LeishMANIAdb
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ADP/ATP translocase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ADP/ATP translocase
Gene product:
adp/ATP carrier-like protein
Species:
Leishmania braziliensis
UniProt:
A4H503_LEIBR
TriTrypDb:
LbrM.07.0590 , LBRM2903_070012300
Length:
362

Annotations

LeishMANIAdb annotations

Highly similar to mitochondrial ADP/ATP antiporters of other Eukaryotes.. Only duplicated sporadically in Strigomonas and T. cruzi.. Localization: Mitochondrial inner membrane (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 13
GO:0016020 membrane 2 13
GO:0019866 organelle inner membrane 4 13
GO:0031090 organelle membrane 3 13
GO:0031966 mitochondrial membrane 4 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A4H503
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H503

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 13
GO:0006811 monoatomic ion transport 4 13
GO:0006820 monoatomic anion transport 5 13
GO:0006862 nucleotide transport 6 13
GO:0009987 cellular process 1 13
GO:0015711 organic anion transport 5 13
GO:0015748 organophosphate ester transport 5 13
GO:0015865 purine nucleotide transport 7 13
GO:0015866 ADP transport 6 13
GO:0015867 ATP transport 6 13
GO:0015868 purine ribonucleotide transport 6 13
GO:0015931 nucleobase-containing compound transport 5 13
GO:0034220 monoatomic ion transmembrane transport 3 13
GO:0051179 localization 1 13
GO:0051234 establishment of localization 2 13
GO:0051503 adenine nucleotide transport 8 13
GO:0055085 transmembrane transport 2 13
GO:0071702 organic substance transport 4 13
GO:0071705 nitrogen compound transport 4 13
GO:0072530 purine-containing compound transmembrane transport 3 13
GO:0098656 monoatomic anion transmembrane transport 4 13
GO:0140021 mitochondrial ADP transmembrane transport 4 13
GO:1901264 carbohydrate derivative transport 5 13
GO:1901679 nucleotide transmembrane transport 3 13
GO:1990542 mitochondrial transmembrane transport 3 13
GO:1990544 mitochondrial ATP transmembrane transport 4 13
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010639 negative regulation of organelle organization 6 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0010821 regulation of mitochondrion organization 6 1
GO:0010823 negative regulation of mitochondrion organization 7 1
GO:0010941 regulation of cell death 4 1
GO:0016043 cellular component organization 3 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0032879 regulation of localization 3 1
GO:0033043 regulation of organelle organization 5 1
GO:0035795 negative regulation of mitochondrial membrane permeability 5 1
GO:0042981 regulation of apoptotic process 6 1
GO:0043066 negative regulation of apoptotic process 7 1
GO:0043067 regulation of programmed cell death 5 1
GO:0043069 negative regulation of programmed cell death 6 1
