Protein kintoun

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kintoun

Gene product:

Nucleolar protein 54, putative

Species:

Leishmania braziliensis

UniProt:

A4H507_LEIBR

TriTrypDb:

LbrM.07.0630 , LBRM2903_070012700

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H507

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H507

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.680
CLV_NRD_NRD_1	24	26	PF00675	0.382
CLV_NRD_NRD_1	284	286	PF00675	0.508
CLV_NRD_NRD_1	31	33	PF00675	0.573
CLV_NRD_NRD_1	314	316	PF00675	0.685
CLV_NRD_NRD_1	39	41	PF00675	0.489
CLV_NRD_NRD_1	416	418	PF00675	0.472
CLV_NRD_NRD_1	419	421	PF00675	0.463
CLV_NRD_NRD_1	6	8	PF00675	0.537
CLV_NRD_NRD_1	64	66	PF00675	0.636
CLV_NRD_NRD_1	99	101	PF00675	0.736
CLV_PCSK_FUR_1	37	41	PF00082	0.653
CLV_PCSK_KEX2_1	184	186	PF00082	0.288
CLV_PCSK_KEX2_1	24	26	PF00082	0.454
CLV_PCSK_KEX2_1	284	286	PF00082	0.508
CLV_PCSK_KEX2_1	316	318	PF00082	0.665
CLV_PCSK_KEX2_1	39	41	PF00082	0.545
CLV_PCSK_KEX2_1	437	439	PF00082	0.540
CLV_PCSK_KEX2_1	63	65	PF00082	0.579
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.288
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.665
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.458
CLV_PCSK_SKI1_1	148	152	PF00082	0.399
CLV_PCSK_SKI1_1	187	191	PF00082	0.443
CLV_PCSK_SKI1_1	259	263	PF00082	0.467
CLV_PCSK_SKI1_1	360	364	PF00082	0.582
CLV_PCSK_SKI1_1	398	402	PF00082	0.523
DEG_SCF_TRCP1_1	320	326	PF00400	0.524
DOC_CYCLIN_RxL_1	239	249	PF00134	0.448
DOC_MAPK_gen_1	147	155	PF00069	0.348
DOC_MAPK_gen_1	184	190	PF00069	0.370
DOC_MAPK_gen_1	61	70	PF00069	0.572
DOC_MAPK_MEF2A_6	148	157	PF00069	0.337
DOC_PP1_RVXF_1	240	247	PF00149	0.434
DOC_PP1_RVXF_1	460	467	PF00149	0.567
DOC_PP2B_LxvP_1	188	191	PF13499	0.380
DOC_PP2B_LxvP_1	262	265	PF13499	0.377
DOC_SPAK_OSR1_1	245	249	PF12202	0.498
DOC_USP7_MATH_1	110	114	PF00917	0.731
DOC_USP7_MATH_1	115	119	PF00917	0.701
DOC_USP7_MATH_1	122	126	PF00917	0.636
DOC_USP7_MATH_1	17	21	PF00917	0.438
DOC_USP7_MATH_1	332	336	PF00917	0.523
DOC_USP7_MATH_1	344	348	PF00917	0.460
DOC_USP7_MATH_1	356	360	PF00917	0.629
DOC_USP7_MATH_1	42	46	PF00917	0.688
DOC_USP7_MATH_1	460	464	PF00917	0.672
DOC_USP7_MATH_1	56	60	PF00917	0.685
DOC_USP7_MATH_1	87	91	PF00917	0.648
DOC_USP7_UBL2_3	104	108	PF12436	0.548
DOC_USP7_UBL2_3	360	364	PF12436	0.686
DOC_WW_Pin1_4	263	268	PF00397	0.574
DOC_WW_Pin1_4	308	313	PF00397	0.764
DOC_WW_Pin1_4	451	456	PF00397	0.578
LIG_14-3-3_CanoR_1	245	254	PF00244	0.426
LIG_14-3-3_CanoR_1	40	50	PF00244	0.562
LIG_14-3-3_CanoR_1	425	430	PF00244	0.466
LIG_BRCT_BRCA1_1	127	131	PF00533	0.545
LIG_BRCT_BRCA1_1	367	371	PF00533	0.466
LIG_BRCT_BRCA1_1	462	466	PF00533	0.537
LIG_FHA_1	220	226	PF00498	0.440
LIG_FHA_1	296	302	PF00498	0.501
LIG_FHA_1	411	417	PF00498	0.521
LIG_FHA_2	42	48	PF00498	0.565
LIG_LIR_Gen_1	428	433	PF02991	0.456
LIG_LIR_LC3C_4	173	177	PF02991	0.394
