Electron transfer flavoprotein-ubiquinone oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron transfer flavoprotein-ubiquinone oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4H510_LEIBR

TriTrypDb:

LbrM.07.0660 , LBRM2903_070013100

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H510

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H510

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022900	electron transport chain	4	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	4	12
GO:0005488	binding	1	12
GO:0009055	electron transfer activity	3	12
GO:0016491	oxidoreductase activity	2	12
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	12
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.559
CLV_C14_Caspase3-7	51	55	PF00656	0.426
CLV_MEL_PAP_1	218	224	PF00089	0.546
CLV_NRD_NRD_1	220	222	PF00675	0.315
CLV_PCSK_KEX2_1	220	222	PF00082	0.567
CLV_PCSK_SKI1_1	116	120	PF00082	0.459
CLV_PCSK_SKI1_1	321	325	PF00082	0.389
CLV_PCSK_SKI1_1	424	428	PF00082	0.443
CLV_PCSK_SKI1_1	459	463	PF00082	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SCF_FBW7_1	100	105	PF00400	0.513
DOC_ANK_TNKS_1	327	334	PF00023	0.339
DOC_CDC14_PxL_1	335	343	PF14671	0.345
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.425
DOC_MAPK_gen_1	502	512	PF00069	0.453
DOC_MAPK_RevD_3	499	514	PF00069	0.200
DOC_PP1_RVXF_1	338	344	PF00149	0.380
DOC_PP2B_LxvP_1	118	121	PF13499	0.433
DOC_PP2B_LxvP_1	356	359	PF13499	0.347
DOC_USP7_MATH_1	114	118	PF00917	0.487
DOC_USP7_MATH_1	15	19	PF00917	0.633
DOC_USP7_MATH_1	367	371	PF00917	0.341
DOC_WW_Pin1_4	449	454	PF00397	0.523
DOC_WW_Pin1_4	98	103	PF00397	0.515
LIG_14-3-3_CanoR_1	188	195	PF00244	0.579
LIG_14-3-3_CanoR_1	3	9	PF00244	0.566
LIG_14-3-3_CanoR_1	404	408	PF00244	0.389
LIG_14-3-3_CanoR_1	419	423	PF00244	0.341
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.345
LIG_CaM_IQ_9	173	188	PF13499	0.301
LIG_CSL_BTD_1	121	124	PF09270	0.562
LIG_eIF4E_1	325	331	PF01652	0.339
LIG_FHA_1	168	174	PF00498	0.554
LIG_FHA_1	213	219	PF00498	0.358
LIG_FHA_1	230	236	PF00498	0.357
LIG_FHA_1	307	313	PF00498	0.379
LIG_FHA_1	434	440	PF00498	0.445
LIG_FHA_1	475	481	PF00498	0.306
LIG_FHA_1	552	558	PF00498	0.348
LIG_FHA_2	327	333	PF00498	0.372
LIG_FHA_2	558	564	PF00498	0.363
LIG_IBAR_NPY_1	295	297	PF08397	0.363
LIG_LIR_Apic_2	239	244	PF02991	0.372
LIG_LIR_Apic_2	292	296	PF02991	0.327
LIG_LIR_Apic_2	466	472	PF02991	0.427
LIG_LIR_Gen_1	105	114	PF02991	0.529
LIG_LIR_Gen_1	25	32	PF02991	0.363
LIG_LIR_Gen_1	332	343	PF02991	0.378
LIG_LIR_Gen_1	95	103	PF02991	0.495
LIG_LIR_Nem_3	105	111	PF02991	0.428
LIG_LIR_Nem_3	154	159	PF02991	0.368
LIG_LIR_Nem_3	25	30	PF02991	0.371
LIG_LIR_Nem_3	332	338	PF02991	0.362
LIG_LIR_Nem_3	398	402	PF02991	0.415
LIG_LIR_Nem_3	406	412	PF02991	0.399
LIG_LIR_Nem_3	427	431	PF02991	0.511
LIG_LIR_Nem_3	477	481	PF02991	0.316
LIG_LYPXL_S_1	155	159	PF13949	0.402
LIG_Pex14_1	4	8	PF04695	0.694
LIG_Pex14_1	428	432	PF04695	0.490
LIG_Pex14_2	403	407	PF04695	0.353
LIG_Pex14_2	422	426	PF04695	0.389
LIG_SH2_CRK	293	297	PF00017	0.327
LIG_SH2_CRK	432	436	PF00017	0.399
LIG_SH2_GRB2like	293	296	PF00017	0.339
LIG_SH2_NCK_1	293	297	PF00017	0.362
LIG_SH2_NCK_1	379	383	PF00017	0.392
LIG_SH2_SRC	193	196	PF00017	0.417
LIG_SH2_SRC	379	382	PF00017	0.413
LIG_SH2_STAP1	379	383	PF00017	0.392
LIG_SH2_STAP1	399	403	PF00017	0.168
LIG_SH2_STAT3	570	573	PF00017	0.505
LIG_SH2_STAT5	133	136	PF00017	0.391
LIG_SH2_STAT5	287	290	PF00017	0.390
LIG_SH2_STAT5	297	300	PF00017	0.331
LIG_SH2_STAT5	402	405	PF00017	0.393