GO:0046902 regulation of mitochondrial membrane permeability 4 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051049 regulation of transport 4 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051129 negative regulation of cellular component organization 5 1
GO:0060548 negative regulation of cell death 5 1
GO:0061024 membrane organization 4 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090559 regulation of membrane permeability 3 1
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 5 1
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 6 1
GO:1905709 negative regulation of membrane permeability 4 1
GO:2001233 regulation of apoptotic signaling pathway 5 1
GO:2001234 negative regulation of apoptotic signaling pathway 6 1
Molecular functions
Term Name Level Count
GO:0000295 adenine nucleotide transmembrane transporter activity 6 13
GO:0005215 transporter activity 1 13
GO:0005346 purine ribonucleotide transmembrane transporter activity 4 13
GO:0005347 ATP transmembrane transporter activity 5 13
GO:0005471 ATP:ADP antiporter activity 5 13
GO:0008509 monoatomic anion transmembrane transporter activity 4 13
GO:0008514 organic anion transmembrane transporter activity 5 13
GO:0015075 monoatomic ion transmembrane transporter activity 3 13
GO:0015215 nucleotide transmembrane transporter activity 4 13
GO:0015216 purine nucleotide transmembrane transporter activity 5 13
GO:0015217 ADP transmembrane transporter activity 5 13
GO:0015291 secondary active transmembrane transporter activity 4 13
GO:0015297 antiporter activity 5 13
GO:0015605 organophosphate ester transmembrane transporter activity 3 13
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 13
GO:0022804 active transmembrane transporter activity 3 13
GO:0022853 active monoatomic ion transmembrane transporter activity 4 13
GO:0022857 transmembrane transporter activity 2 13
GO:0140323 obsolete solute:monoatomic anion antiporter activity 6 13
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 24 28 PF00082 0.524
CLV_PCSK_SKI1_1 241 245 PF00082 0.396
CLV_PCSK_SKI1_1 336 340 PF00082 0.273
CLV_PCSK_SKI1_1 348 352 PF00082 0.329
CLV_PCSK_SKI1_1 88 92 PF00082 0.258
DEG_APCC_DBOX_1 137 145 PF00400 0.407
DEG_APCC_DBOX_1 87 95 PF00400 0.517
DEG_MDM2_SWIB_1 117 124 PF02201 0.517
DOC_CYCLIN_yCln2_LP_2 263 269 PF00134 0.311
DOC_MAPK_gen_1 203 210 PF00069 0.416
DOC_MAPK_gen_1 305 312 PF00069 0.458
DOC_MAPK_MEF2A_6 203 210 PF00069 0.416
DOC_MAPK_MEF2A_6 305 312 PF00069 0.458
DOC_PP2B_LxvP_1 263 266 PF13499 0.335
DOC_USP7_MATH_1 160 164 PF00917 0.308
DOC_USP7_MATH_1 18 22 PF00917 0.666
DOC_USP7_MATH_1 2 6 PF00917 0.680
DOC_USP7_MATH_1 230 234 PF00917 0.453
DOC_USP7_MATH_1 42 46 PF00917 0.737
DOC_USP7_MATH_1 50 54 PF00917 0.677
DOC_USP7_MATH_1 8 12 PF00917 0.645
DOC_USP7_MATH_2 270 276 PF00917 0.379
DOC_WW_Pin1_4 275 280 PF00397 0.274
DOC_WW_Pin1_4 44 49 PF00397 0.680
LIG_14-3-3_CanoR_1 221 225 PF00244 0.427
LIG_14-3-3_CanoR_1 24 31 PF00244 0.736
LIG_14-3-3_CanoR_1 241 246 PF00244 0.120
LIG_14-3-3_CanoR_1 316 326 PF00244 0.426
LIG_BRCT_BRCA1_1 162 166 PF00533 0.315
LIG_BRCT_BRCA1_1 216 220 PF00533 0.433
