
LIG_14-3-3_CanoR_1	188	194	PF00244	0.621
LIG_14-3-3_CanoR_1	79	85	PF00244	0.553
LIG_FHA_1	123	129	PF00498	0.610
LIG_FHA_1	142	148	PF00498	0.707
LIG_FHA_1	31	37	PF00498	0.634
LIG_FHA_1	42	48	PF00498	0.545
LIG_FHA_2	182	188	PF00498	0.662
LIG_IRF3_LxIS_1	43	48	PF10401	0.502
LIG_LIR_Apic_2	7	11	PF02991	0.549
LIG_LIR_Gen_1	174	182	PF02991	0.606
LIG_LIR_Gen_1	192	201	PF02991	0.554
LIG_LIR_LC3C_4	33	36	PF02991	0.510
LIG_LIR_Nem_3	174	180	PF02991	0.601
LIG_LIR_Nem_3	192	196	PF02991	0.577
LIG_Pex14_2	173	177	PF04695	0.667
LIG_PTAP_UEV_1	147	152	PF05743	0.497
LIG_PTB_Apo_2	37	44	PF02174	0.497
LIG_SH2_STAP1	152	156	PF00017	0.634
LIG_SH2_STAT5	111	114	PF00017	0.647
LIG_SH3_3	142	148	PF00018	0.610
LIG_SH3_3	165	171	PF00018	0.578
LIG_SH3_3	33	39	PF00018	0.633
LIG_SH3_4	69	76	PF00018	0.551
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.662
LIG_SUMO_SIM_par_1	143	149	PF11976	0.512
LIG_SUMO_SIM_par_1	2	7	PF11976	0.475
LIG_WRC_WIRS_1	5	10	PF05994	0.476
MOD_CK1_1	136	142	PF00069	0.630
MOD_CK1_1	60	66	PF00069	0.770
MOD_CK1_1	82	88	PF00069	0.750
MOD_CK2_1	181	187	PF00069	0.654
MOD_Cter_Amidation	216	219	PF01082	0.693
MOD_GlcNHglycan	128	131	PF01048	0.777
MOD_GlcNHglycan	148	151	PF01048	0.658
MOD_GlcNHglycan	174	177	PF01048	0.655
MOD_GlcNHglycan	232	235	PF01048	0.680
MOD_GlcNHglycan	249	252	PF01048	0.653
MOD_GlcNHglycan	47	50	PF01048	0.662
MOD_GlcNHglycan	59	62	PF01048	0.787
MOD_GlcNHglycan	87	90	PF01048	0.697
MOD_GSK3_1	122	129	PF00069	0.588
MOD_GSK3_1	132	139	PF00069	0.627
MOD_GSK3_1	241	248	PF00069	0.573
MOD_GSK3_1	41	48	PF00069	0.595
MOD_GSK3_1	56	63	PF00069	0.626
MOD_GSK3_1	79	86	PF00069	0.746
MOD_NEK2_1	120	125	PF00069	0.730
MOD_NEK2_1	191	196	PF00069	0.635
MOD_NEK2_1	45	50	PF00069	0.602
MOD_PIKK_1	181	187	PF00454	0.654
MOD_PKA_1	22	28	PF00069	0.649
MOD_PKA_2	189	195	PF00069	0.626
MOD_PKA_2	21	27	PF00069	0.662
MOD_Plk_1	241	247	PF00069	0.608
MOD_Plk_4	241	247	PF00069	0.634
MOD_Plk_4	30	36	PF00069	0.629
MOD_ProDKin_1	122	128	PF00069	0.605
TRG_ER_diArg_1	188	191	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.793

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P403	Leptomonas seymouri	46%	97%
A0A3S5H5Y8	Leishmania donovani	66%	100%
A4HT86	Leishmania infantum	67%	100%
C9ZUN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AL74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q4QIN0	Leishmania major	66%	100%