LIG_LIR_Nem_3	183	189	PF02991	0.450
LIG_LIR_Nem_3	428	432	PF02991	0.461
LIG_SH2_CRK	186	190	PF00017	0.430
LIG_SH3_3	447	453	PF00018	0.556
LIG_SH3_4	360	367	PF00018	0.608
LIG_SUMO_SIM_par_1	222	228	PF11976	0.324
LIG_TRAF2_1	321	324	PF00917	0.545
LIG_TRAF2_2	161	166	PF00917	0.471
MOD_CDK_SPK_2	308	313	PF00069	0.758
MOD_CDK_SPK_2	451	456	PF00069	0.531
MOD_CDK_SPxxK_3	308	315	PF00069	0.654
MOD_CK1_1	113	119	PF00069	0.550
MOD_CK1_1	125	131	PF00069	0.565
MOD_CK1_1	311	317	PF00069	0.656
MOD_CK1_1	335	341	PF00069	0.566
MOD_CK1_1	346	352	PF00069	0.698
MOD_CK1_1	90	96	PF00069	0.660
MOD_CK2_1	318	324	PF00069	0.563
MOD_CK2_1	389	395	PF00069	0.464
MOD_CK2_1	41	47	PF00069	0.503
MOD_GlcNHglycan	113	116	PF01048	0.694
MOD_GlcNHglycan	117	120	PF01048	0.677
MOD_GlcNHglycan	127	130	PF01048	0.569
MOD_GlcNHglycan	320	323	PF01048	0.669
MOD_GlcNHglycan	334	337	PF01048	0.806
MOD_GlcNHglycan	44	47	PF01048	0.622
MOD_GlcNHglycan	90	93	PF01048	0.609
MOD_GSK3_1	111	118	PF00069	0.526
MOD_GSK3_1	176	183	PF00069	0.337
MOD_GSK3_1	311	318	PF00069	0.725
MOD_GSK3_1	330	337	PF00069	0.734
MOD_GSK3_1	356	363	PF00069	0.623
MOD_GSK3_1	83	90	PF00069	0.586
MOD_N-GLC_1	170	175	PF02516	0.312
MOD_N-GLC_1	292	297	PF02516	0.486
MOD_NEK2_1	131	136	PF00069	0.483
MOD_NEK2_1	273	278	PF00069	0.597
MOD_NEK2_1	399	404	PF00069	0.411
MOD_NEK2_1	446	451	PF00069	0.535
MOD_NEK2_2	252	257	PF00069	0.578
MOD_NEK2_2	460	465	PF00069	0.550
MOD_NEK2_2	56	61	PF00069	0.623
MOD_PIKK_1	170	176	PF00454	0.304
MOD_PIKK_1	246	252	PF00454	0.538
MOD_PKA_1	315	321	PF00069	0.722
MOD_PKA_2	111	117	PF00069	0.566
MOD_PKA_2	246	252	PF00069	0.476
MOD_PKA_2	318	324	PF00069	0.594
MOD_Plk_1	170	176	PF00069	0.304
MOD_Plk_1	252	258	PF00069	0.580
MOD_Plk_1	292	298	PF00069	0.488
MOD_Plk_4	132	138	PF00069	0.567
MOD_ProDKin_1	263	269	PF00069	0.571
MOD_ProDKin_1	308	314	PF00069	0.764
MOD_ProDKin_1	451	457	PF00069	0.577
MOD_SUMO_rev_2	320	329	PF00179	0.804
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.411
TRG_ENDOCYTIC_2	186	189	PF00928	0.401
TRG_ER_diArg_1	256	259	PF00400	0.484
TRG_ER_diArg_1	37	40	PF00400	0.476
TRG_ER_diArg_1	63	65	PF00400	0.649
TRG_ER_diArg_1	77	80	PF00400	0.397
TRG_NLS_Bipartite_1	7	22	PF00514	0.528
TRG_NLS_MonoCore_2	100	105	PF00514	0.500
TRG_NLS_MonoExtC_3	100	106	PF00514	0.661
TRG_NLS_MonoExtC_3	314	319	PF00514	0.761
TRG_NLS_MonoExtC_3	363	369	PF00514	0.673
TRG_NLS_MonoExtN_4	312	319	PF00514	0.721
TRG_NLS_MonoExtN_4	361	368	PF00514	0.672
TRG_NLS_MonoExtN_4	98	105	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB51	Leptomonas seymouri	57%	100%
A0A0S4IW25	Bodo saltans	28%	100%
A0A3R7ME95	Trypanosoma rangeli	38%	100%
A0A3S7WPV8	Leishmania donovani	72%	100%
A4HT71	Leishmania infantum	72%	100%
C9ZUP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	83%
E9AL69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QIN5	Leishmania major	72%	99%
V5BY30	Trypanosoma cruzi	39%	98%