LIG_BRCT_BRCA1_1 222 226 PF00533 0.422
LIG_Clathr_ClatBox_1 71 75 PF01394 0.618
LIG_CtBP_PxDLS_1 300 304 PF00389 0.517
LIG_eIF4E_1 240 246 PF01652 0.311
LIG_FHA_1 1 7 PF00498 0.683
LIG_FHA_1 169 175 PF00498 0.285
LIG_FHA_1 242 248 PF00498 0.328
LIG_FHA_1 276 282 PF00498 0.257
LIG_FHA_1 291 297 PF00498 0.193
LIG_FHA_1 341 347 PF00498 0.296
LIG_FHA_1 351 357 PF00498 0.225
LIG_LIR_Gen_1 119 127 PF02991 0.459
LIG_LIR_Gen_1 181 190 PF02991 0.309
LIG_LIR_Gen_1 200 208 PF02991 0.416
LIG_LIR_Gen_1 250 261 PF02991 0.277
LIG_LIR_Nem_3 116 120 PF02991 0.447
LIG_LIR_Nem_3 181 185 PF02991 0.309
LIG_LIR_Nem_3 200 204 PF02991 0.415
LIG_LIR_Nem_3 223 227 PF02991 0.472
LIG_LIR_Nem_3 250 256 PF02991 0.298
LIG_Pex14_2 117 121 PF04695 0.440
LIG_Pex14_2 164 168 PF04695 0.276
LIG_Pex14_2 220 224 PF04695 0.517
LIG_REV1ctd_RIR_1 336 344 PF16727 0.483
LIG_SH2_CRK 182 186 PF00017 0.314
LIG_SH2_CRK 240 244 PF00017 0.267
LIG_SH2_CRK 253 257 PF00017 0.222
LIG_SH2_NCK_1 177 181 PF00017 0.309
LIG_SH2_PTP2 267 270 PF00017 0.400
LIG_SH2_SRC 267 270 PF00017 0.400
LIG_SH2_STAP1 182 186 PF00017 0.265
LIG_SH2_STAP1 319 323 PF00017 0.458
LIG_SH2_STAT3 159 162 PF00017 0.363
LIG_SH2_STAT3 99 102 PF00017 0.483
LIG_SH2_STAT5 126 129 PF00017 0.517
LIG_SH2_STAT5 177 180 PF00017 0.279
LIG_SH2_STAT5 267 270 PF00017 0.353
LIG_SH2_STAT5 76 79 PF00017 0.531
LIG_SH2_STAT5 99 102 PF00017 0.483
LIG_SH3_3 192 198 PF00018 0.254
LIG_SH3_3 263 269 PF00018 0.291
LIG_SH3_3 355 361 PF00018 0.164
LIG_SH3_3 87 93 PF00018 0.517
LIG_SUMO_SIM_anti_2 353 359 PF11976 0.164
LIG_SUMO_SIM_anti_2 65 73 PF11976 0.491
LIG_SUMO_SIM_par_1 308 315 PF11976 0.515
LIG_SUMO_SIM_par_1 342 347 PF11976 0.396
LIG_SUMO_SIM_par_1 70 75 PF11976 0.588
LIG_TRAF2_1 270 273 PF00917 0.438
LIG_TYR_ITIM 238 243 PF00017 0.234
LIG_TYR_ITIM 251 256 PF00017 0.278
MOD_CK1_1 122 128 PF00069 0.351
MOD_CK1_1 25 31 PF00069 0.723
MOD_CK1_1 275 281 PF00069 0.244
MOD_CK1_1 291 297 PF00069 0.221
MOD_CK1_1 44 50 PF00069 0.763
MOD_GlcNHglycan 11 14 PF01048 0.554
MOD_GlcNHglycan 16 19 PF01048 0.537
MOD_GlcNHglycan 20 23 PF01048 0.536
MOD_GlcNHglycan 271 277 PF01048 0.603
MOD_GlcNHglycan 290 293 PF01048 0.205
MOD_GlcNHglycan 320 323 PF01048 0.240
MOD_GlcNHglycan 52 55 PF01048 0.481
MOD_GSK3_1 14 21 PF00069 0.703
MOD_GSK3_1 22 29 PF00069 0.681
MOD_GSK3_1 286 293 PF00069 0.326
MOD_GSK3_1 340 347 PF00069 0.469
MOD_N-GLC_2 167 169 PF02516 0.551
MOD_NEK2_1 130 135 PF00069 0.400
MOD_NEK2_1 168 173 PF00069 0.248
MOD_NEK2_1 190 195 PF00069 0.358
MOD_NEK2_1 220 225 PF00069 0.493
MOD_NEK2_1 26 31 PF00069 0.685
MOD_NEK2_1 288 293 PF00069 0.288
MOD_NEK2_1 317 322 PF00069 0.468
MOD_PIKK_1 158 164 PF00454 0.273
MOD_PIKK_1 52 58 PF00454 0.646
MOD_PKA_2 220 226 PF00069 0.416
MOD_Plk_1 175 181 PF00069 0.206
MOD_Plk_1 22 28 PF00069 0.608
MOD_Plk_4 116 122 PF00069 0.557
MOD_Plk_4 143 149 PF00069 0.254
MOD_Plk_4 160 166 PF00069 0.250
MOD_Plk_4 170 176 PF00069 0.316
MOD_Plk_4 190 196 PF00069 0.120
MOD_Plk_4 241 247 PF00069 0.303
MOD_Plk_4 67 73 PF00069 0.638