LIG_SH2_STAT5	413	416	PF00017	0.510
LIG_SH2_STAT5	432	435	PF00017	0.186
LIG_SH2_STAT5	8	11	PF00017	0.658
LIG_SH3_3	118	124	PF00018	0.425
LIG_SH3_3	254	260	PF00018	0.491
LIG_WRC_WIRS_1	475	480	PF05994	0.335
MOD_CK1_1	281	287	PF00069	0.212
MOD_CK1_1	37	43	PF00069	0.453
MOD_CK1_1	95	101	PF00069	0.515
MOD_CK2_1	326	332	PF00069	0.353
MOD_CK2_1	389	395	PF00069	0.527
MOD_CK2_1	557	563	PF00069	0.363
MOD_GlcNHglycan	335	338	PF01048	0.498
MOD_GlcNHglycan	36	39	PF01048	0.330
MOD_GlcNHglycan	369	372	PF01048	0.339
MOD_GlcNHglycan	391	394	PF01048	0.521
MOD_GlcNHglycan	486	489	PF01048	0.322
MOD_GlcNHglycan	72	75	PF01048	0.306
MOD_GSK3_1	167	174	PF00069	0.554
MOD_GSK3_1	249	256	PF00069	0.412
MOD_GSK3_1	363	370	PF00069	0.358
MOD_GSK3_1	430	437	PF00069	0.313
MOD_GSK3_1	444	451	PF00069	0.409
MOD_GSK3_1	482	489	PF00069	0.331
MOD_GSK3_1	98	105	PF00069	0.446
MOD_LATS_1	484	490	PF00433	0.340
MOD_N-GLC_1	424	429	PF02516	0.290
MOD_N-GLC_1	454	459	PF02516	0.536
MOD_N-GLC_1	482	487	PF02516	0.323
MOD_N-GLC_1	557	562	PF02516	0.378
MOD_N-GLC_1	98	103	PF02516	0.297
MOD_NEK2_1	2	7	PF00069	0.567
MOD_NEK2_1	291	296	PF00069	0.349
MOD_NEK2_1	403	408	PF00069	0.347
MOD_NEK2_1	430	435	PF00069	0.403
MOD_NEK2_1	448	453	PF00069	0.558
MOD_NEK2_2	114	119	PF00069	0.542
MOD_NEK2_2	201	206	PF00069	0.344
MOD_PIKK_1	551	557	PF00454	0.340
MOD_PKA_2	187	193	PF00069	0.578
MOD_PKA_2	2	8	PF00069	0.565
MOD_PKA_2	210	216	PF00069	0.348
MOD_PKA_2	403	409	PF00069	0.382
MOD_PKA_2	418	424	PF00069	0.396
MOD_Plk_1	266	272	PF00069	0.412
MOD_Plk_1	424	430	PF00069	0.287
MOD_Plk_1	454	460	PF00069	0.536
MOD_Plk_1	557	563	PF00069	0.391
MOD_Plk_2-3	395	401	PF00069	0.381
MOD_Plk_4	201	207	PF00069	0.343
MOD_Plk_4	249	255	PF00069	0.432
MOD_Plk_4	278	284	PF00069	0.277
MOD_Plk_4	403	409	PF00069	0.335
MOD_Plk_4	434	440	PF00069	0.401
MOD_Plk_4	92	98	PF00069	0.514
MOD_ProDKin_1	449	455	PF00069	0.518
MOD_ProDKin_1	98	104	PF00069	0.518
MOD_SUMO_rev_2	389	398	PF00179	0.478
TRG_ENDOCYTIC_2	156	159	PF00928	0.387
TRG_ENDOCYTIC_2	301	304	PF00928	0.336
TRG_ENDOCYTIC_2	409	412	PF00928	0.422
TRG_ENDOCYTIC_2	432	435	PF00928	0.376
TRG_ENDOCYTIC_2	528	531	PF00928	0.322
TRG_ER_diArg_1	220	222	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU17	Leptomonas seymouri	82%	98%
A0A0S4J6T4	Bodo saltans	67%	100%
A0A1X0NPE8	Trypanosomatidae	70%	100%
A0A3S5H5Y7	Leishmania donovani	93%	100%
A0A422N647	Trypanosoma rangeli	71%	100%
A4HT84	Leishmania infantum	93%	100%
C9ZUP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AL72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O22854	Arabidopsis thaliana	49%	91%
P09820	Rhizobium meliloti (strain 1021)	25%	100%
P10331	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	23%	100%
P26484	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	25%	100%
P53572	Azotobacter vinelandii	24%	100%
P55931	Sus scrofa	53%	93%
P87111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	91%
P94132	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	48%	100%
Q08822	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	91%
Q11190	Caenorhabditis elegans	52%	96%
Q16134	Homo sapiens	53%	93%
Q2KIG0	Bos taurus	54%	93%
Q337B8	Oryza sativa subsp. japonica	50%	100%
Q4QIN2	Leishmania major	93%	100%
Q53208	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
Q54XM6	Dictyostelium discoideum	51%	95%
Q5RDD3	Pongo abelii	53%	93%
Q6UPE1	Rattus norvegicus	53%	93%
Q921G7	Mus musculus	53%	93%
Q9HZP5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	49%	100%
V5BTC8	Trypanosoma cruzi	71%	100%