Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H511_LEIBR

TriTrypDb:

LbrM.07.0670 , LBRM2903_070013200

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H511

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H511

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.598
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SPOP_SBC_1	118	122	PF00917	0.747
DOC_MAPK_HePTP_8	56	68	PF00069	0.525
DOC_MAPK_MEF2A_6	59	68	PF00069	0.502
DOC_PP1_RVXF_1	97	104	PF00149	0.384
DOC_PP4_FxxP_1	19	22	PF00568	0.537
DOC_PP4_MxPP_1	37	40	PF00568	0.405
DOC_SPAK_OSR1_1	76	80	PF12202	0.496
DOC_USP7_MATH_1	118	122	PF00917	0.689
DOC_USP7_MATH_1	33	37	PF00917	0.483
DOC_USP7_MATH_1	44	48	PF00917	0.724
DOC_USP7_MATH_1	50	54	PF00917	0.727
DOC_USP7_MATH_1	78	82	PF00917	0.492
DOC_WW_Pin1_4	119	124	PF00397	0.704
DOC_WW_Pin1_4	59	64	PF00397	0.516
DOC_WW_Pin1_4	80	85	PF00397	0.432
LIG_14-3-3_CanoR_1	87	91	PF00244	0.302
LIG_BRCT_BRCA1_1	2	6	PF00533	0.446
LIG_eIF4E_1	90	96	PF01652	0.420
LIG_FHA_1	155	161	PF00498	0.437
LIG_FHA_1	23	29	PF00498	0.423
LIG_FHA_1	33	39	PF00498	0.426
LIG_FHA_1	63	69	PF00498	0.416
LIG_FHA_2	182	188	PF00498	0.707
LIG_LIR_Apic_2	161	167	PF02991	0.335
LIG_LIR_Apic_2	18	22	PF02991	0.546
LIG_LIR_Gen_1	102	107	PF02991	0.375
LIG_LIR_Nem_3	102	106	PF02991	0.368
LIG_LIR_Nem_3	89	93	PF02991	0.426
LIG_LYPXL_S_1	154	158	PF13949	0.483
LIG_LYPXL_yS_3	155	158	PF13949	0.464
LIG_MLH1_MIPbox_1	2	6	PF16413	0.446
LIG_MYND_1	40	44	PF01753	0.445
LIG_PDZ_Class_3	192	197	PF00595	0.510
LIG_SH2_CRK	61	65	PF00017	0.498
LIG_SH2_CRK	90	94	PF00017	0.449
LIG_SH2_NCK_1	164	168	PF00017	0.598
LIG_SH2_NCK_1	61	65	PF00017	0.498
LIG_SH2_STAT5	90	93	PF00017	0.416
LIG_SH3_3	101	107	PF00018	0.493
LIG_SH3_3	35	41	PF00018	0.618
LIG_TRAF2_2	44	49	PF00917	0.555
LIG_TRFH_1	103	107	PF08558	0.451
LIG_TYR_ITIM	88	93	PF00017	0.401
LIG_WW_2	40	43	PF00397	0.440
MOD_CDK_SPxxK_3	80	87	PF00069	0.295
MOD_CK1_1	54	60	PF00069	0.633
MOD_CK1_1	62	68	PF00069	0.518
MOD_CK2_1	182	188	PF00069	0.596
MOD_Cter_Amidation	127	130	PF01082	0.700
MOD_GlcNHglycan	141	144	PF01048	0.717
MOD_GlcNHglycan	171	177	PF01048	0.714
MOD_GSK3_1	154	161	PF00069	0.447
MOD_GSK3_1	23	30	PF00069	0.377
MOD_GSK3_1	50	57	PF00069	0.686
MOD_GSK3_1	95	102	PF00069	0.382
MOD_LATS_1	137	143	PF00433	0.522
MOD_N-GLC_1	139	144	PF02516	0.645
MOD_NEK2_1	27	32	PF00069	0.349
MOD_NEK2_1	95	100	PF00069	0.413
MOD_PIKK_1	131	137	PF00454	0.732
MOD_PIKK_1	27	33	PF00454	0.443
MOD_PKA_2	86	92	PF00069	0.307
MOD_Plk_4	23	29	PF00069	0.365
MOD_Plk_4	33	39	PF00069	0.443
MOD_Plk_4	99	105	PF00069	0.450
MOD_ProDKin_1	119	125	PF00069	0.708
MOD_ProDKin_1	59	65	PF00069	0.512
MOD_ProDKin_1	80	86	PF00069	0.438
MOD_SUMO_rev_2	3	12	PF00179	0.289
TRG_ENDOCYTIC_2	155	158	PF00928	0.464
TRG_ENDOCYTIC_2	61	64	PF00928	0.502
TRG_ENDOCYTIC_2	90	93	PF00928	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E4	Leptomonas seymouri	57%	99%
A0A0S4JAK6	Bodo saltans	36%	100%
A0A1X0NPD6	Trypanosomatidae	35%	100%
A0A3S7WPW4	Leishmania donovani	80%	100%
A0A422N682	Trypanosoma rangeli	39%	94%
A4HT85	Leishmania infantum	80%	100%
C9ZUN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AL73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QIN1	Leishmania major	80%	100%
V5B8I1	Trypanosoma cruzi	38%	71%