MOD_ProDKin_1 275 281 PF00069 0.274
MOD_ProDKin_1 44 50 PF00069 0.679
TRG_DiLeu_BaEn_1 234 239 PF01217 0.365
TRG_ENDOCYTIC_2 182 185 PF00928 0.340
TRG_ENDOCYTIC_2 201 204 PF00928 0.517
TRG_ENDOCYTIC_2 240 243 PF00928 0.241
TRG_ENDOCYTIC_2 253 256 PF00928 0.241
TRG_ER_diArg_1 304 307 PF00400 0.407

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P222 Leptomonas seymouri 30% 100%
A0A0N1P9L0 Leptomonas seymouri 74% 100%
A0A0S4IU86 Bodo saltans 44% 100%
A0A0S4IYL3 Bodo saltans 29% 100%
A0A0S4IZ65 Bodo saltans 25% 100%
A0A0S4IZG7 Bodo saltans 25% 100%
A0A0S4J2G4 Bodo saltans 22% 100%
A0A1X0NPW5 Trypanosomatidae 56% 100%
A0A1X0P6F0 Trypanosomatidae 30% 100%
A0A1X0P6P9 Trypanosomatidae 29% 100%
A0A3Q8IB56 Leishmania donovani 28% 100%
A0A3R7K844 Trypanosoma rangeli 32% 100%
A0A3R7KEL4 Trypanosoma rangeli 56% 100%
A0A3S5H5Y3 Leishmania donovani 85% 99%
A1DI57 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 25% 100%
A2A3V2 Mus musculus 24% 100%
A2ASZ8 Mus musculus 26% 77%
A2CEQ0 Danio rerio 27% 77%
A2R5A0 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 23% 100%
A4H9X7 Leishmania braziliensis 29% 100%
A4H9X8 Leishmania braziliensis 29% 100%
A4HT75 Leishmania infantum 85% 99%
A4HY43 Leishmania infantum 28% 100%
A4RF23 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 24% 100%
A5PJZ1 Bos taurus 26% 76%
A6RF73 Ajellomyces capsulatus (strain NAm1 / WU24) 24% 100%
A6SL61 Botryotinia fuckeliana (strain B05.10) 24% 100%
A7ER02 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 23% 100%
B0G159 Dictyostelium discoideum 23% 77%
B4F8I5 Zea mays 25% 100%
B8ZHC9 Rattus norvegicus 24% 100%
C9ZUP8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
D0A0D8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AL65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 99%
E9ARX1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ARX2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
F4HW79 Arabidopsis thaliana 22% 100%
F4JU70 Arabidopsis thaliana 26% 100%
G2QNH0 Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) 28% 100%
K7VYZ9 Zea mays 26% 100%
O04619 Arabidopsis thaliana 22% 100%
O18757 Oryctolagus cuniculus 25% 76%
O22342 Gossypium hirsutum 28% 94%
O46373 Oryctolagus cuniculus 29% 100%
O49447 Arabidopsis thaliana 29% 96%
O65023 Arabidopsis thaliana 25% 95%
O94502 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 85%
O97470 Dictyostelium discoideum 29% 100%
P02722 Bos taurus 29% 100%
P02723 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 29% 100%
P04709 Zea mays 29% 94%
P04710 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P05141 Homo sapiens 30% 100%
P0C546 Rattus norvegicus 24% 100%
P12235 Homo sapiens 28% 100%
P12236 Homo sapiens 28% 100%
P12857 Zea mays 30% 94%
P16260 Homo sapiens 22% 100%
P18238 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P18239 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P25083 Solanum tuberosum 28% 94%
P27080 Chlamydomonas reinhardtii 29% 100%
P27081 Solanum tuberosum 27% 94%
P29518 Zea mays 23% 83%
P31167 Arabidopsis thaliana 26% 95%
P31691 Oryza sativa subsp. japonica 30% 95%
P31692 Parachlorella kessleri 31% 100%
P32007 Bos taurus 28% 100%
P40941 Arabidopsis thaliana 28% 94%
P48962 Mus musculus 29% 100%
P49382 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 28% 100%
P51881 Mus musculus 29% 100%
Q000K2 Tachyglossus aculeatus aculeatus 29% 100%
Q01888 Bos taurus 24% 100%
Q05962 Rattus norvegicus 29% 100%
Q05AQ3 Xenopus tropicalis 28% 100%
Q09073 Rattus norvegicus 29% 100%
Q09188 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
Q0CEN9 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 23% 100%
Q0P483 Danio rerio 26% 100%
Q0UUH1 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 26% 100%
Q0V7M4 Bos taurus 28% 77%
Q12251 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
Q19529 Caenorhabditis elegans 26% 68%
Q1E7P0 Coccidioides immitis (strain RS) 24% 100%
Q1ECW7 Danio rerio 21% 100%
Q26365 Drosophila melanogaster 28% 100%
Q27238 Anopheles gambiae 29% 100%
Q29RM1 Bos taurus 23% 100%
Q2UCW8 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 24% 100%
Q2YDD9 Bos taurus 29% 100%
Q3V132 Mus musculus 29% 100%
Q41629 Triticum aestivum 28% 100%
Q41630 Triticum aestivum 28% 100%
Q4QDK0 Leishmania major 26% 100%
Q4QIN9 Leishmania major 85% 99%
Q4R8M0 Macaca fascicularis 30% 100%
Q4X022 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 100%
Q54DU1 Dictyostelium discoideum 24% 100%
Q54MZ4 Dictyostelium discoideum 27% 83%
Q5AVW1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 24% 100%
Q5IS35 Macaca fascicularis 23% 100%
Q5NVC1 Pongo abelii 23% 100%
Q5PQ27 Xenopus laevis 26% 100%
Q5R5A1 Pongo abelii 30% 100%
Q5U3V7 Danio rerio 23% 100%
Q5XH95 Xenopus tropicalis 26% 71%
Q5XHA0 Xenopus tropicalis 28% 77%
Q628Z2 Caenorhabditis briggsae 26% 68%
Q66L49 Danio rerio 28% 76%
Q6DHS9 Danio rerio 24% 100%
Q6GQS1 Mus musculus 26% 78%
Q6KCM7 Homo sapiens 28% 77%
Q6NUK1 Homo sapiens 26% 76%
Q6NYZ6 Danio rerio 27% 77%
Q6QRN9 Sus scrofa 27% 100%
Q7PQV7 Anopheles gambiae 28% 100%
Q7S2H8 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 100%
Q7T0U6 Xenopus laevis 28% 77%
Q7ZY36 Xenopus laevis 28% 77%
Q7ZYD5 Xenopus laevis 26% 70%
Q8BMD8 Mus musculus 26% 76%
Q8BVN7 Mus musculus 25% 100%
Q8C0K5 Mus musculus 23% 100%
Q8K3P6 Rattus norvegicus 26% 77%
Q8LB08 Arabidopsis thaliana 25% 100%
Q8N5S1 Homo sapiens 23% 98%
Q8SQH5 Bos taurus 29% 100%
Q8TFH2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q8WUT9 Homo sapiens 23% 100%
Q9BV35 Homo sapiens 26% 77%
Q9DAM5 Mus musculus 24% 100%
Q9FI43 Arabidopsis thaliana 26% 74%
Q9FI73 Arabidopsis thaliana 23% 100%
Q9FLS8 Arabidopsis thaliana 26% 76%
Q9FM86 Arabidopsis thaliana 25% 100%
Q9H0C2 Homo sapiens 30% 100%
Q9HC21 Homo sapiens 23% 100%
Q9LY28 Arabidopsis thaliana 27% 76%
Q9M024 Arabidopsis thaliana 26% 87%
Q9SUV1 Arabidopsis thaliana 26% 92%
V5BTC0 Trypanosoma cruzi 52% 100%
V5BWX9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS